Arterial Hypertension (AH), Diabetes Mellitus along with other metabolic disorders areamong the leading causes of kidney damage worldwide.Objective – to investigate the metabolic pattern, cholecalciferol and ionized calciumblood values in patients with essential AH (EAH) and chronic kidney disease (CKD)depending on gender.Material and methods. 100 EAH patients and 60 practically healthy individuals participatedin the study. All participant underwent a complex of clinical and laboratory examinations.Metabolism was analyzed by the lipid profile (total cholesterol (TC), high-, low densitylipoproteins (HDL-C, LDL-C), atherogenity index (AI), triacylglycerols (TG)), bloodglucose, creatinine, cystatin- C, bilirubin, cholecalciferol, ionized calcium, parathyroidhormone (PTH) and albuminuria values. Body mass index (BMI), waist circumference(WC), hip circumference (HC) and waist to hip ratio (WHR) were also determined.Results. The CKD appearance in EAH patients is accompanied by a higher blood pressure(BP) values (systolic BP – 5.98 % (p=0.012), diastolic BP – 5.57 % (p=0.007)), mainlyin women – 6.34 % (p=0.008) and 5.81 % (p=0.013), respectively; a higher bilirubinblood concentration – 27.79 % (р=0.007), creatinine and cystatin- C regardless of gender(stronger in men) – by 21.76-26.67 % (р<0.001), glucose (significantly in men) – 33.49 %(p=0.035), with a lower level of ionized Ca2+ (p=0.05), HDL-C – 16.81 % (p=0.02),which cause an increase of the AI (reliably in men) – 35.36 % (р=0.027); higher BMI –24.67 % (p=0.003) and WC – 14.97 % (p=0.023) in men. Also, in EAH patients withCKD, more massive albuminuria is observed in general – 32.45 % (p=0.02), reliably onlyin women – 44.20 % (p=0.004). Changes in the vitamin D metabolites concentration andPTH were not associated with CKD in EAH patients in our study.Conclusion. A proatherogenic pattern, hyperglycemia, excess body weight/or obesity(mainly in men), albuminuria and hemodynamic disorders (mainly in women) generallyform metabolic changes in EAH patients with CKD.