Web Of Science For Publications Research Articles

Treatment and Outcome Metrics for Speech-Language Pathology Treatment of Upper Airway Disorders: A Systematic Review.

Clinical treatment strategies and progress metrics for patients with inducible laryngeal obstruction (ILO) and exercise-induced laryngeal obstruction (EILO) have not been systematically applied across clinics. The goals of this review were to identify the intervention strategies used to treat upper airway disorders and determine the clinical metrics by which improvement or resolution of ILO/EILO is determined in clinical studies of speech-language pathology intervention. A systematic review was conducted using the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Systematic Reviews Checklist. English language, full-text publications were identified through MEDLINE (Ovid), APA PsycINFO, and Web of Science for publications that described clinical outcomes following behavioral treatment for ILO provided by a speech-language pathologist (SLP). A total of 238 sources were retrieved, of which 75 were duplicates. Titles and abstracts of 163 were screened, with 22 sources included for full-text review. Citation review yielded nine additional resources. Thirty-one sources were included for data extraction. Most sources described use of respiratory/laryngeal retraining. There was a lack of consistency for clinical and standardized metrics used to evaluate improvement or resolution of upper airway symptoms. Behavioral and standardized outcome metrics for evaluating therapy outcomes from SLP behavioral intervention of ILO/EILO are not consistently applied. Clinical metrics standards for clinicians are needed to provide a means to evaluate graded improvement in treatment and changes in health care utilization as well as for training less-experienced clinicians. https://doi.org/10.23641/asha.27172683.

Technical Innovations and Social Implications: Mapping Global Research Focus in AI, Blockchain, Cybersecurity, and Privacy

This study examines the balance between technical and social focus in artificial intelligence, blockchain, cybersecurity, and privacy publications in Web of Science across countries, exploring the social factors that influence these research priorities. We use regression analysis to identify predictors of research focus and cluster analysis to reveal patterns across countries, combining these methods to provide a broader view of global research priorities. Our findings reveal that liberal democracy index, life expectancy, and happiness are significant predictors of research focus, while traditional indicators like education and income show weaker relationships. This unexpected result challenges conventional assumptions about the drivers of research priorities in digital technologies. The study identifies distinct clusters of countries with similar patterns of research focus across the four technologies, revealing previously unrecognized global typologies. Notably, more democratic societies tend to emphasize social implications of technologies, while some rapidly developing countries focus more on technical aspects. These findings suggest that political and social factors may play a larger role in shaping research agendas than previously thought, necessitating a re-evaluation of how we understand and predict research focus in rapidly evolving technological fields. The study provides valuable information for policymakers and researchers, informing strategies for technological development and international collaboration in an increasingly digital world.

Research on analytical customer relationship management in China: knowledge map analysis based on Citespace

With the rapid development of the social economy, customers have become the most critical resources of companies, and many companies have taken analytical customer relationship management (CRM) as the magic weapon to improve their core competitiveness. As the main driving force of global economic growth, China currently occupies an essential position in the worldwide economy. Using CiteSpace information visualization software, this paper quantitatively analyzed the relevant research of 98 Web of Science (WoS) studies and 616 Chinese papers in China National Knowledge Infrastructure (CNKI) from 2003 to 2023 regarding analytical CRM in China. The research results of analytical CRM in China draw a knowledge mapping to sort out the annual publication volume, topic, publishing institution, and keyword. It was found that Chinese scholars have focused on analytical CRM in China during the last 20 years, and it entered a relatively rapid growth period in 2013, forming a relatively complete body of knowledge. However, the overall number of publications in WoS is low, and the research field is narrow. According to the data, foreign scholars' research has certain limitations, primarily focusing on applying concepts in information technology. The layout between different research topics is scattered and the correlation is low. This paper provides a comprehensive analysis to point out the direction for researchers in the area of analytical CRM to engage in related research, provide data reference, and help to predict the future trend of this research. Future research should fully use big data and information technology and focus on analytical CRM in the network era to help Chinese companies improve their competitiveness.

