Acculturation has a central role in the theorization and research on Latina teens suicide attempts. In this article, we report on a systematic review on the literature to describe and assess what has been thought and studied about the role of acculturation, and related phenomena on the suicidal behaviors of Latina adolescents. Methods. We conducted a systematic review of studies published in English from 2000 to 2020 about Latina adolescents in the U.S. who reported suicidal ideation and behaviors, and included analysis about acculturation, acculturation proxies (e.g., generational status), and/or acculturation stress. Results. Ten articles met inclusionary criteria. Most studies used quantitative methods (n = 7) and enrolled US-born participants of Latino descent (60–74.8 %), who were second-or later generation (74–91.6 %). Latina adolescents who attempted suicide did not differ in their acculturation levels when compared to their non-suicidal peers. Researchers studied four acculturation proxies in relationship to suicidal behaviors: Cultural status (n = 1), country of birth (n = 2), generational status (n = 1), and language spoken at home (n = 1). Cultural status had no impact on suicidal ideation or attempts, and the findings about generational status were not conclusive. Acculturation stress and associate phenomena increased the risk for suicidal ideation (n = 2) and suicide attempts (n = 2). Conclusion. It is essential to approach the risk factors contributing to suicidal behaviors from a multifaceted viewpoint, where acculturation stress and acculturation take part. The current evidence does not uphold the suggested central role of acculturation in the suicidal behaviors of Latina teens.