Grid Chart Research Articles

Inheritance of Some Traits in Crosses between Hybrid Tea Roses and Old Garden Roses.

The limited knowledge about the inheritance of traits in roses makes the efficient development of rose varieties challenging. In order to achieve breeding goals, the inheritance of traits needs to be explored. Additionally, for the inheritance of a trait like scent, which remains a mystery, it is crucial to know the success of parental traits in transmitting them to the next generation. Understanding this allows for accurate parental selection, ensuring sustainability in meeting market demand and providing convenience to breeders. The aim of this study was to assess the success of cross-combinations between scented old garden roses and hybrid tea roses used in cut roses in transferring their existing traits, with the objective of achieving scented cut roses. The evaluated traits included recurrent blooming, flower stem length, flower diameter, petal number, scent, and bud length of both parents and progenies. The inheritance of these traits was evaluated through theoretical evaluations, including calculating heterosis and heterobeltiosis and determining narrow-sense heritability. The combinations and examined traits were assessed using a hierarchical clustering heat map. The results of this study indicated that flower stem length, flower diameter, petal number, and bud length traits had a moderate degree of narrow-sense heritability, suggesting the influence of non-additive genes on these traits. This study observed a low success rate in obtaining progenies with scent in cross combinations between cut roses and old garden roses, indicating the challenges in obtaining scented genotypes. The discrepancy between the observed phenotypic rates and the expected phenotypic and genotypic rates, according to Punnett squares, suggests that the examined traits could be controlled by polygenic genes. The progenies were observed to exhibit a greater resemblance to old garden roses than hybrid tea roses and did not meet the commercial quality standards for cut flowers. The significant negative heterosis observed in 65.12% (petal number) and 99.61% (flower diameter) of the progenies provides strong evidence of resemblance to old garden roses. Considering these findings, it is recommended to consider old garden roses as parents, taking into account their suitability for other breeding objectives.

Flexible functional data smoothing and optimization using beta spline

<p>Functional data analysis (FDA) is a method used to analyze data represented in its functional form. The method is particularly useful for exploring both curve and longitudinal data in both exploratory and inferential contexts, with minimal constraints on the parameters. In FDA, the choice of basis function is crucial for the smoothing process. However, traditional basis functions lack flexibility, limiting the ability to modify the shape of curves and accurately represent abnormal details in modern and complex datasets. This study introduced a novel and flexible data smoothing technique for interpreting functional data, employing the beta spline introduced by Barsky in 1981. The beta spline offers flexibility due to the inclusion of two shape parameters. The proposed methodology integrated the roughness penalty approach and generalized cross-validation (GCV) to identify the optimal curve that best fitted the data, ensuring appropriate parameters were considered for transforming data into a functional form. The effectiveness of the approach was assessed by analyzing the GCV color grid chart to determine the optimal curve. In contrast to existing methodologies, the proposed method enhanced flexibility by incorporating the beta spline into the smoothing procedure. This approach was anticipated to effectively handle various forms of time series data, offering improved interpretability and accuracy in data analysis, including forecasting.</p>

The Colors of Kernels

This article presents a modified version of a “cookbook” laboratory activity that uses colored corn kernels to address the fundamental ideas in classical genetics. The purposeful sequencing of concrete experiences with corn plant structures along with teacher questioning promotes mental engagement and scaffolds students to a deeper and more robust understanding of inheritance, zygosity, genotype and phenotype, and calculating probabilities of inherited alleles using the Punnett Square.

