The accessibility of available wireless access technologies with increasing demand for real time multimedia application becomes an essential part for mobile communication. Mobile users resourcefully utilize the heterogeneous environment for best quality of service (Qos) anywhere and anytime. Efficient handover optimization and intelligent mobility management is a key requirement for designing next generation wireless networks. Therefore, a novel IEEE 802.21 media independent handover (MIH) standard is adopted to provide an associated service for intelligent handover procedures. In addition, dynamic mobility management decision server (MDS) and IEEE 802.21a security extension for MIH services are also integrated in the proposed architectures to support fast, seamless and secure handover optimization in inter-domain mobility. Simulation results prove that the presented work resourcefully minimizes the packet loss, unnecessary handover probability and vertical handover delay by avoiding time consuming scanning process for target network discovery. The system thus achieves Qos guarantee by balancing the network load and throughput improvement for different applications with Proxy MIPv6 mobility management protocol.