Pulse Wave Monitoring Research Articles

Flexible Sphere Elastomer Structural Pressure Sensor for Non-invasive Pulse Wave Monitoring

Flexible Sphere Elastomer Structural Pressure Sensor for Non-invasive Pulse Wave Monitoring

Tapered fiber optic sensor for arterial pulse wave monitoring

Arterial pulse wave monitoring has been recognized as an effective medical diagnostic tool for various cardiovascular diseases. To overcome the barriers in traditional, complex, and expensive detection configurations, new electronic and optical sensors have been developed with their unique advantages. Particularly, various configurations of fiber-optic sensors have been proposed. This paper demonstrates the use of a tapered optical fiber structure to create a sensitive sensor that can detect carotid arterial pulse waves on the skin surface. The demonstrated fiber sensor probe utilizes an in-line Mach-Zehnder interferometer configuration and liquid-gold film coating on the sensor tip to enhance its sensitivity and demonstrate its use by encapsulating the sensor with a flexible elastomer material for detecting arterial pulse waves with a simple testing configuration. Considering the simple fabrication and high sensitivity without a complex demodulation scheme, the proposed sensor has broad implementation in biomedical health monitoring systems.

Minimization of Parasitic Capacitance between Skin and Ag/AgCl Dry Electrodes.

Conventional dry electrodes often yield unstable results due to the presence of parasitic capacitance between the flat electrode surface and the non-uniform skin interface. To address this issue, a gel is typically placed between the electrodes to minimize parasitic capacitance. However, this approach has the drawbacks of being unsuitable for repeated use, limited lifetime due to gel evaporation, and the possibility of developing skin irritation. This is particularly problematic in underserved areas since, due to the cost of disposable wet electrodes, they often sterilize and reuse dry electrodes. In this study, we propose a method to neutralize the effects of parasitic capacitance by attaching high-value capacitors to the electrodes in parallel, specifically when applied to pulse wave monitoring through bioimpedance. Skin capacitance can also be mitigated due to the serial connection, enabling stable reception of arterial pulse signals through bioimpedance circuits. A high-frequency structure simulator (HFSS) was first used to simulate the capacitance when injection currents flow into the arteries through the bioimpedance circuits. We also used the simulation to investigate the effects of add-on capacitors. Lastly, we conducted preliminary comparative analyses between wet electrodes and dry electrodes in vivo with added capacitance values ranging from 100 pF to 1 μF, altering capacitance magnitudes by factors of 100. As a result, we obtained a signal-to-noise ratio (SNR) that was 8.2 dB higher than that of dry electrodes. Performance was also shown to be comparable to wet electrodes, with a reduction of only 0.4 dB using 1 μF. The comparative results demonstrate that the addition of capacitors to the electrodes has the potential to allow for performance similar to that of wet electrodes for bioimpedance pulse rate monitoring and could potentially be used for other applications of dry electrodes.

High‐Resolution Carbon‐Based Tactile Sensor Array for Dynamic Pulse Imaging

AbstractWith the development of modern medicine, the importance of continuous and reliable pulse wave monitoring has increased significantly in physiological evaluation and disease diagnosis. Among them, the 3D reconstruction of the pulse wave is indispensable, and needs rely on ultra‐high resolution sensor arrays, that is, high spatial resolution, temporal resolution, and force resolution. Herein, a flexible high‐density 32 × 32 tactile sensor array based on pressure‐sensitive tunneling mechanism is develpoed. Conformal graphene nanowalls (GNWs) pattern arrays are deposited on micro‐pyramidal structural Si substrate via mask‐assisted plasma enhanced chemical vapor deposition (PECVD) method and are adopted as pressure‐sensitive electrode, exhibiting a spatial resolution of 64 dots/cm2, high sensitivity (222.36 kPa−1) and short response time (2 ms). More importantly, HfO2 tunneling layer can effectively suppress noise current, which made it sense weak pressure signals with 1/1000 force resolution and SNR of 36.32 dB. By leveraging its high‐resolution array, more holistic pulse signals are acquired and the 3D shape of the pulse wave are successfully replicated. This work shows high‐resolution sensors have significant promise for applications in remote intelligent diagnostics.

