Proportion Of Sexual Dysfunction Research Articles

Sexual dysfunction in women suffering from major depressive disorder: A cross-sectional study

AbstractBackground:Compared to a healthy population, sexual dysfunction is higher in major depressive disorder (MDD). Identification and management of sexual dysfunction profoundly impact marital satisfaction, quality of life, and compliance with treatment in patients with depression.Aims and Objectives:The primary objective was to determine the proportion of sexual dysfunction among women suffering from MDD attending the psychiatry department of a tertiary care center. The secondary objectives were (1) to study the correlation between the severity of depression and sexual dysfunction in women with MDD and (2) to study the relationship between sociodemographic and clinical variables with sexual dysfunction.Settings and Design:This was a cross-sectional study carried out among 40 women diagnosed with MDD attending the psychiatry department of our tertiary care institute.Materials and Methods:After taking informed consent, relevant sociodemographic details and clinical variables were recorded using a semi-structured questionnaire. MDD was diagnosed according to the Diagnostic Statistical Manual of Mental Disorders-Fifth Edition, and its severity was assessed using Hamilton rating scale for depression. Sexual dysfunction was measured using the Arizona sexual experience scale.Statistical Analysis:Spearman’s correlation coefficient was used to assess the correlation between the severity of depression and sexual dysfunction. The Chi-square test was used to test the relationship between categorical variables. Analysis of data was done using appropriate statistical software.Results:The proportion of sexual dysfunction among women with MDD was 65%. The most common sexual dysfunction was low sexual desire (57.5%). There was a positive correlation between the severity of depression and the presence of sexual dysfunction, with Spearman’s correlation coefficient (rho = 0.765,P= 0.000). Age, attainment of menopause, history of alcohol and tobacco use in the spouse, and severity of depression were significant with sexual dysfunction using the Chi-square test.Conclusions:The proportion of sexual dysfunction was high among women suffering from MDD. The severity of depression and the presence of sexual dysfunction are positively correlated.

Spolna disfunkcija pri slovenskih pacientih z multiplo sklerozo

Uvod: Spolna disfunkcija je pri pacientih z multiplo sklerozo pogosta, ustreznih podatkov za slovensko populacijo pa ni na voljo. Namen raziskave je bil ugotoviti vrsto in delež spolne disfunkcije, razlike med moškimi in ženskami ter morebitno povezavo med spolno disfunkcijo in značilnostmi pacientov.Metode: Presečna raziskava je bila izvedena pri pacientih z multiplo sklerozo, ki so imeli spolne odnose v zadnjih šestih mesecih in so izpolnili vprašalnik MSISQ-19 (Multiple Sclerosis Intimacy and Sexuality Questionnaire). V raziskavi je sodelovalo 368 pacientov povprečne starosti 40,9 leta in trajanjem bolezni 10,2 leta. Nevrološko prizadetost smo ocenili z EDDS (Expanded Disability Status Scale). Za primerjavo številčnih spremenljivk smo uporabili neparni t-test, za primerjavo kategoričnih spremenljivk hi-kvadrat,povezanost med značilnostmi pacientov ter posamezno obliko spolne disfunkcije pa smo ocenili s pomočjo korelacijskega koeficienta po Spearmanu.Rezultati: Delež spolne disfunkcije, definiran kot odgovor 4 ali 5 na katero koli vprašanje v MSISQ-19, je znašal 37 %, deleži primarne, sekundarne in terciarne spolne disfunkcije pa 39,4 %, 39,9 % in 40,8 %. Med spoloma ni bilo statistično pomembnih razlik. Statistično značilno, a zelo šibko linearno korelacijo smo ugotovili med značilnostmi pacientov (starost, trajanje bolezni, EDSS, trajanje partnerske zveze) ter posamezno obliko spolne disfunkcije.Diskusija in zaključek: Spolno disfunkcijo ima 37 % slovenskih pacientov z multiplo sklerozo. Med spoloma ni statistično pomembnih razlik, kar velja tudi za posamezne vrste spolne disfunkcije, kot so primarna, sekundarna in terciarna.

Epidemiology, diagnosis and management of sexual dysfunction in multiple sclerosis.

