Psychotic Experiences Research Articles

The association between aberrant salience and psychotic experiences in general population twins, and genetic vulnerability as a modifier

BackgroundPrevious studies assessing the hypothesis that the construct of ‘aberrant salience’ is associated with psychosis and psychotic symptoms showed conflicting results. For this reason, the association between measures to index aberrant salience and subclinical psychotic symptoms in a general population sample was analysed. In addition, genetic vulnerability was added to the analysis as a modifier to test the hypothesis that modification by genetic vulnerability may explain variability in the results.MethodsThe TwinssCan project obtained data from general population twins (N = 887). CAPE (Community Assessment of Psychic Experience) scores were used to index psychotic experiences. Aberrant salience was assessed with white noise task and ambiguous situations task.ResultsMeasures of aberrant salience were not associated with psychotic experiences, nor was there evidence for an interaction with genetic predisposition in this association (Z = 1.08, p = 0.282).ConclusionsVarious studies including the present could not replicate the association between aberrant salience and psychotic experiences in general population samples. The conflicting findings might be explained by moderation by genetic vulnerability, but results are inconsistent. If there was evidence for a main effect or interaction, this was in the positive symptom scale only. On the other hand, the association was more robust in so-called ‘ultra-high risk’ patients and first episode psychosis patients. Thus, this association may represent a state-dependent association, present only at the more severe end of the psychosis spectrum.

Associations between polygenic scores for cognitive and non-cognitive factors of educational attainment and measures of behavior, psychopathology, and neuroimaging in the adolescent brain cognitive development study.

Educational attainment (EduA) is correlated with life outcomes, and EduA itself is influenced by both cognitive and non-cognitive factors. A recent study performed a 'genome-wide association study (GWAS) by subtraction,' subtracting genetic effects for cognitive performance from an educational attainment GWAS to create orthogonal 'cognitive' and 'non-cognitive' factors. These cognitive and non-cognitive factors showed associations with behavioral health outcomes in adults; however, whether these correlations are present during childhood is unclear. Using data from up to 5517 youth (ages 9-11) of European ancestry from the ongoing Adolescent Brain Cognitive DevelopmentSM Study, we examined associations between polygenic scores (PGS) for cognitive and non-cognitive factors and cognition, risk tolerance, decision-making & personality, substance initiation, psychopathology, and brain structure (e.g. volume, fractional anisotropy [FA]). Within-sibling analyses estimated whether observed genetic associations may be consistent with direct genetic effects. Both PGSs were associated with greater cognition and lower impulsivity, drive, and severity of psychotic-like experiences. The cognitive PGS was also associated with greater risk tolerance, increased odds of choosing delayed reward, and decreased likelihood of ADHD and bipolar disorder; the non-cognitive PGS was associated with lack of perseverance and reward responsiveness. Cognitive PGS were more strongly associated with larger regional cortical volumes; non-cognitive PGS were more strongly associated with higher FA. All associations were characterized by small effects. While the small sizes of these associations suggest that they are not effective for prediction within individuals, cognitive and non-cognitive PGS show unique associations with phenotypes in childhood at the population level.

Sex Differences in Subclinical Psychotic Experiences: The Role of Daily-Life Social Interactions.

Sex differences in psychosis are reported across the psychosis spectrum, including in subclinical stages. An important factor in understanding these variations is the subjective experience of everyday social interactions (SI). We investigated whether the presence of psychotic experiences (PEs), as well as associated distress, differs between men and women. We focused on the role of daily-life SI quality and whether its association with PEs varies by sex. We included adolescents from SIGMA, a general youth population study in Flanders, Belgium (n = 344; mean age = 18.7; 63.4% female). Psychotic experiences were measured using the PQ-16. We used Experience Sampling Methodology to assess daily-life SI. A multilevel model and multiple linear regressions were used to assess, respectively, the relationship between sex and SI quality and whether PEs and their association with SI quality differ between young men and women. The results of the multilevel linear regression model indicate that the prevalence of and distress associated with PEs were higher in women. No significant difference was observed in the subjective quality of daily SI. Social interaction quality was strongly related to PEs. This association did not seem to vary for the prevalence of PEs, though women's distress about PEs appeared to be more affected by SI quality. Present findings highlight the role of the subjective quality of SI in subclinical psychosis. More research is needed to investigate the mechanisms through which SI quality relates to PEs, and whether these differ between young men and women.

Blunted Cortisol Awakening Response Is Associated with External Attribution Bias Among Individuals with Personality Disorders.

The dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been associated with various mental disorders. One of the most commonly described parameters of HPA axis functioning is the cortisol awakening response (CAR). To date, few studies have been conducted on the relationship between personality disorders and CAR. The present study aimed to compare the CAR between individuals with personality disorders and healthy controls. Moreover, the study aimed to assess the association of CAR with cognitive biases and psychopathological symptoms in people with personality disorders. A total of 43 individuals with personality disorders and 45 healthy controls were enrolled. Participants completed questionnaires measuring the severity of depressive symptoms, anxiety, cognitive biases, and psychotic-like experiences. Cortisol levels were measured in four morning saliva samples: immediately after awakening, and after 15, 30, and 45 min. A significantly lower CAR was found among individuals with personality disorders, even after adjustment for age, sex, and the level of education. However, the receiver operating characteristic (ROC) curve analysis showed a relatively low area under the curve (AUC = 0.362). Furthermore, a significant negative correlation was observed between the CAR and the level of external attribution bias among individuals with personality disorders. No significant associations of the CAR with psychopathological symptoms and other cognitive biases were observed. Findings from this study indicate that the HPA axis activity might be altered in personality disorders. However, the clinical utility of this observation needs further studies in larger samples. External attribution might be related to the HPA axis alterations in this population.

Under the surface: paranoid and unusual thought content are associated with depressive symptoms and suicidal ideation in adolescents entering psychiatric care

ABSTRACT Background Psychotic Like Experiences (PLEs), suicidal ideation, and depressive symptoms are related and common symptoms in adolescents treated in psychiatric services. However, more granular analysis of the associations between the two types of symptoms is sparse. This study aims to investigate the associations between self-reported PLEs and depressive symptoms on a sub-scale and item level, among adolescents attending secondary level psychiatric care. Methods The sample included 328 adolescents (aged 13–18 years) attending adolescent psychiatry outpatient units of the Helsinki University Hospital. Depressive symptoms were assessed using the BDI-1A (total score and separate Suicidal Ideation item score). PLEs were assessed with the PQ-B and analysed as sum scores for the sub-scales Sensory Distortion, Grandiosity, Disorganised Speech, Paranoia, and Unusual Thoughts. Results High scores on PQ-B subscales Paranoia and Unusual Thoughts were both independently associated with more depression and suicidality. Item analysis showed that the associations between PLEs and depression were driven by two PQ-B Paranoia subscale items, and one Unusual Thoughts subscale item. Discussion The findings suggest that the association between PLEs and depressive symptoms is driven by paranoid experiences and unusual thought content. Professionals in psychiatric care should expect this type of co-occurrence.

Suicidal thinking and behavior in young people at Clinical High Risk for Psychosis: Psychopathological considerations and treatment response across a 2-year follow-up study.

Suicidal ideation has high rates among individuals at Clinical High Risk for Psychosis (CHR-P). CHR-P mental states are currently defined as attenuated psychotic symptoms, brief intermittent psychotic symptoms, or genetic risk and functioning deterioration syndrome. However, the relationship between psychotic experiences and suicidality in CHR-P subjects is still not fully understood. Research emphasizes the need to address suicidality in CHR-P individuals due to its incidence and severe socio-economic impact. This study aimed to assess the baseline prevalence and 2-year incidence rates of suicidal thinking and behaviors in an Italian CHR-P sample, investigate the stability of suicidal ideation over 2 years, and examine its associations with treatment outcomes, sociodemographic characteristics, and clinical factors. CHR-P participants were treated in an "Early Intervention in Psychosis" program and completed the PANSS and the GAF scale at baseline and every 12 months. 180 CHR-P individuals were enrolled (92 with suicidal ideation [SI+]). SI+ subjects had a higher baseline prevalence of past suicide attempts. Over 2 years, a decrease in suicidal ideation severity was observed in the total group. Longitudinal improvement in disorganized symptoms was a key predictor of the decrease in suicidal ideation. Participants with a history of suicide attempts were more likely to attempt again. Addressing disorganization is crucial for suicide prevention in the CHR-P population. Continuous risk monitoring and preventive actions are needed for those with past suicide attempts.