Wireless Pulse Wave Monitoring System Based on Reflective Flexible Probe and AFE4490

Pulse rate and blood oxygen levels are crucial physiological parameters that reflect physiological and pathological information within the human body. The system designs a wireless pulse wave monitoring system utilizing a flexible reflective probe and the AFE4490, which is capable of monitoring pulse wave and blood oxygen levels on the human forehead. The system is predominantly based on a reflective flexible probe, the AFE4490, a power supply module, a control microcontroller unit (MCU), and a Wi-Fi module. Post-processing by a slave computer, the collected pulse wave data is wirelessly transmitted to a smartphone. The real-time pulse waveform, pulse rate, and blood oxygen levels are displayed on an application. Following relevant tests and verifications, the system can accurately detect pulse wave signals, meet the requirements for wearable technology, and possesses significant market application potential.

Smart photonic wristband for pulse wave monitoring

Smart photonic wristband for pulse wave monitoring

Graphene-based Two-Stage Enhancement Pressure Sensor for Subtle Mechanical Force Monitoring.

The development of pressure sensors with high sensitivity and a low detection limit for subtle mechanical force monitoring and the understanding of the sensing mechanism behind subtle mechanical force monitoring are of great significance for intelligent technology. Here, we proposed a graphene-based two-stage enhancement pressure sensor (GTEPS), and we analyzed the difference between subtle mechanical force monitoring and conventional mechanical force monitoring. The GTEPS exhibited a high sensitivity of 62.2 kPa-1 and a low detection limit of 0.1 Pa. Leveraging its excellent performance, the GTEPS was successfully applied in various subtle mechanical force monitoring applications, including acoustic wave detection, voice-print recognition, and pulse wave monitoring. In acoustic wave detection, the GTEPS achieved a 100% recognition accuracy for six words. In voiceprint recognition, the sensor exhibited accurate identification of distinct voiceprints among individuals. Furthermore, in pulse wave monitoring, GTEPS demonstrated effective detection of pulse waves. By combination of the pulse wave signals with electrocardiogram (ECG) signals, it enabled the assessment of blood pressure. These results demonstrate the excellent performance of GTEPS and highlight its great potential for subtle mechanical force monitoring and its various applications. The current results indicate that GTEPS shows great potential for applications in subtle mechanical force monitoring.

Recent Progress of Wearable Triboelectric Nanogenerator-Based Sensor for Pulse Wave Monitoring.

Today, cardiovascular diseases threaten human health worldwide. In clinical practice, it has been concluded that analyzing the pulse waveform can provide clinically valuable information for the diagnosis of cardiovascular diseases. Accordingly, continuous and accurate monitoring of the pulse wave is essential for the prevention and detection of cardiovascular diseases. Wearable triboelectric nanogenerators (TENGs) are emerging as a pulse wave monitoring biotechnology due to their compelling characteristics, including being self-powered, light-weight, and wear-resistant, as well as featuring user-friendliness and superior sensitivity. Herein, a comprehensive review is conducted on the progress of wearable TENGs for pulse wave monitoring. Firstly, the four modes of operation of TENG are briefly described. Secondly, TENGs for pulse wave monitoring are classified into two categories, namely wearable flexible film-based TENG sensors and textile-based TENG sensors. Next, the materials, fabrication methods, working mechanisms, and experimental performance of various TENG-based sensors are summarized. It concludes by comparing the characteristics of the two types of TENGs and discussing the potential development and challenges of TENG-based sensors in the diagnosis of cardiovascular diseases and personalized healthcare.

Contact pressure-guided wearable dual-channel bioimpedance device for continuous hemodynamic monitoring.

Wearable devices for continuous monitoring of arterial pulse waves have the potential to improve the diagnosis, prognosis, and management of cardiovascular diseases. These pulse wave signals are often affected by the contact pressure between the wearable device and the skin, limiting the accuracy and reliability of hemodynamic parameter quantification. Here, we report a continuous hemodynamic monitoring device that enables the simultaneous recording of dual-channel bioimpedance and quantification of pulse wave velocity (PWV) used to calculate blood pressure (BP). Our investigations demonstrate the effect of contact pressure on bioimpedance and PWV. The pulsatile bioimpedance magnitude reached its maximum when the contact pressure approximated the mean arterial pressure of the subject. We employed PWV to continuously quantify BP while maintaining comfortable contact pressure for prolonged wear. The mean absolute error and standard deviation of the error compared to the reference value were determined to be 0.1 ± 3.3 mmHg for systolic BP, 1.3 ± 3.7 mmHg for diastolic BP, and -0.4 ± 3.0 mmHg for mean arterial pressure when measurements were conducted in the lying down position. This research demonstrates the potential of wearable dual-bioimpedance sensors with contact pressure guidance for reliable and continuous hemodynamic monitoring.

