Ultrasound Pulse Echo Research Articles

Windowed Radon Transform for Robust Speed-of-Sound Imaging With Pulse-Echo Ultrasound.

In recent years, methods estimating the spatial distribution of tissue speed of sound with pulse-echo ultrasound are gaining considerable traction. They can address limitations of B-mode imaging, for instance in diagnosing fatty liver diseases. Current state-of-the-art methods relate the tissue speed of sound to local echo shifts computed between images that are beamformed using restricted transmit and receive apertures. However, the aperture limitation affects the robustness of phase-shift estimations and, consequently, the accuracy of reconstructed speed-of-sound maps. Here, we propose a method based on the Radon transform of image patches able to estimate local phase shifts from full-aperture images. We validate our technique on simulated, phantom and in-vivo data acquired on a liver and compare it with a state-of-the-art method. We show that the proposed method enhances the stability to changes of beamforming speed of sound and to a reduction of the number of insonifications. In particular, the deployment of pulse-echo speed-of-sound estimation methods onto portable ultrasound devices can be eased by the reduction of the number of insonifications allowed by the proposed method.

An Inverse-Problem Approach to the Estimation of Despeckled and Deconvolved Images From Radio-Frequency Signals in Pulse-Echo Ultrasound

An Inverse-Problem Approach to the Estimation of Despeckled and Deconvolved Images From Radio-Frequency Signals in Pulse-Echo Ultrasound

Signal domain adaptation network for limited-view optoacoustic tomography

Optoacoustic (OA) imaging is based on optical excitation of biological tissues with nanosecond-duration laser pulses and detection of ultrasound (US) waves generated by thermoelastic expansion following light absorption. The image quality and fidelity of OA images critically depend on the extent of tomographic coverage provided by the US detector arrays. However, full tomographic coverage is not always possible due to experimental constraints. One major challenge concerns an efficient integration between OA and pulse-echo US measurements using the same transducer array. A common approach toward the hybridization consists in using standard linear transducer arrays, which readily results in arc-type artifacts and distorted shapes in OA images due to the limited angular coverage. Deep learning methods have been proposed to mitigate limited-view artifacts in OA reconstructions by mapping artifactual to artifact-free (ground truth) images. However, acquisition of ground truth data with full angular coverage is not always possible, particularly when using handheld probes in a clinical setting. Deep learning methods operating in the image domain are then commonly based on networks trained on simulated data. This approach is yet incapable of transferring the learned features between two domains, which results in poor performance on experimental data. Here, we propose a signal domain adaptation network (SDAN) consisting of i) a domain adaptation network to reduce the domain gap between simulated and experimental signals and ii) a sides prediction network to complement the missing signals in limited-view OA datasets acquired from a human forearm by means of a handheld linear transducer array. The proposed method showed improved performance in reducing limited-view artifacts without the need for ground truth signals from full tomographic acquisitions.

Automated Characterization of the Ply Stacking Sequence of a Woven Carbon Fiber Composite Using Pulse-Echo Ultrasound

Carbon fiber composites are a popular design material due to their high specific strength. The directional strength of woven composites can be customized by changing the orientation and sequencing of individual lamina within the ply stack. This allows for the potential of specialized parts designed for specific applications, leading to both performance gains and weight savings. One challenge is the ability to characterize non-destructively the orientations of the individual lamina after the manufacturing process. Current industrial methods used to verify the ply stack are destructive to the part, increasing costs and material waste. This creates the need for a non-destructive technique capable of determining the ply stack, both for quality control and for in-service parts, including when there may be access to just a single side of the composite. This research introduces a procedure to scan a fabricated laminated composite using pulse-echo ultrasound coupled with an automated algorithm to determine the layer-by-layer orientation of the ply stack with a specific focus on woven composites. In this work, 12 unique plain-weave laminates ranging from 3 lamina to 18 lamina thick are studied. The orientations of each stacking sequence are different, with some following standard composite design methodologies and others randomly stacked. The mathematical technique presented in this work correctly characterizes non-destructively the orientation of each individual lamina to within 1° with 73% confidence and to within 3° with 98.3% confidence of the as-manufactured orientation.

