The COVID-19 disease is a calamity that may leave a dreadful psychological indentation on nurses. Nurses take all the necessary measures to protect themselves physically and psychologically. This global pandemic demands a firmly secured nursing staff engagement in clinical management in pursuance of public safety. In the interest of sustaining psychological and physical well-being, nurses should be entitled to fair compensation, access to counseling for mental health care support, and provide job satisfaction, empowering these professionals to survive this crisis and beyond. This study is proposed to provide baseline information on the impact of job stress on Al Dhafra hospitals nurses' job satisfaction during the covid-19 pandemic and the effect of psychological capital as a moderator. Furthermore, the study will open a new aspect for further research to improve and reduce its adverse effects. In addition, it can be used as a reference to create, improve, or modify guidelines and existing protocols, and it can also serve as a reasonable contribution study for further nursing management in future crises. The study employed a quantitative correlation research design, and an online survey was conducted and participated in by 255 nurses who are in direct contact with COVID-19 patients in Al Dhafra hospitals in UAE. The present study's findings indicate a negative relationship between job stress and job satisfaction; on the other hand, The findings also revealed a positive moderating effect of psychological capital on the relationship between job stress and satisfaction. The current study has important implications for hospitals in developing managerial, training, and strategic policies. According to the findings of this study, job stress has a significant impact on nursing satisfaction. In light of this study, hospitals can improve their job satisfaction. Furthermore, this study can be applied to other cultural and demographic contexts to reduce employee stress.