Background: The COPD, a prevalent and manageable condition, leads to diminished airflow and tissue damage.It is associated with structural lung problems caused by prolonged inflammation due to continuous exposure toharmful particles or gases, particularly from cigarette smoke.Purpose: To compare the effectiveness of thoracic squeeze technique and manual diaphragm release technique onsputum clearance among patient with COPD.Materials and Methods: A total of 30 participants were selected according to inclusion and exclusion criteriawere deliberately sampled. Group A (n=15) received thoracic squeeze technique and the Group B (n=15) receivedmanual diaphragm release technique. All individuals were assessed for COPD assessment test as a pre-test priorto the intervention and again after 6 weeks of intervention. The entire process was performed from November2022 to April 2023.Result: Statistical analysis was done for all the collected data using paired t- tests. The test shows significant effects (p<0.0001)in both groups. The test shows that the subjects receiving thoracic squeeze technique have improved sputum clearance amongpatients with COPD.Conclusion: The results and the data obtained from this research was statistically significant and concludedthat there was a definite and positive effect of thoracic squeeze technique on sputum clearance. This can berecommended in Pulmonary Physiotherapy Practise.