Psychosomatic Changes Research Articles

ПСИХОЕМОЦІЙНЕ ВИГОРАННЯ ОСОБИСТОСТІ : ТЕОРЕТИЧНІ АСПЕКТИ ПРОБЛЕМИ

Purpose. The objective is to conduct an analytical review of multidirectional studies on psychoemotional burnout of personality as a phenomenon that negatively impacts and significantly complicates its professional activity and interpersonal communication. Methods. To achieve this objective, the following scientific-theoretical methods were applied: analysis, synthesis, generalization, which allowed for the revelation of substantive and functional parameters of psychoemotional burnout. Results. A range of studies explains the cause-and-effect essence of psychoemotional burnout by the specifics of a person's professional activity. Burnout leads to the appearance of psychological and/or psychosomatic changes, adversely affects affective balance, generates increased stress, heightened anxiety, oppressive frustration, and other depressive feelings, experiences, and behavioral modalities. Monotonous and emotionally exhausting as well as physically amortizing professional activity in a specific field, along with permanent pressure from administration, may stimulate feelings of mental discomfort, increase the frequency of intra- and interpersonal conflicts, stimulate social withdrawal, loneliness, and experiences of disappointment in life values. Conclusions. Psychoemotional burnout is regarded as a complex and branching phenomenon that exerts an unfavorable influence on a person's life and complicates their communicative relationships within the family and at work. Manifestations of psychoemotional burnout and psychophysical exhaustion have been studied extensively with diverse samples (students, police officers, medical professionals, firefighters, athletes, deprived children, etc.). A common feature of the analyzed studies is the recognition of the uncomfortable and destructive pressure of psychoemotional burnout on the affective-cognitive behavioral tactics and strategies of the individual.

Association of the COVID-19 lockdown with health risk behaviors in South Korean adolescents.

Since there is no certainty about when the coronavirus disease 2019 (COVID-19) lockdown will be affected by health risk behaviors, so we investigate the effect of COVID-19-related health risk behavior changes using school-based self-reported data from a nationally representative South Korean adolescent population. We analyzed web-based self-reported data from the Korea Youth Risk Behavior Web-based Survey in 111,878 participants (57,069 in COVID-19 prepandemic); 54,809 in during the COVID-19 pandemic. This study included 12 to 18-year-olds. Self-report questionnaires were used to assess socioeconomic status, health risk behaviors, and psychological factors. Health risk behaviors such as alcohol consumption, substance use, and sexual experience significantly decreased in COVID-19 pandemic than in COVID-19 prepandemic. Psychosomatic changes such as stress levels, violence experience, depression, suicidal ideation, suicidal plans, and suicide attempts were significantly lower in COVID-19 pandemic compared to COVID-19 prepandemic (P < .001). After adjusting for multiple confounding variables, less alcohol consumption (odds ratio [OR] = 0.98; 95% confidence interval [CI] = 0.88-0.93), less exercise (OR = 0.92; 95% CI = 0.89-0.94), less sexual experience (OR = 0.82; 95% CI = 0.77-0.86), less violence experience (OR = 0.61; 95% CI = 0.55-0.67), less stress (OR = 0.86; 95% CI = 0.84-0.88), less depression (OR = 0.85; 95% CI = 0.83-0.88), less suicidal ideation (OR = 0.93; 95% CI = 0.89-0.97), plans (OR = 0.82; 95% CI = 0.76-0.88), attempts (OR = 0.78; 95% CI = 0.71-0.85) were significantly associated with the COVID-19 pandemic compared to COVID-19 prepandemic. The COVID-19 pandemic was associated with changes in health risk behaviors among Korean adolescents, resulting in alcohol drinking, sexual experience, drug use, violence experience, and suicidal behaviors (idea, plan, and attempts) being decreased during the lockdown period.

A new approach to cultural scripts of trauma sequelae assessment: The sample case of Switzerland.

