We present a semi-rigorous justification of Bekenstein's Generalized Second Law of Thermodynamics applicable to a universe with black holes present, based on a generic quantum gravity formulation of a black hole spacetime, where the bulk Hamiltonian constraint plays a central role. Specializing to Loop Quantum Gravity, and considering the inspiral and post-ringdown stages of binary black hole merger into a remnant black hole, we show that the Generalized Second Law implies a lower bound on the non-perturbative LQG correction to the Bekenstein-Hawking area law for black hole entropy. This lower bound itself is expressed as a function of the Bekenstein-Hawking area formula for entropy. Results of the analyses of LIGO-VIRGO-KAGRA data recently performed to verify the Hawking Area Theorem for binary black hole merger are shown to be entirely consistent with this Loop Quantum Gravity-induced inequality. However, the consistency is independent of the magnitude of the LQG corrections to black hole entropy, depending only on the negative algebraic sign of the quantum correction. We argue that results of alternative quantum gravity computations of quantum black hole entropy, where the quantum entropy exceeds the Bekenstein-Hawking value, may not share this consistency.