Pulse-echo ultrasound measurement in osteoporosis screening: a pilot study in older patients.

A mere 25% of patients who need treatment for osteoporosis receive appropriate therapy, partly due to the time-consuming and stressful diagnostic workup for older patients with functional decline. The purpose of the present study was to investigate the accuracy of pulse-echo ultrasound measurement of the lower leg for the detection of osteoporosis in older patients, and evaluate the effect of a proposed diagnostic algorithm. Cortical thickness and the so-called density index (DI) were measured prospectively on the lower leg with a pulse-echo ultrasound (PEUS) device. The accuracy of the device was compared with dual-energy X-ray absorptiometry (DXA) of the hip. We calculated algorithms combining FRAX® scores and PEUS measures as a guide for specific treatment of osteoporosis. Three hundred and thirty-three patients aged on average 81years (82.1% women, 275/333) were included in the study. The sensitivity of the ultrasound device versus DXA for the detection of osteoporosis was 94.4% (84/89), and the specificity was 59% (144/247). The gender-specific sensitivity was 96.2% (75/78) for women and 81.8% (9/11) for men. Clinical decisions for the specific treatment of osteoporosis could be based on the proposed algorithm, without additional DXA measurements, in 90.9% (303/333) of the patients. Older patients with a similar risk profile as in our study population may benefit from PEUS, as it is a non-invasive, cost-effective, and efficient diagnostic tool with high accuracy in screening patients for osteoporosis and the risk of fractures.

Non-Destructive Evaluation of the Quality of Adhesive Joints Using Ultrasound, X-ray, and Feature-Based Data Fusion

The aim of this work is to achieve reliable nondestructive evaluation (NDE) of adhesively bonded aerospace components by developing novel multidimensional data fusion techniques, which would combine the information obtained by ultrasonic and X-ray NDE methods. Separately, both NDE techniques have their advantages and limitations. The integration of data obtained from pulse echo immersion ultrasound testing and radiography holds immense potential to help improve the reliability of non-destructive evaluation. In this study, distinctive features obtained from single techniques, traditional ultrasonic pulse echo testing, and radiography, as well as fused images, were investigated and the suitability of these distinctive features and fusion techniques for improving the probability of defect detection was evaluated. For this purpose, aluminum single lap joints with brass inclusions were analyzed using ultrasound pulse echo and radiography techniques. The distinctive features were extracted from the data obtained, and images of features obtained by both techniques were fused together. Different combinations of features and fusion algorithms were investigated, considering the desire to automate data evaluation in the future.

Pulse-echo speed-of-sound imaging using convex probes

Computed ultrasound tomography in echo mode (CUTE) is a new ultrasound (US)-based medical imaging modality with promise for diagnosing various types of disease based on the tissue’s speed of sound (SoS). It is developed for conventional pulse-echo US using handheld probes and can thus be implemented in state-of-the-art medical US systems. One promising application is the quantification of the liver fat fraction in fatty liver disease. So far, CUTE was using linear array probes where the imaging depth is comparable to the aperture size. For liver imaging, however, convex probes are preferred since they provide a larger penetration depth and a wider view angle allowing to capture a large area of the liver. With the goal of liver imaging in mind, we adapt CUTE to convex probes, with a special focus on discussing strategies that make use of the convex geometry in order to make our implementation computationally efficient. We then demonstrate in an abdominal imaging phantom that accurate quantitative SoS using convex probes is feasible, in spite of the smaller aperture size in relation to the image area compared to linear arrays. A preliminary in vivo result of liver imaging confirms this outcome, but also indicates that deep quantitative imaging in the real liver can be more challenging, probably due to the increased complexity of the tissue compared to phantoms.

