Introduction Hypertension (HT) is a highly prevalent cardiovascular disease and a risk factor for coronary heart disease, stroke, and heart and kidney failure, among others. The obstructive sleep apnea (OSA) is a well-known causative factor of hypertension, but less known is the role of shift work systems and the place in the hierarchy of social organization. Objective: To study the risk factors associated with hypertension in a group of health workers. Materials and methods We conducted a cross-sectional study in a group of health workers, as part of an occupational health program in a public hospital in Santiago, Chile. All subjects underwent a medical evaluation, which included anthropometric parameters, blood pressure measurement, a battery of laboratory tests, and surveys of sleep by Berlin Questionnaire. According to this questionnaire went classified in Low or High Risk of OSA. According to the work schedule, the workers were classified into Daytime work, 3rd Shift, and 4th Shift; and as the plant to which they belonged within the organization in Professional, Administrative, Paramedical technician, and Auxiliary. We examined the association of hypertension with shift work, the risk of OSA, and place within the organizational hierarchy using a logistic regression model adjusted for sex, age, BMI, and smoking. Results The study group consisted of 353 workers, with an average age of 44.2 ± 12.6 years (IQ = 31.8–54.7), of which 266 (75.4%) were women, and 87 (24.6%) were men. Of the total, 87 (24.6%) had hypertension. On the other hand, as the result of the Berlin Questionnaire, 151 (42.8%) had High Risk of OSA. According to the work schedule, 194 (55%) worked in daytime, and 159 (45%) were shift workers (114 in 4th Shift, and 45 in the 3rd Shift). Of the total, 44 (12.5%) were Professionals, 78 (22.1%) Administrative, 148 (41.9%) Paramedical technicians, and 83 (23.5%) Auxiliary. According to logistic regression, the 4th Shift had an OR = 2.03 (95% CI, 0.9–4.58; p = 0.088), 3rd Shift an OR = 4.23 (95% CI, 1, 51–11.83; p = 0.006); the trend test was significant with an OR = 2.05 (95% CI, 1.23–3.41; p = 0.006). The High Risk of OSAS an OR = 4.1 (95% CI, 1.89–8.9; p 0.001). Regarding the location in the organization, the Administrative had an OR = 10.1 (95% CI, 1.76–57.88; p 0.001), Paramedical technicians OR = 5.55 (95% CI, 1.1–28.27; p = 0.039), and the Auxiliary an OR = 5, 76 (95% CI, 1.11–29.86; p = 0.037). Interactions between stratum and shift work and risk of OSA, were not significant in the multiplicative scale. The age variable reached statistical significance ( p = 0.018). The factors sex, BMI, and smoking showed no increased risk associated. Conclusion According to our results, the place within the organizational hierarchy, shift work and sleep-disordered breathing, are independent risk factors of hypertension in health workers. These results also suggest that sex, overweight and obesity, and smoking act through independent risk factors and not by themselves. Acknowledgements To health workers of Felix Bulnes Hospital.