Network Programming Research Articles

Interfacing Complex Coacervates with Natural Cells

Coacervates have been investigated as protocells or synthetic cells, as well as subcellular compartments for the creation of new materials, thus bridging the gap between living and non‐living systems in materials science, synthetic biology, and bioengineering. Given the design flexibility and simplicity of coacervates, along with the functionality and complexity of natural cells, the interfacing of complex coacervates with natural cells is considered significant for various biotechnological and biomedical applications. In this review, the fundamental mechanisms and underlying theories of coacervate systems are introduced. Recent efforts to interface coacervates with natural cells are summarized in three key scenarios: (i) the integration of coacervates with natural cell components for the living material assembly into protocells; (ii) communication between therapeutic synthetic cells and natural cells for drug delivery and cell repair; and (iii) the formation of intracellular condensates for metabolic regulation, followed by the regulation of their phase transitions for pathological elucidation. Finally, the potential of coacervate‐natural cell interfaces is discussed in the context of developing living/synthetic cell constructs, creating precise disease therapy strategies, and advancing programmable metabolic engineering networks.

The California collaborative network to promote data driven care and improve outcomes in early psychosis (EPI-CAL) project: rationale, background, design and methodology.

A prolonged first episode of psychosis (FEP) without adequate treatment is a predictor of poor clinical, functional, and health outcomes and significant economic burden. Team-based "coordinated specialty care" (CSC) for early psychosis (EP) has established effectiveness in promoting clinical and functional recovery. However, California's CSC program implementation has been unsystematic and could benefit from standardizing its processes and data collection infrastructure. To address this, we established a consortium of EP clinics across the state via a Learning Health Care Network (LHCN) framework to develop the Early Psychosis Intervention Network of California (EPI-CAL). EPI-CAL's LHCN developed a core battery of evidence-based measures for service users and family members and linked them together using a unique data collection and visualization application, Beehive. EPI-CAL's LHCN collects, visualizes, and aggregates data at the individual and clinic level for EP programs across California via Beehive. Beehive was designed to: (1) collect outcomes data from service users receiving care at EP programs and their support persons, (2) provide the data to providers on a secure web-based dashboard to support measurement-based care, and (3) allow data to be used for program or research analysis. We will (1) determine the feasibility of implementing an LHCN across a diverse, decentralized network of early psychosis programs, (2) determine if the implementation of an LHCN increases the delivery of measurement-based care, and (3) determine if the implementation of measurement-based care is associated with significant improvements in key service user outcomes. EPI-CAL's network will contribute data to the Early Psychosis Intervention Network (EPINET) program. The current study aims to establish an LHCN of EP clinics in California that implements harmonized data collection using Beehive and assesses the feasibility of establishing such a network. Our goal is for this harmonized data collection approach to be used to inform decisions and develop learning opportunities for service users, staff, and administrators, and to improve outcomes for service users and their supporters in CSC care. Further, the data will enable programs and research teams to examine what elements of care lead to program success and improved treatment outcomes for service users. www. gov , identifier NCT04007510; registered 07/05/2019.

Developments in Dance Research: The UK Dance Research Matters Programme

The 2020 Dance Research Matters (DRM) campaign led to the launch of the £500,000 AHRC-funded Dance Research Matters Network programme towards the end of 2022. The article discusses the challenging backdrop against which it was formed, and how it exemplifies the mutual aims that researchers and funding bodies can achieve by working together. It asks what ‘resilience’ and ‘transformation’ might mean for alternative systems (and ways of being) within and beyond the human domain, and also for models of socio-political organisation at the shifting borders of the dance research sector. Examples and issues arising from the aims and events of the five DRM Networks illustrate how crucial it is when taking an ecological approach to funding dance research, for funders, institutions, researchers, and the Creative Industries to have an awareness of the complex and multi-layered implications involved for individuals, dance-related communities and others.

Toowoomba Healthy Towns: A Citizen Science Initiative on Active Transport in Regional South East Queensland, Australia.

