Pupillometric Study Research Articles

The resolution of proactive interference in a novel visual working memory task: A behavioral and pupillometric study.

Proactive interference (PI) occurs when previously learned information impairs memory for more recently learned information. Most PI studies have employed verbal stimuli, while the role of PI in visual working memory (VWM) has had relatively little attention. In the verbal domain, Johansson and colleagues (2018) found that pupil diameter - a real-time neurophysiological index of cognitive effort - reflects the accumulation and resolution of PI. Here we use a novel, naturalistic paradigm to test the behavioral and pupillary correlates of PI resolution for what-was-where item-location bindings in VWM. Importantly, in our paradigm, trials (PI vs. no-PI condition) are mixed in a block, and participants are naïve to the condition until they are tested. This design sidesteps concerns about differences in encoding strategies or generalized effort differences between conditions. Across three experiments (N = 122 total) we assessed PI's effect on VWM and whether PI resolution during memory retrieval is associated with greater cognitive effort (as indexed by the phasic, task-evoked pupil response). We found strong support for PI's detrimental effect on VWM (even with our spatially distributed stimuli), but no consistent link between interference resolution and effort during memory retrieval (this, even though the pupil was a reliable indicator that higher-performing individuals tried harder during memory encoding). We speculate that when explicit strategies are minimized, and PI resolution relies primarily on implicit processing, the effect may not be sufficient to trigger a robust pupillometric response.

Music in the eye of the beholder: a pupillometric study on preferred background music, attentional state, and arousal

Although background music listening during attention-demanding tasks is common, there is little research on how it affects fluctuations in attentional state and how these fluctuations are linked to physiological arousal. The present study built on Kiss and Linnell (2021) - showing a decrease in mind-wandering and increase in task-focus states with background music - to explore the link between attentional state and arousal with and without background music. 39 students between the ages of 19–32 completed a variation of the Psychomotor Vigilance Task in silence and with their self-selected background music (music they would normally listen to during attention-demanding tasks). Objective arousal measures (pretrial pupil diameter and task-evoked pupillary responses) and subjective attentional state measures (mind-wandering, task-focus, and external-distraction states) were collected throughout the task. Results showed a link between attentional state and arousal and indicated that background music increased arousal. Importantly, arousal mediated the effect of music to decrease mind-wandering and increase task-focus attentional states, suggesting that the arousal increase induced by music was behind the changes in attentional states. These findings show, for the first time in the context of background music listening, that there is a link between arousal and attentional state.

Congruent Prosody Reduces Cognitive Effort in Memory for Spoken Sentences: A Pupillometric Study with Young and Older Adults

ABSTRACTBackgroundIn spite of declines in working memory and other processes, older adults generally maintain good ability to understand and remember spoken sentences. In part this is due to preserved knowledge of linguistic rules and their implementation. Largely overlooked, however, is the support older adults may gain from the presence of sentence prosody (pitch contour, lexical stress, intra-and inter-word timing) as an aid to detecting the structure of a heard sentence.MethodsTwenty-four young and 24 older adults recalled recorded sentences in which the sentence prosody corresponded to the clausal structure of the sentence, when the prosody was in conflict with this structure, or when there was reduced prosody uninformative with regard to the clausal structure. Pupil size was concurrently recorded as a measure of processing effort.ResultsBoth young and older adults’ recall accuracy was superior for sentences heard with supportive prosody than for sentences with uninformative prosody or for sentences in which the prosodic marking and causal structure were in conflict. The measurement of pupil dilation suggested that the task was generally more effortful for the older adults, but with both groups showing a similar pattern of effort-reducing effects of supportive prosody.ConclusionsResults demonstrate the influence of prosody on young and older adults’ ability to recall accurately multi-clause sentences, and the significant role effective prosody may play in preserving processing effort.