Trends in authorship demographics for manuscripts published in endocrine journals - A 70-year analysis

Background: Over the previous few decades, trends in author demographics have significantly changed. Such trends have already been studied for many sub-specialties but endocrinology is among the few branches that are yet to see an analysis of such trends. This paper aims to fill this gap. Methods: Journal of Endocrinology and General & Comparative Endocrinology are two landmark journals that publish articles from around the world. Each decade during the 70-year period from 1961 to 2021 has been examined in this study. Funding source, first author – senior author gender, their demographics and proportion of papers with at least one female author were the parameters considered while studying each publication. It was predicted that the number of female authors per paper would increase with time, as would the range of degrees held by the authors, demographical variations in authorship, and the funding source. The aim was also to determine the distribution of female first authors and senior authors in endocrinology journals over a 70-year period, as well as to check the gender combinations using the Punnett square. Results: Female first authors rose from 7% to 29.6% (p<0.0006) between 1961 and 2021, whereas female senior authors rose from 15.6% to 22.2%. Despite women's small contributions to first and senior authors, female participation rose from 17.48% (25/143) to 70% (170/250) between 1961 and 2021. Male-Female and Female-Male combinations rose with Chi-Square = 124.6, (p<0.0001). Europe and the Americas had the most female academic medical contributors (p<0.0001) Regardless of author status, female participation rose from 17.48% in 1961 to 68% in 2021. Conclusion: In papers published in endocrinology journals, there was a rising trend in female contributions to academic medicine. Even with the large growth of female endocrinologists, there is still a disparity in why the increase in female authors is comparably fewer.

Sequencing individual genomes with recurrent genomic disorder deletions: an approach to characterize genes for autosomal recessive rare disease traits

BackgroundIn medical genetics, discovery and characterization of disease trait contributory genes and alleles depends on genetic reasoning, study design, and patient ascertainment; we suggest a segmental haploid genetics approach to enhance gene discovery and molecular diagnostics.MethodsWe constructed a genome-wide map for nonallelic homologous recombination (NAHR)-mediated recurrent genomic deletions and used this map to estimate population frequencies of NAHR deletions based on large-scale population cohorts and region-specific studies. We calculated recessive disease carrier burden using high-quality pathogenic or likely pathogenic variants from ClinVar and gnomAD. We developed a NIRD (NAHR deletion Impact to Recessive Disease) score for recessive disorders by quantifying the contribution of NAHR deletion to the overall allele load that enumerated all pairwise combinations of disease-causing alleles; we used a Punnett square approach based on an assumption of random mating. Literature mining was conducted to identify all reported patients with defects in a gene with a high NIRD score; meta-analysis was performed on these patients to estimate the representation of NAHR deletions in recessive traits from contemporary human genomics studies. Retrospective analyses of extant clinical exome sequencing (cES) were performed for novel rare recessive disease trait gene and allele discovery from individuals with NAHR deletions.ResultsWe present novel genomic insights regarding the genome-wide impact of NAHR recurrent segmental variants on recessive disease burden; we demonstrate the utility of NAHR recurrent deletions to enhance discovery in the challenging context of autosomal recessive (AR) traits and biallelic variation. Computational results demonstrate new mutations mediated by NAHR, involving recurrent deletions at 30 genomic regions, likely drive recessive disease burden for over 74% of loci within these segmental deletions or at least 2% of loci genome-wide. Meta-analyses on 170 literature-reported patients implicate that NAHR deletions are depleted from the ascertained pool of AR trait alleles. Exome reanalysis of personal genomes from subjects harboring recurrent deletions uncovered new disease-contributing variants in genes including COX10, ERCC6, PRRT2, and OTUD7A.ConclusionsOur results demonstrate that genomic sequencing of personal genomes with NAHR deletions could dramatically improve allele and gene discovery and enhance clinical molecular diagnosis. Moreover, results suggest NAHR events could potentially enable human haploid genetic screens as an approach to experimental inquiry into disease biology.

