Quadriceps Muscle Strength Research Articles

Responders COPD patients to two different home-based rehabilitation programs: a blind, randomized, and controlled clinical trial

Purpose To verify the number of patients with COPD responders to two different home-based rehabilitation programs. Methods This was a blinded, randomized, and controlled clinical trial. The six-minute step test (6MST), one-minute sit-stand test (1-MSTST), six-minute walk test (6MWT), COPD Assessment Test (CAT), modified Medical Research Council (mMRC), monitoring of physical activity in daily life, and isometric quadriceps muscle strength were assessed pre- and post-intervention. A total of 50 patients were randomized into two groups: hybrid rehabilitation (HR), consisting of supervised physical exercise once a week associated with exercises at home, and home-based rehabilitation (HBR), which consisted of a single meeting for guidance related to the physical exercises prescribed. Results Significant differences (p < 0.05) were observed in the following parameters post-intervention and between groups: 6MST (HR = 67.1 ± 25.7 to 93.5 ± 37.2; HBR = 69.6 ± 19.5 to 82.3 ± 25.2 steps), 6MWT (HR = 367.7 ± 84 to 433.2 ± 88.8; HBR = 396.2 ± 97.2 to 418.3 ± 83.8 m), CAT (HR = 19.5 ± 6.8 to 13.0 ± 7.8; HBR = 17.0 ± 7.6 to 15.0 ± 10 points), and mMRC (HR = 2[2-3] to 1[1-2]; HBR = 2[2-3] to 2[1-3] points). However, the response rate was 80% in the HR and 50% in the HBR. Conclusion Both pulmonary rehabilitation programs improved physical capacity, alleviated dyspnea, and reduced the impact of the disease on health status; however, the number of responders was higher in the HR.

Joint Effusion at 3 Months After Anterior Cruciate Ligament Reconstruction: Its Risk Factors and Association With Subsequent Muscle Strength and Graft Remodeling.

Joint effusion at 3 months after anterior cruciate ligament (ACL) reconstruction is a risk factor for ACL reinjury. However, factors associated with joint effusion at 3 months postoperatively and the effect of joint effusion on subsequent quadriceps muscle strength and graft remodeling remain unknown. To identify factors associated with joint effusion and investigate the association between joint effusion and quadriceps muscle strength and graft remodeling in the postoperative period. Case-control study; Level of evidence, 3. In this retrospective multicenter study, the medical records of patients who underwent single-bundle ACL reconstruction between 2015 and 2021 were reviewed. The study included the data of 174 patients (mean age, 23.5 ± 10.6 years). Demographic data, including sex, age at surgery, time from injury to surgery in months, body mass index, preinjury Tegner activity score, presence of meniscus, and chondral injuries, were collected. Magnetic resonance imaging was performed 3 months postoperatively. Joint effusion was defined as grade 3 (range of grades, 0-3) according to the ACL Osteoarthritis Score. Isokinetic strength testing was performed at 60 deg/s, while the limb symmetry index (LSI) of quadriceps strength was evaluated at 6 months postoperatively. Moreover, graft remodeling was evaluated using magnetic resonance imaging-derived signal intensity ratio (SIR) measures at 1 year postoperatively. The authors used multivariate logistic and linear regression analyses to identify the factors influencing joint effusion at 3 months and those associated with postoperative quadriceps strength LSI and SIR values, respectively. Greater preinjury Tegner activity scores (odds ratio, 1.59; 95% CI, 1.08 to 2.34; P = .02) increased the odds of joint effusion at 3 months postoperatively. Multivariable linear regression analysis revealed that joint effusion (β = -23.8; 95% CI, -36.0 to -11.7; P < .001) was an independent factor associated with LSI of the quadriceps. Furthermore, joint effusion (β = 1.33; 95% CI, 0.53 to 2.14; P = .001) was associated with a higher SIR value of the reconstructed graft. The preinjury Tegner activity score was a factor associated with joint effusion at 3 months postoperatively, and joint effusion was associated with subsequent muscle weakness and delayed graft remodeling.