A pupillometric study of developmental and individual differences in cognitive effort in visual word recognition

Throughout the history of modern psychology, the neural basis of cognitive performance, and particularly its efficiency, has been assumed to be an essential determinant of developmental and individual differences in a wide range of human behaviors. Here, we examine one aspect of cognitive efficiency—cognitive effort, using pupillometry to examine differences in word reading among adults (N = 34) and children (N = 34). The developmental analyses confirmed that children invested more effort in reading than adults, as indicated by larger and sustained pupillary responses. The within-age (individual difference) analyses comparing faster (N = 10) and slower (N = 10) performers revealed that in both age groups, the faster readers demonstrated accelerated pupillary responses compared to slower readers, although both groups invested a similar overall degree of cognitive effort. These findings have the potential to open up new avenues of research in the study of skill growth in word recognition and many other domains of skill learning.

Impairment of autonomic emotional response for executive function in children with ADHD: A multi-modal fNIRS and pupillometric study during the Wisconsin Card Sorting Test

ObjectiveChildren with attention deficit hyperactivity disorder (ADHD) often experience difficulties with emotional control and a consequent inability to perform tasks. To clarify the effects of emotional behavior on cognitive functions, we aimed to determine the association between emotional changes and executive functions in children with ADHD by measuring the pupil diameter changes associated with emotional changes. Participants and methodsThis study included 14 children with ADHD and 10 typically developing children (TDC) aged between 10 and 16 years. During the Wisconsin Card Sorting Test (WCST), which is related to context formation and task switching among executive functions, changes in pupil diameter and frontal oxygenated hemoglobin (oxy-Hb) using functional near-infrared spectroscopy (fNIRS) were recorded simultaneously. Pupil diameter changes during “cognitive shift” and “consecutive correction” were compared between both groups. ResultsDuring cognitive shift, the pupils of children with ADHD contracted, whereas those of the TDC were mydriatic. During consecutive correction, the pupils of children with ADHD were mydriatic, whereas those of the TDC tended to contract. These results correlated with WCST performance. Moreover, during cognitive shifts, changes in bilateral frontal blood flow were increased in TDC, but not in children with ADHD. ConclusionThe locus coeruleus-norepinephrine (LC-NE) system plays an important role in pupillary diameter response. These results suggest that the LC-NE system may be dysfunctional in children with ADHD, and the system’s abnormality may lead to affective abnormalities in such patients, which results in poor performance on WCST (i.e., impaired executive functions).

Spontaneous Exploratory Choices Under the Probabilistic Gambling Task Involve the State of conflict: A Pupillometric Study

Spontaneous Exploratory Choices Under the Probabilistic Gambling Task Involve the State of conflict: A Pupillometric Study

Emotional responses to Japanese aesthetic and comic poetries: A pupillometric study

Emotional responses to Japanese aesthetic and comic poetries: A pupillometric study

An Auditory-Perceptual and Pupillometric Study of Vocal Strain and Listening Effort in Adductor Spasmodic Dysphonia

This study evaluated ratings of vocal strain and perceived listening effort by normal hearing participants while listening to speech samples produced by talkers with adductor spasmodic dysphonia (AdSD). In addition, objective listening effort was measured through concurrent pupillometry to determine whether listening to disordered voices changed arousal as a result of emotional state or cognitive load. Recordings of the second sentence of the “Rainbow Passage” produced by talkers with varying degrees of AdSD served as speech stimuli. Twenty naïve young adult listeners perceptually evaluated these stimuli on the dimensions of vocal strain and listening effort using two separate visual analogue scales. While making the auditory-perceptual judgments, listeners’ pupil characteristics were objectively measured in synchrony with the presentation of each voice stimulus. Data analyses revealed moderate-to-high inter- and intra-rater reliability. A significant positive correlation was found between the ratings of vocal strain and listening effort. In addition, listeners displayed greater peak pupil dilation (PPD) when listening to more strained and effortful voice samples. Findings from this study suggest that when combined with an auditory-perceptual task, non-volitional physiologic changes in pupil response may serve as an indicator of listening and cognitive effort or arousal.