Single-point curved fiber optic pulse sensor for physiological signal prediction based on the genetic algorithm-support vector regression model

For hypertensive patients, a real-time human physiological signal monitoring system helps to track blood pressure status and provides valuable data to clinicians for early diagnosis and timely intervention. Optical fiber pulse sensing has superior conditions such as resistance to electromagnetic interference and richness of measured pulse characteristics. In this study, a monitoring system based on a single-point curved fiber pulse sensor (CFPS) was used to collect the pulse wave signal of a human radial artery. The features of the pulse wave signal were used to estimate the pulse wave transit time (PTT) and Blood Pressure—systolic blood pressure (SBP) and diastolic blood pressure (DBP)—based on support vector regression (SVR) optimized by a genetic algorithm (GA) (GA-SVR model). The results show that the root mean square error (RMSE) of SBP, DBP and PTT were 1.571 mmHg, 3.250 mmHg and 5.719 ms, respectively, and the results met the Advancement of Medical Instrumentation (AAMI) criteria. Therefore, a real-time pulse wave monitoring system based on a single-point CFPS can well predict human physiological signals such as PTT, SBP and DBP.

Flexible Piezoelectric Pressure Sensors Fabricated from Nanocomposites with Enhanced Dispersion and Vapor Permeability for Precision Pulse Wave Monitoring

Flexible Piezoelectric Pressure Sensors Fabricated from Nanocomposites with Enhanced Dispersion and Vapor Permeability for Precision Pulse Wave Monitoring

Low-Cost Fiber-Optic Sensing System with Smartphone Interrogation for Pulse Wave Monitoring

Pulse wave measurement is a highly prominent technique used in biomedical diagnostics. The development of novel cost-effective pulse wave sensors will pave the way to more advanced healthcare technologies. This work reports on a pulse wave optical fiber sensor interrogated by a smartphone. The sensor performance was tested in terms of signal to noise ratio, repeatability of demodulated signal and suitability of demodulated signals for the extraction of information about direct and reflected waves. The analysis showed that the observed fluctuations of signal parameters are caused by variability of the state of the cardiovascular system and not by the system noise.

Structural Electronic Skin for Conformal Tactile Sensing.

The conformal integration of the electronic skin on the non-developable surface is in great demand for the comprehensive tactile sensing of robotics and prosthetics. However, the current techniques still encounter obstacles in achieving conformal integration of film-like electronic skin on non-developable surfaces with substantial curvatures for contact pressure detection and tactile mapping. In this paper, by utilizing the 3D printing technology to prepare the 3D electrode array in the structural component following its surface curvature, and covering it with a molded functional shell to form the pressure sensitive iontronic interface, a device is proposed to achieve high-sensitive pressure detection and high-fidelity tactile mapping on a complicated non-developable surface, called structural electronic skin (SES). The SES is prepared in a 3D printed fingertip with 46 tactile sensing units distributed on its curved surface, achieving the integration of both structural and tactile functions in a single component. By integrating the smart fingertip into a dexterous hand, a series of demonstrations are presented to show the dead-zone free pressure detection and tactile mapping with high sensitivity, for instance, 2D pulse wave monitoring and robotic injection in a medical robot, object recognition and compliant control in a smart prosthesis.

Testbed for Simulating Pulsewaveform for Development of Wearable Piezoresistive Pressure Sensors