Trends in authorship demographics for manuscripts published in endocrine journals - A 70-year analysis

Background Over the previous few decades, demographics, gender, and the number of papers published have all changed considerably. One of the fields of medicine that has yet to be extensively investigated is endocrinology. Methods Journal of Endocrinology and General & Comparative Endocrinology are two landmark journals that publish articles from around the world. Each decade during the 70-year period from 1961 to 2021 has been examined in this study. Funding source, first author – last author gender, their demographics and proportion of papers with at least one female author were the parameters considered while studying each publication. It was predicted that the number of female authors per paper would increase with time, as would the range of degrees held by the authors, demographical variations in authorship, and the funding source. The aim was also to determine the distribution of female first authors and senior authors in endocrinology journals over a 70-year period, as well as to check the gender combinations using the Punnett square. Results Female initial authors rose from 7% to 29.6% (p<0.0006) between 1961 and 2021, whereas female senior authors rose from 15.6% to 22.2%. Despite women's small contributions to first and senior authors, female participation rose from 17.48% (25/143) to 70% (170/250) between 1961 and 2021. Male-Female and Female-Male combinations rose with Chi-Square = 124.6, (p<0.0001). Europe and the Americas had the most female academic medical contributors (p<0.0001) Regardless of author status, female participation rose from 17.48% in 1961 to 68% in 2021. Conclusion In papers published in endocrinology journals, there was a rising trend in female contributions to academic medicine. Even with the large growth of female endocrinologists, there is still a disparity in why the increase in female authors is comparably fewer.

Anterior View of Postural Youth Behavior: A Case Study

In the last two decades, incorrect posture has become significantly more widespread, particularly among school-aged children. According to various studies, scoliosis is one of the most prevalent incorrect postural types seen in school-aged children. The purpose of our study is to find out how common "Scoliosis" is among Albanian children. Methodology: About 308 kids aged 10 to 13 years (n = 151 girls, n = 157 boys) were randomly selected from Tirana public schools for this study. This group took part in a Posture Shape Examination (Anterior View), using Grid Chart Postural Analysis and the platform “Posture Screen Mobile®-PSM” (iPod). To provide exact information on their looks, children were photographed from the front (upright standing posture) wearing as little as possible. We analyzed the data statistically using "IBM SPSS Statistics 20," which included Descriptive and Frequency Analyze. Results: Our findings revealed that 34 individuals, or 11.03 % of the youngsters, had Scoliosis. This improper posture was more prevalent in 13-year-old youngsters (19.5%) than in children aged 10, 11, or 12. In comparison to females, boys were more impacted by scoliosis (12.7%) than girls (9.3%). The results reveal a minor difference in the degrees of postural displacement between boys (5.81850) and females (5.43610). Furthermore, postural displacement is greater in 13-year-old males (7.76500) and 12-year-old girls (6.14580). Conclusions and Recommendations: Based on the results of our study we conclude that incidents of anterior postural asymmetry occurred even in Albanian school-age children. Scoliosis, even why is detected more in boys, seems to be present in both genders. Based on these conclusions we recommend that parents, teachers, and children should be more informed about good posture and the problems that might arise from an incorrect posture. Further studies are important to be conducted in this field, in order to prevent the occurrence of these deviations and their aggravation in our young generation.

Inheritance Patterns

Educators usually teach the Mendelian inheritance model using Punnett squares to determine the probability of an offspring having a particular genotype and phenotype. To find the probability of an outcome of a particular cross, students need to understand the underlying biological concepts of these visual representations. However, this approach becomes more complex for cases with three or more characters and shies away from the authentic integration of mathematical and biological concepts. Therefore it is crucial for students to use mathematical algorithms that Mendel used to understand and solve inheritance problems. In this paper, we propose relating two simple probability rules to the laws of inheritance and using a probability tree diagram to predict the combined frequency of traits in the offspring of crosses. We validate the proposed probability rules for various examples.

Punnett Squares or Protein Production? The Expert-Novice Divide for Conceptions of Genes and Gene Expression.

