Pulse Response Research Articles

Prognostic value of heart rate and oxygen pulse response in heart failure with left ventricular ejection fraction over 40%

Prognostic value of heart rate and oxygen pulse response in heart failure with left ventricular ejection fraction over 40%

Laser modulation of the FePS3 memristors.

Ternary two-dimensional (2D) material-based memristors have garnered significant attention in the fields of machine learning, neuromorphic computing due to their low power consumption, rapid learning, and synaptic-like behavior. Although such memristors often exhibit high ON/OFF ratios and exceptional pulse response characteristics, they have also to face some challenges concerning reusability and switching cycles, which arise from the filament instability issues.. Here we propose a modulation strategy to improve performance of 2D-material memristors with synaptic and flexible features. By laser-modulating few-layer FePS3, we induced the formation of conductive filaments, realized a major improvement in performance of the FePS3 memristors, achieving an on/off ratio of nearly 104, low power consumption at approximately 10-7 W of single switching operation, and maintaining stability even after over 500 cycles. The performance promotion has been ascribed to enhancement of conductive filament induced by laser-modulation. Furthermore, we have identified the effectiveness of our laser modulation under strain by building the high-performance flexible FePS3 memristor. Meanwhile, we discovered a novel strain-dominant erasure method for the flexible memristors. Our work confirms that laser modulation is a viable method for enhancing the performance of 2D material-based memristive devices.&#xD.

A Novel Labeling Method of Physiological-based Pressure Pain Assessment Among Patients With and Without Chronic Low Back Pain

Pain, especially chronic pain, is a complicated and subjective experience, threatening global healthcare as one of the most severe health problems. Traditionally, pain is assessed by Visual Analog Scale to indicate the pain intensity by the patient’s self-report, causing them to become biased by various psychosocial factors. In this study, we performed two distinct labeling methods to assess the pressure pain in Quantitative Sensory Testing and to differentiate healthy controls and chronic low back pain patients: time period labels and percentage timestamp labels. Physiological signals such as blood volume pulse and galvanic skin response were collected. The time period labeling method was to segment via fixed time windows. The percentage timestamp labeling method was to select the timestamp labels based on the percentage of the threshold or the tolerance time. Both methods demonstrate different advantages when visualizing the information of different pain states and different participant groups.

Peak oxygen pulse response during maximal cardiopulmonary exercise testing on a treadmill: applicability analysis of the FRIEND registry prediction equation in a Brazilian healthy sample

Abstract Background Peak oxygen uptake (VO2peak), measured by cardiopulmonary exercise test (CPET), is an established variable for prognostic assessment. Other VO2peak-derived variables, such as the peak oxygen pulse (peakO2pulse), also provide valuable information for risk stratification in patients with cardiac diseases. For individualized assessment, the measured peakO2pulse can be compared to reference standards using predictive equations, such as the FRIEND Registry [peakO2pulse = 23.2 – (0.09 × Age) – (6.6 × Sex (female:1; male: 0)]. However, the applicabilty of this equation in a Brazilian population sample has never been evaluated. Purpose To conduct an external validation of the FRIEND registry prediction equation for treadmill peakO2pulse in a sample of healthy Brazilian individuals. Methods Cross-sectional study involving subjects assessed by treadmill CPET in the Brazilian Midwest region from January 2011 to March 2020. Inclusion criteria: healthy individuals aged ≥ 20 years with a peak respiratory exchange ratio ≥ 1.00. Exclusion criteria: history of cardiovascular or pulmonary disease, presence of cardiovascular risk factors (hypertension, diabetes mellitus, current smoking, and obesity), and abnormalities on CPET. Variables were described as median and interquartile range (IQR). Statistical comparisons between measured and predicted values were conducted using the Wilcoxon signed rank test, including the calculation of the median differences and the 95% confidence interval (CI). Furthermore, Bland-Altman agreement analysis was utilized to assess the concordance between measured and estimated values. Results A total of 7,843 CPETs were performed. After applying inclusion and exclusion criteria, 3,544 assessments were included (1,574 females and 1,970 males) aged between 20 to 80 years. In the females, the median and IQR of measured peakO2pulse and predicted values were 10.4 (9.0; 12.1) and 13.1 (12.3; 13.7) ml/beat, respectively. This difference was statistically significant (p < 0.001), with a median difference of 2.54 mL/beat (95% CI: 2.40; 2.69). For males, the measured and predicted values were 17.3 (15.1; 19.7) and 19.7 (19.0; 20.2) ml/beat, respectively. The median difference was statistically significant at 2.26 mL/beat (95% CI: 2.11; 2.46) (p < 0.001) (Figure 1). Bland-Altman agreement analysis indicated a bias of 2.33 mL/beat (95% limits of agreement: -2.17 to 6.83) in females and 2.15 mL/beat (95% limits of agreement: -4.34 to 8.65) in males (Figure 2). Conclusions The study reveals that measured median peakO2pulse values are consistently lower than predicted across both sexes, highlighting a significant bias, which limits the applicability of the FRIEND registry prediction equation in the Brazilian population and underscores the international heterogeneity of the variable. The findings advocate for the development of region-specific reference standards to enhance accuracy in predicting peakO2pulse values.

