The industries significantly rely on information technology for effective operations; however, there are hazards like data breaches and system breakdowns. Information system audits are essential to reducing these risks, ensuring quality control, and optimizing the system. These audits evaluate gaps in controls, non-compliance concerns, and vulnerabilities, allowing for the installation of efficient risk mitigation measures. Information system audits are essential for locating and reducing hazards related to an organization's information systems.Vulnerabilities, threats, and control flaws can be found through routine audits, which then allows for the deployment of the necessary controls and risk-reduction measures. Additionally, audits support quality assurance by assessing data reliability, accuracy, and completeness, as well as system performance, regulatory compliance, and industry best practices.The deployment of remedial steps to improve data integrity and system reliability is made possible by their assistance in assisting organizations in identifying gaps and flaws. Information system audits also aid system optimization by revealing details about the functionality and performance of the system.  An extensive evaluation of the literature and case study analysis was used to perform the research.For the analysis of this research, a sequential mixed technique (qualitative and quantitative) study was conducted. Delphi questionnaires were used twice to conduct the study. It encompasses organizations and entities involved in various aspects including but not limited to logistics companies, freight carriers, shipping and distribution firms, public transportation agencies, and supply chain service providers. Data from the semi-structured interviews for the qualitative study were collected via a Delphi survey, and 14 nodes and six themes were then generated.Audits assist organizations in identifying areas for improvement and informing decisions about system upgrades or alterations by analyzing system utilization, response times, resource allocation, and scalability. The results of this study highlight the importance of information system audits in assuring the prosperity, effectiveness, and resilience of businesses engaged in supply chain operations. Organizations can attain a greater level of enterprise risk management, quality assurance, and system optimization, which will improve supply chain operations in general, by managing risks, improving data quality, and optimizing system performance.