Loss Of Pubic Hair Research Articles

Chemoradiation in female patients with anal cancer: Patient-reported outcome of acute and chronic side effects.

We evaluated acute and chronic side effects of 3D conformal radiotherapy (3D-CRT) and intensity-modulated radiation therapy (IMRT) in female patients with anal carcinoma and accessed correlations between dosimetric parameters and the considered toxicities. For 70 women with anal cancer treated at our department, acute and chronic side effects and quality of life (QoL) were evaluated with questionnaires using the Common Terminology Criteria for Adverse Events (CTCAE v. 4.0.) and Late Effects in Normal Tissue, Subjective, Objective Management and Analytic Scales (LentSoma) before, during, and after the treatment. Forty-seven out of 70 (67%) patients completed the questionnaire and were enrolled in the study. Only poor urinary stream, loss of pubic hair during chemoradiation, and chronic vaginal dryness were observed more frequently in the 3D-CRT group compared to the IMRT group (univariable logistic regression p = .032, p = .04, p = .049, respectively). After the treatment, 43% in the 3D-CRT group and 29% in the IMRT group reported a severe loss of QoL. A higher proportion among the patients receiving a genital V20 ⩾35% showed grade 1-3 side effects such as chronic dyspareunia ( p = .035; Fisher exact test). Our results suggest that the use of IMRT decreases acute and chronic adverse effects although reduced QoL also occurred in the IMRT group. These effects are likely to be underreported in retrospective studies using physician-reported outcome measures.

Trichoscopic features of frontal fibrosing alopecia: Results in 249 patients

Trichoscopic features of frontal fibrosing alopecia: Results in 249 patients

Sixteen years post radiotherapy of nasopharyngeal carcinoma elicited multi-dysfunction along PTX and chronic kidney disease with microcytic anemia

BackgroundThe hypothalamic–pituitary (h-p) unit is a particularly radiosensitive region in the central nervous system. As a consequence, radiation-induced irreversible, progressively chronic onset hypopituitarism (RIH) commonly develops after radiation treatments and can result in variably impaired pituitary function, which is frequently associated with increased morbidity and mortality.Case presentationA 38-year-old male subject, previously having received radiotherapy for treatment of nasopharygeal carcinoma (NPCA) 16 years ago, appeared at OPD complaining about his failure in penile erection, loss of pubic hair, atrophy of external genitalia: testicles reduced to 2×1.5 cm; penile size shrunk to only 4 cm long. Characteristically, he showed extremely lowered human growth hormone, (HGH, 0.115 ng/mL), testosterone (<0.1 ng/mL), total thyroxine (tT4: 4.740 g/mL), free T4 (fT4, 0.410 ng/mL), cortisol (2.34 g/dL); lowered LH (1.37 mIU/mL) and estradiol (22 pg/mL); highly elevated TSH (7.12 IU/mL). As contrast, he had low end normal ACTH, FSH, total T3, free T3, and estriol; high end normal prolactin (11.71 ng/mL), distinctly implicating hypopituitarism-induced hypothyroidism and hypogonadism. serologically, he showed severely lowered Hb (10.6 g/dL), HCT (32.7%), MCV (77.6 fL), MCH (25.3 pg), MCHC (32.6 g/dL), and platelet count (139×103/L) with extraordinarily elevated RDW (18.2%), together with severely lowered ferritin (23.6 ng/mL) and serum iron levels; highly elevated total iron binding capacity (TIBC, 509 g/dL) and transferrin (363.4 mg/dL), suggesting microcytic anemia. Severely reduced estimated glomerular filtration rate (e-GFR) (89 mL/mim/1.73 m2) pointed to CKD2. Hypocortisolemia with hyponatremia indicated secondary adrenal insufficiency. Replacement therapy using androgen, cortisol, and Ringer’s solution has shown beneficial in improving life quality.ConclusionsTo our believe, we are the first group who report such complicate PTX dysfunction with adrenal cortisol insufficiency concomitantly occurring in a single patient.

A case report of Graham-Little–Piccardi–Lassueur syndrome

Graham-Little–Piccardi–Lassueur syndrome is a rare entity which consists of scarring patchy alopecia of the scalp, noncicatricial axillary and pubic hair loss, and lichenoid follicular eruption. Although these three problems can arise simultaneously but usually scalp is the first to be involved with persistent itching and hair loss. Associated cutaneous or mucosal lichen planus is also one of the regular features. Thinning and destruction of nails is also present. The axillary and pubic alopecia is regularly described as noncicatricial, because there is no clinical atrophy. This syndrome has been reported among females of postmenopausal age. Here, we report a male patient of 46 years suffering from this syndrome.