Systematic Mapping of Climate Change Impacts on Human Security in Bangladesh

There is an increasing consensus that climate change undermines human security by exacerbating existing challenges, acting as a “threat multiplier”. Bangladesh is a climate hot spot due to its geographical location, dense population and vulnerable socio-economic infrastructure. Although there is an increasing number of studies on the impacts of climate change in Bangladesh, aggregated research that combines this evidence and provides a comprehensive overview is lacking. The aim of this research is to thoroughly investigate the characteristics of the academic literature on the complex pathways through which climate variability affects different components of human security in Bangladesh, allowing for determination of the trends and research gaps, as well as whether they lead to conflict or cooperation. We used a systematic mapping methodology to search and screen 1839 publications in Web of Science, including 320 publications for the final synthesis. We found a predominant research focus on rural areas, especially in the southwestern region, with declining crop yield, economic loss, migration, water shortage, food scarcity and health hazards being the highlighted impacts of climate change for Bangladesh. The impacts on food, economic, environmental, health and water security have been well studied, but we found significant research gaps in some human security components, especially energy security. Women and the economically disadvantaged are disproportionately affected, and the causal pathways between conflict or cooperation and the ever-changing climate lack research efforts, implying a dire need to focus on under-researched areas before they become more complex and difficult to address. Policies and interventions should prioritise climate-resilient agricultural practices and infrastructure in high-risk areas, building local capacities and integrating climate risk assessments into urban planning, considering the high influx of environmental migrants. This systematic map provides a foundation for future longitudinal studies, establishes a baseline for this era for future comparisons and serves as a reliable database for relevant stakeholders and policy makers.

Exploring the impacts of daytime sleepiness on gait, physical balance, and the occurrence of orofacial trauma: a narrative review

Daytime sleepiness (DS) often accompanies obstructive sleep apnea (OSA), exacerbating its effects. DS can impair cognitive function, attention, reaction time, and motor coordination, increasing the risk of accidents. This study aimed to explore the relationship between DS, changes in gait and balance, and the occurrence of orofacial fractures. A narrative review was conducted using PubMed, Scopus, and Web of Science publications. The analysis revealed the impact of DS and OSA on gait and balance control in older individuals, emphasizing the need for interventions to address these issues and identify associated pathologies. Continuous Positive Airway Pressure (CPAP) therapy was recognized as a potential treatment, although further research is needed to understand DS triggers and treatment options in older populations. The study underscores the importance of analyzing interactions between the central nervous system, medications, balance, and mobility to prevent falls and related injuries. While the literature highlights the vulnerability of elderly individuals and those with OSA to falls, no established link between DS, gait, balance, and orofacial trauma necessitating medical and dental intervention was found. Thus, further research is warranted to address this gap and promote better understanding and management of these conditions.

Effect of wearable activity trackers on physical activity in children and adolescents: a systematic review and meta-analysis

Physical inactivity in children and adolescents has become a pressing public health concern. Wearable activity trackers can allow self-monitoring of physical activity behaviour and promote autonomous motivation for exercise. However, the effects of wearable trackers on physical activity in young populations remain uncertain. In this systematic review and meta-analysis, we searched PubMed, Embase, SPORTDiscus, and Web of Science for publications from database inception up to Aug 30, 2023, without restrictions on language. Studies were eligible if they were randomised controlled trials or clustered randomised controlled trials that examined the use of wearable activity trackers to promote physical activity, reduce sedentary behaviours, or promote overall health in participants with a mean age of 19 years or younger, with no restrictions on health condition or study settings. Studies were excluded if children or adolescents were not the primary intervention cohort, or wearable activity trackers were not worn on users' bodies to objectively track users' physical activity levels. Two independent reviewers (WWA and FR) assessed eligibility of studies and contacted authors of studies if more information was needed to assess eligibility. We also searched reference lists from relevant systematic reviews and meta-analyses. Systematic review software Covidence was used for study screening and data extraction. Study characteristics including study setting, participant characteristics, intervention characteristics, comparator, and outcome measurements were extracted from eligible studies. The two primary outcomes were objectively measured daily steps and moderate-to-vigorous physical activity. We used a random-effects model with Hartung-Knapp adjustments to calculate standardised mean differences. Between-study heterogeneity was examined using Higgins I2 and Cochran Q statistic. Publication bias was assessed using Egger's regression test. This systematic review was registered with PROSPERO, CRD42023397248. We identified 9619 studies from our database research and 174 studies from searching relevant systematic reviews and meta-analyses, of which 105 were subjected to full text screening. We included 21 eligible studies, involving 3676 children and adolescents (1618 [44%] were female and 2058 [56%] were male, mean age was 13·7 years [SD 2·7]) in our systematic review and meta-analysis. Ten studies were included in the estimation of the effect of wearable activity trackers on objectively measured daily steps and 11 were included for objectively measured moderate-to-vigorous physical activity. Compared with controls, we found a significant increase in objectively measured daily steps (standardised mean difference 0·37 [95% CI 0·09 to 0·65; p=0·013]; Q 47·60 [p<0·0001]; I2 72·7% [95% CI 53·4 to 84·0]), but not for moderate-to-vigorous physical activity (-0·08 [-0·18 to 0·02; p=0·11]; Q 10·26 [p=0·74]; I2 0·0% [0·0 to 53·6]). Wearable activity trackers might increase daily steps in young cohorts of various health statuses, but not moderate-to-vigorous physical activity, highlighting the potential of wearable trackers for motivating physical activity in children and adolescents. More rigorously designed trials that minimise missing data are warranted to validate our positive findings on steps and to explore possible long-term effects. The Hong Kong University Grants Committee and Seed Fund for Basic Research of the University of Hong Kong.

