Currently the procurement of road infrastructure projects in Indonesia is mostly carried out using Design Bid Build (DBB), in which the project planning and construction processes are contracted separately. Although this method is well known in its implementation, the long procurement period often results in the slow procurement of infrastructure projects. As an alternative to the procurement method is the Design Build method. This method is believed providing many advantages compared to traditional methods. However, in practice there are obstacles that can hinder the application of this method. The purpose of this study is to analyze the herarchy of the obstacles to applying the Design Build method and formulate efforts to overcome these obstacles. A two-round paired matrix questionnaire survey using the Delphi technique was distributed to obtain consensus from the stakeholders involved in the infrastructure project procurement process. Subsequently, an Interpretive Structural Model (ISM) analysis is carried out to obtainthe hierarchy and the relationship between the constraints that can hinder the implementation of the Design Build method. Fourteen constraints were identified, which form a six-level framework that needs to be addressed in implementation.