Multiple sclerosis (MS) is the most common chronic neurological disorder in young adults, with numerous potential effects on neurologic function. Sexual dysfunction (SD) is a common and very stressful one in persons with MS and represents a significant burden of disease. It has been shown that proportion of SD in MS is greater than in other neurological diseases, and almost five times higher than in the general population. Since there is no consistent definition in the literature for the diagnosis of SD, various studies reported a prevalence of SD of 40-80% in women and 50-90% in men with MS. The nature of sexual changes in this chronic illness is best defined as primary, secondary, and tertiary. Recently, it has been emphasized that detailed sexual history is crucial for all SD assessments and diagnoses. Committee 3 of the international consultation on sexual medicine suggested an updating algorithm for diagnostic evaluation of SD in both genders, with specific recommendations related to sexual history taking and diagnostic evaluation. Because treatments and preventive strategies might manage SD, it is necessary to increase the focus on these aspects of the disease when counselling patients. Management of SD should be comprehensive because the symptoms could be somatic, psychological, or related to relationship problems.

Sexual dysfunctions among patients in a psychiatric hospital

Information regarding sexual dysfunctions in psychiatric patients is insufficient though it affects a patient’s quality of life in various ways. The objective of this study was to assess the proportion and pattern of sexual dysfunctions among patient’s attending at the National Institute of Mental Health (NIMH), Dhaka. It was a cross-sectional study conducted from 01 February 2015 to 30 June 2015. A total of 161 patients (of 18-50 years of age) selected purposively and were interviewed after getting informed written consent. A semi-structured socio-demographic questionnaire and a pre-tested (Bengali version of) Arizona Sexual Experience Scale (ASEX) were used for collecting data. Sexual dysfunctions were diagnosed by using the Diagnostic and Statistical Manual for Mental Disorders, 5th edition (DSM-5). Results showed that the mean age of the respondents was 35.12(± 8.22) years. Most of them (75%) were aged between 20-40 years. The proportion of sexual dysfunctions was 67% and it was found more among males (70.3%) than females (62.9%). Among males, Erectile Disorder (35.1%) in indoor and Premature Ejaculation (27.3%) in outdoor were more common. Among females, most common sexual dysfunction was Sexual Interest/Arousal Disorder, of which 34.9% was in indoor and 44.4% in outdoor respondents respectively. The proportion of sexual dysfunction was higher in the semi- urban group (75%), those who were educated up to primary level (79%) and belonging to age group 40-50 years (79%). As sexual dysfunction and it’s impact on psychiatric patients are tremendous, sexual functioning of every patient needs special attention, care and early interventions for reducing sufferings.
 Bang J Psychiatry December 2017; 31(2): 43-47

Sexual Dysfunction among Women with Diabetes in a Primary Health Care at Semarang, Central Java Province, Indonesia

Sexual dysfunction is associated with pain during sexual intercourse. Diabetes mellitus (DM) has been reported to be one of the causal factors for sexual dysfunction in women. This cross-sectional study was conducted to describe the status of sexual dysfunction in women with DM in the Tlogosari Kulon Primary Health Care, Semarang, Indonesia, in March 2017. A total of 103 women with DM attending the health center participated in this study. Data were collected using a questionnaire-guided interview and through measurements (blood pressure and random blood glucose test). Results showed that 74.8% of women with DM had sexual dysfunction. The proportion of sexual dysfunction was higher among women in the clinical phase, with uncontrolled blood glucose levels, hypertension grade II, prolonged duration of DM of ≥ 5 years, undergoing insulin treatment, in menopause, grand multiparity, having used the tubectomy contraception method, low physical activity, depression, and consumption of antihypertensive drugs. The aging process, menopausal status, and consumption of antihypertensive drugs will increase the risk for sexual dysfunction in women with DM. It is recommended that women with DM maintain their physical activity, blood sugar levels, blood pressure, and their depression status.

The correlation of sexual dysfunction and estrogen receptor gene polymorphism in Chinese Han women with epilepsy

Objective To investigate the correlation between sexual dysfunction(SD)and estrogen receptor (ER) gene polymorphism in Chinese Han women with epilepsy (WWE). Methods A total of 112 married Chinese Han women with epilepsy were collected from outpatients and inpatients of the Affiliated Hospital of Yangzhou University, and 120 matched healthy women were taken as the control group.WWE were treated with antiepileptic drugs (AEDs) for one year or more.The Chinese version of female sexual function index (FSFI) was used to investigate the sexual function of the subjects.The chemiluminescence method was used to detect the sex hormones levels such as prolactin(PRL), follicle-stimulating hormone(FSH), luteinizing hormone(LH), estradiol(E2), progesterone(P) and testosterone(T). Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to determine the ER gene polymorphism.Chi-square test, t-test and binary logistic regression were used for statistical analysis.The differences of the sexual function, sex hormone, ER genotype, and allele frequency were compared between the two groups.And the correlation between SD and ER gene polymorphism was analyzed. Results (1) The proportion of SD in Chinese Han WWE was 70.5%(79/112), while that was 24.2%(29/120) in the control group.The serum prolactin (PRL) level in the WWE group was significantly higher than that in the control group (t=2.072, P=0.039). (2) The allele frequencies of ER PvuII C and AluI A in the WWE group were significantly higher than those in the control group (P=0.001; P=0.001). (3) Binary logistic regression analysis showed that PvuII CC genotype and serum testosterone level were independently correlated with SD (OR=6.074, 95%CI: 1.257-29.352, P=0.025; OR=0.412, 95%CI: 0.201-0.842, P=0.015). Conclusion ERα PvuII polymorphism may be related to the susceptibility of SD in Chinese Han WWE, and PvuII CC genotype may be the risk genotype of SD in WWE. Key words: Epilepsy; Women; Sexual dysfunction; Sex hormone; Estrogen receptor