Management of neo-esophagus-airway fistula after esophagectomy for oesophageal cancer: systematic literature review and meta-analysis.

Neo-oesophageal-airway fistula (NEAF) between gastric conduit and airway is a rare but life-threatening complication of oesophagectomy for oesophageal cancer. Optimal treatment remains unknown. A meta-analysis of good-quality case series may help determine whether nonoperative management (NOM) only, upfront surgery (S), or NOM followed by surgery is associated with better 1-year post-treatment mortality, resumption of oral diet and fistula recurrence. We systematically searched PubMed, EMBASE and Web of Science for publications in English reporting case series of management and survival in patients with NEAF. Of the 177 identified studies, 62 were duplicates and 95 were not relevant to our topic. Three studies were excluded after a full-text review, due to absence of reporting of 1-year survival. Exclusion criteria to identified publications were: abstract only, malignant NEAF, absence of oesophagectomy and esogastric anastomosis, fewer than 5 patients and NEAF not the main focus of the study. Data-extraction was conducted in accordance with MOOSE guidelines. Data were pooled using random-effects model. Seventeen studies (302 patients) were included. One-year post-treatment mortality was considerably lower with NOM followed by surgery [33%; 95% confidence interval (CI), 0.17-0.48] than with NOM (68%; 95% CI, 0.39-0.97) or S (67%; 95% CI, 0.36-0.98). Fistula location was not associated with 1-year mortality. Neither resumption of an oral diet nor fistula recurrence differed significantly across treatment strategies. NOM to prepare patients for surgery followed by surgical repair may provide the highest 1-year survival of patients with NEAF. However, patient selection criteria to each of 3 treatment strategies may have affected our findings.

Abstract PO1-01-04: The optimal neoadjuvant treatment regimen for HR+/HER2+ breast cancer: a network meta-analysis

