ABSTRACT We report the detection of two CH3OH lines (J K = 2 K –1 K and 3 K –2 K ) between the progenitor’s disks (“Overlap”) of the mid-stage merging galaxy VV 114 obtained using the Atacama Large Millimeter/submillimeter Array (ALMA) Band 3 and Band 4. The detected CH3OH emission shows an extended filamentary structure (∼3 kpc) across the progenitor’s disks with relatively large velocity width (FWZI ∼ 150 km s−1). The emission is only significant in the “overlap” and not detected in the two merging nuclei. Assuming optically thin emission and local thermodynamic equilibrium, we found the CH3OH column density relative to H2 ( ) peaks at the “Overlap” (∼8 × 10−9), which is almost an order of magnitude larger than that at the eastern nucleus. We suggest that kpc-scale shocks driven by galaxy–galaxy collision may play an important role to enhance the CH3OH abundance at the “Overlap.” This scenario is consistent with shock-induced large velocity dispersion components of ionized gas that have been detected in optical wavelength at the same region. Conversely, low at the nuclear regions might be attributed to the strong photodissociation by nuclear starbursts and/or a putative active galactic nucleus, or inefficient production of CH3OH on dust grains due to initial high-temperature conditions (i.e., desorption of the precursor molecule, CO, into gas phase before forming CH3OH on dust grains). These ALMA observations demonstrate that CH3OH is a unique tool to address kpc-scale shock-induced gas dynamics and star formation in merging galaxies.