Mental Disorders Research Articles

Intervention programme to improve emotional regulation among adolescent with mental disorders: a systematic review

Adolescence is an important period for developing social and emotional habits that are important for mental well-being. This research aimed to know the effectiveness of intervention programs to improve emotional regulation in adolescents with mental disorders. Preparation using the PICO approach, determination of inclusion and exclusion criteria, and a literature review of scientific English articles published between 2016 and 2023 were conducted. Data were obtained from the SCOPUS, Science Direct, SpringerLink, ProQuest, and SAGE databases. Assessment of the title, abstract, and full text of the article with the keywords "Adolescent," "Child," "Teenager," "Emotion regulation," "Emotion exposure," "Intervention," "Mental Disorders," "Randomised Control Trial." The systematic review report was reviewed critically to ensure that all PRISMA steps and items were included. Nine articles met the inclusion criteria. The choice of programs and methods of intervention may vary depending on the specific mental disorders and individual needs of adolescents. Nursing interventions, including cognitive behavioral therapy, mindfulness-based interventions, group therapy, support groups, and school-based programs, are widely used to manage and treat mental health disorders with the aim of improving well-being and recovery. The effectiveness of intervention programs varies, and selection should consider adolescent needs, resources, and cultural contexts. Consulting mental health professionals or organizations is recommended.

CREB: A Promising Therapeutic Target for Treating Psychiatric Disorders.

Psychiatric disorders are complex, multifactorial illnesses. It is challenging for us to understand the underlying mechanism of psychiatric disorders. In recent years, the morbidity of psychiatric disorders has increased yearly, causing huge economic losses to the society. Although some progress, such as psychotherapy drugs and electroconvulsive therapy, has been made in the treatment of psychiatric disorders, including depression, anxiety, bipolar disorder, obsessive-compulsive and autism spectrum disorders, antidepressants and psychotropic drugs have the characteristics of negative effects and high rate of relapse. Therefore, researchers continue to seek suitable interventions. cAMP response element binding protein (CREB) belongs to a protein family and is widely distributed in the majority of brain cells that function as a transcription factor. It has been demonstrated that CREB plays an important role in neurogenesis, synaptic plasticity, and neuronal growth. This review provides a 10-year update of the 2013 systematic review on the multidimensional roles of CREB-mediated transcriptional signaling in psychiatric disorders. We also summarize the classification of psychiatric disorders and elucidate the involvement of CREB and related downstream signalling pathways in psychiatric disorders. Importantly, we analyse the CREB-related signal pathways involving antidepressants and antipsychotics to relieve the pathological process of psychiatric disorders. This review emphasizes that CREB signalling may have a vast potential to treat psychiatric disorders like depression. Furthermore, it would be helpful for the development of potential medicine to make up for the imperfection of current antidepressants and antipsychotics.

Parental Mental Disorders and Ages of Onset of Severe Mental Disorders in Offspring: A Nationwide Family-link Study

ObjectiveThe current study used a retrospective study design to investigate the association between age of onset of severe mental disorders in offspring and the likelihood of diagnoses of parental mental disorder. MethodWe enrolled 212,333 people with severe mental disorder, including schizophrenia, bipolar disorder (BD), or major depressive disorder (MDD) and 2,123,329 controls matched for age, sex, and demographics from the National Health Insurance Database of Taiwan. Poisson regression models were used to examine the likelihood of diagnoses of five mental disorders in their parents compared to the parents of the controls (reported as odds ratio (OR) with 95% confidence interval), including schizophrenia, BD, MDD, alcohol use disorder (AUD), and substance use disorder (SUD). The study cohort was classified into child-onset, adolescent-onset, and adult-onset groups according to the onset of severe mental disorders in the offspring. ResultThe parents of people with child-, adolescent-, and adult-onset schizophrenia (OR range: 1.73-9.08, all p<0.05) or BD (OR range: 1.97-8.17, all p<0.05) were more likely to be diagnosed with schizophrenia, BD, MDD, AUD, and substance use disorder (SUD) than controls except for AUD in the child-onset group. However, the parents of people with child-, adolescent-, and adult-onset depressive disorder were more likely to be diagnosed with schizophrenia, BD, MDD, AUD, and SUD (OR range: 1.82-4.76, all p<0.05) than controls. Sub-analyses stratified by sex showed different patterns of associations between parental mental disorders and offspring mental disorders. ConclusionNo matter when the severe mental disorder of the offsprings occurred at different onset stages, their parents had a higher likelihood of being diagnosed with schizophrenia, BD, MDD, AUD, and SUD.