Pericapsular nerve group (PENG) block versus supra-inguinal fascia iliaca (SIFI) block for functional outcome in patients undergoing hip surgeries – A randomised controlled study

Background and Aims: In hip surgeries, the pericapsular nerve group (PENG) block and supra-inguinal fascia iliaca (SIFI) block are commonly employed perioperative regional analgesia techniques. This study aimed to compare functional outcomes regarding quadriceps muscle strength and weight-bearing capacity between PENG and SIFI blocks after hip surgery. Methods: In this single-centre, double-blinded, randomised trial, 60 patients undergoing hip surgeries under subarachnoid block were randomised into either Group P (PENG block) or Group S (SIFI block). Blocks were administered under ultrasound guidance with 30 mL of 0.2% ropivacaine and 4 mg dexamethasone. Functional mobility was assessed 24 and 48 h postoperatively by measuring quadriceps strength and maximum weight-bearing capacity. Analgesic efficacy was also evaluated by comparing visual analogue score (VAS) scores at 24 h, total opioid consumption over 24 h, and duration of analgesia. Statistical analysis included Student’s t-test, Chi-square, and Z-test as appropriate, with statistical significance set at P &lt; 0.05. Results: Group P demonstrated significantly higher quadriceps-muscle strength at 24 h (P = 0.025) and 48 h (P = 0.002) post surgery. More patients in Group P achieved superior weight-bearing grades at 24 h (P = 0.002) post surgery compared to Group S. VAS scores were significantly lower in Group P at 24 h post surgery (P = 0.006). Group P also showed a prolonged duration of analgesia (P = 0.019) and lower mean opioid consumption (P = 0.001) compared to Group S. Conclusion: The PENG block may be superior to the SIFI block in terms of functional outcomes with better quadriceps strength, enhanced weight-bearing, and provision of more effective postoperative analgesia in hip surgery patients.

Assessing the effectiveness of EMG-biofeedback on an isometric strengthening program in individuals with multiple sclerosis

The purpose of this randomized controlled experiment was to assess the efficacy of electromyographic biofeedback as an adjunct treatment to isometric exercise in MS patients. 20 patients took part in the research. Patients were randomly assigned to one of two groups: biofeedback (n = 10) or control (n = 10). Over a period of six weeks, participants followed their individual workout plans five days a week. The control group just received an exercise program, whereas the biofeedback group received an electromyographic biofeedback-guided isometric exercise program. The study's endpoints included quadriceps strength, functional impairment, and pain. At baseline, Week 2, Week 4, Week 6, and at a follow-up at Week 12, measurements were obtained. In between-group comparisons, the pain intensity, maximal isometric quadriceps strength and functional disability in the biofeedback group was substantially larger than that of the control group at the end of the sixth week (p< 0.05). For MS patients with quadriceps muscle problems, adding electromyographic biofeedback (EMG-BF) to a 6-week isometric exercise program showed to boost quadriceps muscle strength more than the exercise program alone. The findings, however, should be taken with care owing to research design constraints.

Comparison of Analgesic Efficacy between Ultrasound-guided Supra-inguinal Fascia Iliaca Block and Pericapsular Nerve Group Block following Total Hip Arthroplasty: A Randomized Controlled Trial.

The effectiveness of pericapsular nerve group (PENG) block versus suprainguinal fascia iliaca block (SFIB) for pain relief after hip arthroplasty is a topic of ongoing debate. This study aimed to examine the association of PENG block with lower consumption of opioids during the first 24 hours following surgery compared to SFIB. In this single-center, double-blind, randomized controlled trial, 60 patients scheduled for an elective posterior approach to total hip arthroplasty (THA) were randomized according to two groups: ultrasound-guided PENG block (PENG group) or SFIB (SFIB group). The 24-hour consumption of intravenous fentanyl was the primary outcome. Secondary outcomes included perioperative consumption of intravenous fentanyl, pain scores, sensorimotor function, and functional measures. No significant intergroup difference was observed in 24-hour total fentanyl consumption (SFIB group: 117.4±99.8 μg, PENG group: 145.9±122.7 μg; mean difference: 22.6 μg [95% confidence interval -36.6 to 81.8]; P=0.45). No statistically significant difference in terms of fentanyl consumption in intraoperative, post-anesthetic care unit, at 6-hour and 48-hour postoperatively was observed between the two groups. No statistically significant differences in scores for rest and dynamic pain for all aspects of hip joint and surgical incision were observed between the groups (P>0.05). Better cutaneous sensory perception in the hip region and 12-hour postoperative quadriceps muscle strength at 90° were observed in the PENG group compared with the SFIB group (P<0.05). Compared to SFIB, the addition of PENG block to multimodal analgesia did not reduce fentanyl consumption or pain scores after posterior approach THA.

