Digital trade is an important part of today’s world economy, and the resulting issue of digital trade restrictions has become the focus of attention in international trade negotiations. Studying the influential factors of digital trade restrictions can help to understand the inherent reasons for the differences in digital trade policies across countries. From the perspective of political economy, this paper establishes a government objective function that pays special attention to the welfare of digital trade-related interest groups based on the protection for sale model, and analyzes the endogenous influencing factors of digital trade policy. In this paper, the QCA method is also applied to analyze the configuration of different influencing factors, and finally two paths leading to high digital trade restrictions and three paths leading to non-high digital trade restrictions are found. The research findings have significant implications both theoretically and practically for revealing the factors and internal mechanisms that affect digital trade restrictions.