Exercise as a promoter of neurocognitive improvement in people with psychiatric disorders and comorbid obesity: a randomized controlled trial

IntroductionThe psychiatric disorders and obesity comorbidity is related to neurocognitive impairment and inflammation. Exercise is crucial to improve and maintain healthy lifestyles. This randomized controlled trial tested the efficacy of aerobic exercise as promoter of neurocognitive improvement across psychiatric disorders with comorbid obesity (OB). MethodsPatients with major depressive disorder, bipolar disorder and, schizophrenia and with comorbid OB (n=29) received brief healthy lifestyle counseling and were randomized into two groups: guided physical activity group (GPAG) (n=10) which included 12 weeks of guided-exercise of moderate intensity and frequency, and incentive of autonomous physical activity proposals by the specialist. Standard physical activity group (SPAG) (n=19) continue with their usual daily physical activity, without guidance or incentives, over 12 weeks. Peripheral blood biomarkers of inflammation, oxidative stress, vascular mechanisms, and metabolic activity, as well as neurocognitive and functional performance were assessed twice, before and after intervention. Mixed one-way analysis of variance and linear regression analyses were performed. ResultsIndividuals in GPAG showed better neurocognitive and functional performance than individuals in SPAG after physical activity training (p<0.05; η²p=0.14 to 0.15). A significant improvement in cognition before and after the physical activity training in the GPAG group was found (p<0.0001; η²p=0.29). In all cases, the effect size was from moderate to large. Inflammatory activity (interleukin [IL-6]), oxidative (mitochondrial reactive oxygen species [mROS] and mitochondrial membrane potential [ΔΨm]) and inter cellular adhesion molecule 1 [ICAM1], leukocyte-endothelium adhesion [LEPMN], and p-selectin [PSEL]) levels, and cardio-metabolic (low-density lipoprotein [LDL], systolic blood pressure [SBP], and insulin) processes were significant predicting neurocognitive improve of individuals with psychiatric disorders and comorbid OB. ConclusionsPhysical activity programs may have positive impact on neurocognitive and functional performance in individuals with psychiatric disorders and OB. Exercise influences inflammatory, oxidative, vascular, and cardio-metabolic pathways, and modulate cognition. These findings may have a potential translational utility for early intervention in these disorders.

The West: An autoimmune disease?

ContextThis work explores the paradoxical stress mechanisms in Western societies, marked by consumption and comfort. Despite the perceived well-being of modern capitalist societies, a profound psychosomatic discontent manifests, reflected in the rise of stress-induced illnesses, autoimmune diseases, and psychiatric disorders. The article uses the metaphor of autoimmunity to describe Western societal dysfunction, drawing parallels between biological self-destruction and societal self-harm driven by hyper-individualism, economic pressures, and digital dependencies. ObjectivesThis study aims to analyze the mechanisms through which Western societies contribute to self-destructive processes, paralleling the way autoimmune diseases function within the body. It seeks to demonstrate how excessive control, consumerism, and the digital environment exacerbate stress, which in turn contributes to both physical and psychological deterioration. The philosophical question underpinning this analysis is whether the societal and economic systems in the West are undermining the self-defense mechanisms of their members, akin to an autoimmune response. MethodThe article adopts a qualitative and theoretical approach, integrating concepts from psychology, psychoneuroimmunology, and epidemiology. The author incorporates clinical observations, epidemiological data, and philosophical reflections to explore the effects of chronic stress on mental and physical health. Drawing on psychoneuroimmunology, the research explores the bi-directional interaction between the mind, nervous system, and immune function, focusing on the relationship between stress, inflammation and autoimmune diseases. ResultsOur exploration reveals a significant correlation between the rise of autoimmune diseases and the psychosocial stresses of Western capitalist societies. Epidemiological data support the link between chronic stress, psychiatric disorders, and autoimmune conditions. The article also highlights how the digital economy's manipulation of stress and fear (such as through FOMO) contributes to widespread psychological distress. This stress, in turn, disrupts immune function, leading to a cycle of physical and psychological degeneration. InterpretationWestern societies, through their relentless pursuit of control, comfort, and consumption, create environments of heightened stress that mirror the dysfunctions of autoimmune diseases, where the body turns against itself. The research suggests that modern capitalist structures are pathogenic, exacerbating stress, weakening immune resilience, and fostering mental health crises. The article concludes that a holistic approach is necessary to address this systemic dysfunction, advocating for a reconceptualization of health that integrates mental, physical, and societal well-being.