Effect of Sensorimotor Rehabilitation Protocol on Vertical Ground Reaction Force and Loading Rate in Men with Patellofemoral Pain: A Randomized Controlled Trial

ntroduction: The change of vertical ground reaction force and loading rate rate is a important factor in causing patellofemoral pain (PFP). The aim of this study was the effect of sensory-motor exercises on the vertical ground reaction force and loading rate in patients with PFP when stair descent. Methods: A total of 30 patients with PFP participated and were randomly divided into two experimental and control groups (15 subject in each group). Over a period of twelve weeks, the experimental group engaged in sensorimotor exercises, while the control group did not receive any therapeutic intervention. Pain intensity, fear of movement, quadriceps muscle strength, knee flexion angle, components of vertical ground reaction force and loading rate were evaluated in two stages pre-test and post-test. For data analysis SPSS 16 software and the covariance statistical method were used to compare the results between groups, and the significance level was considered 0.05. Results: The analysis of covariance analysis indicated that sensorimotor exercises in the experimental group compared to the control group had a significant difference in reduced pain (P &lt;0.001), reduced fear of movement (P &lt;0.001), incresed quadriceps muscle strength (P &lt;0.001), incresed knee flexion angle (P &lt;0.001), components of vertical ground reaction force (P &lt;0.001), and reduced loading rate (P &lt;0.001). Conclusion: The finding suggest that the experimental group experienced a boost in in quadriceps muscle strength, leading to diminished pain and fear of movement, an increase in knee flexion angle, and enhanced active shock absorption. Consequently, there was an increase in both peak forces while the loading rate and valley force decreased.

Effects of Nordic Hamstring Exercise on knee joint muscle strength in adolescent soccer players. A pilot study

Objective: Given the emerging imbalances in knee stabilising muscle strength, the aim of the study was to determine whether performing a single NHE intervention would alter the isometric strength of the knee flexor muscles (HAM). Material and Methodology: A group of 56 players of a youth football team (age range 13-16 years), were recruited for a pilot study. The group involved healthy players, training football at the central junior level. After meeting the inclusion criteria inclusion, 32 players were enrolled into the study. Participants were randomly allocated to a study group (A) and a control group (B). In the study group, the intervention consisted of a single NHE exercise in the form of a two series of trunk slumps, eight repetitions each. The control group performed one series of of forward trunk bends, five repetitions each. Participants (group A and B) were tested on the ForceFrame platform before the procedure experiment and immediately after the intervention was performed. Maximum force of the knee extensors (QUAD) and knee flexors (HAM) was measured. Results: Statistical analysis of the results indicated that maximal HAM muscle strength increased after a single NHE intervention (p = 0.04) relative to the control group. At the same time, after the intervention, there was no increase in the strength of the Quadriceps muscles (extensors of the knee joint) relative to the control group. Conclusions: The results obtained indicate that a single performance of the NHE exercise has the effect of increase in the maximum isometric strength of the HAM muscles. This increase, although not statistically significant, correlated with no change in quadriceps muscle strength. The work is pilot study and further research may have benefits in maintaining the balance between the two muscle groups, i.e. HAM and QUAD, which contributes to the prevention of musculoskeletal injuries.

The effectiveness of vitamin D supplementation in patients with end-stage knee osteoarthritis: Study protocol for a double-blinded, randomized controlled trial.

Osteoarthritis (OA) knee is one of the most common chronic degenerative conditions that imposes clinical and economic burdens on individuals and societies worldwide. Previous studies showed vitamin D levels correlated positively with lean muscle mass and grip strength, implying that vitamin D supplementation may improve muscle health in knee OA subjects. This randomized controlled trial (RCT) aims to compare the effects of vitamin D supplementation on knee muscle strength, physical function, pain, and sarcopenia status in patients with end-stage knee OA. Patients and outcome assessors will be blinded to group allocation. Fifty-six end-stage knee OA patients with vitamin D insufficiency fulfilling our inclusion criteria will be invited to participate in this study. Patients will be randomly assigned to take vitamin D supplementation (4,000 IU capsule daily) or placebo for six months. Measurements will be taken at baseline, three and six-month after the commencement of the vitamin D supplement, and 6-month after the interventional period. The primary outcome includes the isometric quadriceps and hamstring muscle strength measured by a hand-held dynamometer. Secondary outcomes include pain, performance-based and self-reported physical function and sarcopenia status. The success of this study will provide scientific evidence of whether the relatively cheap and well-tolerated vitamin D supplement can improve quadriceps muscle strength, physical function, pain symptoms, and sarcopenia status of this increasingly large population for end-stage knee OA patients. The study has great clinical significance given Hong Kong's lengthy and growing waiting list for complete knee replacement procedures. Trial registration: The trial was registered on clinicaltrials.gov (NCT05981534) on 31st July 2023.