Ultrasonic Logging of Creeping Shale

With the end of oil production, the need for safe and economically efficient plug and abandonment (P&A) operations increases. Due to the high costs related to traditional P&A processes, the possibility of shale bonding to the well casing, forming a natural barrier, is explored. Here, we present a unique laboratory experiment of creeping shale in a pressure cell, which is monitored during the creep and bonding processes using the ultrasound pulse-echo (PE) and pitch-catch (PC) measurement techniques. The combination of continuous PE and PC measurements in one direction, with discrete measurements in 5° intervals, and the logging of confining pressure, temperature, and permeability allows an improved understanding of the bonding processes and the interpretation of parameters derived from PE and PC measurements. We find that the initial creep of the shale occurs when the confining pressure is increased from 5 to 9 MPa, resulting in significant changes observed in the acoustic impedances derived from PE and PC measurements. However, as permeability is still high, we assume that channels are still open. With the increase in confining pressure to 13 and 14 MPa, respectively, we observe a decrease in permeability corresponding to an overall decrease in signal strength for the PC data of up to 25 dB and a decrease in the PE group delay parameter of up to 0.6 μs corresponding to a change in acoustic impedance from about 1 MRayl to about 3 to 3.5 MRayl. Large variations with direction can be observed. Combining the information of PE and PC gives a good impression of the bonding processes.

Monitoring early age behavior of mortar by ultrasound technique for environmental issues: Effects of sand grading and salinity of mixing water

This paper aims to study the effects of different sand grading and salinity of mixing water on setting and hardening of cement mortar. For this purpose, a newly developed measurement method based on ultrasound pulse echo technique was used. Using this method, the attenuation coefficient and the modulus of reflection coefficient are measured to characterize the early age behavior of tested mortars. Ultrasound P-waves were generated using a 1 MHz central frequency immersion transducer and mortar samples were prepared with Portland composite cement CPJ 45. Mortar samples were classified into two series: first series considered mortar mixes prepared using fresh water and different sand grading form 56μm to 400μm. These laboratory tests (series 1) aimed to obtain the optimum grain size of respective mortar mixes in terms of optimum workability and rheology. Continually, the optimum grain size (from series 1) is used in the second series of experiments (series 2) mortar mixes prepared using artificial sea water with different concentrations of sea salt, i.e., 0 g/l, 10 g/l, 20 g/l, 37 g/l and 50 g/l. The results show that the increase of sand size grading in mortar allows faster setting and hardening and earlier occurrence of aluminate hydrates phase transition AFt – AFm, precipitates the solid percolation and achieves denser microstructure. Also, the stepwise increase of Sea Salt dosage in mixing water from 0 g/l to 37 g/l resulted in a later achieve of final set and later occurrence of AFt – AFm transition.

Covid-19 given opportunity to use ultrasound in the plaster room to continue secondary fracture prevention care: A retrospective Fracture Liaison Service study

IntroductionFracture Liaison Service (FLS) managed secondary fracture prevention services have been hampered during the COVID-19 pandemic. A challenging opportunity is to use pulse-echo ultrasound (P-EU) in the plaster room. The study had two objectives: can P-EU help our decision to justly avoid DXA/VFA scans in plaster treated women (50–70 years) after fracture and whether its use can encourage or nudge all plaster treated patients (>50 years) who need DXA/VFA scans. Patients and methods1307 patients (cohort: pre-COVID-19) and 1056 patients (cohort: peri-COVID-19), each of them ≥ 50 years after recent fracture, were studied. Only in women aged 50–70 years, we used a P-EU decision threshold (DI) >= 0.896 g/cm2 to rule out further analysis by means of DXA/VFA. All other plaster patients received P-EU as part of patient information. Peri-Covid-19, all performed DXA/VFA scans were counted until three months post-study closure. By then each patient still waiting for a DXA/VFA had received a scan. ResultsPeri-COVID-19, 69 out of 191 plaster-treated women aged 50–70 years were ruled out (36%), for plaster and not in-plaster treated women aged 50–70 years, it was 27%. Comparing all peri-to pre-COVID-19 plaster-treated women and men, a significant P-EU nudging effect was found (difference in proportions: 8.8%) P = .001. ConclusionThe combination of patient information and P-EU in the plaster room is effective to reduce DXA/VFA scans and allow extra patients to undergo DXA/VFA. After all, more than a quarter of 50–70 years old women in plaster did not need to be scanned.