Concepts of molecular biology and genetics are difficult for many biology undergraduate students to master yet are crucial for deep understanding of how life works. By asking students to draw their ideas, we attempted to uncover the mental models about genes and gene expression held by biology students (n = 23) and experts (n = 18) using semistructured interviews. A large divide was identified between novice and expert conceptions. While experts typically drew box-and-line representations and thought about genes as regions of DNA that were used to encode products, students typically drew whole chromosomes rather than focusing on gene structure and conflated gene expression with simple phenotypic outcomes. Experts universally described gene expression as a set of molecular processes involving transcription and translation, whereas students often associated gene expression with Punnett squares and phenotypic outcomes. Follow-up survey data containing a ranking question confirmed students’ alignment of their mental models with the images uncovered during interviews (n = 156 undergraduate biology students) and indicated that Advanced students demonstrate a shift toward expert-like thinking. An analysis of 14 commonly used biology textbooks did not show any relationship between Punnett squares and discussions of gene expression, so it is doubtful students’ ideas originate directly from textbook reading assignments. Our findings add to the literature about mechanistic reasoning abilities of learners and provide new insights into how biology students think about genes and gene expression.

Teaching Hardy-Weinberg Equilibrium using Population-Level Punnett Squares: Facilitating Calculation for Students with Math Anxiety.

Hardy-Weinberg (HW) equilibrium and its accompanying equations are widely taught in introductory biology courses, but high math anxiety and low math proficiency have been suggested as two barriers to student success. Population-level Punnett squares have been presented as a potential tool for HW equilibrium, but actual data from classrooms have not yet validated their use. We used a quasi-experimental design to test the effectiveness of Punnett squares over 2 days of instruction in an introductory biology course. After 1 day of instruction, students who used Punnett squares outperformed those who learned the equations. After learning both methods, high math anxiety was predictive of Punnett square use, but only for students who learned equations first. Using Punnett squares also predicted increased calculation proficiency for high-anxiety students. Thus, teaching population Punnett squares as a calculation aid is likely to trigger less math anxiety and help level the playing field for students with high math anxiety. Learning Punnett squares before the equations was predictive of correct derivation of equations for a three-allele system. Thus, regardless of math anxiety, using Punnett squares before learning the equations seems to increase student understanding of equation derivation, enabling them to derive more complex equations on their own.

An Integrated Risk and Resilience Assessment of Sea Ice Disasters on Port Operation.

Risk and resilience assessment of disasters plays a critical role in decision making for emergency response and postdisaster recovery. Yet, there is still a lack of modeling framework that could capture the effectiveness of economic resilience under uncertain disaster conditions. The objective of this study is to develop a novel integrated framework that is able to help decisionmakers understand the effectiveness of resilience performance under various risk conditions. Using hazard data of the Bohai Sea and throughput data of the Port of Yingkou (China) as an example, the copula-modeling method was adopted for the risk assessment of sea ice disasters on seaport operations. This study shows that the Gumbel Copula method, with consideration of ice thickness level and area of ice cover, provides the most robust risk assessment outcome. In addition, a grid chart system with an overlap of a joint return period and port throughput change provides a straightforward understanding of resilience performance under different risk levels. In particular, economic resilience tactics, such as production recapture and effective management, were confirmed to be effective resilience strategies, especially when a risk level is high, as port operational losses can be avoided up to 86.8%. Overall, the study provides insights that could help stakeholders improve the effectiveness of disaster risk management through an improved understanding of the linkage between risk and resilience.

Mapping Landslide Susceptibility Using Machine Learning Algorithms and GIS: A Case Study in Shexian County, Anhui Province, China