English

English

Comparación del efecto del tipo de histerectomía abdominal sobre la función sexual femenina

OBJETIVO: Comparar el efecto del tipo histerectomía abdominal sobre la función sexual femenina. MATERIALES Y MÉTODOS: Estudio prospectivo descriptivo, de acuerdo al diseño 'sólo después', realizado en el Hospital Regional Docente de Trujillo, Perú, en el cual 54 mujeres sometidas a histerectomía abdominal total (HAT) y 54 mujeres sometidas a histerectomía subtotal (HAsT), por enfermedades benignas, entre enero de 2001 y diciembre de 2003; fueron seleccionadas aleatoriamente para responder un cuestionario que evalúa su función sexual(FSFI). Se determinó las proporciones de disfunción, así como los puntajes de cada uno de los dominios de la función sexual. Las comparaciones fueron hechas usando la prueba chi cuadrado, la prueba z de proporciones y la prueba 't'. RESULTADOS: La proporción de disfunción sexual en las pacientes sometidas a HAsT (40,7%) fue menor que en las sometidas a HAT (48.1%), sin diferencia estadísticamente significativa (p>0.05), no existiendo además relación entre las variables. Los promedios de los dominios del orgasmo (4. 16±1.28 VS. 4.66± 1.34) y la satisfacción (4.57± 1.22 vs. 5.01±0.95) son estadísticamente diferentes entre ambos grupos, siendo mayores en el de HAsT. En los demás dominios, no se encontró diferencias significativas. CONCLUSIONES: No se encontró diferencia entre el efecto del tipo de histerectomía abdominal sobre la función sexual femenina en general, pero si se observó mejor respuesta en los dominios del orgasmo y satisfacción sexual en las mujeres sometidas a histerectomía abdominal subtotal.

T07-O-05 Finasteride 5 mg and sexual side effects. How many of these are related to a nocebo phenomenon?

Introduction Sexual adverse experiences such as erectile dysfunction, loss of libido, and ejaculation disorders have been consistent side effects of Finasteride in a maximum percentage of 15% after one year of therapy as reported in the PLESS-Study. Such data could be seen as far from reality, if compared to a higher percentage that may be found in any common clinical practice. This study wishes to explain the dichotomy between literature's data and clinical practice data. Materials and methods 120 patients with diagnosis of Benign Prostatic Hyperplasia (prostate volume >40 ml), age ranging between 45 and 65, sexually active (IIEF questionnairie > 25) in a stable relationship for at least 6 months; testosterone level in the normal range; never on previous BPH medication were randomized to receive finasteride 5 mg per day for one year with (group 2) or without (group 1) counselling on the drug sexual side effect.The phrase used to inform group 2 patients was “….it may cause erectile dysfunction, decreased libido, problems of ejaculation but these are uncommon “.The estimation of side effect was conducted at 6 months and 12 months with MSF 4 Questionarie and the information reported by patients diary. Results Data are referred to 107 patients who completed the study.Group 2 patients (N= 55) reported a significant higher proportion of sexual side effects as compared to group 1 (N °=52) (43.6 vs 15.3%).The incidence of erectile dysfunction; decrease libido.; ejaculation disorders were 9.6%, 7.7%,5.7% for group 1 and 30,9%; 23,6%; 16,3% for group 2 respectively. Conclusions In the current study Finasteride showed a significantly higher proportion of sexual dysfunction in patients informed on side effects (group 2) as compared to those in which information on side effects was blinded (group 1) (p=0,03). A scenario similar to group 2 of the current study is likely to occur in clinical practice, where the patient has access to the drug information sheet. The burden of this nocebo effect has to be taken into account when managing finasteride sexual side effects.