Effectiveness and cost-effectiveness of online recorded recovery narratives in improving quality of life for people with psychosis experience (NEON Trial): a pragmatic randomised controlled trial

The Narrative Experiences Online (NEON) Intervention provides self-managed web-based access to mental health recovery narratives (n=659). We evaluated effectiveness and cost-effectiveness in improving quality of life for adults resident in England with mental health problems and recent psychosis experience. Prospectively registered pragmatic parallel-group randomised trial controlling for usual care, recruiting from statutory mental health services and through community engagement activities, with a 52-week primary endpoint (ISRCTN11152837). All trial procedures and the NEON Intervention were delivered by an integrated web-application. Randomisation was through an independently generated list (no stratification). Allocation was masked for statistical staff and the Chief Investigator but not participants. Intervention arm participants received immediate NEON Intervention access. Control arm participants received access after completing primary endpoint questionnaires. The primary outcome was quality of life through the Manchester Short Assessment (MANSA). Serious Adverse Events (SAEs) were collected through web-based safety report forms and identified from health service usage data. The primary analysis was by a prospectively described Intention To Treat principle excluding participants who had registered multiple times, with multiple imputation for missing data. Between 9 March 2020 and 1 March 2021, 739 participants were randomised (intervention:370; control: 369), providing more than 90% power to detect a baseline-adjusted difference of 0.25 in the MANSA score. Mean age was 34.8 years (standard deviation (SD) 12.0), 561 (75.9%) were white British, 443 (59.9%) were female, 609 (82.4%) had accessed specialist care mental health services, and 698 (94.5%) had accessed primary care mental health services. Mean baseline MANSA score was 3.7 for control and intervention arms (SD 0.9 and 1.0). 565 (76.5%) participants provided primary endpoint MANSA data with a mean score of 4.1 (SD 1.0) for both arms. We found no significant difference in Quality of Life between the two arms at the primary endpoint (baseline-adjusted difference 0.07, 95% CI-0.07 to 0.21, p=0.35). The incremental cost-effectiveness ratio (£110,501 per quality-adjusted life-year (QALY)) exceeded the prospectively defined cost-effectiveness threshold (£30,000 per QALY). 158(42.8%) control arm and 194 (52.4%) intervention arm participants accessed narratives outside of the NEON Intervention. There were no related serious adverse events (SAEs). 116 unrelated SAEs were reported by control arm participants, and 107 by intervention arm participants. Our findings do not indicate NEON Intervention access for all people with psychosis experience. Future research should consider a) evaluation with current mental health services users; b) optimisation to enable users to find hope-promoting narratives. National Institute for Health and Care Research (NIHR).

Individual & Joint Associations of Sexual Stigma and Mental Distress with PrEP Uptake, Adherence and Persistence Among US Gay and Bisexual Men