Due to their non-invasive method of continuous monitoring of weak human physiological data, flexible and skin-mountable wearable health monitoring devices have attracted a lot of attention in recent years. According to their mode of operation, ultra-sensitive pressure sensors can generally be divided into piezoresistive, capacitive, triboelectric, and piezoelectric sensors. Particularly, piezoresistive sensors have received a lot of attention due to its rapid response, wide detection range, straightforward structure, and comparatively easy signal measuring system. Although previous attempts to obtain the complete pulse waveform of the human heartbeat were successful, their signal capture required the use of unwearable measuring equipment. In order to resolve this shortcoming of the current supposedly wearable systems, we outline three requirements for a sensor to be wearable (i.e. could be paired with a simple and compact signal acquisition device). The first of these is the sensitivity; through a complete literature review we determine the lower limit of sensitivity that if obtained, the sensor can acquire the pulsewaveform from the body peripheries such as wrist or ankle. Second is the response time of the sensor. The piezoresistive sensor must have a shorter response time than the period of fastest heartbeat. And lastly is the cyclability; the durability tests of the sensor must show ample stability and consistency in the signal output after operation for months.To verify that the sensors pass the requirements above, we have custom-built a testbed capable of measuring these three characteristics. The testbed specifically makes use of a secondary pressure sensor to confirm the sensitivity. Secondly, by using an encoder instead of merely relying on a sensor's rise or fall time, it is capable to more accurately determine the response time of the sensor. Furthermore, because the testbed is motorized, it is streamlined to mimic operation over an extended cycles.Finally, in this study we fabricated an exemplary piezoresistive pressure sensor using environmentally friendly materials and tested it in the testbed and then mounted it on the wrist of a human subject and acquired the pulsewaveform with a simple and wearable signal acquisition device to confirm the capability as a wearable pulsewave monitoring device. The details of this study will be presented in the meeting.

Hardware and Protocol for Testing of Piezoresistive Pressure Sensors for Pulse Wave Monitoring

Hardware and Protocol for Testing of Piezoresistive Pressure Sensors for Pulse Wave Monitoring

Wrinkle Clamp Down on Structure Crack Strain Sensor Based on High Poisson's Ratio Material for Home Health Monitoring and Human-Machine Interaction.

Flexible wearable crack strain sensors are currently receiving significant attention because they can be used in a wide range of physiological signal monitoring and human-machine interaction applications. However, sensors with high sensitivity, great repeatability, and wide sensing range remain challenging. Herein, a tunable wrinkle clamp down structure (WCDS) crack strain sensor based on high Poisson's ratio material with high sensitivity, high stability, and wide strain range is proposed. Based on the high Poisson's ratio of the acrylic acid film, the WCDS was prepared by a prestretching process. The wrinkle structures can clamp down the crack to improve the cyclic stability of the crack strain sensor while maintaining its high sensitivity. Moreover, the tensile properties of the crack strain sensor are improved by introducing wrinkles in the bridge-like gold stripes connecting each separated gold flake. Owing to this structure, the sensitivity of the sensor can reach 3627, stable operation over 10 000 cycles is achieved, and the strain range can reach about 9%. In addition, the sensor exhibits low dynamic response and good frequency characteristics. Because of its demonstrated excellent performance, the strain sensor can be used in pulse wave and heart rate monitoring, as well as posture recognition and game control.

Comparison between Speckle Plethysmography and Photoplethysmography during Cold Pressor Test Referenced to Finger Arterial Pressure.

Speckle Plethysmography (SPG) and Photoplethysmography (PPG) are different biophotonics technologies that allow for measurement of haemodynamics. As the difference between SPG and PPG under low perfusion conditions is not fully understood, a Cold Pressor Test (CPT-60 s full hand immersion in ice water), was used to modulate blood pressure and peripheral circulation. A custom-built setup simultaneously derived SPG and PPG from the same video streams at two wavelengths (639 nm and 850 nm). SPG and PPG were measured at the right index finger location before and during the CPT using finger Arterial Pressure (fiAP) as a reference. The effect of the CPT on the Alternating Component amplitude (AC) and Signal-to-Noise Ratio (SNR) of dual-wavelength SPG and PPG signals was analysed across participants. Furthermore, waveform differences between SPG, PPG, and fiAP based on frequency harmonic ratios were analysed for each subject (n = 10). Both PPG and SPG at 850 nm show a significant reduction during the CPT in both AC and SNR. However, SPG showed significantly higher and more stable SNR than PPG in both study phases. Harmonic ratios were found substantially higher in SPG than PPG. Therefore, in low perfusion conditions, SPG seems to offer a more robust pulse wave monitoring with higher harmonic ratios than PPG.

