Pseudo-Meigs Syndrome Research Articles

Struma Ovarii- Association with Pseudo-Meigs Syndrome and Raised S. CA-125: A Case Report

The monodermal mature teratoma known as Struma Ovarii is a rare and uncommon form of ovarian tumours. It is primarily composed of thyroid tissue and is associated with hyperthyroidism, increased levels of S. CA-125 (Cancer Antigen-125), and pseudo-Meigs syndrome. Because the symptoms of this tumour are nonspecific, other extremely frequent ovarian lesions may be misdiagnosed and ignored. The majority of the time, incidental imaging and symptoms are used to make the first diagnosis of the cancer; histopathology is used to confirm the diagnosis. A good prognosis and successful curative treatment can result from surgically removing the tumour. The tumour's rarity makes misdiagnosis frequent. Nonetheless, a total abdominal hysterectomy combined with a bilateral salpingo-oophorectomy may be indicated in premenopausal patients in order to eradicate all symptoms. Ascites, hyperthyroidism, high S. CA-125 levels, and hydrothorax are all rare outcomes of struma ovarii. In this uncommon syndrome with negative cytology, individuals with ascites and pleural effusion should be examined for a differential diagnosis. Bangladesh Armed Forces Med J Vol 57 No (1) June 2024, pp 50-55

Pseudo-Meigs syndrome caused by a rapidly enlarging hydropic leiomyoma with elevated CA125 levels mimicking ovarian malignancy: a case report and literature review

Pseudo-Meigs syndrome is a rare syndrome characterized by hydrothorax and ascites associated with pelvic masses, and patients occasionally present with elevated serum cancer antigen-125 (CA125) levels. Hydropic leiomyoma (HLM) is an uncommon subtype of uterine leiomyoma characterized by hydropic degeneration and secondary cystic changes. Rapidly enlarging HLMs accompanied by hydrothorax, ascites, and elevated CA125 levels may be misdiagnosed as malignant tumors. Here, we report a case of HLM in a 45-year-old Chinese woman who presented with ascites and hydrothorax. Preoperative abdominopelvic CT revealed a giant solid mass in the fundus uteri measuring 20 × 15 × 12 cm. Her serum CA125 level was elevated to 247.7 U/ml, while her hydrothorax CA125 level was 304.60 U/ml. The patient was initially diagnosed with uterine malignancy and underwent total abdominal hysterectomy and adhesiolysis. Pathological examination confirmed the presence of a uterine hydropic leiomyoma with cystic changes. After tumor removal, the ascites and hydrothorax subsided quickly, with no evidence of recurrence. The patient’s serum CA125 level decreased to 116.90 U/mL on Day 7 and 5.6 U/mL on Day 40 postsurgery. Follow-up data were obtained at 6 months, 1 year, and 2 years after surgery, and no recurrence of ascites or hydrothorax was observed. This case highlights the importance of accurate diagnosis and appropriate management of HLM to achieve successful outcomes.

Perioperative Management of Two Cases with Giant Ovarian Tumor Complicated with Pseudo-Meigs Syndrome Just before Surgery

Perioperative Management of Two Cases with Giant Ovarian Tumor Complicated with Pseudo-Meigs Syndrome Just before Surgery

Immature ovarian teratoma with pseudo-Meigs syndrome and gliomatosis peritonei

Pseudo-Meigs syndrome (PMS) and gliomatosis peritonei (GP) are rare conditions associated with ovarian teratomas. We report the case of an 11-year-old female patient suffering from immature ovarian teratoma with PMS and GP. Enhanced computed tomography (CT) revealed a tumor measuring 240 × 150 × 100 mm in the lower abdomen, ascites, and right pleural effusion. Before the operation, the right pleural effusion increased and required chest tube drainage. Right adnexectomy was performed, and peritoneal nodules were detected during surgery. A biopsy was performed and pathological examination revealed a right immature ovarian teratoma (Grade 3) and glial tissue (Grade 0), thus confirming the diagnosis of GP. Postoperatively, ascites and pleural effusion disappeared, confirming the diagnosis of PMS. Eight months after the operation, a metachronous contralateral mature ovarian teratoma developed, for which fertility-sparing surgery was performed. Therefore, long-term follow-up is required in this patient.

A Case of Metachronous Ovarian Metastasis of Rectal Cancer Associated With Pseudo-Meigs Syndrome

A Case of Metachronous Ovarian Metastasis of Rectal Cancer Associated With Pseudo-Meigs Syndrome

Meig's Syndrome with an Elevated CA125 in a 15-Year-Old Girl

Background: An increased CA 125 in conjunction with a pelvic mass is, although, strongly indicative of ovarian cancer, there are a number of other benign diseases that may be linked to a pelvic mass and a higher CA 125. Meigs syndrome is an uncommon condition in women under the age of 30. It consists of a triad of benign fibrous ovarian tumors, ascites, and pleural effusion. When the tumor is removed, the symptoms got resolve completely within two weeks. Case Presentation: It is a case of a 15-year-old girl with fibroma, along with a review of the literature. Although the cause of the fluid accumulations is unknown, it seems to be linked to lymphatic blockage. Abdominal distension, pain, cough, pleuritic chest pain, vomiting, fever, and weight loss are all presenting symptoms. Conclusion: This case report concludes that although a pelvic mass with elevated CA 125 is strongly indicative of malignancy, other illnesses, particularly Meigs syndrome and pseudo-Meigs syndrome in young women presenting with a pleural effusion, should always be evaluated as a differential diagnosis. The fluid buildup typically disappears within two weeks of the tumor being removed.