BackgroundSexual stigma, mental health disorders, and socioeconomic disparities present important yet incompletely understood barriers to PrEP adoption among gay men and other men who have sex with men (MSM). This study examines how these factors interact and affect PrEP uptake, adherence, and persistence among MSM. MethodsData from the 2018 and 2019 American Men's Internet Survey cycles, involving 6,907 adult MSM eligible for PrEP, were analyzed. We assessed sexual stigma heterogeneity among this group using latent class analysis and investigated individual relationships between i) stigma class membership, ii) mental distress, and PrEP engagement (past-year use, adherence, and persistence) using Poisson regression with a robust error variance, considering potential variations based on poverty status. The combined associations of sexual stigma and mental distress with PrEP engagement was evaluated using inverse probability weighting. ResultsFour distinct sexual stigma classes were identified, each exhibiting varied associations with PrEP engagement. Associations with mental distress lost statistical significance after adjusting for confounders. However, having both mental distress and sexual stigma was associated with lower past-year PrEP use, with the strongest association observed for those with anticipated healthcare stigma class membership and mental distress (aPR 0.53 [95% CI: 0.37, 0.76]). Sexual stigma accompanied by mental distress was also associated with significantly increased poor PrEP adherence, particularly among those with family and general social stigma class membership (aPR 2.31 [95% CI: 1.08, 4.97]). ConclusionsPsychosocial factors exert synergistic impacts on PrEP engagement among MSM. Tailored interventions addressing these subtleties may effectively optimize PrEP uptake and improve consistency of use among MSM.

The empathy project: Staff confidence and training needs in psychosocial patient care

IntroductionRadiation Therapists (RT) must balance highly technical procedures and psychosocial patient care during their daily work practices. While RTs are in a unique position to form rapport with patients and provide support and information, many RTs lack confidence in the psychosocial care of patients, and struggle to identify and address emotional cues. This study aimed to assess the confidence, competence, and training needs of RTs regarding psychosocial patient care. MethodsAll RTs at the Radiation Oncology Princess Alexandra Hospital Deparmtents were invited to participate in an electronic survey in May 2021, and May 2023 via email. The survey was distributed using SurveyMonkey and utilised a series of Likert-scale and open-ended questions. ResultsStaff reported high confidence in addressing technical treatment issues (98 % of respondents) and communicating with anxious (78 %) and distressed (78 %) patients. However, lower confidence was indicated with managing patient conflict (58 %) and communicating with patients who were depressed (53 %) or suffering mental health conditions (74 %). Staff were concerned about saying the wrong thing and experienced stress when they couldn't adequately communicate with patients requiring psychosocial support.The most significant barriers to providing adequate psychosocial care included time, staff numbers, and workload. Staff requested training in emotional cues, communication, anxiety and depression, and understanding psychosocial and mental health conditions. ConclusionWhile staff perceptions and motivations of psychosocial care were overwhelmingly positive, further training is required to improve patient psychosocial care. Future steps include implementing psychosocial training resources in the departments, and reassessing staff confidence post training.

Chronic citalopram effects on the brain neurochemical profile and perfusion in a rat model of depression detected by the NMR techniques – spectroscopy and perfusion

BackgroundMajor depressive disorder (MDD) is a mental illness with a high worldwide prevalence and suboptimal pharmacological treatment, which necessitates the development of novel, more efficacious MDD medication. Nuclear magnetic resonance (NMR) can non-invasively provide insight into the neurochemical state of the brain using proton magnetic resonance spectroscopy (1H MRS), and an assessment of regional cerebral blood flow (rCBF) by perfusion imaging. These methods may provide valuable in vivo markers of the pathological processes underlying MDD. MethodsThis study examined the effects of the chronic antidepressant medication, citalopram, in a well-validated MDD model induced by bilateral olfactory bulbectomy (OB) in rats. 1H MRS was utilized to assess key metabolite ratios in the dorsal hippocampus and sensorimotor cortex bilaterally, and arterial spin labelling was employed to estimate rCBF in several additional brain regions. ResultsThe 1H MRS data results suggest lower hippocampal Cho/tCr and lower cortical NAA/tCr levels as a characteristic of the OB phenotype. Spectroscopy revealed lower hippocampal Tau/tCr in citalopram-treated rats, indicating a potentially deleterious effect of the drug. However, the significant OB model–citalopram treatment interaction was observed using 1H MRS in hippocampal mI/tCr, Glx/tCr and Gln/tCr, indicating differential treatment effects in the OB and control groups. The perfusion data revealed higher rCBF in the whole brain, hippocampus and thalamus in the OB rats, while citalopram appeared to normalise it without affecting the control group. ConclusionCollectively, 1H MRS and rCBF approaches demonstrated their capacity to capture an OB-induced phenotype and chronic antidepressant treatment effect in multiple brain regions.

