Proprietary Programs Research Articles

Alternative education in Russian megacities: a chance for a different school

Introduction. The relevance of the study is determined by the search for innovative ways to develop school education. The study of the history and current state of alternative education in the largest Russian cities plays a significant role in this search. Systematisation of private educational projects will help families to better orientate themselves in alternative education and avoid its destructive models. Materials and Methods. An analysis of scientific literature was conducted, and information from the websites of 665 private educational projects was collected and analyzed, including 322 from Moscow, 183 from Saint Petersburg, 57 from Yekaterinburg, and 51 each from Novosibirsk and Kazan. In-depth interviews with their leaders were conducted, focus groups with experts were held, and an analysis of federal state statistics was made. Research Results. The coverage of children by humanistic alternative education practices in Russia is less than 1%. However, over 10 years, there has been a noticeable growth in the number of educational projects outside the system. An analysis of Project websites showed that only 8% of them consider themselves to be alternative education. 43% of Projects have a license for primary educational activities. Most often, projects implement primary general education programs. 23% of projects claim to implement proprietary programs. A small number of projects are based on specific didactic systems, approaches and practices. The typology of Alternative Education Projects is made taking into account the role of the child in the formation and implementation of educational requests. The study identified three spaces of alternative education: projects supporting family education, projects with established didactic systems (program schools), and A-schools. There are destructive practices in alternative education. Conclusion. Alternative education in the large cities of Russia is diverse and includes both humanistic and other pedagogical practices, as well as a degree of uncertainty. The pedagogical practices of alternative education are difficult to typologize. This living organism continuously transforms, sensitively responding to the external environment.

Numerical simulation and validation of laminar flow through a 2D pipe using computational fluid dynamics

In modern times, there has been a significant increase in the use of software to simulate fluid dynamics. There exist a variety of closed-source software packages that are utilized for both modeling and simulating fluid behavior. These proprietary programs have become increasingly common and are widely utilized in numerous industries that require advanced simulations. This work focuses on the use of a commercial software package designed for computational fluid dynamics (CFD) problems to model laminar flow through a pipe, with the objective of gaining a deeper understanding of the dynamic structures and interactions that occur within the laminar flow. In this paper, an accurate computation of two-dimensional flow is performed using the Time Volume Element Methodology. A grid sensitivity analysis with Richardson extrapolation is conducted to determine the grid-independent solutions, ensuring that the results obtained are reliable and accurate. The findings of this study suggest that the relationship between various parameters, such as velocity and pressure, is heavily influenced by the position and shape of the pipe through which the flow occurs. The investigation utilized a grid sensitivity analysis with Richardson extrapolation to determine the percentage error between the analytical and grid-independent solutions for different parameters, revealing that the errors are on the order of 10-1 %.

Dynamic cyclic fatigue resistance of NiTi instruments in a double-curved stainless steel canal with variable distances of displacement

The present study aimed to measure the number of cycles to fracture (NCF) of different instruments using pecking motion at constant and varying distances of movement at body temperature. This study included 20 files from each brand: ProTaper Universal F2, ProTaper Next X2, and WaveOne Gold Primary (Dentsply Sirona, Maillefer, Ballaigues, Switzerland). Instruments from each brand were divided into two groups (ten files for each group) that experienced constant or variable distances in a stainless-steel artificial double-curved canal in a platform that ensured that the instrument rotated at a stable temperature with a minimum fluctuation of the environment. While running, the platform was programmatically controlled to move at any desired distance of instrument displacement to simulate the clinical pecking motion at variable distances. The files were rotated using proprietary programs. The times to fracture were recorded and then transformed into the number of cycles to fracture (NCF). Data were analyzed using Minitab with proper tests. All fragments were observed under a scanning electron microscope to capture and describe the characteristics of the fracture surface. The WaveOne Gold had the highest NCF, while the ProTaper Universal had the lowest NCF. The manufacturer brands and the modes of displacement of the experimental instrument showed interactive effects. The fracture surface revealed no striation. A new design, material, mode of rotation, and different distances of movement have certain effects on the cyclic fatigue resistance of the instrument.