Engaging in active transport will enable individuals across the life course to increase their habitual levels of physical activity. The aim of this study was to engage citizen scientists (CS) to identify factors that influence active transport in their community. The Our Voice citizen science methodology developed at Stanford University was employed. CS completed a "discovery walk," taking photos of things that help or hinder active transport. Three groups were recruited: children aged 10-12years (n = 11), adults (n = 12), and older adults >65years (n = 10). CS rated each photo and provided a narrative explaining their reason for taking the photo. Once all CS in a specific age group had completed the walk, they met for a group discussion. The CS worked together to analyze the data, arranging them into themes and identifying priority actions. Two CS representatives from each age group presented their findings to the local council decision makers. Children highlighted the need for safer crossings, especially from their school to the local park, and suggested zebra crossings as a solution. The adults highlighted that road signs prioritized vehicles, not pedestrians, and requested that this be reversed. Older adults noted that the poor condition of the pavements made it harder for people in wheelchairs to navigate. The CS recommendations have informed the council's walking and cycling network program. Engaging with citizen science provided the community with an opportunity to advocate for meaningful yet realistic improvements in the built environment that could promote neighborhood active transport and physical activity across the lifespan.

A multi-queue-based ECN marking strategy for multi-class QoS guarantee in programmable networks

Currently, network applications are experiencing explosive growth, and various types of network applications are showing a trend of varied demands for quality of network service. However, the existing Explicit Congestion Notification (ECN) marking methods have not taken into account the diversified Quality of Service (QoS) requirements of network applications. This article introduces a multi-queue ECN marking strategy targeting multiple QoS guarantees. The strategy utilizes virtual queues and dynamic weighted round-robin scheduling to achieve traffic partitioning in a programmable data plane. It constructs a multi-queue, multi-class QoS queuing model based on the QoS requirements of different traffic and network conditions. The model is solved by real-time to obtain the ECN marking thresholds and round-robin weights for different queues, in order to achieve dynamic QoS requirements of different network applications. We implemented this strategy in Mininet and BMv2, and compared it with DCQCN, P4QCN, and TCN. The experimental results indicate that this policy demonstrates good performance in terms of queue length, RTT, and throughput, while also ensuring fairness between traffics. Results of the experiment indicate that the proposed approach is superior to DCQCN and P4QCN in the field of performance fluctuation and rapid feedback, and it exhibits notable advantages over TCN, and also ensures the fairness of traffic.

Growing Need for Web-Based Simulation in Low and Middle-Income Countries: A Narrative Review

Web-based simulation programs are poised to offer a productive means of delivering asynchronous training in healthcare professionals’ education. Similarly, web-based simulation programs could also sponsor specialty-specific, web-based fellowships for clinicians of low- and middle-income countries. Web-Based Simulation has been utilized for instruction in critical care fields such as emergency medicine and pediatric anesthesia. Studies have shown that enhanced self-reported knowledge and confidence have been achieved through tele simulation which is in line with in-person simulation. During the COVID-19 pandemic, simulations have helped clinicians hone their use of personal protective equipment and other infection control measures. Additionally, it has helped them in learning new and expanded roles, like processing equipment and assisting infected patients in prone position experiencing respiratory failure. However, web-based simulation programs also have unique challenges that must be satisfied: reliable broadband internet network access, multilingual capability, and programming quality. Studies indicate that cost-effective simulation training can be delivered to learners in remote, low-resource areas worldwide, including South Asia, where access to such education is limited. We aimed to explore the effectiveness, challenges, and strategies for implementing web-based simulation education in low- and middle-income countries, based on a thorough PubMed search focused on web-based simulation programs in medical education.

