Local damage and imperfections may affect the loading capacity of truss core sandwich cylinders. This study develops a numerical model to investigate the effects of missing lattice struts, unbound nodes, openings, and eigenmode-shape imperfections on the buckling and post-buckling behavior of pyramidal core sandwich cylinders. Results from the numerical model show that the pyramidal core sandwich cylinder is sensitive to missing struts and unbound nodes when local buckling is the main failure model. Critical loads show a gradual decrease as the opening damage increases. Pyramidal core sandwich cylinders are not sensitive to eigenmode-shape imperfections compared to the equivalent single-walled shells.