Sea surface salinity (SSS) variability at mesoscales has become an important research topic in recent decades, thanks to satellite missions enabling observations of SSS with global capacity and mesoscale resolution. Here, we analyze the near-global data of the Aquarius/SAC-D along-track SSS, focusing on the slopes of SSS variance spectra in the mesoscale range from 180 to 430 km. In the vast extratropics, the spectral slope is close to −2, indicating a dynamical regime for the inverse cascade of depth-integrated energy identified by the surface quasi-geostrophic theory. However, the spectral slopes in regions near the mouths of the largest rivers are steeper than −2, reaching −3, possibly due to the large river freshwater flux. In addition, data from high-resolution thermosalinograph are used to validate satellite measurements and show good consistency in terms of SSS variance spectral slopes.