Mucocutaneous manifestations of acquired hypoparathyroidism: An observational study

Hypoparathyroidism is a disorder of calcium and phosphorus metabolism due to decreased secretion of parathyroid hormone. Hypoparathyroidism can be hereditary and acquired. Acquired hypoparathyroidism usually occurs following neck surgery (thyroid surgery or parathyroid surgery). Along with systemic manifestations, hypoparathyroidism produces some skin manifestations. Lack of study regarding mucocutaneous manifestations of acquired hypoparathyroidism prompted us to undertake this study. To evaluate the mucocutaneous manifestations of acquired hypoparathyroidism. An observational study done in a tertiary care hospital of Kolkata by comprehensive history taking, through clinical examination and relevant laboratory investigations. Twenty-one patients were included in the study. The commonest form of acquired hypoparathyroidism was neck surgery (thyroidectomy and parathyroidectomy operation). Mucocutaneous manifestations were present in 76.19% of patients. The most frequent mucocutaneous manifestation was found in the hairs like the loss of axillary hair (61.9%), loss of pubic hair (52.38%), coarsening of body hair (47.62%), and alopecia areata (9.52%). The nail changes noted were brittle and ridged nail, followed by onycholysis, onychosezia, and onychomedesis. The most common skin features were xerotic skin in 11 patients (52.38%), followed by pellagra-like skin pigmentation, pustular psoriasis and acne form eruption, bullous impetigo, etc. Mucosa was normal in all the cases excepting the one which showed oral candidiasis.

Central Diabetes Insipidus and Hypothalamic Type of Hypopituitarism Associated with Atypical Location of Rathke's Cleft Cyst

A 68-year-old woman was admitted to determine the pathogenesis of weight loss and polyuria. Physical findings on admission showed BMI of 20.9, blood pressure of 147/69 mmHg, and that she had ciliac, axillar and pubic hair loss. Laboratory findings showed that plasma adrenocorticotropic hormone (ACTH) was 4.6 pg/mL with serum cortisol of 1.2 µg/dL. Serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were markedly reduced. Serum growth hormone (GH) and insulin growth factor (IGF)-1 were 0.054 ng/mL and 25 ng/mL, respectively. Serum prolactin was as high as 85.6 ng/mL. The levels of all the pituitary hormones were elevated in response to a mixture of exogenous corticotrophin-releasing hormone (CRH), luteinizing hormone-releasing hormone (LH-RH), thyrotropin-releasing hormone (TRH), and growth hormone-releasing hormone (GRH). However, there was no response of ACTH and GH release to insulin-induced hypoglycemia and no response of LH and FSH release to clomiphene. Urine volume was more than 4,000 mL, with low urine osmolality of 134 mmol/kg. Plasma arginine vasopressin (AVP) was 0.8 pg/mL. There was no increase in urine osmolality and plasma AVP in response to 5% hypertonic saline load. Magnetic resonance imaging revealed Rathke's cleft cyst at the pituitary stalk level, but there was no abnormal finding in the hypothalamus. These findings indicate central diabetes insipidus and hypothalamic type of hypopituitarism, resulting from the atypical location of Rathke's cleft cyst.

Effect of hair autotransplantation with intact follicle on congenital loss of pubic hair

Objective To explore the effect of autotransplantation of hair with intact follicle on pubic hair reconstruction in patients with congenital loss of pubic hair. Methods The scalps strips of 12 female patients were harvested from the back of the head, close to the hairline. Under the microscope, the strip was then divided into a series of follicular-unit micrografts. The hair was transplanted to defective pubic area with the needle of syringe (0.9 mm × 38. 0 mm). Four hundred to 700 follicle units (U) were transplanted for small areas with the shape of inverted triangle or diamond. The density of transplanted hair was 20 U/cm2 in the area of mons pubis. The further from the area of mons pubis the distance was, the lower the density was. But it was not less than 10 U/cm2. Results The patients were followed-up for nine months to two years. The hairs transplanted grew well. The appearance was close to the normal distribution of pubic hair. All of the patients were treated by this one-session operation, and satisfied with the results. The incision scar of donor area on the back of the head was inconspicuous. Conclusions The above-mentioned technique is a simple, safe and effective method for pubic hair reconstruction. It might be an ideal method for pubic hair reconstruction with the appearance much closer to a normal pubic hair. Key words: Hair; Transplantation; Pubic hair; Hair follicle

Aesthetic Pubic Reconstruction After Electrical Burn Using a Portion of Hair-Bearing Expanded Free-Forehead Flap

Electrical burn in the pubic region usually results in a severe and contractive scar with pubic hair loss. The aesthetic restoration of this area often has become very difficult. A 22-year-old male electrical engineer experienced severe pubic scarring with hair loss after electrical burn. He was treated successfully with an expanded free-forehead flap including a portion of hair-bearing scalp after microsurgical vascular anastomoses between the bilateral superficial temporal vessels and the bilateral deep inferior epigastric vessels. The donor forehead site was closed directly in the frontal hairline without visible scarring. The pubic area was repaired functionally and cosmetically with the flap, and the pubic hair was growing well after a 1-year following-up period. This successful case strongly indicates that a microsurgical tissue transfer can be a good option for reconstruction of a pubic defect and that the expanded forehead flap could fulfill the high cosmetic demands of pubic reconstruction with minimal donor morbidity.