Gender Differences in the Emotional Response and Subjective Sexual Arousal Toward Non-Consensual Sexual Intercourse: A Pupillometric Study

BackgroundGender differences in sexual response have targeted individuals' emotional appraisal of mainstream erotica. Yet, evidence reveals that men and women commonly endorse non-normative sexual interests, and no evidence has been collected on their emotional responses toward deviant sexual stimuli. AimThis study was aimed at evaluating gender differences in the emotional responses toward non-consensual sexual intercourse, thus revealing individuals' appraisal of non-normative sexual contents. In order to provide an initial background to interpret findings, this study further tested the association between individuals' emotional responses and sexual self-schemas (SSSs). Methods29 men and 45 women (all heterosexual) were voluntarily exposed to audiovisual presentations of non-consensual/physically forced sexual intercourse in a laboratory context. Markers of emotional response were collected by psychophysiological and self-report means. OutcomesPupil activation, namely pupil diameter ratio, during exposure to the video clips was captured with an eye tracker. Positive and negative emotions and subjective sexual arousal toward the clips were also collected. In addition, participants responded to the SSS scale assessing individuals' sexual self-perceptions. ResultsFindings revealed a small degree of gender differences. While men reported significantly more positive emotions toward the clip displaying a woman as recipient to non-consensual sex, no further differences were found. Also, participants revealed an increased pupil diameter ratio only in the first moments of the video clips. SSSs, including themes of aggression and power, were associated with men's emotional responses toward the clips, while no associations were found in women. Clinical TranslationDespite its preliminary nature, the current study provides evidence on the emotional mechanisms underpinning human sexual response, and may eventually translate to conceptualizing models with a focus on non-normative sexual behavior. Strengths & LimitationsTo our best knowledge, this is the first study researching gender specificities in the emotional appraisal of non-consented sex. Current findings may help to understand individuals' deviant sexual interests and establish a framework for future research in this area. However, it is worth noting that lack of previous research prevents the generalization of findings and limits our interpretation of data. ConclusionFindings revealed a small degree of gender differences in the emotional appraisal of non-consensual sexual intercourse, and suggested partial evidence in the relationship between sexual self-perceptions and emotional responses to forced sex.Carvalho J, Rosa PJ. Gender Differences in the Emotional Response and Subjective Sexual Arousal Toward Non-Consensual Sexual Intercourse: A Pupillometric Study. J Sex Med 2020;17:1865–1874.

CHANGES IN BINOCULAR PUPILLOMETRY IN ATHLETES AFTER HIGH EXERCISE STRESS

Aim. The article deals with studying the changes in binocular pupillometry to establish vegetative activity in athletes after high exercise stress. Materials and methods. 25 male athletes aged 19–34 years with no health limitations participated in the study. We estimated a set of the commonly accepted parameters of pupillometry (pupil diameter, pupil reaction initiation time, pupil constriction diameter, pupil constriction velocity) by measuring pupil reaction to a light stimulus with the help of a non-contact pupilometer (KVAZAR, Moscow). The examination was conducted prior to physical stress and 5, 15, and 30 minutes after. Intertrack-750 treadmill (SchillerAG, Switzerland) was used for testing. Results. The results obtained in a pupillometric study prove that there is a predominance of the sympathetic component in athletes at maximal load accompanied by emotional stress. After physical stress accompanied by fatigue and nervous system exhaustion, there is a pronounced predominance of the parasympathetic component. Conclusion. The data obtained prove that binocular pupillometry can be effectively used in sports medicine to estimate vegetative tone and regulatory mechanisms in athletes.