Static and Dynamic Cyclic Fatigue Resistance of Nickel-Titanium Rotary Instruments in a Double-Curved Stainless Steel Artificial Canal

The present study aims to measure the number of cycles leading to fracture (NCF) of instruments in static and dynamic cyclic fatigue situations under body temperature in stainless steel double-curved canals. The framework was constructed to establish the movement of instruments occurring at a stable body temperature. A step motor, a holding system for an endodontic handpiece, created the movement in and out of the artificial canal of the file mounted on the handpiece. A total of 30 instruments of ProTaper Universal and ProTaper Next (Dentsply Sirona, Maillefer, Ballaigues, Switzerland) were divided into three groups of 10 per group. For group 1 (10 PTU F2), files were rotated in static cycles. For groups 2 (10 PTU F2) and 3 (10 PTN X2), files were rotated in dynamic cycles. Files were rotated using proprietary programs, and the times the files were rotated before fracture were recorded. Data were analyzed using survival probabilities and regression with life data. The ProTaper Next in the dynamic cycles had the largest NCF, and the ProTaper Universal in the static condition had the least. New modes of rotation, material, and design have affected the cyclic fatigue resistance of the instrument.

369 Toward a Complete Mechanism of Action in Epidural Spinal Cord Stimulation - Including Threshold Accommodation

INTRODUCTION: Multiple waveform variations have been introduced for treating neuropathic pain with epidural spinal cord stimulation. These include higher frequencies (eg up to 10kHz) and different cadences of bursting signals. Prior understanding of mechansims of action for reducing pain have relied upon the reduction in WDR cell firing through retrograde stimulation of the largest Ab axons in the dorsal columns. However, prior models did not include details about diameter dependent threshold changes in the dorsal column axons. We sought to include this critical detail toward determining a deeper understand of how all of the waveform variations, including non-paresthetic stimuli, might also acheive pain relief. METHODS: Prior FEM and axonal models were used to achieve this analysis with additional adjustments of adding empirically-derived threshold accomodation to the axon membrane properties. These were calibrated based on axon diameter. Software was programmed in COMSOL and Mathematica, as well as proprietary programs using C++, Java, and JavaScript. RESULTS: Tonic stimulation above 100-300Hz and with increasing PW show accomodation changes and threshold inversions. Also, however, Burst and HF waveforms also showed threshold inversions and led to non-paresthetic activity within dorsal column fibers. Amplitudes were found to achive this phenomenon within typically-used clinical ranges. CONCLUSION: By accounting for known threshold accommodation, related to axon diameters within the dorsal coulmns, a clear mechnism of action could be ascribed to all known waveforms being used clinically. The results show that there would likely not be paresthesia experienced at clinically relevant amplitudes for many of these waveforms and a coherent complete mechanism of action for achieving pain relief is derived from this approach.

Artificial Intelligence for Education, Proctoring, and Credentialing in Cardiovascular Medicine.

Artificial intelligence and machine learning are rapidly gaining popularity in every aspect of cardiovascular medicine. This review discusses the past, present, and future of artificial intelligence in education, remote proctoring, credentialing, research, and publication as they pertain to cardiovascular procedures. This review describes the benefits and limitations of artificial intelligence and machine learning and the exciting potential of integrating advanced simulation, holography, virtual reality, and extended reality into disease diagnosis and patient care, as well as their roles in cardiovascular research and education. Nonetheless, much of the available data resides in electronic medical records or within industry-sponsored proprietary programs that are not compatible or standardized for current clinical application. Many areas in cardiovascular medicine would benefit from the introduction or increased use of artificial intelligence. Web-based artificial intelligence applications could be used to address unmet needs for education, on-demand procedural proctoring, credentialing, and recredentialing for interventionists and physicians in remote locations. Further progress in artificial intelligence will require further collaboration among computer scientists and researchers in order to identify and correct the most relevant problems and to implement the best data-based approach to achieving this goal. The future success of artificial intelligence in cardiovascular medicine will depend on the degree of collaboration between all pertinent experts in this field. This will undoubtedly be a prolonged, stepwise process.

