Pyoderma, refers to any clinical picture that results in the accumulation of neutrophilic exudates of varying degrees in conjunction with a bacterial infection. A longitudinal study was conducted among 178 dogs brought to the small animal dermatology unit of Teaching Veterinary Clinical Complex, Mannuthy and University Veterinary Hospital, Kokkalai, Thrissur, Kerala to document the age, breed and sex predispositions and to identify any environmental influence or managemental practice that predisposes to pyoderma. The overall prevalence of pyoderma was 7.5 per cent. Statistical analyses using Chi square test revealed that there was significant difference in the proportion of animals affected with pyoderma among different categories of age, breed, housing system, bathing practices, kennel hygiene, access to oral coat conditioners and feed supplements. The distribution of animals affected with pyoderma was statistically significant between different seasons also. The condition was commonest in dogs between one to three years of age (46.07 per cent). The Labrador retrievers were more predisposed to developing pyoderma. More females (53.37 per cent) were infected when compared to males (46.63 per cent). Majority of the cases (52.25 per cent) were housed outdoors in a separate kennel and were bathed (68.54 per cent) regularly and groomed (36.52 per cent) at least once a month. The analyses of the epidemiological profile of dogs affected with pyoderma revealed that apart from the host factors, the environmental and managemental aspects also plays an important role in the occurrence of pyoderma.