Childhood maltreatment in patients with mental illness as a risk factor for obesity

Childhood maltreatment in patients with mental illness as a risk factor for obesity

Conceptualizing Recovery from Mental Illness in Indonesia: A Scoping Review

Conceptualizing Recovery from Mental Illness in Indonesia: A Scoping Review

Food Consumption and Mental Health in Children and Adolescents: A Systematic Review Protocol

Mental illnesses are prevalent among children and adolescents worldwide and may be associated with food consumption and unhealthy lifestyles. This study aims to evaluate the association between food consumption and mental health in children and adolescents through a systematic review and meta-analysis. The electronic search will include keywords related to childhood, adolescence, mental health issues (e.g., anxiety, stress, depression), and eating behaviors (e.g., eating patterns, ultra-processed foods), verified using MeSH terms. The systematic review will follow the PRISMA 2020 guidelines, employing the PECOS strategy, and will include quantitative observational and mixed-methods studies. A search will be conducted in the following databases: Scopus, CINAHL, SPORTDiscus, LILACS, Web of Science, APA-PhysioNET, PubMed (Medline) and EMBASE. Identifying the association between mental health and food consumption will contribute to the development of preventive and intervention strategies aimed at improving the health and well-being of children and adolescents. The analysis of the data will provide results on how psychological factors are linked to the consumption of various food groups, implying the formulation and updating of public policies. These guidelines can assist managers and researchers in creating effective interventions to promote mental health and healthy eating behaviors, ultimately leading to long-term positive impacts on public health..

Disorder Contained: Mental Breakdown and the Modern Prison in England and Ireland, 1840–1900 by Catherine Cox and Hilary Marland, and: Out of His Mind: Masculinity and Mental Illness in Victorian Britain by Amy Milne-Smith, and: Male Suicide and Masculinity in 19th-Century Britain: Stories of Self-Destruction by Lyndsay Galpin (review)

Disorder Contained: Mental Breakdown and the Modern Prison in England and Ireland, 1840–1900 by Catherine Cox and Hilary Marland, and: Out of His Mind: Masculinity and Mental Illness in Victorian Britain by Amy Milne-Smith, and: Male Suicide and Masculinity in 19th-Century Britain: Stories of Self-Destruction by Lyndsay Galpin (review)

Association between self-reported child maltreatment and risk of hospital-treated infectious diseases in middle-aged and older adults: A UK Biobank cohort study.

This study aimed to explore the association between child maltreatment and hospital-treated infectious diseases in middle-aged and older adults. 145,151 participants aged 38-72 years from the UK Biobank between 2006 and 2010 were enrolled and interviewed. Child maltreatment included five types: physical abuse, physical neglect, emotional abuse, emotional neglect, and sexual abuse. Patterns of maltreatment were identified using latent class analysis (LCA). Cox regression was employed to estimate the associations between child maltreatment (number of types, individual types, and patterns) and infectious diseases. Further, we evaluated potential mediators using mediation analysis. Over a median follow-up of 13.4 years, 22,688 participants (12.26 per 1000 person-years) were hospitalized for an infectious disease. Participants reporting any maltreatment had elevated infectious diseases risk (HR 1.18, 95 % CI: 1.15-1.21) than those without maltreatment. A dose-response relationship was observed between the number of maltreatment types and infectious disease (one, HR 1.09 [95 % CI 1.06-1.13]; two, HR 1.17 [95 % CI 1.12-1.23]; three to five, HR 1.48 [95 %CI 1.41-1.55]; Ptrend < 0.001). Each type of maltreatment was associated with increased infectious diseases risk. LCA identified four patterns (low maltreatment, child neglect, child abuse, and poly-maltreatment), with those experiencing poly-maltreatment exhibiting the highest infectious diseases risk (HR 1.51, 95 % CI: 1.43-1.59). The association between child maltreatment and infectious diseases was mediated by C-reactive protein, phenotypic age acceleration, loneliness, psychiatric disorders, and unhealthy lifestyles. Child maltreatment may increase susceptibility to a broad spectrum of infectious diseases in adulthood, highlighting the need for early-life maltreatment prevention policies.