A Case of Long-Term Recurrence-Free Survival after Surgery for Synchronous Ovarian Metastasis of Descending Colon Cancer with Pseudo-Meigs Syndrome in a Young Patient

A Case of Long-Term Recurrence-Free Survival after Surgery for Synchronous Ovarian Metastasis of Descending Colon Cancer with Pseudo-Meigs Syndrome in a Young Patient

Peritoneal gliomatosis: a case report

Peritoneal gliomatosis is the mature neuroglial tissue in peritoneum, this is commonly associated with immature teratoma. Can be associated with ascites alone or ascites and pleural effusion in which case it is called pseudo Meigs syndrome, the lymph node invasion has been described. In the imaging studies such computed tomography they can be show as multiple peritoneal nodules, the positron emission tomography has shown utility in cases of doubt of recurrence of mature teratoma without evidence of primary tumor with elevated tumor marker. The initial treatment depends on the treatment of the teratoma, reserving the surgical treatment of the peritoneal gliomatosis in the presence of complications related to the implants. A 21-year-old woman without chronic degenerative disease story with clinical presentation of abdominal distension, a CT scan is performed that shows a right ovary tumor; a laparotomy was performed in which ascites and peritoneal nodules were evidenced suggesting the presence of carcinomatosis. Histopathological study demonstrated peritoneal gliomatosis.

"High Grade Serous Ovarian Cancer Presenting as Pseudo-Meigs Syndrome: A Case Report"

"High Grade Serous Ovarian Cancer Presenting as Pseudo-Meigs Syndrome: A Case Report"

Ovarian metastasis from breast cancer mimicking a primary ovarian neoplasm: A case report.

Ovarian metastasis (OM) from breast cancer accounts for 3-38% of all ovarian neoplasms and is associated with various characteristic clinical presentations, such as pseudo-Meigs syndrome and Krukenberg tumor. Accurate diagnosis of OM may be challenging, as such lesions are frequently asymptomatic until they reach a large size. Occasionally, metastatic ovarian cancer is detected prior to the diagnosis of the primary tumor. Immunohistochemistry plays an important role in distinguishing primary ovarian tumors from extraovarian tumor metastases and may be helpful for identifying the primary tumor site. We herein report a case of OM from breast cancer masquerading as primary ovarian cancer. However, the correct diagnosis was made based on histopathological and immunohistochemical examinations. The patient had bilateral breast cancer, namely invasive lobular carcinoma of the left breast and ductal carcinoma of the right breast. Due to the presence of bilateral synchronous breast tumors, the possibility that the patient had hereditary breast and ovarian cancer syndrome or other relevant genetic factors was considered. Immunohistochemistry plays a key role in distinguishing between primary ovarian tumors and OM, and it was also important for confirming the metastatic nature of the ovarian lesion and diagnosing the primary tumor in the present study.

From a clinical case to a review of literature: Struma ovarii associated with ascites and high serum CA125

Struma ovarii is a rare dermoid tumor of the ovary (1% of all ovarian tumors and 2,7% of ovarian teratomas), with more than 50% of the overall tissue being thyroid. Approximately one third of the cases present ascites. Pseudo-Meigs syndrome has been reported in fewer than 10 cases and 5-8% present thyroid hyperfunction. However, only 26 cases reported the association of ascites or pseudoMeigs’ syndrome, elevated cancer antigen 125 and benign struma ovarii in the literature. The authors submit a case of benign struma ovarii that presented as a pelvic mass with ascites and highly elevated CA 125 serum levels and an extensive literature survey on this topic.

GIANT OVARIAN FIBROMA WITH ASSOCIATED PSEUDO-MEIGS' SYNDROME: A CASE REPORT AND LITERATURE REVIEW

Meigs' syndrome is a rare condition characterized by the presence of a benign broma of the ovary, ascites and pleural effusion. When either of ascites or pleural effusion is associated with the broma it is termed pseudo-Meigs' syndrome. Though bromas are the most common benign solid tumours of the ovary, they rarely present in clinical practice and diagnosis is made difcult by symptoms that usually mimic disseminated malignancy. The gold standard of treatment is laparotomy, denitive diagnosis is by histology, and by denition of the syndrome, the symptoms resolve after removal of the tumour and the patients become asymptomatic. We present a patient with a giant ovarian broma with associated pseudo Meigs syndrome who was successfully managed without any complications.

