Abstract Background and Aims The most prevalent hereditary kidney disease is autosomal dominant polycystic kidney disease (ADPKD). Multiple cysts developing in the kidneys are a defining feature of this systemic, progressive disease. The quality of life, psychosocial load, and discomfort associated with renal volume in people with ADPKD have not been well studied. This study aimed to examine the relationship between renal volume, psychological issues brought on by pain and the burden of the disease, and deteriorating sleep quality in ADPKD patients. Method The study included sixty patients who were being treated in the nephrology clinic at the Bursa Uludag University Faculty of Medicine Hospital. The ADPKD Pain and Discomfort Scale (ADPKD-PDS), Beck Depression Inventory Questionnaire, Beck Anxiety Scale, Pittsburgh Sleep Quality Scale (PSQI), and Insomnia Severity Index (ISI) were assessed. The computed tomography ellipsoid formula was used to determine the total kidney volume, and kidney volume adjusted for body size was obtained for each patient. The eGFR values computed using the CKD-EPI algorithm and the patients' baseline biochemical parameters were recorded. Results The mean age at diagnosis was 31±13, and the mean total kidney volume (TKV) was 1526.35±1595.90. Eight (13.3%) individuals were determined to have mild mood disorders, whereas seven (11.7%) patients had borderline clinical depression. Four individuals (6.7%) were found to have severe anxiety. It was shown that 25% of the patients had poor sleep quality. There was no statistically significant difference in kidney volume between the depression groups or between the pain and discomfort scale sub-dimensions. (Table-1) Conclusion It was shown that, in accordance with the literature, the severity of depression increased as the patients' sleep quality declined in ADPKD patients. However, there was no significant relationship between kidney volume and the degree of anxiety, depression, pain or discomfort.