Abstract Background In patients with the HR+/HER2+ breast cancer (BC) subtype, it can be more challenging to achieve pathological complete response (pCR) after neoadjuvant therapy compared with the HR-/HER2+ subtype. The importance of neoadjuvant therapy and the association of pCR with long-term clinical benefits have been widely demonstrated in HER2+ BC. This network meta-analysis aimed to identify the optimal anti-HER2 regimen, the role of endocrine therapy, and the better chemotherapy choice for the neoadjuvant treatment of HR+/HER2+ BC patients. Methods Literature for neoadjuvant clinical trials in HR+/HER2+ breast cancer was searched in Medline, EMBASE, Cochrane Library, and Web of Science for publications released before June 2023. Single-arm trials, retrospective studies, and observational studies were excluded, as well as studies containing no neoadjuvant phase and/or no anti-HER2 drugs. A network meta-analysis with the fixed-effect model in a Bayesian framework was performed. Odds ratios (ORs) with 95% confidence intervals (CI) for pathological complete response (pCR) analysis and hazard ratios (HRs) with 95% CI for event-free survival (EFS) were calculated. A ranking of treatment patterns was performed using SUCRA. (Registered in PROSPERO: CRD42023385644 Results 2,844 records were identified by the literature search, 60 trials were included after the screening, and valid data were extracted. 19 trials and 2,883 patients were included in the primary analysis of pCR. Compared with trastuzumab + chemotherapy (CT), three treatment regimens showed significantly higher pCR rates, T-DM1 based treatment (T-DM1, OR: 2.83, 95% CI: 1.90, 4.27; which includes T-DM1 alone, T-DM1 + pertuzumab or T-DM1 + endocrine therapy), trastuzumab + pertuzumab + CT (PH, OR: 2.57, 95% CI: 1.70, 3.94), and trastuzumab + tyrosine kinase inhibitor (TKI)+ CT (H+TKI, OR: 1.60, 95% CI: 1.22, 2.09; TKI includes lapatinib, neratinib and pyrotinib). The SUCRA ranking of pCR showed that T-DM1 was ranked first (SUCRA: 0.94), followed by PH (SUCRA: 0.85) and H+TKI (SUCRA: 0.60). PH came first in the SUCRA ranking of EFS (SUCRA: 0.74) as well as cumulative SUCRA combining pCR and EFS (SUCRA: 0.79). For chemotherapy strategies, platinum-containing regimens showed no significant increase in pCR rate compared to no platinum regimens (OR: 1.27, 95% CI: 0.95, 1.69), regimens with anthracycline also had no statistical difference from those without anthracycline (OR: 0.74, 95% CI: 0.51, 1.07). When assessing the impact of endocrine therapy, no significant difference in pCR rate was observed with or without endocrine therapy (OR: 1.18, 95% CI: 0.80, 1.73). Conclusions The PH regimen remains the best neoadjuvant treatment choice for HR+/HER2+ early BC patients considering pCR and EFS outcomes simultaneously. H+TKI did not show significant benefits, so it is not recommended to be given priority in clinical practice. The platinum-containing regimen’s potential benefit compared to the non-platinum regimen is uncertain and needs more clinical investigation. The necessity of adding endocrine therapy is not proven due to limited data availability. Funding: This study was sponsored by Shanghai Roche Pharmaceuticals Ltd. Disclosure: Hao Tang, Shanghai Roche Pharmaceuticals Ltd.: Employee (Ongoing), Salary (Ongoing) Yajing Feng, Shanghai Roche Pharmaceuticals Ltd.: Employee (Ongoing), Salary (Ongoing) Xin Yu, Shanghai Roche Pharmaceuticals Ltd.: Employee (Ongoing), Salary (Ongoing) Citation Format: Hao Wang, Shiwei Liu, Miao Yu, Kun Mi, Exian Mou, Li Xia, Weimin Xie, Hao Tang, Yajing Feng, Xin Yu. The optimal neoadjuvant treatment regimen for HR+/HER2+ breast cancer: a network meta-analysis [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO1-01-04.

Chatbots and ChatGPT: a bibliometric analysis and systematic review of publications in Web of Science and Scopus databases

Chatbots and ChatGPT: a bibliometric analysis and systematic review of publications in Web of Science and Scopus databases

Chatbots and ChatGPT: A Bibliometric Analysis and Systematic Review of Publications in Web of Science and Scopus Databases

Chatbots and ChatGPT: A Bibliometric Analysis and Systematic Review of Publications in Web of Science and Scopus Databases

Professional Ethics, Challenges and Opportunities for Blockchain Technology in Healthcare Sector: A Systematic Review

Background:: The healthcare sector faces numerous issues, such as insurance fraud, electronic medical record management, interoperability, insecure dissemination of information, etc. The novel Blockchain technology holds tremendous potential to transform the healthcare sector by addressing these rising challenges in the industry. It provides a secure platform for storing, disseminating, and retrieving sensitive patient data and health records while preserving the ethical principles of the healthcare sector. Method:: In this study, we systematically reviewed the literature on blockchain technology in healthcare using PRISMA and highlighted how blockchain technology might promote innovation and deliver major improvements in the healthcare sector. Result:: Our goal is to examine the present status of this discipline, focusing on limits and potential advances. Queries were used to gather Scopus, PubMed, SpringerLink, IEEE Xplore, and Web of Science publications that met the criteria for the selection of papers. Conclusion:: This article, thus, analyses the potential for blockchain in the healthcare industry and outlines blockchain-based products in healthcare. Our study enhances and complements prior healthcare blockchain research.