The novel concept of cultural scripts of trauma sequelae captures culture-specific expressions of posttraumatic distress (e.g., cognitive, emotional, interpersonal, psychosomatic changes) and their temporal associations. Cultural scripts of trauma sequelae complement pan-cultural (etic) diagnoses, such as posttraumatic stress disorder (PTSD) and Complex PTSD, as well as the cultural syndromes concept. This study aimed to develop the cultural scripts of trauma inventory (CSTI) for German-speaking Switzerland and to explore temporal associations of script elements. Five semi-structured focus groups were conducted with psychotraumatologists (n = 8) and Swiss trauma survivors (n = 7). The interview schedule included open questions about different domains of potential posttraumatic changes (emotions, cognitions, worldviews, interpersonal relationships, body-related experiences, behavior, and growth). Data were analyzed using qualitative content analysis. The Swiss CSTI includes 57 emic elements that represent salient trauma sequelae (30 conformed with a theoretically derived item pool, 27 were newly phrased). Temporal script associations were visualized in a network, whereby self-deprecation, the urge to function and overcompensate, and the urge to hide and endure suffering had the highest number of connections. While many posttraumatic changes identified in the present work seem to mirror pan-cultural phenomena represented in the Complex PTSD concept (e.g., self-deprecation), others (e.g., urge to function and perform, urge to hide and endure suffering) may be prominently related to Swiss culture with its value orientations. Knowledge about cultural scripts of trauma sequelae may provide a culture-specific framework that can help to understand individual experiences of distress and enable mental health practitioners to administer culturally sensitive interventions. Pending further validation, the Swiss CSTI bears the potential to advance culture-sensitive assessment of trauma sequelae.

Advanced Dental Rehabilitation in Case of Severe Tooth Wear Caused by Gastroesophageal Reflux Disease and Bruxism During COVID-19 Pandemia: A Case Report

Stomatological manifestations of psychosomatic diseases can be associated, culminating in advanced oral alterations. These psychosomatic changes have also increased during the COVID-19 pandemic. In this perspective, parafunctional habits, such as bruxism and clenching, and gastro-oesophageal reflux disease can develop major dental destruction. Thus, various types of treatment are required in the rehabilitation of these patients. The purpose of this article is to present the case of a patient who developed severe tooth wear due to the association between gastro-oesophageal reflux disease and bruxism, during the COVID-19 pandemic. The patient was treated with a bite raising, direct composite restorations and removable prostheses.

Dental students’ self-perception of security and biosafety measures in times of pandemic by COVID-19

The study investigated the factors associated with the self-perception safety of dental students in clinical activities during the COVID-19 pandemic. This cross-sectional study was based on a semi-structured online (google forms) self-applied questionnaire, sent by e-mail to three private Dental Schools in Brazil. The variables were: 1) sociodemographic information; 2) questions about the measures adopted by dental schools before returning to clinical activities; 3) dental students’ self-perception of security; 4) the General Health Questionnaire. Data were submitted to Fisher’s exact test (p&lt;0.05). Of the 294 eligible students, 97% were evaluated and 100% received previous specific biosafety training predominantly theoretical (72.16%) longer than one hour (51.55%). Most students (81.44%) felt secure performing clinical care during the COVID-19 pandemic. Students undergoing specific biosafety training for longer than one hour felt safer than those perfoming training for up to 1 hour (p=0.004). Students from schools where the aerosol-producing restriction was applied felt safer than those without restrictions (p=0.016). Women reported feeling less secure than men (p=0.046), and students who submitted to COVID-19 Specific Biosafety Training felt safer in clinical activities than those submitted to theoretical training only (p=0.011). Students from private universities presenting psychosomatic changes felt less secure in practicing clinical dental care activities (p=0.006). In conclusion, time-spent training in biosafety, restriction of the use of aerosol-producing procedures, and the gender of students were associated with the self-perception safety of students. Students with practical training felt safer in clinical activities for patients with COVID-19 than those who had only theoretical training.

Autonomic dysfunction and psychosomatic changes in patients after cholecystectomy and gastroesophageal reflux disease

Autonomic dysfunction and psychosomatic changes in patients after cholecystectomy and gastroesophageal reflux disease

Влияние новых частично гидрированных пиридинов, производных цианотиоацетамида, на морфологические показатели печени крыс с дексаметазоновым сахарным диабетом