Improvement in the Quantification of Foreign Object Defects in Carbon Fiber Laminates Using Immersion Pulse-Echo Ultrasound.

This research presents a new technique using pulse echo ultrasound for sizing foreign objects within carbon fiber laminates. Carbon fiber laminates are becoming increasingly popular in a wide variety of industries for their desirable properties. It is not uncommon for manufacturing defects to occur within a carbon fiber laminates, causing waste, either in the discarding of failed parts or the overdesign of the initial part to account for these anticipated and undetected errors. One such manufacturing defect is the occurrence of a foreign object within the laminate. This defect will lead to a localized weakness within the laminate including, but not limited to, stress risers, delamination, and catastrophic failure. This paper presents a method to analyze high-resolution c-scan full waveform captured data to automatically capture the geometry of the foreign object with minimal user inputs without a-priori knowledge of the shape of the defect. This paper analyzes twelve samples, each a twelve-lamina carbon fiber laminate. Foreign objects are made from polytetrafluoroethylene (PTFE) measuring 0.05 mm (0.002 in.) thick and ranging in diameter from 12.7 mm (0.5 in) to 1.588 mm (0.0625 in), are placed within the laminates during fabrication at varying depths. The samples are analyzed with a custom high-resolution c-scan system and smoothing, and edge detection methods are applied to the collected c-scan data. Results are presented on the sizing of the foreign objects with an average error of 6% of the true area, and an average absolute difference in the estimation of the diameter of 0.1 mm (0.004 in), an improvement over recently presented ultrasonic methods by a factor of three.

Trivalent Dopant Size Influences Electrostrictive Strain in Ceria Solid Solutions.

The technologically important frequency range for the application of electrostrictors and piezoelectrics is tens of Hz to tens of kHz. Sm3+- and Gd3+-doped ceria ceramics, excellent intermediate-temperature ion conductors, have been shown to exhibit very large electrostriction below 1 Hz. Why this is so is still not understood. While optimal design of ceria-based devices requires an in-depth understanding of their mechanical and electromechanical properties, systematic investigation of the influence of dopant size on frequency response is lacking. In this report, the mechanical and electromechanical properties of dense ceria ceramics doped with trivalent lanthanides (RE0.1Ce0.9O1.95, RE = Lu, Yb, Er, Gd, Sm, and Nd) were investigated. Young’s, shear, and bulk moduli were obtained from ultrasound pulse echo measurements. Nanoindentation measurements revealed room-temperature creep in all samples as well as the dependence of Young’s modulus on the unloading rate. Both are evidence for viscoelastic behavior, in this case anelasticity. For all samples, within the frequency range f = 0.15–150 Hz and electric field E ≤ 0.7 MV/m, the longitudinal electrostriction strain coefficient (|M33|) was 102 to 104-fold larger than expected for classical (Newnham) electrostrictors. However, electrostrictive strain in Er-, Gd-, Sm-, and Nd-doped ceramics exhibited marked frequency relaxation, with the Debye-type characteristic relaxation time τ ≤ 1 s, while for the smallest dopants—Lu and Yb—little change in electrostrictive strain was detected over the complete frequency range studied. We find that only the small, less-studied dopants continue to produce useable electrostrictive strain at the higher frequencies. We suggest that this striking difference in frequency response may be explained by postulating that introduction of a dopant induces two types of polarizable elastic dipoles and that the dopant size determines which of the two will be dominant.

Bayesian Approach for a Robust Speed-of-Sound Reconstruction Using Pulse-Echo Ultrasound.