In this study, Logistics Regression (LR), Support Vector Machine (SVM), Random Forest (RF), Gradient Boosting Machine (GBM), and Multilayer Perceptron (MLP) machine learning algorithms are combined with GIS techniques to map landslide susceptibility in Shexian County, China. By using satellite images and various topographic and geological maps, 16 landslide susceptibility factor maps of Shexian County were initially constructed. In total, 502 landslide and random safety points were then using the “Extract Multivalues To Points” tool in ArcGIS, parameters for the 16 factors were extracted and imported into models for the five algorithms, of which 70% of samples were used for training and 30% of samples were used for verification, which makes sense for date symmetry. The Shexian grid was converted into 260130 vector points and imported into the five models, and the natural breakpoint method was used to divide the grid into four levels: low, moderate, high, and very high. Finally, by using column results gained using Area Under Curve (AUC) analysis and a grid chart, susceptibility results for mapping landslide prediction in Shexian County was compared using the five methods. Results indicate that the ratio of landslide points of high or very high levels from LR, SVM, RF, GBM, and MLP was 1.52, 1.77, 1.95, 1.83, and 1.64, and the ratio of very high landslide points to grade area was 1.92, 2.20, 2.98, 2.62, and 2.14, respectively. The success rate of training samples for the five methods was 0.781, 0.824, 0.853, 0.828, and 0.811, and prediction accuracy was 0.772, 0.803, 0.821, 0.815, and 0.803, respectively; the order of accuracy of the five algorithms was RF > SVM > MLP > GBM > LR. Our results indicate that the five machine learning algorithms have good effect on landslide susceptibility evaluation in Shexian area, with Random Forest having the best effect.

Modeling inherited physiological structures based on hyperbolic numbers

The article is devoted to using the mathematics of multi-dimensional hyperbolic numbers and their matrix representations for modeling of different inherited biosystems, which are parts of the holistic body. The list of considered models includes phyllotaxis sequences; Punnet squares of the Mendelian genetics; the main psychophysical Weber-Fechner law, and some others. This modeling approach reveals hidden structural interconnections among different biosystems and leads a deeper understanding of their commonality related to the commonality of their genetic basis. At the same time, it shows the structural connection of inherited biosystems with formalisms of the theory of resonances of oscillatory systems with many degrees of freedom. This complements works of many authors - from antiquity to the present day - on the importance of coordinated oscillations and resonances in the life of living organisms. The modeling approach based on hyperbolic numbers and their bisymmetric matrices reveals that the structural commonality of different inherited biosystems is related to the harmonic progression 1/n and the harmonic mean, which are long known in arts and culture. They are used in the Pythagorean teaching on the musical harmony and the aesthetics of proportions. Besides, the using - for biosystems modeling - of multi-dimensional hypercomplex numbers, which are one of the main tools in modern mathematical natural sciences, opens a bridge between these sciences and biology for their mutual enrichment.

Telemedicine for Glaucoma Patients in COVID-19 Era

In that Era with crowded hospitals and the need for social distance, telemedicine emerges as a solution for many problems. In ophthalmology Telemedicine has been started many years ago with limits. Now we have to widen the scope and applications of telemedicine (1-3)Glaucoma patients needs a special follow-up regimen with intraocular pressure (IOP) measurement, fundus examination, and visual acuity (V/A) assessment. Regular visits to the hospital are required; however, in the telemedicine protocol, we can decrease their visits to the hospitals. (4-6)Excluding emergencies, patients with glaucoma can follow the following protocol:History taking: by phone or video call with health provider (3)Visual acuity assessment: Patients can use Amsler's grid chart or smart applications for visual acuity and color vision. (7) Iop: I CARE tonometer can be a valuable tool; however, it is expensive.Visual field: There are Apps and devices to monitor the central 10, degrees including the commercially available preferential hyperacuity perimeter ForSee® device (Notal Vision) and discrimination apps such as mVT® (Vital Art and Science) application(8,9). Smart phone retinal imaging is available, but not yet designed for patients to use at home. (10-13)Video call: with the health care provider to discuss the condition and guide the patient to either the hospital or drug prescription.Future prospective: We aim at provide an optical coherence tomography (OCT) smart phone like apparatus. Intraocular devices for continuous IOP measurement are required.

Probabilities of Sickle Cell Disease

Sickle cell disease is a very common disease throughout the world. We used it to contextualize probability for upper elementary school students. Using Punnett squares, activities guide students' evaluation of inheritance using theoretical probability. Then, students perform trials using tools to compare theoretical and experimental probabilities.

