Prophylaxis Of Cystoid Macular Edema Research Articles

Role of Cold Balanced Salt Solution (BSS) in the Prophylaxis of Cystoid Macular Edema After Cataract Surgery: A Prospective Randomized Study.

PurposeTo evaluate the postoperative effect on central retinal macular thickness of a cooled irrigating eye solution used during cataract surgery.Patients and MethodsIn this prospective, single-center study, 100 eyes of 50 patients (26 males and 24 females) were evaluated with spectral domain optical coherence tomography (SD-OCT) before and after phacoemulsification for senile cataract. Eyes were randomly divided into two groups based on the irrigating solution used during surgery: Group 1, 50 eyes received intraoperative irrigating solution at room temperature (~20.0±0.1°C); and Group 2, 50 fellow eyes received cold intraoperative irrigating solution (2.7±0.1°C). Changes in central macular thickness (CMT) were evaluated in both groups by SD-OCT macular raster scan for the nine Early Treatment of Diabetic Retinopathy Study (ETDRS) subfields and total macular volume, performed pre-surgery, and 1 and 4 weeks post-surgery.ResultsDespite there being no significant differences in variables between the two groups preoperatively, significant increases in CMT were observed at 1 week after surgery in both groups (p=0.02 and p=0.03, respectively), as well as in total macular volume (p<0.0001 and p=0.02, respectively). Inter-subgroup analysis showed a significant reduction in CMT (p=0.03) and total macular volume (p=0.001) at 1 week post-surgery in Group 2 compared to Group 1, whereas no significant differences were observed at 4 weeks.ConclusionThe use of a cooled irrigating eye solution during phacoemulsification may be beneficial in preventing the possible development of postoperative macular thickening. Further clinical studies may support this finding.

Review of the Evidence for Topical Nonsteroidal Anti-inflammatory Drugs Post-cataract Surgery

In this article, we review the recent literature surrounding the use of topical nonsteroidal anti-inflammatory drops for prophylaxis of cystoid macular edema following uncomplicated cataract surgery. As has been found with past research, most recent studies suggest that topical NSAIDs may help reduce the incidence of postoperative cystoid macular edema. The effect may be minimal in patients at low risk for macular edema, and more pronounced in those at high risk. The evidence suggests that the effect is maximized when used in combination with topical corticosteroids. Although there remain several limitations to the research on this topic that restrict our ability to draw firm conclusions, the bulk of the evidence supports the use of postoperative topical NSAIDs for cataract surgery in patients at high risk for macular edema. However there is no consensus regarding the ideal choice of NSAID, or the ideal dosing regimen following surgery.

Comparison of Topical Nepafenac 0.1% and Topical Rimexolone 1% in the Prophylaxis of Cystoid Macular Edema after Cataract Surgery

Comparison of Topical Nepafenac 0.1% and Topical Rimexolone 1% in the Prophylaxis of Cystoid Macular Edema after Cataract Surgery