Distribution of the Culex pipiens mosquito in mainland Portugal: a geospatial modelling study

Abstract Background The mosquito Culex pipiens is a vector for several pathogens, such as the West Nile virus. As the most abundant mosquito in Portugal, understanding its spatial distribution can support vector-borne diseases control and robust public health planning, given the mainland’s favourable climate for this vector. Information on its spatial distribution at a national level is limited, especially its association with climate variables. Thus we aimed to predict the suitability of Culex pipiens distribution in mainland Portugal, considering climate factors. Methods We used presence records for adult and larvae of Culex pipiens mosquitoes sampled across mainland Portugal from January 2017 to October 2023, as part of the Portuguese Vector Surveillance Network program (REVIVE). Between May-October, in random locations and throughout the year in point-of-entry sites, adult mosquito collection used CDC light traps and BG-Sentinel traps, and larvae collection used dippers in breeding sites. Sampling bias was corrected by filtering presence sites, retaining one record per each cell grid of 1 km2. Climatic data (including temperature, precipitation and elevation) were used as predictors in a maximum entropy (MaxEnt) model of the Culex pipiens geographical distribution. Results From the dataset of 6859 records, 1416 unique sites were obtained after filtering. Suitable habitats seem to be mainly distributed on the coast, particularly in Minho, Porto and Lisbon metropolitan areas, and Tagus Valley, with precipitation as the most important predictor. Conclusions Most West Nile Virus case reports come from the south of Portugal, but the potential distribution of Culex pipiens covers the whole mainland territory, with seemingly higher distribution on the north coast. However, bias due to convenience sampling could be present. West Nile vector surveillance should be a priority across all regions to accurately assess transmission risk and implement effective control measures. Key messages • The suitability of Culex pipiens distribution covers the entire mainland of Portugal, with higher presence in the north. • The distribution of Culex pipiens in the country points towards a need for developing region-specific strategies regarding West Nile Virus prevention and control.

Dissecting the temporal genetic networks programming soybean embryo development from embryonic morphogenesis to post-germination

Key messageDesiccation-stage transcription factors perform similar functions, with early ones focused on desiccation tolerance and later ones on development. Gene networks governing late embryo development diverge between soybean and Arabidopsis.To understand gene activities programming seed embryo development, we profiled the soybean embryo transcriptome across embryonic morphogenesis through post-germination. Transcriptomic landscapes across embryo development feature highly prevalent transcripts, categorized into early and late groups, with shared and distinct functions. During the mid-storage reserve accumulation stage, the upregulated genes are enriched with regulatory tasks at both the transcriptional and chromatin levels, including DNA methylation and chromatin remodeling. The epigenetic-related functions also dominate in the upregulated genes during germination, involving core histone variants and histone chaperones. Gene network analysis reveals both stage-specific modules and modules active across multiple stages. The desiccation-associated gene module integrates diverse transcription factors (TFs) that are sequentially active during different desiccation stages, transitioning from abiotic stress functions early on to developmental functions later. Two TFs, active during the early and mid-desiccation stages were functionally assessed in Arabidopsis overexpression lines to uncover their potential roles in desiccation processes. Interestingly, nearly half of the Arabidopsis orthologs of soybean TFs active in the desiccation-associated module are inactive during Arabidopsis desiccation. Our results reveal that chromatin and transcriptional regulation coordinate during mid-storage reserve accumulation, while distinct epigenetic mechanisms drive germination. Additionally, gene modules either perform stage-specific functions or are required across multiple stages, and gene networks during late embryogenesis diverge between soybean and Arabidopsis. Our studies provide new information on the biological processes and gene networks underlying development from embryonic morphogenesis to post-germination.

