The data of the cross–section is required for understanding nuclear reaction mechanism, developing and testing validity of available nuclear reaction models as much as it has been used in the applied fields of nuclear physics. Reliable experimental data is importance of comparison with theoretical nuclear model calculations for testing predictive ability. In the event that experimental data failure appearance, theoretical models are filling this gab for supplying with calculated data. Because of these reasons, both of experimental and theoretical studies need of each other. For a long time, theoretically studies have been carried out for proton total reaction cross section calculation. At the end of these studies, several analytical equations have been proposed by their authors. Comparison of the suggested equations and rearrangement for different value of parameters are enormously important for reaching successfully results. In this study, proton total reaction cross sections have been calculated for 112,114,116,118,120,122,124Sn isotopes using proton-nucleus interaction analytic equation that was proposed by M.A. Alvi. Also, optical model calculations carried out for same reactions by TALYS code. Excitation functions have been plotted with collected experimental data up to 80 MeV proton incident energy. Coefficient comparisons have been made via determined excitation function curves. The obtained results have been discussed by way of the excitation function graphics and compared with the available experimental data. Satisfactory agreements have been seen between calculated data and its measured equivalents. A validation of used theoretical model has been confirmed and tested via obtained results for these Sn isotopes and these energy ranges.