At the quantum many-body level, atom-light interfaces generally remain challenging to solve for or understand in a non-perturbative fashion. Here, we consider a waveguide quantum electrodynamics model, where two-level atoms interact with and via propagating photons in a one-dimensional waveguide, and specifically investigate the interplay of atomic position disorder, multiple scattering of light, quantum nonlinear interactions and dissipation. We develop qualitative arguments and present numerical evidence that such a system exhibits a many-body localized~(MBL) phase, provided that atoms are less than half excited. Interestingly, while MBL is usually formulated with respect to closed systems, this system is intrinsically open. However, as dissipation originates from transport of energy to the system boundaries and the subsequent radiative loss, the lack of transport in the MBL phase makes the waveguide QED system look essentially closed and makes applicable the notions of MBL. Conversely, we show that if the system is initially in a delocalized phase due to a large excitation density, rapid initial dissipation can leave the system unable to efficiently transport energy at later times, resulting in a dynamical transition to an MBL phase. These phenomena can be feasibly realized in state-of-the-art experimental setups.
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