To study and optimize the crushing chamber performance of the gyratory crusher, the impact of the crushing chamber shape on the gyratory crusher performance is explored in this paper. The discrete element method (DEM) analysis model of ore particle and gyratory crusher is established, where ore particle crushing is realized based on the Ab-t10 breakage model, and its validity is verified based on actual working conditions. On this basis, the performance of the gyratory crusher under different crushing chamber shapes is studied by combining the DEM simulation with the response surface method (RSM), and the performance prediction model is obtained based on multiple nonlinear regression. Further, the productivity is considered as the main optimization objective, the mass percentage of effective particles and the crushing force are used as auxiliary optimization objectives. The multi-objective optimization is implemented and the optimized effects are analysed by DEM simulation, and the optimized quartic equation coefficients of the concave curve are obtained. Finally, the results show that the productivity, mass percentage of effective particles, and crushing force are increased to varying degrees. Meanwhile, the clogged layer area increases to some extent, which promotes the crushing of ore particles.