Social scene perception in autism spectrum disorder: An eye-tracking and pupillometric study

ABSTRACTTypically, developing humans innately place subjective value on social information and orient attention to it. This can be shown through tracking of gaze patterns and pupil size, the latter of which taps into an individual’s cognitive engagement and affective arousal. People with Autism Spectrum Disorder (ASD) present with atypical social, communicative and behavioral patterns, but underlying substrates of these behavioral differences remain unclear. Moreover, due to high comorbidity with other neurodevelopmental disorders, it is often difficult to distinguish which differences are distinctive to ASD. In this study, a group of 35 adolescents and young adults with neurodevelopmental disorders were tested to investigate the processing of social and non-social scenes in individuals who meet the diagnostic criteria for autism and those who do not. Eye tracking and pupillometry measures were collected while participants observed images of tightly controlled natural scenes with or without a human being. Contrary to individuals without autism diagnosis, participants with autism did not show greater pupillary response to images with a human. Participants with autism were slower to fixate on social elements in the social scenes, and this latency metric correlated with clinical measures of poor social functioning. The results confirm the clinical relevance of eye-tracking and pupillometric indices in the field of ASD. We discuss the clinical implications of the results and propose that analysis of changes in visual attention and physiological level to social stimuli might be an integral part of a neurodevelopmental assessment.

Focused attention predicts visual working memory performance in 13-month-old infants: A pupillometric study

Attention turns looking, into seeing. Yet, little developmental research has examined the interface of attention and visual working memory (VWM), where what is seen is maintained for use in ongoing visual tasks. Using the task-evoked pupil response – a sensitive, real-time, involuntary measure of focused attention that has been shown to correlate with VWM performance in adults and older children – we examined the relationship between focused attention and VWM in 13-month-olds. We used a Delayed Match Retrieval paradigm, to test infants’ VWM for object-location bindings – what went where – while recording anticipatory gaze responses and pupil dilation. We found that infants with greater focused attention during memory encoding showed significantly better memory performance. As well, trials that ended in a correct response had significantly greater pupil response during memory encoding than incorrect trials. Taken together, this shows that pupillometry can be used as a measure of focused attention in infants, and a means to identify those individuals, or moments, where cognitive effort is maximized.

A pupillometric study of task switching under mental fatigue

Alzheimer's disease (AD) is one of the most prevalent dementia types affecting the elderly population. On-time detection of the AD is valuable to find new approaches for the AD treatment. Artificial intelligence (AI) is an effective technique for AD detection as these methods are employed as a computer-aided diagnosis (CAD) system in clinical practices and play a crucial role in identifying variations in the brain images to detect AD. This chapter reviews and summarizes the recent investigations, advances and some related challenges in AI techniques employed for medical image processing and image analysis in AD detection. Several studies have discovered and employed different techniques, including AI techniques for CAD of AD detection. The main concentration lies in getting a reliable, but simple and fast model for automatic AD detection. The approaches to identify AD are based on the application of AI techniques. In this chapter, the concentration will be on AI techniques for AD detection from brain images. Furthermore, some of the image processing, feature extraction, and machine learning methods which were applied to AD detection is overviewed. Then the chapter will be concluded with a summary of the current state of the art, a critical discussion of new directions and open challenges for future research.

Motivation alters implicit temporal attention through sustained and transient mechanisms: A behavioral and pupillometric study.

Temporal expectations aid performance by allowing the optimization of attentional readiness at moment of highest target probability. Reward enhances cognitive performance through its action on preparatory and reactive attentional processes. To elucidate how motivation interacts with mechanisms of implicit temporal attention, we studied healthy young adult participants (N=73) performing a sustained attention task with simultaneous pupillometric recording, under different reward conditions (baseline: 0 c; reward: 10 c/fast response). Target timing was temporally unpredictable (variable foreperiod: 2-10s, uniformly distributed), in which case implicitly formed timing expectations. Trials were binned according to current foreperiod (FPn ; short: 2-6s; long: 6-10s) and preceding foreperiod (FPn-1 ; short: 2-6s; long: 6-10s). Overall, performance data showed the expected temporal attention effects, with slower responses after shorter FPn s, particularly when they followed longer FPn-1 s. Moreover, these temporal effects were significantly reduced in the reward condition. While performance improved in all trial types, the largest benefit appeared in trials that were normally most disadvantaged by invalid temporal expectation. Furthermore, reward motivation was accompanied by an increase in sustained (prestimulus) and transient (poststimulus response) pupil diameter. The latter effect was particularly evident following short FPn s. The current findings suggest that reward motivation can improve overall attentional performance and reduce implicit temporal bias, both through preparatory and reactive attentional mechanisms.