Behavioral finance: Evolution from the classical theory and remarks

AbstractBehavioral finance has emerged from the divergences observed to explain and address the traditional theories of finance and serves as supplement to classical finance by introducing behavioral aspects to decision‐making. This study provides academics with a comprehensible and complete synopsis of the evolution of behavioral finance, as well as critical insight is provided. The synopsis was based on the search for publications in Web of Science (WoS) and Scopus and the use of R, Gephi and Tree of Science ‐ToS‐ software, using citation analysis, graphos and classification analysis. The results showed psychological aspects, investment in stocks and cognitive biases with the highest visibility. A tree‐like structure of hierarchization was developed by ToS. The clusters of publications with the greatest literary contribution were analyzed and the publications with the greatest visibility in each cluster identified. This study provides insights into the current trend in finance towards better understanding of the essential factors in the investor´s decision making.

Determining the Characteristics of Papers That Garner the Most Significant Impact: A Deep Dive into Mexican Engineering Publications

Engineers make things, make things work, and make things work better and easier. This kind of knowledge is crucial for innovation, and much of the explicit knowledge developed by engineers is embodied in scientific publications. In this paper, we analyze the evolution of publications and citations in engineering in a middle-income country such as Mexico. Using a database of all Mexican publications in Web of Science from 2004 to 2017, we explore the characteristics of publications that tend to have the greatest impact; this is the highest number of citations. Among the variables studied are the type of collaboration (no collaboration, domestic, bilateral, or multilateral), the number of coauthors and countries, controlling for a coauthor from the USA, and the affiliation institution of the Mexican author(s). Our results emphasize the overall importance of joint international efforts and suggest that publications with the highest number of citations are those with multinational collaboration (coauthors from three or more countries) and when one of the coauthors is from the USA. Another interesting result is that single-authored papers have had a higher impact than those written through domestic collaboration.

Environmental valuation: a systematic review using bibliometrics

Environmental valuation has been applied since 1987. In this article, a bibliometric approach was employed between the years 1987 and 2022 using the Web of Science (WoS) and Scopus databases to examine the scientific production on this subject. The VOSviewer software was used, and a sample of 712 publications in WoS and 743 in Scopus was found. The highest number of publications in WoS was in 2018, while in Scopus it was in 2017. During the research period, the United States had the highest number of publications on environmental valuation in WoS, while the United Kingdom had the highest number in Scopus. The most frequently appearing keyword was "environmental valuation" in both platforms. The author with the highest number of publications was Nick Hanley from the University of Glasgow in Scotland, in both platforms. The topic of environmental valuation has gained importance over the years due to increased interest in the environment, as a response to the damages incurred. It aims to assist decision-making and enable the accounting of costs and benefits associated with natural capital.

The role of syphilis self-testing as an additional syphilis testing approach in key populations: a systematic review and meta-analysis

Syphilis is causing epidemics in many countries. Syphilis self-testing (SST) has potential to increase testing and treatment coverage in the same manner as documented for self-testing of, for example, HIV, hepatitis C virus, and COVID-19. We aimed to synthesise current evidence on the utility of SST. We conducted a systematic review and, where possible, meta-analysis. We searched MEDLINE, Embase, CINAHL, Scopus, and Web of Science for publications published from Jan 1, 2000, to Oct 13, 2022. We included publications with original data on any syphilis rapid tests, including dual HIV-syphilis tests. Study populations were not restricted. We used random-effects meta-analysis to calculate the pooled proportion of people offered SST who undertook the test. The systematic review was registered in PROSPERO (CRD42022302129). In total, 40 499 citations were identified. 11 publications from seven studies from the USA, Zimbabwe, and China met eligibility criteria. Of those, four studies reported data from men who have sex with men and five studies used dual HIV-SST. Using data from one randomised controlled trial and three observational studies, the pooled proportion of people who received SST kits who undertook the test was 88% (95% CI 85-91). No studies provided data on the sensitivity or specificity of SST. Overall, user and provider preference for SST was high, with participants reporting convenience, privacy, rapid results, autonomy, trust in blood-based tests, decreased facility contact, and time savings, with individuals being able to correctly self-test. Publications from China reported that SST had lower costs per person tested than existing facility-based testing options. Our review builds on the literature for self-testing across different disease areas and demonstrates that SST has the potential to reach underserved populations. As this review found that SST use was acceptable and feasible to implement, SST can be used as an additional syphilis testing approach. Since no data on the sensitivity and specificity of SST were found, further implementation research will be required to guide the best strategies for SST service delivery and future scale-up. WHO, Australian National Health and Medical Research Council, and Unitaid.

