With the progress of hematopoietic stem cell transplantation technology, the reduction of pretreatment intensity, the shortening of bone marrow suppression time and the reduction of infection risk, as well as the prominent physical and psychological stress for doctors and patients caused by rigorous protection procedures, the strategies for protective environment need to be reconsidered. Regardless of whether total environment protection is implemented, there is no significant difference in the outcomes of chemotherapy patients with neutropenia. The advantages and disadvantages of total environment protection have been weighed and reviewed for patients receiving hematopoietic stem cell transplantation. The protective environment strategies for hematopoietic stem cell transplantation patients have developed rapidly in the past two decades, from the initial replacement of laminar flow equipment by high-efficiency filtration devices to the development of home care after transplantation. In this article, the progress of protective environment strategies for hematopoietic stem cell transplantation patient was reviewed, and further reflections were posed, providing reference for future improvement.
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