Introduction. On the basis of the Chemex Scientific Lab of the Vladimir Dahl Lugansk State University we have synthesized and selected 4 samples of partially hydrogenated pyridine derivatives via in silico screening, containing a furan fragment in the fourth position (codenamed cv-150, cv-140, cv-083 and jen09-039), the effect of which on the course of dexamethasone-induced diabetes mellitus (DM) is of interest. Aim. To study the morphological parameters of the liver of dexamethasone-induced diabetic rats during a period of pronounced senile changes in the setting of pharmacological treatment with new partially hydrogenated pyridines, cyanothioacetamide derivatives. Materials and methods. The experiment was carried out with 92 18-month-old albino male rats, by administering per os 4 samples of 1,4-dihydropyridine at a dose of 1 mg/kg to each individual group of animals with dexamethasone-induced diabetes mellitus. Simultaneously, a control group (dexamethasone-induced diabetes) and a group of intact animals (without steroid-induced diabetes) were used. Dexamethasone was administered for 13 days. The intact and control group of animals consisted of 12 individuals. Four experimental groups of animals consisted of 17 individuals in each group. Animals of the experimental groups received one of the study compounds cv-150, cv-140, cv-083 and jen09-039 via gastric tube at a dose of 1 mg/kg body weight for 21 days. Results. During the experiment, 10 animals died from late complications of DM. Death was recorded in the control and experimental groups treated with cv-083 and jen09-039 compounds. The most pronounced hepatomegaly was found in animals of the control group, the absolute liver weight averaged 16.43 g (3.4% of body weight) with indicators in intact animals group of 14.44 g (2.8% of body weight). The liver weight of rats treated with the cv-150 compound was 12.90 g (2.74% of body weight). The minimal number of pathological changes of the liver was detected in animals receiving partially hydrogenated pyridine cv-083 – 28.6%. The maximum number of pathological changes was registered in control animals receiving dexamethasone without pharmacological treatment – 88.9%. No liver changes were detected in intact rats. Conclusion. Positive metabolic and psychosomatic changes were observed during the experiment in groups of animals treated with cv-150 and cv-140 compounds. There was no mortality in these experimental groups. According to necroptic study, hepatoprotective activity was found in these compounds. The result of using the cv-083 compound is questionable. The jen09-039 compound did not have any positive effect on the course of dexamethasone-induced diabetes.

Лікування стрес індукованих розладів у жінок з лейоміомою матки на фоні гормонотерапії у військовий час

The purpose of the study was to assess psychosomatic changes and determine clinical and laboratory indicators in women with uterine fibroids under the conditions of using hormonal therapy and a drug with anxiolytic effect. Materials and methods. The study analyzed the results of 60 women with uterine fibroids who had anxiety disorder symptoms. The patients were divided into two groups: Group I – patients with uterine fibroids who took combined oral contraceptives (n=30); Group II – patients with uterine fibroids who took the anxiolytic medication fabomotizole concurrently with combined oral contraceptives (n=30). Results and discussion. The research established that patients with uterine fibroids had a change in their psycho-emotional state with a tendency to a high level of anxiety and depression. Treatment with combined oral contraceptives and fabomotizole demonstrated a more stable emotional background as compared to patients who took only combined oral contraceptives. The percentage of patients with the low level anxiety increased and the percentage of patients with the high level anxiety decreased. Among women who were treated with combined oral contraceptives only, there was still a considerable proportion of patients with high levels of anxiety and depression. It was found that the use of combined oral contraceptives in combination does not result in changes regrading the size of the tumor compared to the indicators of patients who did not take the drug with an anxiolytic effect. However, this group of patients demonstrated a tendency to stabilize the growth of nodes, to decrease clinical manifestations in the form of pain and intermenstrual bleeding in the first months of taking combined oral contraceptives. It should be noted that in patients who were not administered fabomotizole, the studied indicators remained at a lower level compared to the indicators of patients who were prescribed this drug. Probably, restoration of the psycho-emotional state in women with uterine fibroids under the influence of fabomotizole increases the effectiveness of hormonal therapy. Conclusion. The patients of both studied groups were shown to have developed pronounced anemia, which was confirmed by low values of hemoglobin in the blood, and the levels of ferritin and transferrin in the blood serum decreased. An increase in the studied indicators was observed after combined oral contraceptive treatment, and specifically after treatment with a combination of combined oral contraceptives and fabomotizole. However, the levels of ferritin and transferrin remained at a lower level compared to normal values