Punnett squares and hybrid crosses: how Mendelians learned their trade by the book

AbstractThe rapid reception of Gregor Mendel's paper ‘Experiments on plant hybrids’ (1866) in the early decades of the twentieth century remains poorly understood. We will suggest that this reception should not exclusively be investigated as the spread of a theory, but also as the spread of an experimental and computational protocol. Early geneticists used Mendel's paper, as well as reviews of Mendelian experiments in a variety of other publications, to acquire a unique combination of experimental and mathematical skills. We will analyse annotations in copies of Mendel's paper itself, in early editions and translations of this paper, and in early textbooks, such as Reginald Punnett'sMendelism(1905) or Wilhelm Johannsen'sElemente der exakten Erblichkeitslehre(1909). We will examine how readers used copies of such works to reproduce the logic behind Mendelian experiments, either by recalculating results, or by retracing the underlying combinatorial reasoning. We will place particular emphasis on the emergent role of diagrams in teaching and learning the practice of Mendelian genetics.

Evaluation of Mobile Electronic Devices in Detecting Optic Disc and Visual Field Parameters in Patients with Glaucoma at a Tertiary Hospital in Northeastern Tanzania

Background: Glaucoma is a serious public health problem since it causes visual impairment impacting social, mental and physical health of an individual. Diagnosis and management of glaucoma continue to be a challenge due to few qualified personnel and high cost of the equipment. The use of portable Eye Examination Kit such as Smartphone and tablets can be used in glaucoma screening for taking high-resolution fundus photos for optic disc and visual field parameters, respectively. This study was conducted to evaluate the applicability of mobile electronic device to detect optic disc and visual field parameters for glaucoma in a resource limited setting. Objective: To evaluate the applicability of mobile electronic devices to detect optic disc and visual field parameters for glaucoma. Methodology: Across-sectional study was conducted at KCMC Eye department from October 2018 to June 2019. Study included 140 participants attending eye clinic of which 67 had glaucoma and 73 without glaucoma. Clinical and socio-demographic data were collected using a structured questionnaire and analysed using Stata 15. Glaucoma examination was made on the right eye and photo comparison made between those with and without glaucoma. PEEK Smartphone fundus photo examination was compared with the gold standard machine (Slit Lamp Biomicroscopy), Amsler grid chart installed on a tablet (Microsoft surface, internal storage 256 GB, 2013) and contrast sensitivity compared with Humphrey field analyser (i series, model 740117434, Carl Zeiss Meditec). Results: The kappa (k) agreement between Slit lump biomicroscopy fundus view image and PEEK Smartphone concerning the optic disc measurement was 0.92 with sensitivity and specificity of 90.32% (95% CI: 80.12 - 96.37) and 93.59% (95% CI: 85.67 - 97.89) with a p < 0.001 respectively. An agreement between Amsler grid and Humphrey Field Analyser was 0.67 with sensitivity of 33.33% (95% CI: 20.76 - 47.92) and specificity of 86.52% (95% CI: 77.63 - 92.83) with a p < 0.005. An agreement for contrast sensitivity and Humphrey Field Analyser was 0.51 with sensitivity of 48.91% (95% CI: 38.3 - 59.56) and specificity of 54.17% (95% CI: 39.17 - 68.63) and p value of 0.729. Conclusion: PEEK Smartphone fundus image specificity was almost in perfect agreement compared with Amsler grid and Contrast sensitivity. The PEEK Smartphone fundus view optic disc parameter for vertical cup to disc ratio has a potential to enhance detection of glaucoma and thus improve its management in resource-limited settings.

