This study explores the relationship between institutional trust and elements of religion in contemporary American society. Using a nationally representative survey, we utilize latent class and regression analyses to assess the contours of these relationships. Our findings reveal a diverse institutional trust profile, with pronounced distrust in democratic institutions, especially Congress, although the group with low institutional trust is the smallest one within the society. While trust in religious institutions, and to an extent broader institutional trust, predict religiosity, this is less so with the case of spirituality. Institutional trust similarly shows modest positive relationships to public religious practice, while a clear negative relationship to private religious practice. Interpreting these findings through the lens of secularization and privatization of religion, we hope to provide a strong empirical contribution to the literature regarding intersections of institutional trust and the evolving religious and spiritual orientations of today’s American landscape.