The moderating effect of insomnia severity in the association between noise annoyance and psychotic experiences in adolescents

ABSTRACT Adolescence has been identified as a particularly vulnerable age group with a high prevalence of insomnia and a heightened susceptibility to experiencing psychotic experiences, which in turn increases the risk of developing psychotic disorders. In particular, insomnia symptoms were found to be predominant among noise-sensitive adolescents exhibiting a higher level of noise annoyance. This study aimed to assess the moderating effect of insomnia severity between noise annoyance and psychotic disorders among Lebanese adolescents. A cross-sectional study was conducted among 527 Lebanese adolescents. Participants filled a self-administered online questionnaire. Insomnia moderated the association between noise annoyance and psychotic disorders. Noise annoyance was significantly associated with a higher risk of emergence of psychotic disorders. At low and moderate levels of insomnia severity, higher noise annoyance was significantly associated with higher psychotic experiences. Understanding how these variables interact provide valuable insights into the underlying mechanisms leading to psychotic disorders among adolescents.

Exploring associations between psychotic experiences and structural brain age: a population-based study in late adolescence.

Neuroimaging studies show advanced structural "brain age" in schizophrenia and related psychotic disorders, potentially reflecting aberrant brain ageing or maturation. The extent to which altered brain age is associated with subthreshold psychotic experiences (PE) in youth remains unclear. We investigated the association between PE and brain-predicted age difference (brain-PAD) in late adolescence using a population-based sample of 117 participants with PE and 115 without PE (aged 19-21 years) from the Avon Longitudinal Study of Parents and Children. Brain-PAD was estimated using a publicly available machine learning model previously trained on a combination of region-wise T1-weighted grey-matter measures. We found little evidence for an association between PEs and brain-PAD after adjusting for age and sex (Cohen's d = -0.21 [95% CI -0.47, 0.05], p = 0.11). While there was some evidence for lower brain-PAD in those with PEs relative to those without PEs after additionally adjusting for parental social class (Cohen's d = -0.31 [95% CI -0.58, -0.03], p = 0.031) or birth weight (Cohen's d = -0.29 [95% CI -0.55, -0.03], p = 0.038), adjusting for maternal education or childhood IQ did not alter the primary results. These findings do not support the notion of advanced brain age in older adolescents with PEs. However, they weakly suggest there might be a younger-looking brain in those individuals, indicative of subtle delays in structural brain maturation. Future studies with larger samples covering a wider age range and multimodal measures could further investigate brain age as a marker of psychotic experiences in youth.

Psychotic Experiences Questionnaire. Part 2

BACKGROUND: On the basis of the concept of psychotic and psychotic-like experiences, delusions and auditory hallucinations presented in Part 1 of this article, the structure of the links between psychotic experiences and social anxiety and its components and psychological parameters is analyzed. A mediator model of the relationship between social anxiety and the phase of psychotic alienation — "experiencing external control" — is discussed. AIM: To investigate the parameters and stages of development of psychotic and psychotic-like experiences registered with the Psychotic Experiences Questionnaire in the context of analyzing the structure of relationships with psychological variables (social anxiety, metacognitive and cognitive phenomena). Тo construct a mediator model of the indirect effect of social anxiety components on the “experience of being controlled externally” mediated by thought suppression (“polar bear effect”). MATERIALS AND METHODS: The sample — 122 respondents, includes non-clinical and two clinical groups — with symptoms of the affective spectrum and with symptoms of the psychotic spectrum. The author's ‘Psychotic Experiences Questionnaire’ was used to assess the severity of psychotic experiences, the scales of which represent the phases of the unfolding of the experiences. Social anxiety and its components (author's “Social Anxiety and Social Anxiety Disorder Questionnaire”), cognitive (“Cognitive Flexibility Questionnaire”, “Behavioural Self-Regulation Style — SSPM 2020” questionnaire) and metacognitive (Thought Suppression Scale, author's “Self-Focused Attention Questionnaire”) strategies were determined. RESULTS: Pearson correlation analysis showed significant ‘direct’ associations of early and moderate psychotic and psychotic-like experiences with social anxiety and its components, metacognitive (self-focused attention and thought suppression) parameters, and ‘inverse’ links with cognitive parameters (cognitive component of conscious self-regulation and cognitive flexibility). Correlations with psychological parameters become insignificant in intense psychotic experiences. Using mediator analysis, the full indirect effects of the social anxiety components influence on the enhancement of “experiencing being controlled externally” as a phase of psychotic experiences maximum intensity were measured (mediator — thought suppression). CONCLUSION: Metacognitive strategies, social anxiety, disturbed self-regulation and flexibility play an important role in the genesis and maintenance of psychotic experiences. Significant correlations of the parameters with psychotic experience are shown, but at the height of alienation the significant correlations weaken. At the height of psychotic experience in the absence of direct effects it is possible to explicate the indirect influence of the predictor — social anxiety on the experience of controllability from the outside, mediated by thought suppression. This article is a continuation of the article by Sagalakova OA, Truevtsev DV, Zhirnova OV. Psychotic Experiences Questionnaire. Part 1. Neurology Bulletin. 2024;56(1):23–36. DOI: https://doi.org/10.17816/nb623959