Electronic evidence

Relevance of the problem outlined in the article is due to increasing levels of crime in the sphere of illicit trafficking in narcotic drugs, psychotropic substances, their analogues or precursors using information and telecommunication systems. The aim of the article is a comprehensive analysis of the problem of the use of electronic evidence in proving crimes of trafficking in narcotic drugs, psychotropic substances, their analogues or precursors. To achieve the goal were used to theoretical, historical comparative methods and logical analysis; application of dialectical method allowed to reveal the meaning of concepts "electronic evidence The article presents the most common methods of communication in the sale of drugs, psychotropic substances, their analogues or precursors through such means of communication as messengers, social networks, online games, proprietary programs. It is established that the main causes of drug trafficking crimes include: insufficient legal regulation of cyberspace, the lack of geographical boundaries, the spread of information about drugs on the Internet, especially in Darknet), the uncontrolled development of the cryptocurrency market. The definition of electronic proof in the Ukrainian legal system, as well as the forms and features of electronic proof are considered.

PREFERENCE MODELLING IN R: A TRIAL ON HOME BUYERS’ WILLINGNESS TO PAY

Modelling stated preferences is an almost mystical science and as there is no data explaining how the sustainable feature in homes would effectively encourage homebuyers to invest in sustainable housing, it is important to investigate the buyers’ willingness to pay (WTP) for sustainable housing. The study of stated preferences often requires the use of specialised software or proprietary programs, which can be difficult and/or expensive to use. This study proposes to re-purpose the ‘support.CEs’ package, a program written in the R programming language, from its agronomic roots to measure home buyer preferences for sustainable housing. These are demonstrated through a stated preference discrete choice experiment of choosing model houses with differing levels of energy savings, renewable energy generation, landscaping, soundproofing, ventilation, and price differences. A pilot study was performed using an online survey, constructed using the LMA design tool provided in the ‘support.CEs’ package. The survey was also separated into six blocks of six questions each to reduce the cognitive burden on respondents. The survey was distributed through social media channels. Preliminary results with a limited sample of 20 respondents with mixed income, age, and occupational demographics, analysed using the package’s clogit function, that performs conditional logit estimations, have shown that the results have a statistically reliable adjusted rho-squared value and that all coefficients show the expected signs. From this study, it can be concluded that the ‘support.CEs’ package can be used to model home buyer preferences and that adequate blocking allows for the measurement of a higher number of variables despite having smaller sample sizes.

Abstract A42: Development and validation of diagnostic biomarkers for B-cell lymphoma using EpiSwitchTM profiling of whole blood: From humans to canines

Abstract Backgound: Changes in chromosome conformation are strongly associated with different clinical phenotypes and outcomes for a variety of diseases. Here, we used the EpiSwitchTM platform technology to evaluate chromosome conformation signatures (CCS) as biomarkers for detection of canine diffuse large B-cell lymphoma (DLBCL). We examined whether established, systemic liquid biopsy biomarkers previously characterized in human DLBCL patients by EpiSwitchTM would translate to dogs with the homologous disease. Orthologous sequence conversion of CCS from humans to dogs was first verified and validated in control and lymphoma canine cohorts. Methods: Blood samples from dogs with DLBCL and from apparently healthy dogs were obtained as part of the comparative cancer genomics and veterinary clinical trials programs of the Animal Cancer Care and Research Program of the University of Minnesota. Dog owners provided signed informed consent, and all studies were done under protocols approved by the Institutional Animal Care Committee of the University of Minnesota. All of the dogs diagnosed with DLBCL were part of the LICKing Lymphoma trial. Blood samples were obtained from each dog prior to initiating treatment at day+5 after the experimental intervention, but prior to initiating doxorubicin chemotherapy. EpiSwitchTM technology (Oxford Biodynamics) was used to monitor systemic epigenetic biomarkers for CCS. This application was based on published methodology for validated predictive biomarkers for response to treatment, systemic blood-based monitoring of oncologic conditions, and proprietary programs in collaboration with Roche/Genentech for liquid biopsy development for DLBCL prognosis. Results: A 11-marker classifier was generated with whole blood from 28 dogs, 14 diagnosed with DLBCL and 14 controls with no apparent disease, from a pool of 75 EpiSwitchTM CCSs identified in human DLBCL. Validation of the developed diagnostic markers was performed on a second cohort of 10 dogs: 5 with DLBCL and 5 controls. The classifier delivered stratifications for DLBCL vs. non-DLBCL with 80% accuracy, 80% sensitivity, 80% specificity, 80% positive predictive value (PPV), and 80% negative predictive value (NPV) on the second cohort. Conclusions: The established EpiSwitchTM classifier contains strong systemic binary markers of epigenetic deregulation with features normally attributed to genetic markers: the binary status of these classifying markers is statistically significant for diagnosis, and it is translatable across species. The data suggest that certain features of the higher-order structural chromatin organization associated with DLBCL, and perhaps other homologous cancers, may be evolutionarily conserved. Altogether, these findings highlight the potential of the EpiSwitchTM approach for disease diagnosis and further applications using liquid biopsies in humans and dogs. Citation Format: Lauren J. Mills, Ewan Hunter, Aaron L. Sarver, Davis Seelig, Jennifer Back, Louis James, Navin Jandor, Polina Brayer, Thomas Lavin, Ryan Powell, Matthew Salter, Jayne Green, Aroul Ramadass, Alexandre Akoulitchev, Jaime F. Modiano. Development and validation of diagnostic biomarkers for B-cell lymphoma using EpiSwitchTM profiling of whole blood: From humans to canines [abstract]. In: Proceedings of the AACR Special Conference on Advances in Liquid Biopsies; Jan 13-16, 2020; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2020;26(11_Suppl):Abstract nr A42.