Computed ultrasound tomography in echo mode (CUTE) is a promising ultrasound (US) based multi-modal technique that allows to image the spatial distribution of speed of sound (SoS) inside tissue using hand-held pulse-echo US. It is based on measuring the phase shift of echoes when detected under varying steering angles. The SoS is then reconstructed using a regularized inversion of a forward model that describes the relation between the SoS and echo phase shift. Promising results were obtained in phantoms when using a Tikhonov-type regularization of the spatial gradient (SG) of SoS. In-vivo, however, clutter and aberration lead to an increased phase noise. In many subjects, this phase noise causes strong artifacts in the SoS image when using the SG regularization. To solve this shortcoming, we propose to use a Bayesian framework for the inverse calculation, which includes a priori statistical properties of the spatial distribution of the SoS to avoid noise-related artifacts in the SoS images. In this study, the a priori model is based on segmenting the B-Mode image. We show in a simulation and phantom study that this approach leads to SoS images that are much more stable against phase noise compared to the SG regularization. In a preliminary in-vivo study, a reproducibility in the range of 10 ms-1 was achieved when imaging the SoS of a volunteer's liver from different scanning locations. These results demonstrate the diagnostic potential of CUTE for example for the staging of fatty liver disease.

Noninvasive multiparametric characterization of mammary tumors with transmission-reflection optoacoustic ultrasound

Development of imaging methods capable of furnishing tumor-specific morphological, functional, and molecular information is paramount for early diagnosis, staging, and treatment of breast cancer. Ultrasound (US) and optoacoustic (OA) imaging methods exhibit excellent traits for tumor imaging in terms of fast imaging speed, ease of use, excellent contrast, and lack of ionizing radiation. Here, we demonstrate simultaneous tomographic whole body imaging of optical absorption, US reflectivity, and speed of sound (SoS) in living mice. In vivo studies of 4T1 breast cancer xenografts models revealed synergistic and complementary value of the hybrid imaging approach for characterizing mammary tumors. While neovasculature surrounding the tumor areas were observed based on the vascular anatomy contrast provided by the OA data, the tumor boundaries could be discerned by segmenting hypoechoic structures in pulse-echo US images. Tumor delineation was further facilitated by enhancing the contrast and spatial resolution of the SoS maps with a full-wave inversion method. The malignant lesions could thus be distinguished from other hypoechoic regions based on the average SoS values. The reported findings corroborate the strong potential of the hybrid imaging approach for advancing cancer research in small animal models and fostering development of new clinical diagnostic approaches.

Incident and reflected two waves correlation with cancellous bone structure

The correlation in bone microstructure for ultrasound pulse echo technique is still less accurate compared to through transmission technique. Previous works demonstrated, reflected two modes wave has significant association with bone porosity. The paper aims is to conduct simulation using pulse echo technique to examine the relationship between fast and slow waves with porosity of 2-dimensional cancellous bone models by comparing the result to through transmission technique. The “incident” and “reflected” waves were separated using bandlimited deconvolution method by estimating time threshold of fast and slow waves' transfer function. The parameters of the waves were computed, plotted versus porosity for six different thicknesses and the correlation coefficients between them were compared. The incident and reflected fast wave attenuations show marginally significant correlation with porosity for both bone models orientations. Wave propagation for parallel orientation dominated by incident and reflected fast wave, meanwhile, perpendicular orientation dominated by incident slow wave. The thickness factor affected wave amplitude but less affected the attenuation. Because of propagation loss, reflected wave shows lower correlation to porosity compared to incident wave. Hence, analyzing fast and slow waves might improve the measurement accuracy of pulse echo technique compared to using single mode wave to estimate bone quality.

Azimuthally Scanned Angled-Beam Pulse-Echo Ultrasound for Characterization of Impact Damage in Composites

Abstract Characterization of barely visible impact damage (BVID) in polymer matrix composites (PMCs) is necessary to use slow crack growth damage tolerance models and evaluate remaining life of PMC components. Azimuthally scanned angled-beam pulse-echo ultrasound is investigated as a complimentary technique to normal incidence ultrasound inspection of BVID in PMCs to characterize delamination fields. It is found that there is a correlation between signals present in the azimuthally scanned angled-beam pulse-echo ultrasound C-scans and transverse cracks seen in X-ray computed tomography inspection. These transverse cracks are not readily identifiable as transverse cracks in normal incidence C-scan inspection.