Effect of serum 25-hydroxyvitamin D level on quadriceps strength: a systematic review and meta-analysis

BackgroundVitamin D deficiency has been linked to poor muscle function, cartilage degeneration, and the development of knee osteoarthritis. However, the impact of serum 25-hydroxyvitamin D [25(OH)D] level on quadriceps muscle strength remains inconclusive, largely due to variations in study designs, differences in study populations, and the influence of confounding factors such as co-supplementation with other vitamins. The existing literature presents mixed findings, highlighting the need for a comprehensive evaluation of the available evidence.PurposeThis systematic review and meta-analysis aim to summarise.Study designSystematic review; Level of evidence, 4.MethodsSearches were conducted using Medline (Ovid), Embase (Ovid), CINAHL (EBSCOhost), and SPORTDiscus (EBSCOhost), which aimed to summarise recent (published after 2000 and before March 1st, 2024) studies reporting the effects of serum 25(OH)D levels on quadriceps strength. Appraisal tool for Cross-Sectional Studies (AXIS) for cross-sectional studies and Quality in Prognosis Studies (QUIPS) for longitudinal studies. Results from the AXIS and QUIPS tools were used for GRADE quality assessment. The review was carried out using PRIMSA guidelines and registered in PROSPERO (ID: CRD42022313240).ResultsFour hundred studies were screened and 28 studies with 5752 participants were included. 28 published studies (24 cross-sectional and 4 longitudinal) were identified. Key results supported the significant positive correlation between serum 25(OH)D levels and isokinetic quadriceps strength at 180°/s in elderly and athletic populations with a correlation coefficient of 0.245 (95%CI: 0.078–0.398, p = 0.004). However, no significant correlation was found with isometric quadriceps strength or isokinetic strength at 60°/s (r = 0.190, p = 0.085). There was only a weak negative correlation with MVC.ConclusionThis review found a statistically significant positive correlation between serum 25(OH)D levels and isokinetic quadriceps strength. This has important clinical implications, especially in the elderly cohort, with higher 25(OH)D levels being associated with a reduced incidence of falls and fragility fractures.

Are pelvic floor muscle function, quadriceps femorismuscle, gluteus mediusmuscle, hand grip strength and functional performance affected by incontinence types in elderly people with urinary incontinence?

The aim of this study is to examine the relationship between incontinence type and pelvic floor muscle function, gluteus mediusmuscle, quadriceps femorismuscle, hand grip strength, functional performance and balance in elderly people with incontinence. This cross-sectional study was conducted in a nursing home with 78 elderly people with stress (SUI, n: 20), urgency (UUI, n: 27) and mixed (MUI, n: 31) urinary incontinence. "Urogenital Distress Inventory-6, Incontinence Impact Questionnaire Form-7, Overactive Bladder-8" were used to evaluate incontinence symptoms and severity. Superficial electromyography was used to evaluate the function of the PFM. A hand dynamometer was used to evaluate hand grip strength, and a digital manual muscle tester was used to evaluate quadriceps femoris (QF) and gluteus medius muscle strength. Short Physical Performance Battery and Time Up and Go Test were performed for functional performance. There was no significant difference between PFM contraction and relaxation functions, gluteus medius, QF muscle strength, functional performance (p > 0.05) but hand grip strength was highest in the group with UUI (ptotal: 0.022).The group with the highest rate of low hand grip strength is MUI (38.7%). A weak positive correlation was found between QF muscle strength and PFM Work Average value in the MUI group (r: 0.370, p: 0.048). In the MUI group, a moderate positive correlation was found between hand grip strength and gluteus medius muscle strength (r: 0.499, p: 0.005). Our findings show that hand grip strength is related to the type of incontinence in the elderly people. The average hand grip strength was highest in the elderly people with UUI. Additionally, there was a positive relationship between gluteus medius and hang grip strength in MUI. It may provide guidance for evaluation and risk factors in elderly people with incontinence.

The Role of Cystic Fibrosis Transmembrane Conductance Regulator in Skeletal Muscle Contractile Function