Flexible Sensors Array Based on Frosted Microstructured Ecoflex Film and TPU Nanofibers for Epidermal Pulse Wave Monitoring

Recent advances in flexible pressure sensors have fueled increasing attention as promising technologies with which to realize human epidermal pulse wave monitoring for the early diagnosis and prevention of cardiovascular diseases. However, strict requirements of a single sensor on the arterial position make it difficult to meet the practical application scenarios. Herein, based on three single-electrode sensors with small area, a 3 × 1 flexible pressure sensor array was developed to enable measurement of epidermal pulse waves at different local positions of radial artery. The designed single sensor holds an area of 6 × 6 mm2, which mainly consists of frosted microstructured Ecoflex film and thermoplastic polyurethane (TPU) nanofibers. The Ecoflex film was formed by spinning Ecoflex solution onto a sandpaper surface. Micropatterned TPU nanofibers were prepared on a fluorinated ethylene propylene (FEP) film surface using the electrospinning method. The combination of frosted microstructure and nanofibers provides an increase in the contact separation of the tribopair, which is of great benefit for improving sensor performance. Due to this structure design, the single small-area sensor was characterized by pressure sensitivity of 0.14 V/kPa, a response time of 22 ms, a wide frequency band ranging from 1 to 23 Hz, and stability up to 7000 cycles. Given this output performance, the fabricated sensor can detect subtle physiological signals (e.g., respiration, ballistocardiogram, and heartbeat) and body movement. More importantly, the sensor can be utilized in capturing human epidermal pulse waves with rich details, and the consistency of each cycle in the same measurement is as high as 0.9987. The 3 × 1 flexible sensor array is employed to acquire pulse waves at different local positions of the radial artery. In addition, the time domain parameters including pulse wave transmission time (PTT) and pulse wave velocity (PWV) can be obtained successfully, which holds promising potential in pulse-based cardiovascular system status monitoring.

Noninvasive Monitoring of Intracranial Pulse Waves.

The clinical management of several neurological disorders benefits from the assessment of intracranial pressure and craniospinal compliance. However, the associated procedures are invasive in nature. Here, we aimed to assess whether naturally occurring periodic changes in the dielectric properties of the head could serve as the basis for deriving surrogates of craniospinal compliance noninvasively. We designed a device and electrodes for noninvasive measurement of periodic changes of the dielectric properties of the human head. We characterized the properties of the device-electrode-head system by measurements on healthy volunteers, by computational modeling, and by electromechanical modeling. We then performed hyperventilation testing to assess whether the measured signal is of intracranial origin. Signals obtained with the device on volunteers showed characteristic cardiac and respiratory modulations. Signal oscillations can be attributed primarily to changes in resistive properties of the head during cardiac and respiratory cycles. Reduction of end-tidal CO2, through hyperventilation, resulted in a decrease in the signal amplitude associated with cardiovascular action. Given the higher CO2 reactivity of intracranial vessels compared to extracranial ones, the results of hyperventilation testing suggest that the acquired signal is, in part, of intracranial origin. If confirmed in larger cohorts, our observations suggest that noninvasive capacitive acquisition of changes in the dielectric properties of the head could be used to derive surrogates of craniospinal compliance.

A Flexible Pressure Sensor with a Mesh Structure Formed by Lost Hair for Human Epidermal Pulse Wave Monitoring

Flexible pressure sensors with the capability of monitoring human vital signs show broad application prospects in personalized healthcare. In this work, a hair-based flexible pressure sensor (HBPS) consisting of lost hair and polymer films was proposed for the continuous monitoring of the human epidermal arterial pulse waveform. A macroscale mesh structure formed by lost hair provides a simplified spacer that endows the triboelectric-based flexible pressure sensor with sufficient contact-separation space. Based on this mesh structure design, the hair-based flexible pressure sensor can respond to the slight pressure change caused by an object with 5 mg weight and hold a stable output voltage under 1-30 Hz external pressure excitation. Additionally, the hair-based flexible pressure sensor showed great sensitivity (0.9 V/kPa) and decent stability after 4500 cycles of operation. Given these compelling features, the HBPS can successfully measure the human epidermal arterial pulses with obvious details at different arteries. The proposed HBPS can also be used to monitor the pulse signals of different subjects. Furthermore, the three different pulse wave transmission time (PTT) values (PTT-foot, PTT-middle, and PTT-peak) can be obtained by simultaneously monitoring human pulse and electrocardiogram signals, which has enormous application potential for assessing cardiovascular system health.