As refrigerant regulations become increasingly stringent, R466A has garnered attention as a potential replacement for R410A. Despite its potential benefits, a lack of study on the condensation heat transfer coefficient (HTC) and frictional pressure drop (FPD) of R466A hinders its application in heat pumps. In this study, the condensation HTCs and FPDs of R466A and R410A in smooth and micro-fin tubes were measured at mass fluxes of 200–600 kg m−2 s−1, vapor qualities of 0.1–0.9, and saturation temperatures of 35 °C and 45 °C. R410A exhibited 8.8–14.1% higher average condensation HTC and 24.2–35.4% higher average FPD than R466A owing to its lower vapor density. Furthermore, the heat transfer enhancement factor and pressure drop penalty factor of R466A in the micro-fin tube were 1.34 and 1.37, respectively, at G = 300 kg m−2 s−1. New condensation HTC and FPD correlations for R466A and R410A in the micro-fin tube were formulated using the measured data. The newly developed correlations exhibited average deviations of −3.9% and 7.2% and average absolute deviations of 6.3% and 16.3%, respectively.
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