312 Personality and psychosexual correlates of sexual and emotional responses to rape: a pupillometric study with community men

Past research on the psychophysiological markers underpinning the processing of sexual violence has shown that non-criminal samples of men (i.e., community men) present increased genital responses to raping scenes. The aim of the present study was to expand upon previous literature, by assessing the personality and psychosexual correlates of the sexual and emotional responses to a raping scene. Findings will provide evidence on the psychological mechanisms behind the processing of sexual violence in community men. Thirty-six men were exposed to a raping scene. The emotional activation to the scene was measured by self-report and psychophysiological means (i.e., pupil diameter, using a Tobii T60 eye tracker). Participants further reported on the levels of subjective sexual arousal to the film clip, and have completed a set of self-report questionnaires aimed at measuring personality and psychopathic traits, raping myths, and sexual self-schemas; these measures were tested as correlates of the sexual and emotional responses to the raping scene.

Parallel graded attention in reading: A pupillometric study

There are roughly two lines of theory to account for recent evidence that word processing is influenced by adjacent orthographic information. One line assumes that multiple words can be processed simultaneously through a parallel graded distribution of visuo-spatial attention. The other line assumes that attention is strictly directed to single words, but that letter detectors are connected to both foveal and parafoveal feature detectors, as such driving parafoveal-foveal integrative effects. Putting these two accounts to the test, we build on recent research showing that the pupil responds to the brightness of covertly attended (i.e., without looking) locations in the visual field. Experiment 1 showed that foveal target word processing was facilitated by related parafoveal flanking words when these were positioned to the left and right of the target, but not when these were positioned above and below the target. Perfectly in line with this asymmetry, in Experiment 2 we found that the pupil size was contingent with the brightness of the locations of horizontally but not vertically aligned flankers, indicating that attentional resources were allocated to those words involved in the parafoveal-on-foveal effect. We conclude that orthographic parafoveal-on-foveal effects are driven by parallel graded attention.

Modulatory Effect of Motivation on the Association of Trait Anxiety and Cognitive Performance: A Pupillometric Study

The attentional control theory (ACT) proposes that trait anxiety disrupts functional efficiency of executive control of attention relating to working memory system such as shifting. ACT also emphasizes the modulatory role of motivation in anxiety on cognitive task performance. The present study investigated the association of trait anxiety-related inefficiencies in attentional shift and working memory performance in conjunction with the level of motivation. A variation of complex span paradigm is designed to systematically manipulate the time constraint on shifting attentional focus back and forth between working memory contents and processing task was used in this study. In the experiment, participants high and low in trait anxiety were allocated either high or low motivation induction conditions, and performed a series of complex span tasks. They also completed a state anxiety measure before and after the experimental task. Motivational states were assessed by the pupil dilation, which is known to reflect the amount of cognitive effort invested on the task at hand. Results showed that, only in low motivation condition, high trait-anxious individuals exhibited greater difficulty, relative to those low in trait anxiety, in maintaining working memory contents as the task demand increased. State anxiety showed no relation to working memory performance regardless of the level of motivation and task demands. Pupillary responses revealed that, in high motivational state, high trait-anxious individuals invested more effort than those low in trait anxiety when the task demand was low, F(1, 132) = 6.65, p = 0.0110, to moderate, F(1, 132) = 8.441, p = 0.00043. In accordance with ACT, these findings suggest that motivation can modulate the association between trait anxiety and cognitive performance along with the levels of task demand. Clinical implication is briefly discussed.