Prevalence of psychotic-like experiences and their association with depression symptoms among patients entering adolescent psychiatric care

Background Psychotic-like experiences (PLEs) are common in clinical adolescent samples and form a continuum based on their frequency and intensity. PLEs can have harmful effects on both behaviour and affect. Methods Prevalence and subjective distress due to PLEs were assessed with the Prodromal Questionnaire-Brief (PQ-B) and depressive symptoms with the Beck Depression Inventory (BDI-21A) among adolescents (N = 399; 71.7% female, mean age 14.9 years, range 13–18) entering specialized adolescent psychiatric services. Various PQ-B Distress scale cut-off points were tested for their ability to detect high and low BDI scores using the superiority index, the effect size for mean difference, and spline regressions. Results The mean number of endorsed PLEs assessed with the PQ-B was 3.27 (SD 3.64; males: M 1.75; SD 2.78; females: M 3.89; SD 3.78), while mean PQ-B Distress scores were 20.33 (SD 18.03; males: M 11.84; SD 13.90; females: M 23.74; SD 18.40). The most common PLE within both genders were experiences of paranoia and suspiciousness, with a prevalence of 59.9%. BDI scores and PQ-B distress scores were strongly associated (r = 0.534, p<.001). Superiority indices, effect sizes, and spline regressions indicated that a low PQ-B Distress cut-off of 2 or 3 was most informative both when using BDI as a continuous variable and when dichotomized as mild depression (≥10) or major depressive disorder (≥16). Conclusion PLEs are common among adolescent entering psychiatric care. Even a relatively small amount of distress due to PLEs indicates clinical levels of depressive symptoms.

Sex-specific association between schizophrenia polygenic risk and subclinical schizophrenia-related traits

BackgroundAccording to the dimensional view of psychiatric disorders, psychosis is expressed as a continuum in the general population. However, the investigation of the putative genetic aetiological continuity between its clinical and subclinical phenotypes has yielded mixed results. We aimed to replicate previous findings regarding the association of polygenic risk for schizophrenia with subclinical traits (i.e., schizotypy traits and psychotic-like experiences), and to examine the role of sex in this association in a large nonclinical sample. MethodsThe Multidimensional Schizotypy Scale and the Community Assessment of Psychic Experiences were assessed in 919 nonclinical participants. Polygenic Risk Scores for schizophrenia (SZ-PRSs) were computed using the PRS-CS method based on the latest genome-wide association study of schizophrenia. Summary statistics derived from the total GWAS sample and stratified by sex were used. Linear regression analyses tested the associations of the SZ-PRSs with the psychometric variables, both in the total sample and by sex. ResultsNo associations were found between the SZ-PRSs and the positive, negative or disorganized dimensions of schizotypy in the total sample. Likewise, no associations were found with psychotic-like experiences. However, the sex-stratified analyses revealed a male-specific association with positive schizotypy. Similar results were obtained with the PRSs derived from the sex-stratified summary statistics. DiscussionOur results are consistent with the lack of clear evidence of an association between SZ common genetic risk and its subclinical phenotypes. Nevertheless, the male-specific association found suggests that this PRS might explain better the male phenotype, as reported in previous studies. Future studies should put a focus on the role of sex in this association to unravel its sex specificities.

Content-based clustering of hallucinations across sensory modalities in a large online survey

Hallucinations can have rather heterogeneous aetiology and presentation. This inspired the concept of different subtypes based on symptom profiles, especially in the field of auditory hallucinations. As many people experience hallucinations in more than one sensory modality, it seems important to investigate potential hallucination subtypes across different sensory modalities. We assessed the content of hallucinations as part of a large survey among the general Dutch population (n = 10,448) using the Questionnaire for Psychotic Experiences. Based on their descriptions, thematic categories were created in a data-driven cluster analysis. 2594 participants who experienced hallucinations over the past week that contained at least 2 different thematic categories were selected. Clustering of their hallucination content was performed with the HDBSCAN method. We identified 4 clusters, i.e., subtypes, which can be typified as 1. hallucinations of foul odors, 2. complex visual scenes, 3. a vast variety of rather common hallucinations possibly related to heightened alertness, and 4. possibly bereavement hallucinations. The bereavement subtype showed an increase in emotional loneliness and the presence of delusions. Our findings suggest that the content of hallucinations can be informative, especially when investigated across sensory modalities. Such subtypes may help to better understand their underlying mechanisms.