Estimation of Thickness and Speed of Sound in Cortical Bone Using Multifocus Pulse-Echo Ultrasound.

Most bone loss during the development of osteoporosis occurs in cortical bone at the peripheral skeleton. Decreased cortical thickness (Ct.Th) and the prevalence of large pores at the tibia are associated with reduced bone strength at the hip. Ct.Th and cortical sound velocity, i.e., a surrogate marker for changes of cortical porosity (Ct.Po), are key biomarkers for the identification of patients at high fracture risk. In this study, we have developed a method using a conventional ultrasound array transducer to determine thickness (Ct.Th) and the compressional sound velocity propagating in the radial bone direction (Ct. ν11 ) using a refraction-corrected multifocus imaging approach. The method was validated in-silico on porous bone plate models using a 2-D finite-difference time-domain method and ex vivo on plate-shaped plastic reference materials and on plate-shaped cortical bovine tibia samples. Plane-wave pulse-echo measurements provided reference values to assess precision and accuracy of our method. In-silico results revealed the necessity to account for inclination-dependent transmission losses at the bone surface. Moreover, the dependence of Ct. ν11 on both porosity and pore density was observed. Ct.Th and Ct. ν11 obtained ex vivo showed a high correlation ) with reference values. The ex-vivo accuracy and precision for Ct. ν11 were 29.9 m/s and 0.94%, respectively, and those for Ct.Th were 0.04 mm and 1.09%, respectively. In conclusion, this numerical and experimental study demonstrates an accurate and precise estimation of Ct.Th and Ct. ν11 . The developed multifocus technique may have high clinical potential to improve fracture risk prediction using noninvasive and nonionizing conventional ultrasound technology with image guidance.

Multipoint-Detection Strain Sensor with a Single Electrode Using Optical Ultrasound Generated by Carbon Nanotubes.

With the development of wearable devices, strain sensors have attracted large interest for the detection of human motion, movement, and breathing. Various strain sensors consisting of stretchable conductive materials have been investigated based on resistance and capacitance differences according to the strain. However, this method requires multiple electrodes for multipoint detection. We propose a strain sensor capable of multipoint detection with a single electrode, based on the ultrasound pulse–echo method. It consists of several transmitters of carbon nanotubes (CNTs) and a single polyvinylidene fluoride receiver. The strain sensor was fabricated using CNTs embedded in stretchable polydimethylsiloxane. The received data are characterized by the different times of transmission from the CNTs of each point depending on the strain, i.e., the sensor can detect the positions of the CNTs. This study demonstrates the application of the multipoint strain sensor with a single electrode for measurements up to a strain of 30% (interval of 1%). We considered the optical and acoustic energy losses in the sensor design. In addition, to evaluate the utility of the sensor, finger bending with three-point CNTs and flexible phantom bending with six-point CNTs for the identification of an S-curve having mixed expansion and compression components were carried out.

Determining Porosity of Monolithic Zones in Aircraft Parts and Assemblies Made of PCMs Using Ultrasound Pulse Echo Method

At present, when inspecting aircraft parts and assemblies made of polymer composite materials, it is also necessary to estimate porosity over the entire area of these parts during the main search for defects. As a result of research, techniques have been developed to evaluate the porosity of the parts and assemblies of an airplane wing made of polymer composite materials using the ultrasonic pulse-echo method. A feature of these techniques is that data for further processing and producing the design values of porosity is collected simultaneously with the main testing without increasing its labor intensity. Correlation dependences have been constructed between the value of porosity and the amplitude of a bottom echo signal in carbon plastics produced by autoclave molding and by infusion. Results of estimating errors in determining porosity using the developed techniques are provided. The main causes of these errors are formulated.

Analysis of the attenuative behaviour of accelerated cement based materials through a series of ultrasound Pulse Echo measurements

Analysis of the attenuative behaviour of accelerated cement based materials through a series of ultrasound Pulse Echo measurements