THE USE OF TRANSCUTANEOUS SUPRAORBITAL NERVE STIMULATION IN THE TREATMENT OF ASTHENIC SYNDROME AFTER COVID-19

Resume. Aim: to assess the efficacy of Transcutaneous Supraorbital Nerve Stimulation (t-SNS) with the Cefaly® Device on the parameters of asthenia and anxiety, as the main components of psychosomatic changes after suffering COVID-19. Materials and methods: an open prospective study in parallel groups was conducted. 60 patients, 30 men and 30 women, average age (61,3 ± 4,1) years, after a coronavirus infection (COVID-19) more than 6 months ago, meeting the following criteria: age from 60 to 75 years old, presence of asthenic syndrome, no contraindications to supraorbital neurostimulation was included. By the envelope method, patients were randomized into two groups. In the Cefaly® group (30 people), patients underwent 10 procedures (3 times a week) of t-SNS with the Cefaly® Device (Cefaly Technology sprl, Herstal, Belgium) in combination with restorative treatment according to temporary methodological guidelines for medical rehabilitation for a new coronavirus infection (COVID-19), in the control group (30 people), patients received only rehabilitation treatment. The results were evaluated using the Multidimensional Fatigue Inventory (MFI-20) and the Hamilton Anxiety Rating Scale (HAM-A) at baseline and after 24 days of therapy. Results: Cefaly® in addition to the standard rehabilitation program effectively reduces the severity of asthenia symptoms -in the Cefaly® group it was 33,6 %, in the control group - 14,4 %. The use of Cefaly® affects all components of the asthenic syndrome (reduced activity, reduced motivation, physical and mental asthenia). The standard rehabilitation program had an effect only on physical asthenia and reduced activity, but not on parameters of reduced motivation and mental asthenia. The reduction in total score from baseline on the HAM-A anxiety scale in the Cefaly® group was 55,16%, in control group -19,74 %. Cefaly® therapy had the greatest effect on insomnia and tension. It should be noted that the standard rehabilitation program has little effect on anxiety scores. However, after treatment, both groups maintained a high mean total asthenia score (MFI-20 - 42,5 points in the Cefaly® group, 63 points in the control group), which once again confirms that post-COVID changes (Long COVID) are long-term in nature even with availability of adequate therapy. Conclusions: The use of transcutaneous supraorbital nerve stimulation can more effectively reduce the severity of symptoms of asthenia and anxiety in people who have recovered from COVID-19.

Role of total cryotherapy in combination with transcranial magnet therapy in the change of microcirculation and psychological status in patients with menopausal syndrome

To study the effect of total cryotherapy alone and in combination with transcranial magnet therapy on the microcirculation state and psychological status in patients with MS. The study included 62 female patients (mean age was 51±1.9 years). Thirty-five (56%) patients had mild menopausal syndrome and 27 (44%) moderate severity. All patients were divided into two clinically and functionally comparable groups by simple randomization: Group 1: 30 patients who received total cryotherapy (TCT); Group 2: 32 patients who received complex treatment including TCT and transcranial magnet therapy. The blood lipid spectrum was studied in all patients before and after the treatment course. The psychological examination was carried out using the well-being/activity/mood test (WAM). The microcirculation state was assessed by laser Doppler flowmetry (LDF). The majority of the patients had abnormalities in the lipid spectrum, decreased psychological adaptation, and worsened microcirculation indices (according to LDF data). After a treatment course, improvement in the lipid spectrum, LDF, and WAM test scores according to all scales was more pronounced in group 2 patients receiving complex therapy. The combined effect of total cryotherapy and transcranial magnet therapy had a more pronounced positive impact on the lipid spectrum, psychoemotional state, and microcirculatory processes in patients with menopausal syndrome compared with the total cryotherapy alone. It can be assumed that this complex will be effectively used in practical healthcare.

Psychosomatic symptoms in patients suffering from morphea

Objective. To study the features of psychosomatic pathology in patients with morphea.Materials and methods. We used the Symptom Check List-90 Revised (SCL-90-R) to assess patterns of phychological signs in 95 patients suffering from morphea. The control group included 30 respondents without the skin pathology.Results. The patients with morphea revealed higher values in the Global Severity Index (GSI), Positive Symptom Distress Index (PSDI), Positive Symptoms Total (PST). The group of the patients with morphea showed higher distress levels according to the somatization, obsessive and compulsive disorders, depression, anxiety scales.Conclusion. Patients with morphea have a wider range of psychosomatic symptoms. The prevalent characteristics of psychosomatic changes are somatization, obsessive and compulsive disorders, depression, anxiety.

