The global drug abuse crisis continues to pose significant public health challenges, necessitating comprehensive prevention strategies. Pharmacists, as accessible and trusted healthcare professionals, are increasingly recognized for their pivotal role in drug abuse prevention. This paper explores pharmacist-led public health campaigns and interventions designed to mitigate drug abuse, particularly through education, outreach, and collaboration with other healthcare providers. It examines core components of effective campaigns, including targeting at-risk populations such as youth and high-risk communities. Additionally, the paper discusses global prevention strategies, addressing the cultural, economic, and legal barriers that pharmacists face while highlighting opportunities for their leadership in international drug prevention efforts. The conclusion emphasizes the need for policy recommendations to enhance the pharmacist’s role in drug abuse prevention, alongside future directions leveraging digital health technologies and international collaboration to achieve more effective global outcomes.