Error performance analysis for OOK modulated optical camera communication systems

Integrating image sensors’ imaging capabilities into the receiver for visible light communication is a prominent characteristic of optical camera communication (OCC). However, the exposure effect during imaging distorts received waveforms and introduces inter-symbol interference (ISI), leading to decreased OCC reliability. This paper aims to provide an in-depth analysis of the impact of image sensor exposure effects on the error performance of OCC systems. Analytical expressions of the pixel signal-to-interference and noise ratio (PSINR) are derived using the pulse response function (PRF) for an on-off keying (OOK) modulated OCC system with varying exposure times. Furthermore, the bit error rate (BER) performance is evaluated analytically using PSINR, and a straightforward BER measurement scheme is proposed for experimental validation. Results from analyses and experiments conducted under different exposure times indicate that longer exposures lead to increased ISI and decreased PSINR, thereby increasing the error probability of data demodulation. Additionally, a combined impact of noise and exposure on OCC system reliability is observed, highlighting noise-limited and interference-limited characteristics under low and high signal-to-noise ratio (SNR) conditions, respectively. By utilizing PSINR as a bridge, this paper precisely analyzes OCC system reliability under exposure effects, laying a theoretical foundation for system design and optimization.

Assessment of aging degradation in rubber using quasi-static components of ultrasonic longitudinal waves

Abstract Aging degradation is the main form of failure of rubber in service, leading to a decline in its physical and mechanical properties. This paper presents an efficient method for assessing the aging degradation of rubber using the quasi-static component (QSC) of ultrasonic longitudinal waves induced by acoustic radiation. The experiments quantitatively observe the response of the QSC pulse to different levels of ageing degradation. A pulse-echo ultrasonic transducer is employed to simultaneously capture the primary longitudinal wave (PLW) and QSC echoes, enabling the determination of the acoustic nonlinearity parameter of QSC with a single transducer excitation. The results suggest that, in comparison to traditional linear ultrasonic techniques based on attenuation coefficient and wave velocity measurements, the relative acoustic nonlinear parameter of QSC proves to be more sensitive to aging degradation in rubber. Particularly, the amplitude of the QSC pulse undergoes a significant change with increasing aging degradation, even when the PLW tone burst is completely attenuated. These findings confirm the effectiveness of QSC as a method for evaluating aging degradation in highly attenuative materials.

Plant Movement Response to Environmental Mechanical Stimulation Toward Understanding Predator Defense.

Plants are fascinating living systems, possessing starkly different morphology to mammals, yet they have still evolved ways to defend themselves, consume prey, communicate, and in the case of plants like Mimosa pudica even move in response to a variety of stimuli. The complex physiological pathways driving this are of great interest, though many questions remain. In this work, a known responsive plant, M. pudica is mechanically stimulated, in terms of wounding via removal of pinnae, nonwounding mechanical poking, and nonwounding pulses of air through a designed small nozzle approach. Removal of clusters called pinnae resulted in rapid, asymmetric response in the adjacent pinnae, while mechanical poking and air pulse responses are slower and more localized. Additionally, while the response from poking propagated across the plant, wind stimuli consistently resulted in the actuation of only the leaflets directly stimulated, suggesting unique sensing mechanisms. Mechanical damage may imply a potential predator, while mechanical stimulation from airflow may be processed as wind, which is of little danger. These findings demonstrate an intricate, stimulant-dependent mechanical sensing process, which is important in plant physiology, mechanobiology, and future biohybrid soft robotic designs.