Dysregulation of the autonomic nervous system in adult attention deficit hyperactivity disorder. A systematic review

ABSTRACT Background: Adult Attention Deficit Hyperactivity Disorder (aADHD) is characterised by inattention, hyperactivity, impulsivity, and emotional instability, all of which were linked to altered modulation of the autonomic nervous system. This and the clinical effectiveness of sympathomimetic medication raised the question if autonomic modulation is altered in aADHD patients. Methods: We systematically searched PubMed, Cochrane Library, and Web Of Science for publications investigating autonomic modulation in aADHD and controls during resting-state and/or under task conditions. Results: We reviewed 15 studies involving 846 participants (424 aADHD and 422 controls), including 4 studies on sympathetic tone at rest, 13 studies on sympathetic modulation during tasks, 3 studies on resting state parasympathetic modulation and 3 papers on task-related parasympathetic modulation. Studies comprised measurements of electrodermal activity, heart rate variability, blood pressure variability, blood volume pulse, pre-ejection period, and baroreflex sensitivity. 2 studies reported reduced sympathetic tone in aADHD; 7 papers described lower sympathetic reactivity to task demands in this cohort. One study linked aADHD to impaired vagal tone, while no indications of altered tasks-related parasympathetic reactivity in aADHD patients were reported. Conclusion: The reviewed data revealed impaired cardiovascular autonomic modulation in aADHD patients, predominantly in sympathetic modulation and during stress exposure.

Improving our understanding of open access: how it relates to funding, internationality of research and scientific leadership

As open publication has become a goal in scholarly communication, interest in how it relates to other features of the research process has grown. This paper focuses on the relationship between funding and open access (OA) in the Spanish National Research Council’s Web of Science publications in three scientific fields with different research practices, namely, Biology & Biomedicine (BIOL), Humanities & Social Sciences (HSS) and Materials Science (MATE). Firstly, the three fields are characterised in relation to OA practices (OA status and OA routes) and acknowledged funding (funding status and funding origin). Secondly, the relationship between OA and funding is explored, and the role of additional influential factors, such as the internationality of research and national/foreign leadership of papers, is unravelled through logistic regression. BIOL shows a higher OA share (66%) than do the other two fields (around 33%). Funded research shows higher OA rates than unfunded research in the experimental fields, but not in HSS, where it is related to a shift towards more publications with article-processing charges. The internationality of research, measured through international collaboration or foreign funding, increases OA, albeit with differences across fields. Foreign-funded papers are more likely to be led by foreign researchers in all three fields, but a foreign first author increases the chances of OA publication in HSS only, perhaps because Spanish leaders in this field have not internalised the importance of OA. The research’s policy implications are reviewed.

Trends in Knowledge Management within Open Government

In realizing the aspirations as a democratic nation, the provision of high-quality information transparency by the government is essential, especially for the legislative body as the people's representation. To transform information into a fundamental consideration for public policies, effective knowledge management is needed from the community, who act as active users of this information transparency. This study aims to analyze the trends in research concerning knowledge management and open government. Data sources were obtained through the Web of Science for publications from 2019 to 2023, focusing on the fields of political science, management, and social reform. The applied method utilized bibliometric analysis with tools such as VOSviewer and Biblioshiny. The study's results identified a total of 2251 keywords, which were then refined to 259 keywords through data selection. From the VOSviewer analysis, the study yielded 1144 links and 4 clusters, indicating the interconnectedness among keywords. This interconnectedness was further illustrated through Network Visualization, Overlay Visualization, and Density Visualization. Meanwhile, the Biblioshiny analysis, conducted using the R Application, involved visualizations like WordCloud, TreeMap, and Trend Topics related to the keywords.