Wykorzystanie arteterapii w resocjalizacji penitencjarnej

<p>Celem proponowanego referatu jest zwrócenie uwagi na możliwość zastosowania arteterapii w pracy resocjalizacyjnej z osobami nieprzystosowanymi społecznie, ze szczególnym uwzględnieniem resocjalizacji penitencjarnej. Oddziaływania arteterapeutyczne przedstawione zostaną z perspektywy praktyki penitencjarno-resocjalizacyjnej. Autorka odniesie się do problemów i szans związanych z wyborem arteterapii jako głównej metody prowadzenia oddziaływań wobec skazanych na kary długoterminowego pozbawienia wolności. W ostatniej<br />części referatu zawarte zostaną refleksje uwzględniające doświadczenia z realizacji autorskich programów w zakładach karnych.</p>

Revised Scientific Review: Minimum Age for Swim Lessons

The question addressed in the original scientific review (2009) was rephrased as Does sufficient scientific evidence exist to support setting a minimum age for swimming lessons? for this triennial review. Addressing the research question is significant because strong differences of opinion about the appropriate age(s) for initiating learn-to-swim lessons have existed among the pediatric medical profession, aquatic professionals and agencies, and proprietary programs and swim schools for over four decades. The question has implications for the appropriate purposes, pedagogies, and outcomes associated with swimming experiences for infants and young children that will be addressed in a subsequent review. The revised statement now supports as a guideline that children older than 1 year of age can benefit from swim lessons with a lower risk of drowning; parents should make their decision to enroll based upon individual child considerations as proposed in this review.

Use of cross-compiling in the programming of an intelligent device for measuring electrical quantities

A device for voltage and direct current measurement, built by coupling a Raspberry Pi microcomputer with an Arduino series microcontroller is presented in this paper. The structure of the device is presented and the method of implementing proprietary programs for both devices is described. A touch screen of the device allows the user to decide on the measurement mode (automatic or manual) and on the method of archiving and visualizing the effects of measurements. The application uses the so-called cross-compiling, thanks to which it is possible to effectively couple such different platforms as Raspberry Pi and Arduino.

R and Its Applications on the Ecological Research

The increase of research activities in recent years has generated a lot of data to be analysed. Research-related communities need a powerful software to perform their analyses. And, it can be a problem, particularly for those who live in developing countries, where their financial capability is low to buy the proprietary programs. R may provide the solution to this obstacle. Since it is an open source software, which can be installed on major operating systems. In addition, it is highly maintained by R Core Team, which ensures that the program and its packages work well on across platforms. The increase usage of R, especially in universities is not only a proof that the program can be relied on, but it is also a guarantee that the software will continue developing. R and its capability for ecological research activities particularly will be described on this short note

ACP Journal Club: review: some commercial or proprietary weight-loss programs increase weight loss.

