The catalyst support materials demonstrate great influence on the performance and durability of oxygen reduction reaction (ORR) electrocatalysts. Metal organic frameworks (MOFs) have been the focus of many Pt alloyed catalyst supports due to their large surface areas and well-defined pore structures. MOF-based carbon supports and a special class of MOFs that have a zeolite-type structure, and Zeolitic imidazolate frameworks (ZIFs) offer high ORR activity and enhanced stability of Pt-alloyed catalysts due to their porous structure, large surface area, and good electrical conductivity. In this study, we used two different MOF-based supports, Mn-NC and ZIF-67 derived Co-NC, to synthesize a nitrogen (N)-doped intermetallic PtNi catalyst. The synthesized material exhibits enhanced ORR activity and stability in an acidic electrolyte that is superior to commercial Pt/C catalyst. The rotating disk electrode (RDE) measurements of the PtNi/Co-NC catalyst demonstrated that the mass activity (MA) and specific activity (SA) are 0.9 A mgPt -1 and 1.8 mA cm-2, respectively at 0.9 V. The synthesized PtNi/Mn-NC catalyst demonstrated 1.4 A mgPt -1 and 2.1 mA cm-2 at 0.9 V, which are higher than those achieved with the commercial Pt/C. The MEA performance of the MOF-based PtNi catalysts will also be discussed. The mechanism of the enhanced performance of the catalysts is being formulated, based on in situ X-ray absorption spectroscopy (XAS) analysis. This work provides a promising approach to improve the activity and stability of binary and ternary Pt-based electrocatalysts for ORR by the use of MOF-based supports.