Enhancing Software‐Defined Networking With Dynamic Load Balancing and Fault Tolerance Using a Q‐Learning Approach

ABSTRACTThe Software‐Defined Networking (SDN) paradigm represents a fundamental shift in networking by decoupling the control plane from the data plane in network devices. This architectural change offers numerous advantages, including network programmability and centralized management capabilities, which improve scalability and efficiency compared to conventional network architectures. However, the dynamic nature of network traffic presents overload challenges, both temporally and spatially, especially in multi‐controller SDN settings. To address these challenges, this paper presents an approach leveraging network traffic patterns for dynamic load balancing. The proposed framework optimizes migration strategies to reduce costs and enhance in‐packet request‐response rates. By exploiting load ratio variance across controllers, the architecture identifies optimal migration triplets, encompassing migration‐in and migration‐out domains by selecting a subset of switches. The architecture utilizes online Q‐learning technology to achieve optimal controller load balancing while minimizing associated expenses. The proposed approach ensures stability and scalability by imposing limits to maintain maximum efficiency and reduce migration conflicts. It iteratively converges to an optimal policy through a comprehensive set of simulations performed on switches under a wide range of load distribution situations. These results highlight the effectiveness and adaptability of the proposed methodology in addressing the intricacies present in dynamic network settings, encouraging further progress in the field of SDN technologies and their real‐world applications.

Visual Modeling Method for Ship Piping Network Programs in Engine Simulators

Visual Modeling Method for Ship Piping Network Programs in Engine Simulators

Computing Precise Control Interface Specifications

Verifying network programs is challenging because of how they divide labor: the control plane computes high level routes through the network and compiles them to device configurations, while the data plane uses these configurations to realize the desired forwarding behavior. In practice, the correctness of the data plane often assumes that the configurations generated by the control plane will satisfy complex specifications. Consequently, validation tools such as program verifiers, runtime monitors, fuzzers, and test-case generators must be aware of these control interface specifications (ci-specs) to avoid raising false alarms. In this paper, we propose the first algorithm for computing precise ci-specs for network data planes. Our specifications are designed to be efficiently monitorable —concretely, checking that a fixed configuration satisfies a ci-spec can be done in polynomial time. Our algorithm, based on modular program instrumentation, quantifier elimination, and a path-based analysis, is more expressive than prior work, and is applicable to practical network programs. We describe an implementation and show that ci-specs computed by our tool are useful for finding real bugs in real-world data plane programs.

The Importance of the Role of Emergency Paramedics in Quickly Transporting Traffic Accident Cases to Health Facilities

This study aims to know the effect of ambulance transportation in reducing the rate of injuries for people injured in traffic accidents, the importance of the role of emergency paramedics in reducing the rate of injury for people transported to health facilities, a questionnaire was prepared via Google Drive and distributed to the population between the ages of 25-55 years from Men and women in the holy city of Mecca. The questionnaire was distributed via the social networking program (WhatsApp) for the purpose of distancing. 400 questionnaires were distributed, and 380 responses were obtained via email to the principal researcher. it concluded that everyone mentioned the importance of paramedics in transporting all dangerous cases (whether traffic accidents or other) in record time and with a very high degree of professionalism.

The Role of Nursing in Community Participation in Health Facilities

This study aims to the role of nursing in motivating the community to participate with health facilities, the impact of linking the community with health facilities for the benefit of tracking community participation and speeding up its resolution, the role of nursing with the community, especially in the presence of diseases and epidemics. , A questionnaire was prepared via Google Drive and distributed to the population aged 25-55 years, men and women, in the city of Mecca. As for the questionnaire, it was distributed via the social networking program (WhatsApp) for the purpose of distancing for fear of the presence of the Corona virus, 390 questionnaires were distributed, and 380 responses were obtained via email to the principal researcher.

Exploring the programmability of autocatalytic chemical reaction networks

Networks of chemical reactions exhibit emergent properties under out-of-equilibrium conditions. Recent advances in systems chemistry demonstrate that networks with sufficient chemical complexity can be harnessed to emulate properties important for neuromorphic computing. In all examples, autocatalysis appears an essential element for facilitating the nonlinear integration of the input and self-regulatory abilities in the output. How this chemical analogue of a positive feedback mechanism can be controlled in a programmable manner is, however, unexplored. Here, we develop a strategy that uses metal ions (Ca2+, La3+, and Nd3+) to control the rate of a trypsin-catalysed autocatalytic reaction network. We demonstrate that this type of control allows for tuning the kinetics in the network, thereby changing the nature of the positive feedback. The simulations and experiments reveal that an input with one or more metal ions allow for temporal and history-dependent outputs that can be mapped onto a variety of mathematical functions.

