Inspired by superior gas sensing properties of PtSe2 monolayer and tunable gas sensing properties of Janus MoSSe monolayer, we study the gas sensing properties of the Janus PtSSe monolayer for CO, CO2, H2O, NH3, NO and NO2 gas molecules using first-principles density functional calculations. We calculate adsorption height and adsorption energies of the gas molecules to assess the adsorption strength of the gas molecules. Then the charge transfer from PtSSe to gas molecules is evaluated. We also investigate the effects of strain and external electric field on the gas sensing properties of Janus PtSSe monolayer. We finally reveal the origin of the superior gas sensing properties from projected density of states analysis. Our results suggest that the Janus PtSSe monolayer is a promising gas sensor with superior and tunable sensing properties.