Objective To investigate the effect of fatigue of witness and quality of external chest compression according to the requirement of 2010 guidelines for cardiopulmonary resuscitation.Methods A total of 96 volunteer participants in basic life support training course were recruited from the College of Automation in the Guangdong University of Technology.All volunteers were randomly (random number) divided into two groups:2010 guidelines group and 2005 guidelines group.The instructors explained the procedures of external chest compression as required as per different guidelines and then guided the trainees to practice CPR as they learned.Trainees,who completed entire training course and passed the examination,were eligible into the study.In the final investigation,trainees of two groups were asked to perform 8-min continuous external chest compression of CPR.The demographics of trainees such as age,gender,tallness,body weight,heart rate (HR),systolic blood pressure (SBP),diastolic blood pressure (DBP),blood lactate and rating of perceived exertion (RPE) were recorded before and immediately after CPR.Results Of them,42 and 39 subjects were finally enrolled into 2010 group and 2005 group,respectively.There was no statistically significant difference in basic status of trainees between two groups.After 8-min external chest compression,trainees in 2010 guidelines group brought about greater compression depth and rate than those in 2005 guidelines group (P <0.05).On the contrary,HR,SBP and lactate were also higher in 2010 guidelines group than those in 2005 guidelines group (P < 0.05).Furthermore,the quality of external chest compression declined to a sub-optimal pattern [(47.63 ±7.87) mm vs.(40.26 ±5.93) mm,P =0.000] even though RPE value still indicated a status of relative easiness [(11.35 ± 1.29) vs.(10.54 ± 1.74),P =0.000].Conclusions When the recommendation of 2010 guidelines for cardiopulmonary resuscitation was followed,trainees in current study could perform optimal compression depth and rate even in the occurrence of increased fatigue.Therefore,study on this manikin showed it had better to conduct rescuer-exchange in every minute so as to get high quality of external chest compression. Key words: 2010 guideline for cardiopulmonary resuscitation; Quality of chest compression; Degree of fatigue; Manikin
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