Psychotic experiences and psychological distress in adolescents: an examination of longitudinal bidirectional effects across sex

BackgroundAlthough the co-occurrence of psychotic experiences (PEs) and psychological distress symptoms is growingly recognized in several previous studies, there is still a lack of literature, which clearly outlines how these two psychopathological entities affect each other over time. This study is intended to add to the literature by examining: (a) the longitudinal, bidirectional associations between PEs and psychological distress in a sample of Tunisian adolescents, and (b) whether these associations are moderated by sex.Methods510 adolescent students (mean age of 16.05 ± 1.01 years, 61.2% females) took part in a prospective longitudinal study. PEs and psychological distress were measured at three occasions over a one-year period. The cross-lagged panel modeling approach was adopted.ResultsThe current results showed that the experience of PEs at baseline tended to temporally precede prospective increases in psychological distress (at 6 months), which had in turn led to further exacerbation of psychological distress at 12 months of follow-up. Temporally primary psychological distress symptoms were not a significant predictor for the development of later psychotic symptoms in the whole sample. However, temporal patterns between adolescent distress and psychotic symptoms differed for girls and boys. Endorsing PEs at baseline was followed by greater psychological distress at 6 months, which was in turn associated with a significant increased risk of subsequent exacerbation of PEs at 12 months in boys, whereas psychological distress at 12-month follow-up was significantly predicted by pre-existing PEs in girls.ConclusionThese findings suggest that clinicians and support workers are recommended to take into account different social risk profiles for boys and girls when considering interventions to address PEs and distress in adolescents.

Characteristics and factors associated with psychotic-like experiences in remission: a cross-sectional study of 4208 college students in China

ObjectivesPrevious research has extensively explored the factors associated with psychotic-like experiences (PLEs). However, the characteristics and associated factors of remitted PLEs, which refer to the absence of current PLEs following...

Febrile seizures and childhood epilepsy and risk of internalizing and psychotic symptoms.

To assess whether children with febrile seizures and/or epilepsy were at increased risk of experiencing internalizing symptoms or psychotic-like experiences at age 11 years. This cohort study includes 44 819 children from the 11-year follow up of the Danish National Birth Cohort. Information on childhood seizures was retrieved from the Danish National Patient Registry, whereas child psychiatric symptoms were assessed in a web-based questionnaire using the Adolescent Psychotic-like Symptom Screener and the Strength and Difficulties Questionnaire. Adjusted odds ratios (aORs) with corresponding 95% confidence intervals (CIs) for the association between childhood seizures and internalizing symptoms (symptom score ≥8) and psychotic-like experiences (≥2 definite experiences) were obtained using logistic regression models. A total of 1620 children with febrile seizures (3.6%), and 311 children with epilepsy (0.7%) were identified. When adjusted for potential confounders, no association between febrile seizures and psychiatric symptoms was observed, and no association was observed between epilepsy and psychotic-like experiences. However, the OR for internalizing symptoms was 1.76 (95% CI: 1.20-2.58) in children with epilepsy compared to children without. This higher risk was evident mainly in boys (OR 2.30, 95% CI 1.37-3.85), children with ≥2 epilepsy-related hospital admissions (OR 2.79, 95% CI 1.81-4.32), and children whose age at first epilepsy-related hospital admission was 0-3 years (OR 2.47, 95% CI 1.45-4.19). No association was found between febrile seizures and psychiatric symptoms or epilepsy and psychotic-like experiences at age 11. However, boys with epilepsy were at higher risk of experiencing internalizing symptoms.

The Classification and Stability of Psychotic-Like Experiences

Abstract: We examined psychotic-like experiences in adults. In Session 1, 404 participants completed domain measures of the Big Five and HEXACO. We identified 25 potential Psychoticism markers in Session 2, which was roughly 3 weeks later. Exploratory factor analyses (EFAs) of the Session 1 and Session 2 scales revealed six factors: the Big Five, plus Psychoticism. Eighteen scales marked the Psychoticism factor; in addition, five scales assessing negative symptoms of schizotypy defined low Extraversion. Finally, we identified a semioverlapping set of 22 potential Psychoticism markers in Session 3 ( N = 292), which was roughly 9.5 months after Session 2. EFAs of the Session 1 and Session 3 scales produced the same six factors. Sixteen scales defined Psychoticism; four scales assessing negative symptoms of schizotypy again formed a bipolar factor with Extraversion. Scores on the Psychoticism factors correlated .78 ( N = 287) across this 9.5-month interval, demonstrating a trait-like level of stability.