CRITICAL ANALYSIS OF SUTIKA PARICHARYA AND ITS SIGNIFICANCE IN MODERN ERA IN SAFE MOTHERHOOD

Mortality and morbidity of mother are most challenging problems of our country. In our day to day life, we see many mothers complaining of increase in their physical problems like back-ache, anemia, joint pains and many other infections after puerperium. Frequent post-partum morbidity and its association with adverse perinatal outcome suggest the need for post-partum care in developing countries for both mother and baby. Lady after delivery of placenta is called as Sutika (puerperal woman). Sutikakala (duration of puerperium) is the period following childbirth during which all body tissues revert back approximately to a pre-pregnant state. Duration of this period varies according to different Ayurvedic classics. It is well known that certain psycho-somatic changes take place during Sutikakala such as loss of weight, loss of body fluid, lacerated genital tract, constipation, mental stress etc. Most of these changes lead to ati-aptarparpana (emaciation) of mother during Sutikakala. This status causes Vata-vriddhi which is responsible for different types of health problems such as puerperal sepsis, Stanyadushti (vitiated breast milk), anaemia, prolapse of uterus etc. According to Kashyapa Samhita, treatment of Sutika is as difficult as cleaning of unclean, tattered and old cloth. In olden days, ladies used to follow strict guidelines during early postpartum days i.e. in Sutikakala, which helped them for early recovery from stress and strain caused during delivery. It also improves the quality and quantity of breast milk and it also avoids various neonatal infections. Mothers who breast feed their babies are at low risk for breast cancer. In modern era due to changing lifestyle and Mithya aahaar-vihaar (abnormal dietetics and mode of Life), pregnant lady is usually prone to Vataprakopa. Many modern Sutika feel ancient guidelines during early puerperal days as age old and time consuming to follow. Hence, guided Sutika paricharya with logical use of classical referenced medicine would be the proper solution to avoid psycho-somatic disorders in order to promote early recovery of mother.

Vocal Feminization for Transgender Women: Current Strategies and Patient Perspectives.

Voice feminization for transgender women is a highly complicated comprehensive transition process. Voice feminization has been thought to be equal to pitch elevation. Thus, many surgical procedures have only focused on pitch raising for voice feminization. However, voice feminization should not only consider voice pitch but also consider gender differences in physical, neurophysiological, and acoustical characteristics of voice. That is why voice therapy has been the preferred choice for the feminization of the voice. Considering gender difference of phonatory system, the method for voice feminization consists of changing the following four critical elements: fundamental frequency, resonance frequency related to vocal tract volume and length, formant tuning, and phonatory pattern. Voice feminizing process can be generally divided into non-surgical feminization and surgical feminization. As a non-surgical procedure, feminization voice therapy consists of increasing fundamental frequency, improving oral and pharyngeal resonance, and behavioral therapy. Surgical feminization usually can be achieved by external approach or endoscopic approach. Based on three factors (length, tension and mass) of vocal fold for pitch modulation, surgical procedure can be classified as one-factor, two-factors and three-factors modification of vocal folds. Recent systematic reviews and meta-analysis studies have reported positive outcomes for both the voice therapy and voice feminization surgery. The benefits of voice therapy, as it is highly satisfactory, mostly increase vocal pitch, and are noninvasive. However, the surgical voice feminization of three-factors modification of vocal folds is also highly competent and provides a maximum absolute increase in vocal pitch. Voice feminization is a long transition journey for physical, neurophysiological, and psychosomatic changes that convert a male phonatory system to a female phonatory system. Therefore, strategies for voice feminization should be individualized according to the individual’s physical condition, the desired change in voice pitch, economic conditions, and social roles.

