Abscopal effects have been reported predominantly in metastatic cancers, indicating aradiographic response in alesion that has not been included in the radiotherapy target volume. The response is interpreted as ahumoral immune response to radiotherapy-generated tumour-specific antigens. In this case study, we present the first histologically confirmed multifocal low-grade meningioma with spontaneous regression of all other lesions after conventionally fractionated stereotactic radiotherapy (RT). Two localisations, right frontal and right spheno-orbital, were resected at the time of the initial diagnosis in a66-year-old woman. RT was performed 1year later to aprogressive occipital lesion at the cerebral falx. Regular magnetic resonance imaging (MRI) showed slightly decreasing tumour volume in untreated lesions 1year after RT and continued during further follow-up. Up to > 7years after treatment, MRI demonstrated an almost complete response of all initial lesions. Two prior reports withmeningioma were published in onepatient with an atypical meningioma after conventionally fractionated RT and anotherpatient with an intracranial meningiomatosis after radiosurgery. This case study supports the concepts of treating only progressive or symptomatic meningioma lesions locally and careful regular MRI surveillance for further assessment. Potential active interventions to trigger an abscopal effect are currently not known. Further research of this beneficial effect for our patients should be supported.