P-714 Clinical utility of FMR1 screening: risk factor or monogenic cause for POI

Abstract Study question Is there a risk factor association or a monogenic relationship between FMR1 premutation and developing Fragile X-associated primary ovarian insufficiency (FXPOI)? Summary answer There is an association between FMR1 premutation and FXPOI rather than a monogenic relationship, which is highly dependent on ethnicity. What is known already Among the 40 genes involved in primary ovarian insufficiency (POI), identified in our recent systematic review (Van Der Kelen et al., 2022), the FMR1 premutation is considered as the most common cause of POI. A premutation in the FMR1 gene is defined as a CGG trinucleotide repeat length between 55 and 200 in the 5′ untranslated region. The term FXPOI is used for women with premutation in FMR1 who have a loss of normal function of the ovaries before the age of 40. There is conflicting evidence about the relationship between POI and length of premutation FMR1 alleles. Study design, size, duration Curated publications identified in PubMed and Web of Science on genetics of human female infertility and sex development by using the MESH terms, key words and inclusion/exclusion criteria described in our comprehensive systematic review were subjected to screening for “FMR1 gene.” The articles included cover a period from 1988 to the 1st of November 2021. Participants/materials, setting, methods A total of 161 publications in PubMed and 61 unique publications in Web of Science were identified, and subsequently screened for triplet expansion, primary ovarian insufficiency, and/or early menopause. Of these, 56 papers were selected, excluding publications exclusively on males as well as studies on non-human species, pediatric cases, reviews, and expression studies. The study and control groups repeat numbers, ethnicity, and conclusions in the article are listed. Main results and the role of chance Expansion in CGG trinucleotide repeat length happens at female meiosis and the risk for expansion increases with an increasing number of CGG repeats. There is an intermediate zone between 45 and 55 CGG repeats when the allele may be stable or unstable. Among 56 publications, 54 describing FMR1 triplet repeat size in women with POI, 34 were studying only the women with POI (observational) while 20 were including also control group (comparative). 2 publications were meta-analyses in which 13 and 11 case control studies were included respectively, 5 studies being in common. POI-associated premutations showed a wide range of repeat sizes. Women carrying midsize range repeats (&amp;gt;70-&amp;lt;100) potentially have a higher risk for POI compared to the general population. In recent decades, population-based screenings have indicated that FMR1 premutations are not as prevalent in women with ovarian insufficiency as previous estimates have suggested, but they still represent a substantial cause of POI. When present, the number of AGG interruptions and the size of uninterrupted CGG repeats are directly correlated with the ovarian reserve. No increased risk of POI associated with a premutation was reported among populations of non-European descent, such as the Han Chinese, Indian, and Jordan populations. Limitations, reasons for caution Available reports are difficult to compare because the ethnicity and number of patients analyzed, availability of clinical data and the quality of results are different in each study. Additionally, an effect of X-inactivation in POI women with premutation was not studied. Wider implications of the findings Owing to the low penetrance and a molecular mechanism that has not yet been fully elucidated, the clinical utility of FMR1 screening in women with reduced ovarian reserve needs further investigation before clinical implication. Trial registration number N/A

Characterization of global research trends and prospects on platinum-resistant ovarian cancer: a bibliometric analysis.

In the last decades, growing attention has been focused on identifying effective therapeutic strategies in the orphan clinical setting of women with platinum-resistant ovarian cancer (PROC), generating thousands of original articles. However, the literature involving bibliometric analysis of PROC has not been published yet. This study hopes to gain a better understanding of the hot spots and trends in PROC by conducting a bibliometric analysis, as well as identify potential new research directions. We searched the Web of Science Core Collection (WOSCC) for PROC-related articles published between 1990 and 2022. CiteSpace 6.1.R2 and VOS viewer 1.6.18.0 were primarily utilized to evaluate the contribution and co-occurrence relationships of various countries and regions, institutes, and journals and to identify research hotspots and promising future trends in this research field. A total of 3,462 Web of Science publications were retrieved that were published in 671 academic journals by 1135 authors from 844 organizations in 75 countries and regions. The United States was the leading contributor in this field, and the University of Texas MD Anderson Cancer Center was the most productive institution. Gynecologic Oncology was the most productive journal, while the Journal of Clinical Oncology was the most cited and influential. Co-citation cluster labels revealed the characteristics of seven major clusters, including synthetic lethality, salvage treatment, human ovarian-carcinoma cell line, PARP inhibitor resistance, antitumor complexes, folate receptor, and targeting platinum-resistant disease. Keywords and references burst detection indicated that biomarkers, genetic and phenotypic changes, immunotherapy, and targeted therapy were the most recent and most significant aspects of PROC research. This study conducted a comprehensive review of PROC research using bibliometric and visual techniques. Understanding the immunological landscape of PROC and identifying the population that can benefit from immunotherapy, especially in combination with other therapeutic options (such as chemotherapy and targeted therapy), will continue to be the focal point of research.