Purpose: Genetic mutations in cystic fibrosis (CF) result in CF transmembrane conductance regulator (CFTR) dysfunction. CFTR is expressed in human skeletal muscle; its effect on skeletal muscle abnormalities is unknown. The study objective is to investigate the role of CFTR in skeletal muscle contractile function. Methods: We conducted a prospective, cross-sectional study comparing 34 adults with minimal and 18 with residual function CFTR mutations, recruited from Toronto Adult CF Centre, St. Michael's Hospital, Unity Health Toronto. Quadriceps, biceps brachii, and handgrip strength was measured with dynamometers; leg muscle power with the stair climb power test. Quadriceps muscle contractility was determined by quadriceps muscle strength normalized to quadriceps muscle size, measured with ultrasound images. Multivariable regression was used for analysis. Results: People with residual function CFTR mutations had higher quadriceps muscle torque normalized to quadriceps layer thickness and to rectus femoris cross-sectional area by 27.5 Nm/cm [95% CI (2.2, 52.8) Nm/cm, P = .034] and 5.6 Nm/cm2 [95% CI (0.3, 10.9) Nm/cm2, P = .041], respectively, compared with those with minimal function CFTR mutations. There were no differences in quadriceps muscle torque (P = .58), leg muscle power (P = .47), biceps brachii muscle force (P = .14), or handgrip force (P = .12) between the 2 mutation groups. Conclusions: CFTR protein may play a role in muscle contractility, implying a limited capacity to exert muscle force per unit of muscle size in people with CF. This suggests that building a greater muscle mass through resistance exercises focusing on muscle hypertrophy in exercise prescription may improve muscle strength in people with CF.

Quadriceps muscle strength of the affected limb in medial meniscus posterior root tears is negatively correlated with the progression of postoperative medial joint space narrowing

AbstractPurposeThe effect of quadriceps muscle strength on medial joint space (MJS) narrowing after repair for medial meniscus (MM) posterior root tears (MMPRTs) has not yet been determined. This study aimed to evaluate the effect of preoperative and postoperative quadriceps muscle strength on the change in MJS (ΔMJS) in MMPRTs.MethodsThirty patients who underwent pullout repair for MMPRTs were retrospectively evaluated. The MJS width using fixed‐flexion view radiographs, MM extrusion (MME) using magnetic resonance imaging, quadriceps muscle strength using the Locomo Scan‐II and clinical scores were measured and compared preoperatively and 1 year postoperatively. Correlations between the ΔMJS, change in MME (ΔMME), and preoperative and postoperative quadriceps muscle strength were evaluated using Spearman's rank correlation coefficient.ResultsMJS narrowing and MME progressed significantly at 1 year postoperatively (p &lt; 0.001). Quadriceps muscle strength in MMPRT knees and all clinical scores significantly improved at 1 year postoperatively (p &lt; 0.001). ΔMJS and ΔMME showed a significant positive correlation (0.50 ± 0.70 and 1.22 ± 0.92 mm, respectively; r = 0.516, p = 0.004). Both preoperative and postoperative quadriceps muscle strength in MMPRT knees showed significant negative correlations with ΔMJS (preoperative: r = −0.529, p = 0.003; postoperative: r = −0.477, p = 0.008) and ΔMME (preoperative: r = −0.431, p = 0.018; postoperative: r = −0.443, p = 0.014).ConclusionsIn pullout repair for MMPRTs, preoperative and postoperative quadriceps muscle strength in MMPRT knees was negatively correlated with the progression of MJS narrowing and MME. Rehabilitation with a focus on quadriceps muscle strengthening, including preoperative rehabilitation, may delay knee‐osteoarthritis progression after pullout repair for MMPRTs.Level of EvidenceLevel IV.

Associations Among Changes in Body Composition, Activity, Muscle Recovery, and Obesity Following Total Knee Arthroplasty: A Retrospective Study.

Total knee arthroplasty (TKA) is expected to improve knee pain and enable patients to regain the ability to walk, but the associations between preoperative and postoperative changes in body composition, muscle strength, and activity remainunclear. In this study, we investigated the association between changes in body composition before and after TKA surgery, the recovery process of muscle strength, and changes in activity, as well as the effects of obesity on TKA. A total of 124 patients with unilateral knee osteoarthritis (OA) who underwent TKA were retrospectively evaluated. Body weight (BW) and body composition (body fat percentage (BFP) and diseased limb muscle mass (DLMM)), measured by bioelectrical impedance analysis, quadriceps muscle strength (QMS), measured using theisometric muscle strength meter, number of steps (NOS), and Japanese Orthopaedic Association (JOA) OAknee diseases treatment outcome criteria (JOA score) before the operation, at postoperative six months (PO6M), and at postoperative one year (PO1Y) after the operation were investigated and compared between the non-obese (BMI< 25 kg/m2) group, including underweight (<18.5 kg/m2) and normal weight patients (18.5 to 24.9 kg/m2),and obese (BMI ≥ 25 kg/m2) group, including overweight (25.0 to 29.9 kg/m2) or obese patients (≥30.0 kg/m2). In all patients, JOA scores significantly improved from 59.7 preoperatively to 81.2 at PO6M, and 82.7 at PO1Y (both p < 0.01). QMS significantly increased from 112.4 N preoperatively to 144.0 N at PO6M, and 151.0 N at PO1Y (both p < 0.01). On the other hand, there was no significant change in BW, BFP, NOS, and DLMM. A comparison between the obese (n = 76) and non-obese (n = 48) groups demonstrated that there was no significant difference in JOA scores preoperatively, but scores at PO1Y were significantly higher in the non-obese group (p < 0.01), and QMS increased significantly postoperatively in both groups, but the enlargement rate at PO1Y was 1.4% in the obese group versus 10.4% in the non-obese group (p = 0.04). In the body composition of TKA patients, BW, BFP, and DLMM/BW did not change significantly from preoperatively to PO1Y, but QMS and JOA scores showed significant improvement at PO6M and PO1Y compared to preoperatively. The obese patients showed less improvement in JOA scores than non-obese patients, and the rate of increase in QMS at PO1Y was smaller, suggesting that rehabilitation focusing on muscle-strengthening training is necessary even at PO6M, especially in obese patients.