High-Linearity Ta2O5 Memristor and Its Application in Gaussian Convolution Image Denoising.

In the image Gaussian filtering process, convolving with a Gaussian matrix is essential due to the numerous arithmetic computations involved, predominantly multiplications and additions. This can heavily tax the system's memory, particularly with frequent use. To address this issue, a W/Ta2O5/Ag memristor was employed to substantially mitigate the computational overhead associated with convolution operations. Additionally, an interlayer of ZnO was subsequently introduced into the memristor. The resulting Ta2O5/ZnO heterostructure layer exhibited improved linearity in the pulse response, which enhanced linearity facilitates easy adjustment of the conductance magnitude through a linear mapping of the number of pulses and the conductance. Subsequently, the conductance of the W/Ta2O5/ZnO/Ag bilayer memristor was employed as the weights for the convolution kernel in convolution operations. Gaussian noise removal in image processing was achieved by assembling a 5 × 5 memristor array as the kernel. When denoising was performed using memristor arrays, compared to denoising achieved through Gaussian matrix convolution, an average loss of less than 5% was observed. The provided memristors demonstrate significant potential in convolutional computations, particularly for subsequent applications in convolutional neural networks (CNNs).

An enhanced gated MCP-PMT for neutron detection in laser fusion experiments

The microchannel plate photomultiplier tube (MCP-PMT) is a photodetector that utilizes microchannel plates for signal amplification, offering rapid pulse response time of sub-nanosecond with a compact design and low dark current. A series of enhanced gated MCP-PMTs have been developed by incorporating a gating electrode between the photocathode and the MCPs, which have been employed in neutron detection during the double-cone ignition laser fusion experiment at the SGII Upgrade laser facilities.

Choosing the right electrode representation for modeling real bioelectronic interfaces: a comprehensive guide

Objective.Producing realistic numerical models of neurostimulation electrodes in contact with the electrolyte and tissue, for use in time-domain finite element method simulations while maintaining a reasonable computational burden remains a challenge. We aim to provide a straightforward experimental-theoretical hybrid approach for common electrode materials (Ti, TiN, ITO, Au, Pt, IrOx) that are relevant to the research field of bioelectronics, along with all the information necessary to replicate our approach in arbitrary geometry for real-life experimental applications.Approach.We used electrochemical impedance spectroscopy (EIS) to extract the electrode parameters in the AC regime under different DC biases. The pulsed electrode response was obtained by fast amperometry (FA) to optimize and verify the previously obtained electrode parameters in a COMSOL Multiphysics model. For optimization of the electrode parameters a constant phase element (CPE) needed to be implemented in time-domain.Main results.We find that the parameters obtained by EIS can be used to accurately simulate pulsed response only close to the electrode open circuit potential, while at other potentials we give corrections to the obtained parameters, based on FA measurements. We also find that for many electrodes (Au, TiN, Pt, and IrOx), it is important to implement a distributed CPE rather than an ideal capacitor for estimating the electrode double-layer capacitance. We outline and provide examples for the novel time-domain implementation of the CPE for finite element method simulations in COMSOL Multiphysics.Significance.An overview of electrode parameters for some common electrode materials can be a valuable and useful tool in numerical bioelectronics models. A provided FEM implementation model can be readily adapted to arbitrary electrode geometries and used for various applications. Finally, the presented methodology for parametrization of electrode materials can be used for any materials of interest which were not covered by this work.