Право на особистий простір у кримінально-виконавчих установах

The article draws attention to the fact that in accordance with international documents in the detention of prisoners and the provision of places for sleep it is necessary to treat them with respect for human dignity, with the possibility of seclusion in a separate room. Meanwhile, the criminal-executive legislation of Ukraine, the practice of punishment in the form of imprisonment, the spatial structure of correctional colonies do not provide such an opportunity. Since its introduction in 1920, imprisonment only involves collective retention of the convicts first in the barracks, now in the dormitories, that is the material embodiment of the idea of correction of the convicts «in the collective and through the collective.» It is not about any personal space of the convicted person, since placement in dormitories, where the living space is provided in 4 m2, excludes the possibility of solitude neither in the daytime nor at night. Under such conditions, the result of living of prisoners in dormitories due to the large crowding of people in a confined space is a manifestation of anxious-depressive, negative-depressive and negative-hysterical reactions among them. Accommodation in such dormitories causes irreparable harm to the individual, contributing to the development of psychological fatigue, alienation, tension, irritation, anxiety and depression, that leads to neuro-psychological overload, conflicts and breakdowns. Prolonged being of convicts in an aggressive environment of their own without any possibility of seclusion with inevitability leads to psychosomatic changes, that become irreversible after 5–6 years of imprisonment. Thus, the placement of convicts in dormitories acquires signs of cruel, inhuman and degrading treatment. The purpose of the article is to develop proposals aimed at eliminating the shortcomings of imprisonment with serving it in correctional colonies, in order to replace the deprivation of liberty, that involves the residence of prisoners in dormitories, with imprisonment. that provides private space in a separate room for each prisoner. This material allows to submit the following proposals: it is necessary to abandon such a type of punishment as imprisonment introduced in 1920 by the Provisional Instruction of the People’s Commissariat of Justice; instead of imprisonment, there should be punishment in the form of imprisonment only for violent crimes against a person; taking into account the negative impact on the health of a person of a prolonged isolation, the maximum term of imprisonment may not be more than five years; the possibility of imprisonment for minors should be ruled out; there is a need to abandon the «ideal zone» and introduce a new for Ukraine architectural model of a prison where there would be no placement of convicts in dormitories, and each prisoner would be provided with a living room of a hotel type that complies with the European prison rules, with sanitary compliance of the hygienic requirements to the living space and the cubic area at least at the level of the nineteenth century, which was in solitary cells of the royal prisons, that is, an area of at least 10 m2 and, accordingly, a cubature not less than 28 м3.

A PSYCHOSOMATIC VICIOUS CIRCLE OF MYOCARDIAL INFARCTION

The review presents recent studies demonstrating somatic shifts in psychological processes regarded as the risk factors for myocardial infarction: depression, stress, anxiety. Based upon a metaphorical term “a perfect storm”, inflammatory, immunological, neuro-humoral predisposing factors are presented, important for myocardial infarction development, as such shifts themselves, which are the somatic substrate for psychological states mediating myocardial infarction development through behavioral and biological risk factors: “sickness behavior”, “depression illness”. Both directions complete a vicious circle of psychosomatic changes. The emphasis is set on the importance of individual approach to rehabilitation and secondary prevention of myocardial infarction, as, from biopsychosocial point of view, the bottom-up and top-down psychosomatic links are unique for any patient.

Features of coping in patients with cerebrovascular pathology at different stages of diseases

Coping is an important component in adapting a person to stressful events and maintaining a psychological balance. The aim of this work was to study the features of coping in patients with cerebrovascular pathology (CVP) in the dynamics of its development at different stages of the disease. At Kharkiv Regional Clinical Hospital - Emergency and Emergency Medicine Center during 2016-2018, observed 383 patients with cerebrovascular pathology on different stage of diseases. The coping assessed by using the Ways of Coping Questionnaire R. Lazarus &amp; S. Folkman. In persons with high risk of CVP, clinical manifestations of CVP and patients after a stroke generally defined more tension of coping than in somatic healthy people. There occurred an imbalance forms of coping with low and high efficiency, dominated confrontation, distancing, avoidance versus problem solving, positive revaluation, increasing the role of social support as external psychosocial resource. Therefore, patients at various stages of CVP had unstable stress coping-profile that was on the one hand the basis for the development of stressrelated psychosomatic changes, on the other – not correctly solve the existing stress. Detection and psychological correction of ineffective coping strategies in patients with CVP is an important component of psychological help for this contingent of patients.