Posterior Hip Pericapsular Block (PHPB) with pericapsular nerve group (PENG) block for hip fracture: a case series

BackgroundPain after total hip arthroplasty (THA) for femoral neck fracture (FNF) can be severe, potentially leading to serious complications. PENG block has become an optional local analgesic strategy in hip fracture surgery, but it cannot provide effective pain relief for the posterior capsule of the hip joint. Therefore, we modified the traditional sacral plexus nerve block and named it Posterior Hip Pericapsule Block (PHPB) to complement the blockade of the relevant nerves innervating the posterior hip capsule region. Thereby, we detail the analgesic effect of PHPB combined with PENG block on five hip fracture patients and the effect on their hip motor function.MethodsThis case series was conducted from December 2023 to February 2024. We performed ultrasound-guided PHPB combined with PENG block on five patients with hip fractures. Numerical Rating Scale (NRS) pain scores at rest and maximum NRS pain scores during limb movement of the five patients were recorded within 48 h after surgery. Their hip flexion, abduction, adduction, keen flexion and quadriceps muscle strength were also recorded. Serious postoperative complications, including wound infection, hematoma formation, or nerve injury, were recorded.ResultsThey experienced effective pain control within 48 h postoperatively, with NRS pain scores at rest decreasing from 3.0 (3.0, 4.5) to 0.0 (0.0, 1.0) and maximum NRS pain scores during limb movement from 8.0 (7.5, 8.5) to 1.0 (0.5, 2.0). They can autonomously perform hip flexion, abduction, adduction, and knee flexion within 48 h postoperatively without any signs of movement disorders or quadriceps muscle weakness. No severe postoperative complications, such as wound infections, hematoma formation or nerve damage, were observed in any of the patients.ConclusionsUltrasound-guided PENG block combined with PHPB provided effective analgesia for hip fracture patients in the perioperative period. It maintained hip joint motor function and quadriceps muscle strength within 24 h after THA.

Predictors of Gait Variability in Older Inpatients: An Exploratory Study Among Orthopedic Patients.

Aim Older inpatients have reduced physical function and walking ability with a higher risk of falls after being discharged home. Gait variability can assess ambulation and is strongly related to the risk of falls. However, the clinical factors affecting gait variability in inpatients have not been identified. The purpose of this study was to investigate the predictive factors affecting gait variability in older inpatients. Methods A total of 42 older orthopedic inpatients with fractures of the hip, spine, and other segments and 18 healthy volunteers as the control group were enrolled in this study. Inpatients wore tri-axial accelerometers for a 10m walk before discharge. Gait variability was assessed by the coefficient of variation (CV) based on five consecutive stride times. Clinical assessment of muscle strength, joint mobility, balance, pain, and activities of daily living were also evaluated. Results The CV in inpatients was higher than that in healthy elderly. Quadriceps muscle strength, ankle dorsiflexion range of motion, and balance described the CV. When model 2 (adjusted R2 = 0.473) was compared with model 1 (adjusted R2 = 0.293), the quadriceps muscle strength and ankle dorsiflexion range of motion had a major effect on CV, while balance had not a greater influence than these two factors when compared with model 3 (adjusted R2 = 0.537). Conclusions Poor knee extension strength, balance, and restriction of ankle dorsiflexion mobility have influenced gait variability in older inpatients.

