This study aims to develop an inverse approach to identifying the cell-wall material properties of closed-cell aluminum (Al) foams, which is based upon indentation tests, numerical simulation and optimization technique. Vickers nano-indentation tests are conducted on the cell-wall of foams, and the residual surface deformation is measured by a high definition confocal microscopy. To enhance identification efficiency, a combined 2D with 3D micromechanics modeling strategy is proposed here, in which the load-depth curve and residual imprint (pile-up) of the indentation tests are considered. In this study, the cell-wall material properties such as the yield strength and strain-hardening exponent are identified using this proposed inverse approach, while the Young's modulus is obtained directly for the unloading part of the indentation load-depth curves. The identification results indicate that the proposed inverse procedure can provide a well-posed solution to the cell-wall material properties by introducing the pile-up information. Microscopic computed tomography (μCT) technique is also utilized to reconstruct accurate 3D image-based representative volume element (RVE) model of foam structure, through which the numerical simulation is conducted for uniaxial compression. The identified cell-wall material parameters are validated by comparing the numerical simulation with the experimental data in terms of the deformation/failure modes and quantitative results. It is noted that the cell-wall of aluminum foams that are commonly made of melt foaming processes exhibits a quite different stress-strain relation when compared with the raw material of cell-wall. This study is expected to provide an effective approach for identifying the material properties that may be not easily determined through conventional testing methods.