Psychosomatic changes of male climacteric syndrome

男性更年期是男性由中年步入到老年的过渡时期。在此阶段多数男性没有任何临床症状，但大约40%男性会出现不同程度的性功能减退、心理障碍、潮热、注意力不集中、记忆力减退及情绪不稳定等临床症状和体征，并影响许多器官系统的功能，从而影响生命质量。男性更年期综合征可以通过筛查量表进行诊断性筛查，评估需要治疗的患者。生活方式干预与睾酮补充治疗可以用于改善精神心理状态，减轻和缓解更年期相关的临床症状。

Polyvictimization Experiences and Depression Among Youth Living in Foster Care

Current research indicates that violence against youth contributes to adverse psychological outcomes but has yet to focus on violence against youth while living in foster care and the associated psychosomatic changes over time. Multilevel modeling regression was used to analyze self-reported depression for a sample of 354 youth living in foster care from one Midwestern state. The present study found that changes in depression levels over time among the foster care youth who experienced polyvictimization, compared to the youth who experienced child maltreatment alone, were conditional upon gender and varied significantly by race. Policy implications are discussed.

Noradrenaline from Locus Coeruleus Neurons Acts on Pedunculo-Pontine Neurons to Prevent REM Sleep and Induces Its Loss-Associated Effects in Rats.

Normally, rapid eye movement sleep (REMS) does not appear during waking or non-REMS. Isolated, independent studies showed that elevated noradrenaline (NA) levels inhibit REMS and induce REMS loss-associated cytomolecular, cytomorphological, psychosomatic changes and associated symptoms. However, the source of NA and its target in the brain for REMS regulation and function in health and diseases remained to be confirmed in vivo. Using tyrosine hydroxylase (TH)-siRNA and virus-coated TH-shRNA in normal freely moving rats, we downregulated NA synthesis in locus coeruleus (LC) REM-OFF neurons in vivo. These TH-downregulated rats showed increased REMS, which was prevented by infusing NA into the pedunculo-pontine tegmentum (PPT), the site of REM-ON neurons, normal REMS returned after recovery. Moreover, unlike normal or control-siRNA- or shRNA-injected rats, upon REMS deprivation (REMSD) TH-downregulated rat brains did not show elevated Na-K ATPase (molecular changes) expression and activity. To the best of our knowledge, these are the first in vivo findings in an animal model confirming that NA from the LC REM-OFF neurons (1) acts on the PPT REM-ON neurons to prevent appearance of REMS, and (2) are responsible for inducing REMSD-associated molecular changes and symptoms. These observations clearly show neuro-physio-chemical mechanism of why normally REMS does not appear during waking. Also, that LC neurons are the primary source of NA, which in turn causes some, if not many, REMSD-associated symptoms and behavioral changes. The findings are proof-of-principle for the first time and hold potential to be exploited for confirmation toward treating REMS disorder and amelioration of REMS loss-associated symptoms in patients.

Deciphering the Clinico-Biochemical Mileau of Perimenopausal and Postmenopausal women with a note on beneficial effects of Yoga and Exercise

Background & Objectives: Psychosomatic disturbances faced by women approaching their fifth decade have been a matter of concern since many years. Many approaches have been tried to help them, including nutritional, pharmacologic and hormone replacement therapies. However, the importance of regular yoga practice is not much debated though it is believed to improve blood glucose levels & serum lipid concentrations and also to combat oxidative stress. The current study was designed to broadly analyze the clinico-biochemical challenges encountered by such women and to suggest better measures to face them. Methods: A total of 90 women aged around 40-60 years were grouped into perimenopausal, postmenopausal and healthy control groups and were checked for anthoropometric and biochemical parameters like FBS, HbA1c, lipid profile, calcium, magnesium, copper, ceruloplasmin, TSH, uric acid, alkaline phosphatase (ALP) and total proteins. Results: Age of the subjects, their BMI, blood pressure and waist hip ratio (WHR) together with levels of glycated Hb, LDL cholesterol, TGs, calcium, magnesium, copper, ceruloplasmin and uric acid levels exhibited significant variation among the groups. Conclusions: Several psychosomatic changes encountered in and around menopause and few biochemical changes can be better handled by persistent yoga practice, either alone or in combination with conventional treatment, as it can effectively bring down the oxidative stress levels, chances of developing metabolic syndrome, risk of CVD events and improve the quality of life in such women. Keywords: Perimenopause, Postmenopause, FBS, HbA1c, Lipid profile, Calcium, Yoga