Y-Balance Test after ACL Reconstruction: The relationship with knee and hip muscle strength, ankle dorsiflexion range of motion and postural stability

BackgroundY-Balance Test (YBT) assesses postural stability. When is applied to patients after anterior cruciate ligament reconstruction (ACLR), it is not clear which variables influence its result. ObjectiveTo connect YBT and postural stability, quadriceps, hamstring, and gluteus complex muscle strength, ankle dorsiflexion range of motion (ADFROM). Study designCross-sectional. MethodsFifty-nine participants (52 males and 7 females) with ACLR ≥6 months were evaluated. YBT anterior, posterolateral, posteromedial, and composite, isokinetic peak torque of the knee, strength of the gluteal complex with Hip Stability Isometric Test, ADFROM with Weight-Bearing Lunge Test, postural stability with Stability Index of Biodex Balance System® were applied. ResultsIn the ACLR limb, the multivariate regression linear models pointed out an association between the quadriceps muscle strength and ADFRM with anterior, posteromedial and composite reaches (R2 = 0.30; 0.23; 0.26). Hamstring muscle strength and ADFRM with posterolateral (R2 = 0.13). In the uninjured limb, overall stability index and ADFRM with anterior reach (R2 = 0.25), strength of gluteal complex with posteromedial (R2 = 0.31), hamstring muscle strength, Overall and lateromedial stability indexes with posterolateral (R2 = 0.20), hamstring muscle strength, Overall stability index, ADFRM and strength of gluteal complex with composite (R2 = 0.32). ConclusionsThe quadriceps muscle strength and ADFRM are important variables for YBT performance in the ACLR limb. In the uninjured limb, ADFROM, the strength of the gluteal complex and hamstring, overall and lateromedial stability indexes are associated with YBT performance. We question the utility of the YBT to measure postural stability given the lack of association with other postural stability measures.

The Efficacy of Blood Flow Restriction Training to Improve Quadriceps Muscle Function after ACL Reconstruction.

Blood flow restriction training (BFRT) is a popular rehabilitation intervention after anterior cruciate ligament reconstruction (ACLR). However, there are a lack of clinical trials establishing the efficacy of using BFRT during rehabilitation to improve quadriceps muscle function. To evaluate the efficacy of blood flow restriction training to improve quadriceps muscle strength, morphology, and physiology, and knee biomechanics in individuals after ACLR in a double-blind, randomized, placebo-controlled clinical trial (NCT03364647). 48 athletes (20 females/28 males) were randomly assigned to low-load strength training with active BFRT or standard of care strength training with a sham unit. Treatment occurred for 1-month pre-surgery and 4-5 months post-surgery with both groups following the same standard rehabilitation protocol. Outcome variables were measured at baseline and 4-5 months post-surgery. Quadriceps muscle strength (isometric and isokinetic peak torque and rate of torque development) was measured on an isokinetic dynamometer. Quadriceps muscle morphology (physiological cross-sectional area, fibrosis) was determined using magnetic resonance imaging. Quadriceps muscle physiology (fiber type, fiber cross-sectional area, satellite cell abundance, collagen content, fibro-/adipo-genic progenitor cells) was evaluated with muscle biopsies of the vastus lateralis. Knee extensor moment and knee flexion angle were measured via three-dimensional gait analysis. Change scores were calculated as: post-intervention-baseline. Two sample t-tests were then used to assess between-group differences for each outcome variable. No significant between-group differences were found for any outcome variable. The addition of BFRT to a rehabilitation program for athletes pre- and post- ACLR was no more effective than standard rehabilitation for improving quadriceps muscle function. Clinicians should consider the value of BFRT relative to the cost, time, and discomfort for patients in light of these results.

Quadriceps Muscle Geometry and Strength Throughout Maturation in National-Level Male Soccer Players: A Cross-Sectional Study.

Adolescent soccer players experience distinct physiological changes due to chronological and biological maturation, impacting their soccer performance. Here, we explored age-related variations and associations between quadriceps geometry and strength in male national-level adolescent soccer players. We used ultrasonography to examine the regional architecture and morphology of the rectus femoris (RF) and vastus lateralis (VL) muscles, and we assessed knee extension strength by isometric and isokinetic dynamometry. Players were categorized into four age groups: under (U) 15 (n=18, age=13.7±0.5 years), U16 (n=15, age=14.7±0.5), U17 (n=19, age=15.7±0.5), U18 (n=18, age=16.7±0.5) and U21 (n=25, age=18.5±0.5). The absolute and relative strengths were higher in the U16 compared to U15 by 12-15% and 6-8%, 11-12% and 6-7% in the U17 compared to U16, 5-7% and -1-2% in the U18 compared to U17 and 0-15% and -1-11% in the U21 compared to U18 age groups, respectively. VL architecture did not change relevantly between the age groups. The muscle anatomical cross-sectional area (ACSA) of the VL and RF differed non-uniformly and muscle region-specific by 10-36%, with highest values in the U21 age group. Moderate correlations between the VL architecture and knee extension strength in both legs were observed only in the U16 age group. The quadriceps ACSA showed age-specific correlations with knee extension strength. Our findings highlight non-uniform differences in quadriceps muscle morphology and absolute and relative strength among male national-level adolescent soccer players in different age groups. The correlations observed between muscle morphology or architecture and strength were muscle, muscle region, leg and age dependent.