Percent Predicted Peak Exercise Oxygen Pulse Provides Insights Into Ventricular-Vascular Response and Prognosticates HFpEF

BackgroundPeak oxygen consumption and oxygen pulse along with their respective percent predicted measures are gold standards of exercise capacity. To date, no studies have investigated the relationship between percent predicted peak oxygen pulse (%PredO2P) and ventricular-vascular response (VVR) and the association of %PredO2P with all-cause mortality in heart failure with preserved ejection fraction (HFpEF) patients. ObjectivesThe authors investigated the association between: 1) CPET measures of %PredO2P and VVR; and 2) %PredO2P and all-cause mortality in HFpEF patients. MethodsOur cohort of 154 HFpEF patients underwent invasive CPET and were grouped into %PredO2P tertiles. The association between percent predicted Fick components and markers of VVR (ie, proportionate pulse pressure, effective arterial elastance) was determined with correlation analysis. The Cox proportional hazards model was used to identify predictors of mortality. ResultsThe participants’ mean age was 57 ± 15 years. Higher %PredO2P correlated with higher exercise capacity. In terms of VVR, higher %PredO2P correlated with a lower pressure for a given preload (effective arterial elastance r = −0.45, P < 0.001 and proportionate pulse pressure r = −0.22, P = 0.008). %PredO2P distinguished normal and abnormal percent predicted peak stroke volume and correlated positively with %PredVO2 (r = 0.61, P < 0.001). Participants had a median follow-up time of 5.6 years and 15% death. Adjusted for age and body mass index, there was a 5% relative reduction in mortality (HR: 0.95, 95% CI: 0.92-0.98, P = 0.003) for every percent increase in %PredO2P. ConclusionsIn HFpEF, %PredO2P is a VVR marker that can stratify invasive parameters such as percent predicted peak stroke volume. %PredO2P is an independent prognostic marker for all-cause mortality and those with higher %PredO2P exhibited longer survival.

The characteristics of the new dual-cycle development pattern and systemic financial risk based on TVP-SVAR and MS-VAR model analyses

The new development pattern of the dual cycle is an important strategic deployment by the Chinese government in response to the complex and changing economic environment and a new stage of economic development. Based on the perspective of this new dual-cycle development pattern, this paper explores the time-varying nonlinear relationship between this new development pattern and systemic financial risk by constructing two models: the TVP-SVAR-SV and the MS-VAR. The empirical results show that, first, there was a significant negative impulse response effect between the new dual-cycle development pattern and systemic financial risk. The inhibitory effects of the domestic cycle and short-term pulse response were more significant than those of the international cycle and medium- and long-term pulse responses. In addition, the inhibitory effect of the new dual-cycle development pattern on systemic financial risk exerted different impact effects at different timepoints, with significant variability. Second, there was a significant nonlinear relationship between the new development pattern and systemic financial risk. The MSIH(2)-VAR(1) model identified two regional states: the financial risk release stage and the financial risk accumulation stage. This effect lasted longer in zone 2 (financial risk accumulation phase), with a sample size of more than 60 % of the total sample and a duration of 6.12. Third, in the impulse response analysis of different zones, a mutually reinforcing effect was found between the domestic and international cycles, and both exerted a significant suppressive effect on systemic financial risk, which was more significant in zone 1. The findings of this paper have important theoretical and practical significance for constructing and perfecting the new dual-cycle development pattern, promoting the high-quality development of China's financial market, and preventing the accumulation and occurrence of systemic financial risk.

Moment analysis method for determination of rate constants of solute permeation across interface of spherical molecular aggregates by means of high-performance liquid chromatography

A moment analysis method was developed for the study of solute permeation at the interface of spherical molecular aggregates. At first, new moment equations were developed for determining the partition equilibrium constant (Kp) and permeation rate constants (kin and kout) of solutes from the first absolute (μ1A) and second central (μ2C) moments of elution peaks measured by using high-performance liquid chromatography (HPLC). Then, the method was applied to the analysis of mass transfer phenomena of three solutes, i.e., hydroquinone, resorcinol, and catechol, at the interface of sodium dodecylsulfate (SDS) micelles. HPLC data were measured by using an ODS column and an aqueous phosphate buffer solution (pH = 7.0) as the mobile phase solvent. Pulse response experiments were conducted while changing SDS concentration (5 - 20 mmol dm−3) in the mobile phase under the conditions that the surface of ODS stationary phase was dynamically coated by SDS monomers. In order to demonstrate the effectiveness of the moment analysis method using HPLC, the values of Kp, kin, and kout were determined for the three solutes as 35 - 69, 2.4 × 10−8 - 1.4 × 10−6 m s−1, and 7.0 × 10−10 - 2.1 × 10−8 m s−1, respectively. Their values increase with an increase in the hydrophobicity of the solutes. The method has some advantages for the study of interfacial solute permeation of molecular aggregates. For example, neither immobilization nor chemical modification of both solute molecules and molecular aggregates is required when elution peaks are measured by using HPLC. Interfacial solute permeation takes place in the mobile phase without any chemical reaction or physical action on molecular aggregates. The values of Kp, kin, and kout were analytically determined from those of μ1A and μ2C by using the moment equations. The results of this study must contribute to the dissemination of an opportunity for studying the interfacial solute permeation of molecular aggregates to many researchers because of extremely high versatility of HPLC.