Guidelines for Pubic Hair Restoration

Although the loss of pubic hair is a relatively frequent condition, there have been few reports about pubic hair restoration. This report aims to describe the demarcation and technical guidelines for pubic hair restoration using follicular micrografts. Demarcation is described and based on anatomic parameters such as the level of the greater trochanters and the labium majus. The angle of micrograft insertion and direction also are described. The use of micrografts for pubic hair restoration is a procedure that promotes very natural results. The described parameters of demarcation and technical details are important issues that should be considered to obtain a natural result in pubic hair restoration.

The incidence of Sheehan’s syndrome after obstetric hemorrhage

To estimate the incidence of Sheehan's syndrome in a well-described cohort of patients with obstetric hemorrhage. Retrospective cohort study. Tertiary care center. Two hundred patients. Questionnaires were sent to study and comparison patients asking about menstrual dysfunction, lactation difficulty, cold intolerance, fatigue, axillary and pubic hair loss, and secondary infertility. Women who experienced two or more symptoms were referred for hormone testing of insulin-like growth factor 1 (IGF-1), T4, PRL, and early morning cortisol (F) levels. A total of 109 patients responded to the survey, a 55% response rate. Fourteen of 55 (25%) patients in the hemorrhage group identified themselves as suffering from two or more symptoms on the questionnaire. Eight of the 14 patients were tested, but none had hormonal evidence of hypopituitarism. Four of 54 (7%) comparison patients also identified themselves as suffering from two or more symptoms, but neither of the two tested had hormonal evidence of hypopituitarism. Among women with postpartum hemorrhage, subsequent development of clinical symptoms does not correlate well with laboratory evidence of hypopituitarism. Clinically significant Sheehan syndrome is an uncommon consequence of obstetric hemorrhage in today's environment.

The incidence of Sheehan’s syndrome after obstetric hemorrhage

The purpose of this study was to determine the incidence of Sheehan’s syndrome in a well described cohort of patients with obstetric hemorrhage. A retrospective cohort study. Women who delivered at Prentice Women’s Hospital from July 1998 through February 2002 who had a post partum hemorrhage were matched by day of delivery and route of delivery to women who did not hemorrhage. Charts were reviewed to ensure blood loss was as stated and to gather information on delivery and interventions (hypotension, transfusion, hysterectomy, intensive care unit admission). Questionnaires were sent to 200 women asking about symptoms including menstrual dysfunction, lactation difficulty, cold intolerance, fatigue, axillary and pubic hair loss, and secondary infertility. Women who experienced two or more symptoms were referred for hormone testing of insulin-like growth factor 1 (IGF-1), free thyroxine (T4), prolactin and early morning cortisol levels. A total of 109 patients responded to the survey, a 55% response rate. 14 (27%) patients in the hemorrhage group identified themselves as suffering from two or more symptoms on the questionnaire. 8 of the 14 patients were tested, but none had hormonal evidence of hypopituitarism. 4 (7.5%) control patients also identified themselves as suffering from two or more symptoms, but none of 2 tested had hormonal evidence of hypopituitarism. Clinically significant Sheehan’s syndrome is an uncommon consequence of obstetric hemorrhage in today’s environment.

OBSERVATIONS ON BODY HAIR IN OLD PEOPLE

ABSTRACT This survey of 167 men and 189 women over 60 years of age was carried out to assess the diagnostic value of absent or reduced body hair in old people. The state of axillary, pubic, chest, abdominal, limb and eyebrow hair was examined in both sexes, and facial hair in females. Most or all axillary hair was lost in one sixth of the males and half of the females. This loss was progressive with age. Detectable loss of pubic hair occurred in one fifth of the men and one third of the women, but only 1 man and 5 women had complete loss of pubic hair. Thus only loss of all pubic hair is of diagnostic significance in old age. One sixth of patients of both sexes had lost the outer third of their eyebrows, although appearing euthyroid. Coarse facial hair was present in three quarters of the women, and its incidence did not increase with age. Hair was rarely seen on the sides of the face, but was common on the upper lip and chin. Limb hair had a definite pattern of disappearance which was similar in both sex...

Acute and chronic adrenal insufficiency in a patient showing polyglandular deficiency and acromegaly.

THIS patient presented such unusual clinical features that the case merits reporting and discussion. The occurrence of acromegaly (inactive or “burnt out”)> and acute adrenal insufficiency is a rare combination to which there is scant reference in the literature (1, 2, 3, 4). CASE REPORT W.D. was a 41-year-old, unmarried, white, lumbermill foreman, who entered the hospital on February 17, 1949, in a state of semicoma. He had been well until fortyeight hours prior to admission when severe prostration developed and he lost his appetite. On the day of his admission he became irrational and semicomatose and had diarrhea. The past history later obtained from the patient and from members of his family was as follows: In 1932 he consulted a physician because of undue fatigability and was told that he had heart disease. At that time he had no other symptoms and the fatigability disappeared spontaneously. About 1936 there was loss of axillary hair and partial loss of pubic hair.