Pylori Infection In General Population Research Articles

Prevalence of Helicobacter pylori infection in the general population evaluated by a resident-register-based epidemiological study.

The current status of Helicobacter pylori infection in Japan has not been investigated. We evaluated the status of H. pylori infection in a Japanese general population using large-scale resident-register-based sampling. All 6069 adults in a rural town and 6000 adults in two urban cities (3000 each), selected by register-based random sampling, were enrolled in our health check-up program. Antibody titers against Helicobacter pylori (cut-off value was 3 U/mL by Eiken E-plate) were evaluated, and subjects with a positive result were encouraged to undergo further examinations. A total of 1586 subjects participated in serum sampling. The overall prevalence of H. pylori infection was 40.0% (634/1586), and it increased with age both in rural and urban areas. Although the overall positive rate was higher in the rural area (49.4%) than in the urban areas (35.6 and 32.3%), there was no difference in H. pylori status of younger subjects between the two areas. Among 634 patients with a positive titer, 374 (59.0%) underwent further examinations including endoscopic examination, and 180/634 (28.4%) patients received eradication therapy. Gastric neoplasms (three adenocarcinomas and one adenoma) were found in our screening program. We clarified population-based random sampling data of H. pylori infection in a Japanese general population. In younger subjects, a decrease in the prevalence of H. pylori infection was confirmed both in rural and urban areas. This provides basic information for establishing a strategy to reduce gastric cancer deaths.

The occurrence of Helicobacter pylori in hydatid liver disease

ObjectiveTo detect the prevalence of Helicobacter pylori (H. pylori) in hydatid liver disease. MethodsA total of 58 patients with hydatid liver disease attending AL-Sadder Teaching Hospital in Al-Najaf and Al-Basrah governorate from February to August, 2008 were included in the study and served as group A. One hundred and twenty 1st degree relative patients (group B) and 20 normal persons including 10 male and 10 female (group C) as control were detected for the presence of H. pylori infection in general population. Chest X-ray was done for the above groups to exclude lung hydrated cyst. The patients were screened by ultrasound to obtain intra abdominal hydrated cyst and enzyme-linked immuno sorbent assay (ELISA) test was utilized to detect the H. pylori infection. ResultsFifty eight patients from group A with hydatid liver disease, 30 male (51.7%) and 28 female (48.3%) were screened for the presence of H. pylori infection by using ELISA test. We found that 28 patients from group A had positive ELISA test including 19 male (32.8%) and 9 female (15.5%) (P<0.01). However, there were no positive results of H. pylori infection in group B and C by chest X-ray, ultrasound and ELISA test. ConclusionsIt can be concluded that there is a strong relationship between hydatid liver disease and presence of H. pylori.

Clinical findings and prevalence of helicobacter pylori in patients with gastritis B in Al-basrah governorate.

To detect the prevalence of H. pylori in patients with gastritis B. This study involved 58 patients (group A) with gastritis B attending the Al-Sadder teaching hospital from January to November 2008. 120 of family's patients (group B) and normal 20 people, 10 males 10 females (group C) were taken as controls for presence of H. pylori infection in general population. Endoscopy was carried for all patients to diagnose gastritis B. Urease, ELISA test, and culturing on Columbia agar used to detect the presence of H. pylori in these patients Fifty-eight patients; 30 males (51.7%) and 28 females (48.3%) were infected with gastritis B. The results showed that 81% of the patients gave positive results of serum IgG anti body. The results showed that for screening and determining the clinical features of gastritis B, at least two methods for H. pylori are required to give positive result at the same time for the same patient, in order to identify an infected patient with from H. pylori.