Quality Of Life In Stages Research Articles

A meta-analysis of randomized controlled trials comparing breast-conserving surgery and mastectomy in terms of patient survival rate and quality of life in breast cancer.

The study aimed to assess the effects of breast-conserving surgery (BCS) versus mastectomy on survival and quality of life in Stages I, II, and III breast cancer, providing solid evidence for clinical decisions. We conducted a meta-analysis of randomized controlled trials on breast cancer treatments, searching databases such as PubMed and the Cochrane Library to compare BCS, and mastectomy's effects on survival and quality of life. A combined total of 16 734 patients in the control group and 17 435 patients in the experimental group were included in this analysis. This meta-analysis used RevMan 5.3 (Cochrane Collaboration, Copenhagen, Denmark) software for analysis. Our meta-analysis of 34 169 patients from 11 studies showed that BCS significantly reduced the overall recurrence rate at a median follow-up of 29 months, with a mean difference of 1.27 and a 95% confidence interval of 1.19-1.36, strongly supporting its effectiveness (P < .00001). Furthermore, our analysis found no significant increase in 5-year local recurrence rates for BCS versus mastectomy, indicating its long-term effectiveness with a mean difference of 1.13 (95% confidence interval: [1.03, 1.24], P = .01). Additionally, there was a notable decrease in tissue ischaemic necrosis among patients who had received BCS, with a mean difference of 0.37 (95% confidence interval: [0.33, 0.42], P < .00001), underscoring its benefits and long-term viability. BCS resulted in fewer cases of tissue ischaemic necrosis and higher body image scores compared with mastectomy, suggesting that it is a preferable option for better cosmetic outcomes and potentially favourable effects on prognosis and quality of life.

Association between Nutritional Status and Quality of Life in Stages 3 to 5 Chronic Kidney Disease Patients

Association between Nutritional Status and Quality of Life in Stages 3 to 5 Chronic Kidney Disease Patients

Efficacy of biofeedback on quality of life in stages I and II pelvic organ prolapse: A Pilot study

ObjectivesPelvic organ prolapse (POP) is a prevalent disorder which seriously affects the sufferer’s quality of life. The main goal of this study was to evaluate biofeedback impact on quality of life in women with mild to moderate POP. Study design40 females in stages I and II POP were allocated into 2 groups. One group received pelvic floor muscle exercise and lifestyle advice in addition to biofeedback twice a week for 4 weeks, while the other received a lifestyle advice sheet and pelvic floor muscle exercise without biofeedback. A valid Persian version of P-QOL questionnaire was applied to assess the patients̕ quality of life at baseline, 4 weeks and 12 weeks follow up. Pressure biofeedback and Physical examination were also performed in order to determine pelvic floor muscle strength and staging of the prolapse, respectively. Collected data were analyzed by mixed ANOVA test using SPSS 22. ResultsBiofeedback improved the quality of life in seven of nine P-QOL domains. However, it had no significant impact either on pelvic floor muscle strength or on the stage of the prolapse. ConclusionBiofeedback could be considered as a non-invasive treatment leading to quality of life promotion in women with stages I and II POP.

Cáncer colorrectal

EpidemiologyColorectal cancer (CRC) is the most common malignancy in Spain and the third worldwide. Approximately 80% are sporadic, 20% exhibit familial clustering and 5% occur within a well-defined hereditary syndrome. PathogenyAlthough sometimes CRC originates from a previously healthy colonic mucosa, in most cases CRC arises from malignant transformation of an adenomatous polyp. DiagnosisScreening in average-risk populations has proven to decline mortality by 30-70% and to be cost-effective. Colonoscopy is the most sensitive and specific method but its limited acceptance and high cost have positioned immunological faecal occult blood testing as the initial procedure in screening programs. TreatmentSurgery remains the most effective treatment preceded by chemoradiotherapy in locally advanced rectal cancer. Chemotherapy has been shown to improve overall survival and quality of life in stages III and IV. In this review we update the most relevant molecular, epidemiological, diagnostic and therapeutic aspects of this entity.

Evaluación retrospectiva de la sustitución valvular tricúspide en el tratamiento de las valvulopatías adquiridas

Acquired tricuspid valvular heart disease maintains interest among cardiovascular surgeons because we now have an undisputed technique that has definitely solved the ``tricuspid challenge". the disappearance of rheumatic disease in developed countries has ignored our failure, which will be evident in developing countries when they have access to the world's advanced diagnostic and surgical techniques.In the 1970s and 1980s in spain, we identified this problem and faced it with a solution that we understood better, though not without mistakes, mainly the lack of identification of groups of risk before surgery: pulmonary hypertension with fixed high resistances versus rheumatic poly-valvulitis in young patients in short evolution.Our results matched those of other groups, with late mortality growing exponentially 10 years after surgery, which highlighted the risk of tricuspid valve replacement. it also occurs in the conservative attitude to annuloplasty repair that frequently leads to reoperation because of failure of the repair or an unacceptable quality of life in stages III and IV.We argue for the indication of mechanical valves for surgery involving tricuspid valve replacement when other prostheses in the left position were or need to be implanted. unlike other groups, we believe that the deterioration of a bioprosthesis, especially in younger patients, necessitates a second and often a third intervention.The tricuspid challenge will reappear in developing countries.