Summary Two populations of the conspicuous, semi-sessile medusae of the rhizostome genus Cassiopea, both morphologically similar to Cassiopea andromeda from the Red Sea and Indopacific, were recently studied on Oahu (Hawai'i), one from a sheltered saltwater pond (the Hilton Lagoon) next to Ala Wai Harbor, Honolulu, and the second from the canals of a fish farm near Kahuku on NE Oahu. Gonad differentiation, checked in 1998, and again in 1999 and 2000, was unexpectedly different in medusae from these two locations. Contrary to all earlier reports and personal observations of strict gonochorism in C. andromeda, the majority of the Hilton Lagoon medusae collected in 1998 were hermaphroditic with female and male parts intermingling in the gonads. This is an exceptional case in scyphozoans. However, this hermaphroditic condition, which was observed again in 1999, was not stable over time. All six medusae taken from the same lagoon in 2000 were distinctly gonochoristic; four were males, and two were females brooding egg masses on the oral disk. Planula larvae hatching in the laboratory were successfully reared to the scyphopolyp stage. By contrast, medusae sampled from the population were all males in 1998, 1999, and 2000. Polyps were found abundantly on dark, deteriorating leaves of the Red Mangrove, occasionally on other plant remnants, and on discarded plastic materials in the canals. The polyps propagated asexually both by strobilation of ephyrae and by production of motile, larva-like buds that settled to form additional polyps. We speculate on a clonal origin of this male population. Asexually formed propagules were induced to form polyps by exposure to either the peptide Z-GPGGPA or biogenic substrata as has been shown before in other Cassiopea species. The serine/threonine protein phosphatase inhibitor cantharidin stimulated bud development too, but interfered strongly with pattern formation, polarity, and the sequence and timing of morphogenetic events. It did not induce typical bud-to-polyp metamorphosis.