The HEXACO–Disintegration (HEXACOD) Personality Model in Early and Late Adolescence

Abstract: This study investigated the robustness of the seven-factor HEXACO–Disintegration (HEXACOD) personality model in children and adolescents, across three age groups (10–13, 14–15, and 16–18 years). Using exploratory structural equation modeling (ESEM), we assessed the invariance of the proposed seven-factor model. The results supported the HEXACOD model's metric invariance across age groups. The Disintegration factor lay outside the HEXACO traits, corroborating the claim that the HEXACO model does not capture a wide range of psychotic-like experiences and behaviors (PLEBs). Moderated nonlinear factor analysis (MNLFA) also showed stability of the HEXACOD model across ages. Furthermore, the results show that Disintegration presents a trait-like disposition on the same level of coherence and robustness as HEXACO traits even in children and adolescents.

Internal Consistency of the DELTA Scale Assessing Psychotic-Like Experiences

Abstract: This study’s objective was to conduct a reliability generalization meta-analysis of the DELTA scale capturing Disintegration, i.e., proneness to psychotic-like experiences and behaviors. Eligible studies applied various versions of the DELTA scale; 573 α coefficients nested in 76 reports were identified. The pooled effect of all included α coefficients was calculated by applying a 4-level meta-analytic random-effects model. Test length, sample type, demographic sample characteristics (mean age, share of females), language, the proportion of reverse-keyed items, publication status, documentation quality of reliability estimates (reported vs. post hoc computed reliabilities), and DELTA score M and SDs were tested as moderators. The model yielded an average Cronbach’s α for DELTA and its facets of .86 (95% CI [.84, .88]), with medium and long DELTA versions reaching .96 (95% CI [.94, .96]) and .97 (95% CI [.95, .98]), respectively. Moderators explaining the heterogeneity among α coefficients were as follows: test length (expectedly, higher reliability estimates for longer tests), mean scores and SD of the DELTA scores (lower α estimates for larger means and lower SDs), and language (highest α estimates for the German language). Overall, the DELTA scales used in past research showed high-reliability estimates.

Can the “Shotgun Wedding” of Openness and Psychoticism Be Justified Based on Apophenia as the Disposition to Commit False-Positive Errors?

Abstract: Apophenia – the tendency to perceive meaningful patterns in randomness – has been proposed as a unifying framework for Openness and Psychoticism. While there is substantial evidence supporting a positive correlation between apophenia and susceptibility to psychotic-like experiences, the hypothesized connection to Openness lacks empirical support. In the present study, the association between apophenia and personality traits, particularly Openness and Psychoticism, was examined in three studies. Adult participants from two Serbian ( N = 127 and N = 256) and one German community sample ( N = 384) completed the HEXACO-PI to measure six personality traits, a Disintegration (Psychoticism) inventory assessing proneness to psychotic-like experiences, and several measures of apophenia. Application of various analytical tools revealed a robust positive relationship between apophenia and Disintegration in all studies. Openness showed either no significant or even a negative association with apophenia. These results cast doubt on the proposed unified role of apophenia in conceptualizing Openness and Psychoticism as manifestations along a shared personality continuum.

Personality Correlates of Certain Clinical Characteristics of Patients With Psychotic Disorders

Abstract: Our study aimed to link personality traits (Big Five plus proneness to psychotic-like experiences and behaviors, conceptualized as Disintegration) with clinical characteristics (gender, age, density of episodes, average antipsychotic doses, functionality, and symptom scores). We analyzed 137 patients with psychotic disorders (ICD-10: F20–F29) who had at least one psychotic episode, with illness duration ≤10 years, in remission. Canonical correlation analysis revealed that (1) Psychotic fragility (defined by high density of illness episodes, older age, and more severe symptoms) is associated with high Disintegration and Neuroticism; (2) Disorder severity (high antipsychotic doses, dysfunctionality, severe symptoms, younger age) is linked to low Agreeableness and Openness; and (3) Well-functioning patients (better functionality, milder symptoms) are predicted by a resilient personality profile. These findings deepen our understanding of personality–psychopathology relationships.