Quality Of Life In Obese Women Research Articles

Improvement of sleep by resistant dextrin prebiotic in type 2 diabetic women coincides with attenuation of metabolic endotoxemia: involvement of gut-brain axis.

Resistant dextrin, as a prebiotic and functional food, may possess favorable effects in type 2 diabetes. This study was conducted to assess whether supplementation with resistant dextrin can improve sleep and quality of life in obese type 2 diabetic women. In this randomized controlled trial, female obese type 2 diabetic patients (n=76) were randomly assigned into intervention group (n=38) and placebo group (n=38), and received 10 g day-1 of resistant dextrin or maltodextrin for a period of 8 weeks, respectively. Sleep quality and quality of life (QOL) were assessed by Pittsburgh Sleep Quality Index (PSQI) and SF-36 health survey, respectively. Fasting blood samples were driven to measure serum bacterial endotoxin, fasting blood sugar, glycosylated hemoglobin (HbA1c), pro-inflammatory/anti-inflammatory biomarkers (IL-18, IL-6, IL-10, TNF-α), and biomarkers of hypothalamic-pituitary-adrenal (HPA) axis function [tryptophan (TRP), adrenocorticotropic hormone (ACTH), kynurenine (KYN), cortisol]. Supplementation with resistant dextrin improved sleep (P< 0.001) and QOL (P< 0.001) significantly. It also caused a significant decrease in levels of endotoxin, HbA1c, IL-18, IL-6, TNF-α and a significant increase in IL-10 levels. Significant and positive correlations were found between endotoxin (r=0.488, P=0.003), IL-6 (r=0.436, P=0.008), IL-18 (r=0.475, P=0.003), cortisol (r=0.545, P=0.048), KYN/TRP (r=0.527, P=0.001), and PSQI scores. It is concluded that resistant dextrin improves sleep and QOL in obese women with type 2 diabetes. Its beneficial effects may be attributed in part to modulation of glycemia, metabolic endotoxemia and subsequently a decrease in biomarkers of inflammation and HPA axis activity. © 2022 Society of Chemical Industry.

Quality of Life in Obese Patients- Gender Differences

Objective: To assess the gender differences in Quality of Life (QoL) in patients with obesity.Methods: A descriptive survey was conducted among 220 patients (110 males and 110 females) attendingOPDs of a tertiary care hospital, Kerala using a standardized questionnaire SF 36 (version 1.0). Conveniencesampling technique was usedFindings: The major co morbidity found among the subjects was diabetes mellitus ie.72 (65.5%) in malesand 56 (50.9 %) in females .The percentage of males as per the obesity category i.e. Class I, II, III were 40,36.5 and 23.5, where as that of the females were 60.9, 31.8 and 7.3 respectively. The mean QoL was found tobe slightly above average for males (51.19+/- 12.54) than the females (48.79 +/- 12.86.). Of the 8 domains,the QoL in males were found to be poor in two domains where as in females it was poor in four domains.The physical component scores (PCS) were found to be better in both sexes i.e. 55.89 +/- 19.07 and 52.68+/-21.04 compared to the mental component scores (MCS) i.e. 50.03+/-13.35 and 48.84+/-14.01.Conclusion: The study has highlighted a poor QoL in obese women especially in the mental componentscores in spite of a higher proportion of morbid obesity and DM in men.

Motivational interviewing in obese women with polycystic ovary syndrome – a pilot study

Lifestyle intervention is first line treatment in obese women with polycystic ovary syndrome (PCOS). The effect of motivational interviewing (MI) as add on to standard advice (SA) on weight loss and quality of life (QoL) has not been evaluated in obese women with PCOS. We aimed to examine whether MI as add on to SA induced higher weight loss and improved QoL in obese women with PCOS. Thirty-seven obese women with PCOS (BMI ≥30 kg/m2) were randomized to MI + SA (n = 19) vs. SA (n = 18) for six months. Anthropometric measures (BMI, waist) and questionnaires (World Health Organization-5 (WHO-5), Major Depression Index (MDI), Short Form-36 (SF-36) and PCOS-Questionnaire (PCOS-Q)) were performed at baseline and at follow-up, www.clinicaltrials.gov, NCT02924025. Twenty-eight (14 + 14) women completed the study. At baseline, 24/28 women had WHO-5 scores <67 and 12/28 women had MDI scores indicating depression. Changes in weight and QoL were similar between MI + SA vs. SA group. However, WHO-5 (p=.028) and MDI (p=.008) scores improved significantly in the 12/24 women with MDI scores indicating depression. MI as add on to SA did not improve QoL or weight loss. Obese women with PCOS had low QoL.