Previous research has proved that pyramidal core sandwich panel is an excellent kind of passive Thermal Protection Systems (TPSs) for hypersonic aerospace aircrafts suffered from in-service environment. To explore its further insulation performance and load-bearing capability, four kinds of actively cooled pyramidal core sandwich panels are designed and investigated in this paper. Convection flow mechanism for cooling channels is described in details. Influences of the coolant velocity, channel height ratio and flow direction of the two layers on thermal performance are firstly studied and discussed in an appropriate way. Analysis of thermomechanical performance is then performed. The effect of the cover board thickness on thermomechanical performance is also studied. In consequence, a light-weight, structural and thermal integrated thermal protection system (ITPS) has been designed to protect hypersonic aircrafts from intense radiation heat flux in service.