Normative Data for the D-KEFS Color-Word Interference and Trail Making Tests Adapted in Greek Adult Population 20-49 Years Old.

This study was designed to adapt the Delis-Kaplan Executive System (D-KEFS) version of the Color-Word Interference (CWIT) and Trail Making Tests (TMTs) for the Greek adult population from 20 to 49 years old, since it is of research as well as clinical importance to detect executive functions' impairment in young adults with neurological or/and psychiatric conditions. Norms for the Greek adult population have been calculated to be available for neuropsychologists and health professionals who work in relevant settings. The study sample consisted of 101 healthy adults (41% male and 60% female) aged 20 to 49 years (M = 32.16, SD = 11.57) with education from 12 to 19 years of schooling (M = 14.51, SD = 0.89). A Pearson correlation test as well as a chi square test were conducted to examine potential associations between gender, age, education, and participants' performance. Afterwards, we calculated normative data using raw scores and transformed them into percentile scores. Finally, Greek norms were compared to the original raw scores, which were transformed into scaled scores by Delis et al. (2001). The findings showed that age was the only variable which affected CWIT, whereas level of education as well as age were predictive factors for most TMT conditions, except for the visual scanning test (Condition 1). Gender did not affect both tests. Finally, D-KEFS norms for CWIT and TMT are available for the Greek adult population to help clinicians detect executive functions' deficits and therefore adjust tailored therapeutic strategies. Additionally, it is of great importance to use these tests for research purposes. Given that executive functions are assumed as high-level skills, which are highly related to everyday functionality, adapted tests contribute not only to assess the progression of any existing neurological as well as psychiatric disorders, but they can also be used to evaluate patients' ability to live independently, as well as their access to work.

Investigation of Clinical Features, EEG Findings, and Brain Imaging in Psychiatric Patients With Epilepsy at Razi Psychiatric Hospital

Objectives: This study aimed to assess the clinical features, Electroencephalography (EEG) findings, and brain imaging results in psychiatric patients diagnosed with epilepsy at Razi Psychiatric Hospital. Methods: This retrospective descriptive-analytical study was carried out on patients with epilepsy and psychiatric disorders admitted to Razi Psychiatric Hospital over two years. A total of 94 patient files seizure and epilepsy comorbidity, recorded in the hospital’s health information system (HIS), were reviewed. Data collection involved a demographic checklist and an epilepsy scale; the latter, developed by DiIorio, Colleen, et al., encompassed personal characteristics, mental disorders, epilepsy, and seizures. The Kruskal-Wallis and Mann-Whitney non-parametric tests were utilized to compare the mean scores of variables, with SPSS software, version 21 facilitating the analysis. Results: Out of 94 patients with seizure and epilepsy, 9.6% had focal seizure, 26.6% had generalized epilepsy, 36.1% had focal-generalized seizure, and 26.8% had unknown seizure. About 12% had a structural etiology, while the remaining 88% had an etiology that remained unidentified. Conclusion: The findings indicate that epilepsy, affecting individuals from adolescence through to old age, can lead to psychiatric disorders. For many patients, the etiology of their condition remains elusive, and EEG findings and brain imaging appear normal in the majority of cases.

The Relationship Between Prenatal, Perinatal, and Postnatal Factors and ADHD: The Role of Nutrition, Diet, and Stress.

Attention-Deficit Hyperactive Disorder (ADHD) is a neurobehavioral syndrome affecting children aged 6-17 with symptoms manifesting before age 12. ADHD presents heterogeneously and is associated with various psychiatric disorders. The cause remains elusive, but genetic and environmental factors, brain region maturation delays, and neurotransmitter dysregulation are implicated. Effective treatment requires a multi-disciplinary approach, primarily involving pharmacological and behavioral intervention. Stimulants like methylphenidate and amphetamines are first-line medications, but non-stimulants may be considered for some patients. However, stimulants face challenges related to misuse, dependence, and long-term tolerability issues. The etiology of ADHD involved genetic predisposition, environmental influences, and prenatal, perinatal, and postnatal factors. Prenatal causes encompass maternal diet, alcohol consumption, viral infections, and stress. Postnatal factors include head trauma, meningitis, toxin, nutritional deficiencies, as well as iodine deficiency and hypothyroidism. The gut microbiome's role in ADHD is emerging, influencing neurodevelopment through microbiota-gut-brain axis. Understanding these diverse etiological factors is essential for comprehensive ADHD management.