A novel resistorless memristor emulator circuit and its implementation of chaotic Jerk system

This work presents a novel resistorless memristor emulator circuit designed in both grounded and floating configurations. The grounded memristor consists of a Current-Controlled Current Conveyor Transconductance Amplifier (CC-CCTA) and a capacitor. On the other hand, a floating memristor includes a CC-CCTA and a capacitor, along with an additional Operational Transconductance Amplifier (OTA). These proposed emulators are electronically controllable owing to the internal structures of active elements. Theoretical analysis and simulation results have been obtained for the proposed designs. Simulation results have been conducted utilizing the LTspice program and TSMC 180 nm technology has been used for internal structures. In these results, the effects of the changing capacitor values, different frequencies, electronic tunability, reactions to temperature change, and pulse response have been investigated. Subsequently, a chaotic Jerk circuit has been implemented incorporating the proposed memristor emulator. The chaotic behavior of the floating memristor has been investigated using the LTspice simulation software.

Nanosecond-level second-order characteristics in dynamic calibration of thin film thermocouples by short-pulse laser

In this study, we explore the dynamic response of thin-film thermocouples (TFTCs) to transient temperature changes, emphasizing their nanosecond response capabilities. Traditionally, TFTCs are modeled as first-order systems. By employing magnetron sputtering, we have prepared NiCr/NiSi TFTCs with a novel integrated lead method. A 7.6 ns short-pulse laser served as the heat source, capturing the TFTCs’ transient response with a high-speed collector at 200 M/s. Unexpectedly, the TFTCs’ response curves exhibited oscillations at high acquisition rates. Through frequency response analysis, we have established a pulse response model for the TFTCs that is highly consistent with experimental results. For the first time, we confirmed the TFTCs’ second-order dynamic characteristics. Furthermore, our findings that various substrate materials and lead methods impact the damping characteristics of TFTCs led us to conduct pulsed laser damage experiments. These experiments revealed a correlation between damping properties and the extent of damage.

Design of a high‐frequency transformer based on amorphous cut cores for insulation breakdown testing

AbstractInnovative test methods are required to keep up with the increased demand for insulation materials which can withstand the high‐frequency square‐wave voltages generated by power‐electronic equipment. Test systems using high‐voltage, high‐frequency transformers have proven versatile and easy to realise. The authors investigate the application of amorphous cut cores in such transformers. Analytical and numerical models for the transformer and its frequency response are developed, aiding the design process. An amorphous core‐based transformer is designed for 8 kVpk output at 100 kHz and compared to two previous designs based on ferrite cores. The frequency and pulse response, as well as the high‐voltage and thermal performance, are evaluated. The comparison shows that while the low parasitics of the amorphous‐based transformer allow for superior frequency response, they are unsuitable for long‐duration tests with high pulse repetition frequencies (25–100 kHz) due to increased core losses. The partial discharge inception and flashover voltage are comparable to the ferrite‐based transformers.