Developmental changes in autonomic emotional response during an executive functional task: A pupillometric study during Wisconsin card sorting test

ObjectiveThe autonomic nervous system has a deep relationship with the cognitive network when performing cognitive tasks. We hypothesize that autonomic emotional responses can affect cognitive function, especially executive function. The aim of this study was to clarify the involvement of the autonomic system during an executive functional task via developmental changes assessed using pupillometry. Subjects and methodsSubjects were 16 healthy children and 9 healthy adults. Children were divided into 3 groups (Group A, 7–9years; Group B, 10–14years; Group C, 15–17years). Pupil diameter was recorded using an eye mark recorder during cognitive shift (CS) during the Wisconsin card sorting test (WCST). The rate of pupil variations was integrated and compared within each group, focusing on performance during CS. ResultsCategories achieved (CA) in the behavioral results of WCST increased with age, with significant differences between Group A and other groups. The change of pupillary diameter was increased with CS and decreased at the correct answers after CS in adults. Changes of pupillary diameter with CS showed a linear increase with age, and the pattern of the pupillary response at the age of 10–14years was comparable to adults. The integrated rate of pupil diameter with CS increased with age, and there was a significant difference between Group A and adults. In addition, the degree of mydriasis correlated with the number of CA. ConclusionThese findings suggest that autonomic emotional response play an important role as a part of the process for executive function.

Dysregulation of the descending pain system in temporomandibular disorders revealed by low-frequency sensory transcutaneous electrical nerve stimulation: a pupillometric study.

Using computerized pupillometry, our previous research established that the autonomic nervous system (ANS) is dysregulated in patients suffering from temporomandibular disorders (TMDs), suggesting a potential role for ANS dysfunction in pain modulation and the etiology of TMD. However, pain modulation hypotheses for TMD are still lacking. The periaqueductal gray (PAG) is involved in the descending modulation of defensive behavior and pain through μ, κ, and δ opioid receptors. Transcutaneous electrical nerve stimulation (TENS) has been extensively used for pain relief, as low-frequency stimulation can activate µ receptors. Our aim was to use pupillometry to evaluate the effect of low-frequency TENS stimulation of μ receptors on opioid descending pathways in TMD patients. In accordance with the Research Diagnostic Criteria for TMD, 18 females with myogenous TMD and 18 matched-controls were enrolled. All subjects underwent subsequent pupillometric evaluations under dark and light conditions before, soon after (end of stimulation) and long after (recovery period) sensorial TENS. The overall statistics derived from the darkness condition revealed no significant differences in pupil size between cases and controls; indeed, TENS stimulation significantly reduced pupil size in both groups. Controls, but not TMD patients, displayed significant differences in pupil size before compared with after TENS. Under light conditions, TMD patients presented a smaller pupil size compared with controls; the pupil size was reduced only in the controls. Pupil size differences were found before and during TENS and before and after TENS in the controls only. Pupillometry revealed that stimulating the descending opioid pathway with low-frequency sensory TENS of the fifth and seventh pairs of cranial nerves affects the peripheral target. The TMD patients exhibited a different pattern of response to TENS stimulation compared with the controls, suggesting that impaired modulation of the descending pain system may be involved in TMD.

Examining implicit metacognition in 3.5-year-old children: an eye-tracking and pupillometric study.

The current study examined early signs of implicit metacognitive monitoring in 3.5-year-old children. During a learning phase children had to learn paired associates. In the test phase, children performed a recognition task and choose the correct associate for a given target among four possible answers. Subsequently, children's explicit confidence judgments (CJs) and their fixation time allocation at the confidence scale were assessed. Analyses showed that explicit CJs did not differ for remembered compared to non-remembered items. In contrast, children's fixation patterns on the confidence scale were affected by the correctness of their memory, as children looked longer to high confidence ratings when they correctly remembered the associated item. Moreover, analyses of pupil size revealed pupil dilations for correctly remembered, but not incorrectly remembered items. The results converge with recent behavioral findings that reported evidence for implicit metacognitive memory monitoring processes in 3.5-year-old children. The study suggests that implicit metacognitive abilities might precede the development of explicit metacognitive knowledge.