Non-Attendance in Randomized Remote Mental Health Clinical Trial During the COVID-19 Pandemic

During the COVID-19 pandemic, a significant increase in psychiatric symptoms was found among essential service professionals (professionals or interns from the health and educational sector) who were exposed to high-risk contamination areas. These symptoms impair functionality, impacting quality of life, work, autonomy, and relationships. Recent data show that brief interventions are effective; however, between 20 and 30% of those individuals often do not attend their scheduled appointments. This study aimed to identify variables related to non-attendance for remote telepsychotherapy among participants with COVID-19-related emotional distress compared to those who initiated treatment. We included 2097 essential service professionals with PROMIS (Patient-Reported Outcomes Measurement Information System) T-scores ≥70 for anxiety, depression, or irritability who scheduled a remote mental health appointment. Participants completed clinical and sociodemographic data, mental health risk and protective factors, and PROMIS subscales. We conducted a binary logistic regression, using attendance vs. non-attendance as the dependent variable and these demographic and clinical characteristics as independent variables. Of the 2097 participants, 230 (11%) did not attend the first session despite three rescheduling attempts. Non-attendance was associated with the presence of irritability and seeking treatment during the second COVID-19 wave. In contrast, anxious symptoms, older age, and coping mechanisms that typically include intellectual and reading activities were associated with attendance. Our findings shed light on non-attendance patterns in mental health services, revealing that personal characteristics and environmental factors significantly contribute to missed appointments. Understanding these dynamics can improve patient engagement and adherence to mental health treatments, particularly in the context of telepsychotherapy during the COVID-19 pandemic.

Curcumin Derivatives Linked to a Reduction of Oxidative Stress in Mental Dysfunctions and Inflammatory Disorders.

Stress is a critical factor in the etiology of inflammation and neurodegeneration. The risk factor for the majority of psychiatric disorders is oxidative stress-induced depression. Mitochondrial damage and oxidative stress are associated with the development of neurodegenerative disorders. During aging, the brain and associated regions become more susceptible due to oxidative stress. The leading cause of oxidative stress is the continuous generation of ROS (reactive oxygen species) and RNS (Reactive nitrogen species) endogenously or exogenously. In this review, discussion on a potent antioxidant natural constituent "curcumin" has been made to alleviate many pathological and neurological disorders. A focused compilation of vast and informative research on the potential of curcumin as a magical moiety used therapeutically has been done in search of its role in controlling the neurological and similar disorders induced by oxidative stress.

Emerging trends in the evolution of neuropsychology and artificial intelligence: A comprehensive analysis

Neuropsychological evaluations are valuable in neurosurgery because they comprehensively evaluate cognitive, affective, and behavioral functioning to optimize patient outcomes. Incorporating artificial intelligence (AI) into neuropsychology offers optimistic advances, with machine learning models assisting in classifying behavioral, cognitive, and functional impairments while minimizing the number of tests. AI-based approaches have demonstrated accurate classification outcomes, providing potential alternatives to time-consuming and non-ecological conventional evaluations. This research uses data from the Scopus database to examine the trends of neuropsychological-based AI in cognitive neuroscience, mental health, and neurodegenerative disorders. The study emphasized the potential of artificial intelligence in neuropsychology research and identified several research themes. The analysis of bibliometrics may efficiently assess the developments and impact of neuropsychology research, providing insights into academic output and predicting future trends. Future research should consider utilizing alternative databases, employing a multisource strategy, incorporating additional keywords, and building upon the foundational knowledge provided by this study. Despite its limitations, this study provides significant insights and paves the way for future neuropsychology-based artificial intelligence research. Furthermore, investigating significant topics and key issues in the neuropsychology and artificial intelligence debate adds new perspectives to the corpus of literature. This analysis can help identify gaps, controversies, and areas of future exploration within the field. The study also highlights the importance of learning and intelligent computation in neuropsychology, providing a conceptual methodology based on a comprehensive review of the most recent research.