P043 The oxygen pulse response during cardiopulmonary exercise testing in our paediatric cystic fibrosis population

P043 The oxygen pulse response during cardiopulmonary exercise testing in our paediatric cystic fibrosis population

Anomalous X-ray pulse responses in MAPbBr3 single crystal-based detectors

Organic-inorganic perovskite single crystals (SCs) are considered promising semiconductors for high-sensitivity X-ray detectors because of their strong X-ray interaction, low-temperature processability, and excellent properties such as long diffusion length, low defect density, and long carrier lifetime. However, the specific pulse response of MAPbBr3 SC-based X-ray detectors frequently exhibits a tail and over/undershoots at several conditions, which degrades the X-ray image quality; however, no detailed analysis of these characteristics has been reported thus far. For high-resolution X-ray imaging, it is necessary to obtain an ideal pulse response that is free of tails and over/undershoots. In this study, we investigated the specific X-ray responses of solution-grown MAPbBr3 SC-based X-ray detectors under various externally applied voltages. Based on the study on charge carrier dynamics, we analyzed the origin of the tail and over/undershoots in X-ray pulse response shapes. We theoretically verified that the unideal pulse response in perovskite SC-based X-ray detectors is attributed to the defect states inherent in perovskite SCs.

Investigation of Characteristics of Ultraviolet Light Pulse Weak Signal Communication System Based on Fourth-Order Frequency-Shift Keying Modulation

In ultraviolet (UV) communication, On–Off Keying (OOK) is the primary modulation technique. Compared to OOK, frequency modulation offers stronger resistance to path attenuation. Currently, research on frequency modulation demodulation schemes for UV communication is limited, mainly employing waveform detection and laser pulse response methods, which require high detection sensitivity to light. This study presents a novel frequency modulation communication scheme using discrete Poisson channel distribution and optical pulse signal processing algorithms, enhancing the signal processing sensitivity of the existing frequency modulation scheme to the level of photons. The proposed system model is rigorously evaluated through theoretical derivations and simulations. Additionally, a hardware system integrating optical pulse counting, frequency detection, and clock data recovery algorithms is developed. Experimental results show the system achieving a 5 kbps transmission rate under frequency modulation. In non-line-of-sight (NLOS) scenarios, communication reaches up to 65 m, with the receiver elevation angle ranging from 10° to 25° and the bit error rate (BER) stabilized at 10−4, while in line-of-sight (LOS) situations, the BER remains at 10−5 up to 400 m and 10−4 up to 700 m, achieving the farthest distance and fastest communication rate achievable in the current FSK modulation scheme of ultraviolet communication systems. The integrated components enhance its applicability in communication systems. This study offers a valuable addition to UV communication technology.

Carbon budget concept and its deviation through the pulse response lens

Abstract. The carbon budget concept states that the global mean temperature (GMT) increase is roughly linearly dependent on cumulative emissions of CO2. The proportionality is measured as the transient climate response to cumulative emissions of carbon dioxide (TCRE). In this paper, the deviations of the carbon budget from the strict linear relationship implied by the TCRE are examined through the lens of a temperature response to an emission pulse (i.e., pulse response) and its relationship with a nonlinear TCRE. Hereby, two sources of deviation are distinguished: emission scenario and climate state dependence. The former stems from the scenario choice, i.e., the specific emission pathway for a given level of cumulative emissions and the latter from the change in TCRE with changing climatic conditions. Previous literature argues for scenario independence using a stylized set of emission scenarios, and offers a way to fit a nonlinear carbon budget equation. This paper shows how the pulse response, viewed as a Green's function, gives a unifying perspective on both scenario and state dependence. Moreover, it provides an optimization program that tests the scenario independence under the full range of emission pathways for a given set of constraints. In a setup chosen in this paper, the deviations stemming from emission pathway choices are less than 10 % of the overall temperature increase and gradually diminish. Moreover, using the pulse response as a Green's function, the scenario-dependent effects of a reduced-complexity climate model were replicated to a high degree, confirming that the behavior of scenario-dependent deviations can be explained and predicted by the shape of the pulse response. Additionally, it is shown that the pulse response changes with climatic conditions, through which the carbon budget state dependency is explained. Using a pulse response as an approximation for a state-dependent TCRE, an alternative method to derive a nonlinear carbon budget equation is provided. Finally, it is shown how different calibrations of a model can lead to different degrees of carbon budget nonlinearities. The analysis is done using FaIRv2.0.0, a simple climate emulator model that includes climate feedback modifying the carbon cycle, along with a one-box model used for comparison purposes. The Green's function approach can be used to diagnose both models' carbon budget scenario dependency, paving the way for future investigations and applications with other and more complex models.