A Rare Case of Giant Ovarian Serous Cystadenoma presenting as Psuedo-Meigs Syndrome

Meigs’ syndrome is a rare condition characterized by the presence of a benign fibroma of the ovary, ascites and pleural effusion. Other benign cysts of the ovary (such as struma ovarii, mucinous cystadenoma, serous cystadenoma and teratomas), leiomyoma of the uterus, and secondary metastatic tumours to ovary if associated with hydro thorax and ascites are referred to as ‘Pseudo‐Meigs” syndrome. It very uncommon and diagnosis is made difficult by symptoms that usually mimic disseminated malignancy or tuberculosis. The gold standard treatment is laparotomy and, by definition of the syndrome, after tumor removal, the symptoms resolves and the patients become asymptomatic. We presented an 18 years old girl with giant ovarian serous cystadenoma with associated pseudo-meigs syndrome, successfully managed in a low resources setting.

A rare case of giant ovarian serous cystadenoma presenting as psuedo-meigs syndrome

Meigs’ syndrome is a rare condition characterized by the presence of a benign fibroma of the ovary, ascites and pleural effusion. Other benign cysts of the ovary (such as struma ovarii, mucinous cystadenoma, serous cystadenoma and teratomas), leiomyoma of the uterus, and secondary metastatic tumours to ovary if associated with hydro thorax and ascites are referred to as ‘Pseudo-Meigs” syndrome. It very uncommon and diagnosis is made difficult by symptoms that usually mimic disseminated malignancy or tuberculosis. The gold standard treatment is laparotomy and, by definition of the syndrome, after tumor removal, the symptoms resolves and the patients become asymptomatic. We presented an 18 years old girl with giant ovarian serous cystadenoma with associated pseudo-meigs syndrome, successfully managed in a low resources setting.

Struma ovarii-associated pseudo-Meigs− syndrome with concomitant abdominopelvic tuberculosis masquerading as ovarian malignancy

Pseudo-Meigs' syndrome (PMS) is a rare disease characterized by the triad of (1) an ovarian neoplasm, other than a fibroma or thecoma, (2) ascites, and (3) pleural effusion. Tumors such as struma ovarii, mucinous and serous cystadenomas, and germ cell tumors have been linked with the condition. Due to its clinical features combined with the elevation of serum cancer antigen 125 (CA-125) levels, it is often mistaken and treated as a malignant ovarian tumor. Ascites or pleural effusion could be massive leading to various life-threatening complications. Despite its presentation, this entity has an excellent prognosis when surgical excision of the tumor is performed. This article presents an unusual case of a 41-year-old gravida 10 para 10 (10-0-0-9) who was diagnosed with a case of struma ovarii associated PMS with concomitant abdominopelvic tuberculosis and elevated CA-125 resembling an ovarian malignancy.

Highly differentiated follicular carcinoma arising from struma ovarii (strumosis) presenting as pseudo-Meigs syndrome with elevated CA125 level: a case report

Highly differentiated follicular carcinoma arising from struma ovarii (strumosis) presenting as pseudo-Meigs syndrome with elevated CA125 level: a case report

A Pseudo-Meig Syndrome Associated with Malignant Brenner Tumor and Small Cell Carcinoma of the Ovary (FIGO IIIC)

A Pseudo-Meig Syndrome Associated with Malignant Brenner Tumor and Small Cell Carcinoma of the Ovary (FIGO IIIC)

A Giant Cystic Leiyomyoma with Pseudomeig Syndrome Mimicking Ovarian Malignancy: A Case Report and Review of Literature

A Giant Cystic Leiyomyoma with Pseudomeig Syndrome Mimicking Ovarian Malignancy: A Case Report and Review of Literature

Síndrome de pseudo-Meigs por tumor de células de la granulosa

Definimos síndrome de Meigs como la triada de tumor ovárico benigno, derrame pleural y ascitis, una condición clínica rara que se resuelve con la resección del tumor. Estas mismas características pueden presentarse en el síndrome de pseudo-Meigs que se asocia a tumores malignos, que agregan un aumento importante de los niveles del marcador CA-125. Es conocido por muchos años, pero su fisiopatología aún no está clara. Se presenta un caso de síndrome pseudo-Meigs y se hace una breve revisión bibliográfica de sus características más importantes.

Pseudo-Meigs syndrome secondary to endodermal sinus tumor.

Ovarian tumors are the most common gynecological tumors seen in girls. Approximately 60-70% of them are germ cell tumors. Pseudo-Meigs syndrome is characterized by the presence of pelvic tumoral mass (benign or malign), pleural effusion, and massive acid. If the tumor is removed, acid and hydrothorax disappear. Endodermal sinus (yolk sac) tumor is a very rare cause in the diagnosis of Pseudo-Meigs syndrome, and only a few cases have been reported. This case is one of the rare cases presenting with Pseudo-Meigs syndrome and pathologically diagnosed as yolk sac tumor.