Pyeloplasty In Kidneys Research Articles

Evaluation of the Outcome of Pyeloplasty in Children with Poorly Functioning Kidneys due to Unilateral Ureteropelvic Junction Obstruction.

To analyze the outcome of upfront pyeloplasty in kidneys of children with unilateral ureteropelvic junction obstruction (UPJO). Thirty-three consecutive cases with split renal function (SRF) of ≤20% on dynamic renal scintigraphy (DRS) underwent upfront pyeloplasty with a nephrostomy tube and trans-anastomotic stent. Outcome was analyzed based on symptomatic relief, nephrostomy output, surgical complications and changes noted in pre-and post-operative findings on renal ultrasound (US), and DRS. The most common symptom was abdominal lump in <5-year age group (79%) and abdominal pain in >5-year age group (93%). Postoperatively, symptoms were relieved in all (100%), parenchymal thickness (PT) on US improved in 82% and SRF improved significantly (>5%) in 75.8% of patients. The improvement was more significant in patients with abdominal lump and large kidneys. The mean nephrostomy output showed an inverse relationship with age at pyeloplasty and a direct correlation with the change in PT and SRF. The degree of improvement in SRF also was inversely related to the age at pyeloplasty with a significantly better outcome in <2-year-age. Although age at pyeloplasty, nephrostomy output and change in PT individually showed significant correlation with change in SRF, multiple regression analysis showed PT as the only significant factor. Upfront pyeloplasty should be the first option in children with poorly functioning kidneys as it has a favorable outcome in almost all the cases with a very low incidence of complications. The degree of improvement in SRF can be predicted by the nephrostomy output and improvement in PT on US.

Renal functional improvement after pediatric pyeloplasty in kidneys with split renal function less than 20%: a single institute experience

BackgroundPediatric pyeloplasty in ureteropelvic junction obstruction (UPJO) is indicated in renal impaired drainage or renal function deterioration. The improvement of renal function after pediatric pyeloplasty is still controversial in poorly functioning kidneys. Past studies on poorly functioning kidneys had a variable SRF specification, and these studies often had a limited number of patients so that they did not achieve statistical significance. The study aims to detect the renal functional improvement after pediatric Anderson-Hynes pyeloplasty (AHP) with split renal function (SRF) less than 20% (poor renal function).ResultsA retrospective study included 46 pediatric patients with unilateral UPJO who underwent open AHP with SRF < 20% on a renal isotope scan from August 2012 to October 2018. Success was defined based on either improvement in symptoms, improvement in drainage on postoperative renography, and/or improvement or stability in SRF on the renal scan done 6 months postoperatively and yearly thereafter. Deterioration of SRF by more than 5% was deemed to be deterioration. An increase in SRF of more than 5% was deemed to be an improvement.A total of 46 patients with a mean age of 32 months with poor renal function on isotope renogram (SRF < 20%) were included. All patients had an obstructive pattern on the preoperative radionuclide scans. The median preoperative SRF was 9.26%. The mean (range) follow-up was 30 months. The success rate was 91.3%. Three patients underwent redo pyeloplasty, whereas a secondary nephrectomy was necessary for one. The remaining (42) patients showed stability or improvement of SRF with no further symptoms. Renal scintigraphy at 6 and 12 months after surgery revealed significantly increased SRF compared to preoperative one.ConclusionPoorly functioning renal unit with SRF < 20% can show functional improvement and recoverability after pediatric pyeloplasty.

Early outcome of pediatric pyeloplasty in kidneys with split renal function less than 10%: A prospective study of 25 cases

ObjectivesTo detect the outcome of pyeloplasty in kidneys with split renal function (SRF) less than 10% in the pediatric age group. Subjects and methodsWe prospectively analyzed the data from 25 cases of ureteropelvic junction obstruction (UPJO) candidate for pyeloplasty with SRF less than 10%. Abdominopelvic ultrasonography and diuretic renogram using technetium-99m diethylenetriamine Penta acetic acid (DTPA) were done in all cases. We studied the improvement in pelvic anteroposterior diameter (APD) postoperatively. We compared pre and postoperative SRF after six months and one year. ResultsThe median age was 24 months (3 months–11 years), male to female 2:1. The median preoperative SRF was 5% (range: 0%–10%) and the median APD of the renal pelvis was 3cm (range: 2.2–5). There was significant improvement of median APD 0.8cm (range: 0.5–1.9) (P value <0.05). There was a significant postoperative improvement in the median SRF (P-value <0.05) as the median SRF after 6 months and 1year were 21% and 20%, respectively but there was no significant difference between SRF at six months and one year (P value 0.174). ConclusionPyeloplasty provides high rates of functional success even in very poorly functioning kidneys with SRF ≤10% by DTPA renogram in pediatric age group.

554 - Outcome of pediatric pyeloplasty in kidneys with split renal function less than 10%: A prospective study of 25 cases

554 - Outcome of pediatric pyeloplasty in kidneys with split renal function less than 10%: A prospective study of 25 cases

Outcome of hydronephrosis diagnosed antenatally

We evaluated 23 neonates with prenatally diagnosed dilatation of the renal pelvis involving 33 renal units. The dilatation was graded from 0 to 4 by ultrasonography. Diuresis renography was used to evaluate differential renal function. The patterns of the excretory curve following administration of furosemide were analyzed. Antegrade pyelography and pressure flow studies were done in selected patients. The mean follow-up was 34 weeks. The single most important prognostic indicator in this group of patients was the degree of dilatation on ultrasonography. Six of 7 renal units with grade I hydronephrosis improved and 1 remained stable on follow-up. Four of the 12 renal units with grade II hydronephrosis improved spontaneously; 1 remained stable. Three of 11 renal units with grade III hydronephrosis either improved or remained stable. The measurement of differential renal functions on DTPA renography did not correlate well with the degree of dilatation when renal size and parenchymal thickness were adequate. The excretory curves after lasix administration were not helpful to determine treatment in the neonatal period. Seventeen renal units (7 grade II, 9 grade III, 1 grade IV) were treated surgically due to persistent dilatation, evidence of obstruction on either DTPA renography or the Whitaker test, or because of impaired renal function. Sixteen of the 33 renal units diagnosed prenatally improved with observation. Of all the parameters studied only the degree of dilatation on ultrasonography correlated well with the prognosis. We conclude that a period of observation between 6 months and 1 year prior to performing a pyeloplasty in kidneys with good renal function is not detrimental to function and will allow one half of the dilated renal units to improve spontaneously.