For the analysis of gas pulsation characteristics in the pipeline systems of low density polyethylene (LDPE) hyper compressors, a time-domain calculation method for compressor pipeline gas pulsation based on real gas properties is proposed. First the thermophysical property tables are prepared with gas state parameters as independent and dependent variables. Then one-dimensional unsteady flow equations and characteristic equations for pipeline flow are established based on real gas properties. After setting pipeline parameters and boundary conditions, the flow equations are discretized using a two-step method at the inner points of the pipeline. The characteristic equations are discretized using the trapezoidal integration method at the boundary points. Thus, the time-domain solving of pulsating flow field in the pipeline is realized. A self-developed numerical code was used to conduct the time-domain calculation and analysis of gas pulsation in the discharge pipeline of a two-stage hyper compressor. The calculated pressure pulsation curves based on real gas properties are in good agreement with experimental data, with a maximum difference lower than 4% of the local average pressure, which is smaller than the difference between the results calculated based on the plane wave theory and the measured data. The analysis of gas pulsation characteristics shows that the pressure pulsation in the main pipeline is mainly contributed by the fundamental and second harmonics. The pressure pulsation in the safety valve branch is higher than that in the main pipeline, and the harmonic components falling into the acoustic resonance frequency range of this branch have significant amplitudes. The acoustic resonance frequency of the branch pipeline is not affected by the main pipeline. Pressure pulsation varies with changes in rotational speed and back pressure, and the pulsation level is more significantly affected by rotational speed compared to back pressure. The renovation scheme of connecting the safety valve branch and expansion tube in series can effectively reduce the pressure pulsation levels of the main pipeline and branch pipeline.