Source Citation Gudzune KA, Doshi RS, Mehta AK, et al. Efficacy of commercial weight-loss programs: an updated systematic review. Ann Intern Med. 2015;162:501-12. 25844997

Ancestry and characterization of U.S. contemporary proprietary garden pea (Pisum sativum L. convar. medullare Alef.) germplasm

A major objective of this work is to elucidate the ancestry and genetic background of contemporary U.S. garden pea (Pisum sativum L. convar. medullare Alef.) cultivars used as cultivated vegetables. This is facilitated through pedigree analysis of 147 cultivars registered during the era from 1990 through 2010 by collecting data from U.S. Plant Variety Protection, U.S. utility patent, and journal publication. Proprietary breeding programs developed 141 cultivars and public programs six, with over half (82 of 147 cultivars) originating from the two (Seminis Vegetable Seeds, Inc. and Syngenta Seeds, Inc.) largest proprietary breeding programs. During this era, the semi-leafless (afila) trait was bred into cultivars to decrease lodging, and 43 % of the cultivars were afila. Registered cultivars were 86 % of determinate growth habit. Bi-parental breeding crosses were used in the development of 78 % of these cultivars. The lineages of the cultivars ‘Bolero’, ‘Spring’, ‘Genie’, and ‘Rally’ made large contributions to the genetic composition of this germplasm, ‘Bolero’ contributed 6.5 % (29 progeny), ‘Spring’ 6.4 % (29), ‘Genie’ 4.0 % (18), and ‘Rally’ 3.6 % (23) of the genes. The garden pea ancestor cultivar ‘Perfection’ fostered the most descendants (75) among the 147 cultivars of this era.

Genetic Composition of Contemporary U.S. Commercial Dent Corn Germplasm

ABSTRACTGermplasm of contemporary U.S. dent corn (Zea mays L.) is predominately from proprietary programs. Although publicly developed inbred lines contributed to the genetic foundation of these programs, their role is not known. The objective of this work is to identify and characterize major progenitors of contemporary proprietary germplasm through pedigree analysis of a set of 305 corn inbreds registered during the years 2004 through 2008 by U.S. Plant Variety Protection (PVP) and/or utility patent. Major progenitors found were the inbred lines Dekalb DK3IIH6 (12.2% genetic contribution), B73 (11.7%), and Pioneer Hi‐Bred International (PHI) PH207 (9.5%). Using commercial hybrids as breeding germplasm was common during the 1980s and facilitated the introgression of PHI Iodent germplasm into competitor breeding programs. Of these, the PHI commercial hybrid 3737 has the greatest impact to contemporary germplasm by contributing 15.6% of the genes. Pedigree analysis of 1132 U.S. PVP and/or utility patent registered corn inbreds from 1984 through 2008 indicates that the genetic contribution of the public line Mo17 has decreased (from 8.6 to 1.7%) and the contribution of the public line Oh43 increased (from 1.5 to 3.9%), whereas the contribution of B73 remained constant. The contribution of Iodent germplasm increased concomitantly with use across commercial breeding programs.

Tensor3D: A computer graphics program to simulate 3D real-time deformation and visualization of geometric bodies

Tensor3D is a geometric modeling program with the capacity to simulate and visualize in real-time the deformation, specified through a tensor matrix and applied to triangulated models representing geological bodies. 3D visualization allows the study of deformational processes that are traditionally conducted in 2D, such as simple and pure shears. Besides geometric objects that are immediately available in the program window, the program can read other models from disk, thus being able to import objects created with different open-source or proprietary programs. A strain ellipsoid and a bounding box are simultaneously shown and instantly deformed with the main object. The principal axes of strain are visualized as well to provide graphical information about the orientation of the tensor's normal components. The deformed models can also be saved, retrieved later and deformed again, in order to study different steps of progressive strain, or to make this data available to other programs. The shape of stress ellipsoids and the corresponding Mohr circles defined by any stress tensor can also be represented. The application was written using the Visualization ToolKit, a powerful scientific visualization library in the public domain. This development choice, allied to the use of the Tcl/Tk programming language, which is independent on the host computational platform, makes the program a useful tool for the study of geometric deformations directly in three dimensions in teaching as well as research activities.