Variables tangibles e intangibles sobre productos y servicios: la creacción de itness application ‘punnett square’ (faps)

La industria fitness y salud (H&amp;F) siempre marcó más las variables tangibles de los productos antes de las intangibles. Hoy en día, en los modelos de negocios que funcionan, se ha demostrado como estas resultan increíblemente útiles. La aplicabilidad y usabilidad de recursos fitness (productos, servicios o soluciones mixtas) se planean sobre el innovador enfoque que define estas calidades más escondidas. Esta revisión de la literatura académica tiene el reto de evidenciar este ‘lado B’. La introducción de la herramienta nombrada Fitness Applications ‘Punnett Square’ (FAPS) ayudará a entender de forma mejor los recursos del sector fitness que siguen en continuo desarrollo. También, resultará aplicable a todos los profesionales del sector que utilizan equipos (físicos o menos) en su día a día en instalaciones deportivas. Bien para todo lo que ya está en posesión para aumentar los niveles de valoracción, tanto como para todas las elicciones frente a acciones futuras. Health and fitness (H&amp;F) industry has always highlighted product’s tangible variables over untouchable ones. Nowadays conspicuous market models are proving that these facets are increasingly required by international societies and contexts and are demonstrated to be incredibly useful. The applicability and usability of fitness resources (products, services or mixed solutions) depends upon a genuinely innovative approach to the definition of those hidden intangible variables. This literature analysis underline that also academic contributions focus more attention on ‘touchable’ variables, but it’s now the time for the ‘B side’. The introduced Fitness Applications ‘Punnett Square’ (FAPS) tool helps to better understand the ever-growing world of fitness industry resources. It is also direct applicable to all those sector professionals who operate in their daily-life facility routine, with the final goal to increase levels of assessment of H&amp;F product and service knowledge, for what already own and for emergent choices or purchasing actions.

Total plant performance evaluation based on big data: Visualization analysis of TE process

Abstract The performance evaluation of the process industry, which has been a popular topic nowadays, can not only find the weakness and verify the resilience and reliability of the process, but also provide some suggestions to improve the process benefits and efficiency. Nevertheless, the performance assessment principally concentrates upon some parts of the entire system at present, for example the controller assessment. Although some researches focus on the whole process, they aim at discovering the relationships between profit, society, policies and so forth, instead of relations between overall performance and some manipulated variables, that is, the total plant performance. According to the big data of different performance statuses, this paper proposes a hierarchical framework to select some structured logic rules from monitored variables to estimate the current state of the process. The variables related to safety and profits are regarded as key factors to performance evaluation. To better monitor the process state and observe the performance variation trend of the process, a classification-visualization method based on kernel principal component analysis (KPCA) and self-organizing map (SOM) is established. The dimensions of big data produced by the process are first reduced by KPCA and then the processed data will be mapped into a two-dimensional grid chart by SOM to evaluate the performance status. The monitoring method is applied to the Tennessee Eastman process. Monitoring results indicate that off-line and on-line performance status can be well detected in a two-dimensional diagram.

Gaming to improve vision: 21st century self-monitoring for patients with age-related macular degeneration.

Improved vision self-monitoring tools are required for people at risk of neovascular complications from age related macular degeneration (AMD). to report the self-monitoring habits of participants with intermediate AMD using the Amsler grid chart, and the use of personal electronic devices and gameplay in this over 50 year old cohort. single-centre descriptive study carried out at the Centre for Eye Research (CERA), Melbourne, Australia. 140 participants over 50 years of age, with a diagnosis of intermediate AMD and best-corrected visual acuity (BCVA) of ≥6/12 in each eye. structured questionnaire survey of participants who were enrolled in natural history of AMD studies at CERA. frequency of vision self-monitoring using the Amsler grid chart, and frequency of general use of personal electronic devices and gameplay. Of 140 participants with mean age of 70.5 years, 83.6% used an Amsler grid chart, but only 39.3% used it once per week. Most participants (91.4%) used one or more personal electronic devices. Of these, over half (54.7%) played games on them, among whom 39% played games once a day. Of participants aged 50-69 years, 92% (95%CI 85.1-98.9) were willing to play a game to monitor their vision, compared to 78% (95%CI 69.0-87.0) of those aged 70 years and older (P < 0.05). a large proportion of AMD patients already use personal electronic devices. Gamification techniques are likely to increase compliance with self-monitoring, leading to earlier detection in the next generation of patients with neovascular AMD.