Existing and Emerging Measures of Muscle Strength and Mass in the Assessment of Sarcopenia

Abstract Background Sarcopenia, an accelerated loss of muscle strength and mass is a major driver of adverse health outcomes in older people. The European Working Group on Sarcopenia recommends muscle strength assessment with handgrip strength (HGS) or five chair stands test (5CST) and muscle mass assessment with dual energy X-ray absorptiometry or bioelectrical impedance analysis (BIA). However, these methods can be contraindicated, unavailable or patients can be unable to perform them. We sought to compare the existing measures HGS, 5CST and BIA to emerging measures: quadriceps muscle strength (QMS) and muscle ultrasound. Methods Thirty-one participants from a local healthy ageing group (mean age 71±5 years, 80% female) were recruited to the FRAILMatics Physiological Cohort. Max HGS was assessed using the Jamar Plus+ dynamometer and 5CST timed from a standard height chair. Max QMS was measured with the Actiforce hand-held dynamometer. BIA was performed with the TANITA DC-430 MAP and the Sergi equation used to estimate appendicular skeletal muscle mass (ASMM). Rectus femoris muscle thickness (RFMT), vastus lateralis muscle thickness (VLMT) and anterior thigh muscle thickness (ATMT) measurements were taken using the linear array transducer on the GE Vscan Air point of care ultrasound system. Pearson correlation was used to examine the relationship between measures. Results Strong correlation was seen between max QMS and max HGS (r = 0.73, P &amp;lt;0.001); moderate correlation between RFMT, VLMT, ATMT and ASMM (r = 0.51, P &amp;lt;0.01; r = 0.56, P&amp;lt;0.01; r = 0.40, P &amp;lt;0.05). 5CST was not correlated with any of the measures (P &amp;gt;0.05). Conclusion In the assessment of sarcopenia, QMS and muscle ultrasound could be alternatives to HGS and BIA respectively, especially in cases where the latter are not available or contraindicated. 5CST appears less useful in the assessment of sarcopenia and may be more appropriate as a test of physical performance.

Effects of Lower Limb Heat Therapy, Exercise Training, or a Combined Intervention on Vascular Function: A Randomized Controlled Trial.

To compare the effects of 8 weeks of no intervention (CON), lower limb heat therapy (HEAT), moderate-intensity exercise training (EX), or combined training and therapy (HEATEX) in young, healthy recreationally active adults. Sixty participants (23 ± 3 years, 30 females) were randomly allocated into either CON (n = 15), HEAT (n = 15), EX (n = 14), or HEATEX (n = 16). The primary outcome was vascular function, assessed through brachial artery flow-mediated dilation tests (BA FMD). Secondary measures included arterial stiffness (pulse wave velocity, PWV); cardiorespiratory fitness (VO2peak); body composition; and quadriceps muscle strength. There were no differences in BA FMD between the groups before and after the interventions (all p > 0.05). Both interventions with a heating component were associated with within-group reductions in carotid-femoral PWV, and increases in absolute and relative VO2peak after 8 weeks (HEAT: ∆-0.27 [-0.53, -0.02] m/s, ∆0.18 [0.06, 0.29] L/min, ∆2.18 [0.60, 3.76] ml/kg/min, respectively; HEATEX: ∆-0.33 [-0.58, -0.09], ∆0.21 [0.11, 0.32] L/min, ∆2.59 [1.06, 4.12] ml/kg/min, respectively), but no between-group differences were observed (p = 0.25, p = 0.21, and p = 0.55, respectively). There was also a within-group decrease in body fat percentage with EX (∆-1.37 [-2.45, -0.29] %), but no changes in leg strength in any of the groups (p = 0.79). This randomized controlled trial is the first to examine the efficacy of lower limb heating against traditionally prescribed exercise training. In our young cohort, 8 weeks of training and/or therapy was insufficient to improve vascular function. More intense protocols and longer interventions involving lower limb heating may be required to elicit improvements in health outcomes.