OSL 3.0: A Better License for Open Source Software

There are many ways to license open source software. Given the attention paid recently to the General Public License (GPL) and its latest version (GPLv3), you may be interested to know that there are other licenses that satisfy the principles of free and open source software without the confusion and polemics that surround the GPL. Other open source licenses have been approved by Open Source Initiative and adopted by commercial companies and by open source projects. Most of those other licenses are professionally written by lawyers to express clearly the licensing objectives of software copyright and patent owners and to ensure that they are valid and enforceable in all important jurisdictions. I wrote one of those licenses, the Open Software License. The third version of this license, OSL 3.0, was approved by Open Source Initiative in 2005. This article explains why it is a better license for software than the GPL. Software licensors choose their licenses based upon their particular philosophy and business models, and they intend their licenses to define the expected behavior of their licensees around the world. Because philosophies and businesses differ, so do licenses. In the open source world, there are two general categories of licenses: (1) Those licenses that allow derivative works of the software to be used and distributed as part of proprietary programs, and (2) those that require derivative works to be distributed under the same open source license as the original. The BSD license is the archetype of the first kind, what I call academic licenses. The GPL (version 2) is the most popular of the second kind, the so-called reciprocal or copyleft licenses. The license philosophies of these two categories of licenses are inherently irreconcilable, the first being compatible with proprietary derivative works and the other not, but they each make a valid point about the freedom to copy, change, and use software. I pass no judgment between them, since it is a licensor's right to choose a license for his own copyrightable works, not his lawyer's choice. The complete text (which is shorter than this article) of OSL 3.0 and its companion licenses is posted at www. rosenlaw.com/OSL3.0-comparison.pdf.

Pedigree Pedigree Background Changes in U.S. Hybrid Maize between 1980 and 2004

Monitoring genetic diversity helps determine whether plant breeders are successful at maintaining germplasm resources sufficient to provide a continued basis for genetic gain and to avoid vulnerabilities potentially associated with a narrowing genetic base. This study used pedigree data of public and proprietary maize (Zea mays L.) inbred lines and sets of Pioneer brand hybrids that were cultivated widely during the period 1980 to 2004 to report on changes in genetic diversity. Pedigree backgrounds for a set of inbred lines bred by different proprietary programs were more diverse (42 founders) than a set of publicly bred inbred lines that were widely used in 1980 (30 founders). Pedigrees of Pioneer hybrids traced to 82 founders. Most of the pedigree backgrounds were contributed collectively by 25 to 50% of the founders. Germplasm was associated into three groups: (i) older public lines, newer proprietary inbreds, and two sets of later maturity Pioneer hybrids; (ii) other later maturity Pioneer hybrids and earlier maturity Pioneer hybrids used in 1980 to 1981; and (iii) remaining early maturity Pioneer hybrids. Differences in proportions of founders already present in U.S. maize germplasm, notably Reid Yellow Dent, Iodent, SMPRS5, Minnesota 13, and Leaming, contributed most as usage changed from older public lines to increased usage of proprietary lines during 1980 to 2004. Changes for Pioneer hybrids involved generally small percentages for several founders, although changes for Reid and Iodent were greater. Future genetic gains are dependent on the deployment of useful genetic diversity. Regular assays of hybrid genetic diversity using molecular markers are recommended.

Influence of tumor type, disease status, and patient age on self-reported interest regarding participation in cancer clinical trials

6100 Background: There is limited data available regarding the reasons cancer patients decide to enter clinical trials. Methods: To explore this issue, aggregate responses to the question, “Are you interested in learning about clinical trials for your condition?” obtained from > 115,000 cancer patients (or their families) who entered data into one of several proprietary decision-support programs embedded within approximately 100 cancer-related Internet sites, were analyzed. Results: The proportion of patients (or their families) who expressed interest in learning of the availability of clinical trials ranged from as low as 21% (endometrial and cervix cancer patients > 80 years old; n=178) to as high as 85% (recurrent ovarian cancer patients, aged 51–60; n=842). Patients > 80 years old, regardless of sex, tumor type, or disease status, were substantially less likely to desire such information. Patients with self-declared more “serious conditions” (e.g., metastatic breast cancer [71%; n=5,444], recurrent prostate cancer [70%; n=4,121]), and those with cancers widely known to have a poor prognosis (e.g., non-small cell lung cancer [75%; n=23,298]), were more likely to request data on trials, than those with an overall more “favorable” prognosis (e.g., newly diagnosed prostate cancer [46%; n=21,348]). There were no observed differences in interest between men and women with similar conditions. Conclusion: In this large data base, major differences in self-expressed interest regarding availability of clinical trails were observed. Particularly notable were the reduced interest among the very elderly, and the increased interest by patients with the most serious cancer-related conditions. [Table: see text]