Coordinated active-reactive power optimization considering photovoltaic abandon based on second order cone programming in active distribution networks

On the basis of predecessors’ coordination optimization of active and reactive power in distribution network, For the necessity of the optimal operation in the distribution network, part of power generated from photovoltaic (PV) cannot be sold to users, and cannot enjoy subsidies. Similarly, the network loss in the power transmission will also bring a certain economic loss. This paper comprehensively considers the economic loss caused by the network loss and PV abandon of the distribution system, and establishes a model to minimize the economic loss. To solve this problem efficiently, the method of DistFlow equation and mixed integer second order cone programming (MISOCP) is used to solve the problem, in this method, the original mixed integer nonlinear programming non-convex problem is transformed into a convex problem, which makes the optimization problem easy to solve. The modified IEEE 33 and IEEE 69 distribution networks are tested by the above method. The optimized results are able to meet the target and have very small relaxation gaps, and the voltage level is also optimized. This coordinated optimization approach helps to optimize the economic operation for active distribution networks with PVs.

The Role of Nursing in Crises and Disasters

The current study aims what is the meaning of disasters, what is the relationship between national disasters and high rates of disease and mortality? what is the relationship between nursing care during emergencies and disasters? Is there a specialized department concerned with disasters and crises in Saudi Arabia? Are there courses and training plans dealing with disasters and crises in the workplaces? A questionnaire was prepared via Google Drive and distributed to the population aged 25-55 years, men and women in city of mecca. As for the questionnaire, it was distributed via the social networking program (WhatsApp) for the purpose of distancing for fear of the presence of the Corona virus. 380 questionnaires were distributed, 365 responses were obtained via email to the principal researcher. This study concluded that nursing provides many nursing services to the injured during emergencies, crises, and natural disasters, checking for fractures or dislocations in the body or limbs, and if the bones are visible, they must be covered with a clean, sterile bandage, and not move the injured person if the fracture is in the spine. Apply clean, sterile bandages to other wounds. The patient should also be closely monitored and given any possible nursing care with any type of belt and chemical, manual, or mechanical restraints according to the doctor’s orders and instructions, according to the opinions of 94.4% of participants.

Importance of Time Management for Nursing Specialization

The current study aims the impact of time management on nursing time management on health services, and its impact on time management among patients and workers in health facilities.? A questionnaire was prepared via Google Drive and distributed to the population aged 25-55 years, men and women in city of mecca. As for the questionnaire, it was distributed via the social networking program (WhatsApp) for the purpose of distancing for fear of the presence of the Corona virus. 390 questionnaires were distributed, 385 responses were obtained via email to the principal researcher. find that most of the participants agreed that the nurse’s time management is important for the rest of the day on time for all patients by 100%, and that time management is important in reducing fatigue and ensuring the quality of patient care by 100%, and that planning saves the nurse a lot and thus he can focus a lot of 100% tasks.

The Role of Nursing is to Alert Patients to take Treatment in a Timely Manner

This study aims The aim of the study is the effect of taking treatment by patients in a timely manner, the effect of taking treatment in a timely manner in preventing the side effects of the disease, the role of taking treatment in preventing other diseases for the patient, A questionnaire was prepared via Google Drive and distributed to the population aged 25-55 years, men and women, in the city of Mecca. As for the questionnaire, it was distributed via the social networking program (WhatsApp) for the purpose of distancing for fear of the presence of the Corona virus. 410 questionnaires were distributed, and 390 responses were obtained via email to the principal researcher.

The Importance of Nursing in Modern Health Care Developments

This study aims to ,the impact of nursing on modern health care for patients and patients, the impact of nursing on health services provided to patients and patients, the impact of health services provided by nursing on patients in health facilities., A questionnaire was prepared via Google Drive and distributed to the population aged 25-55 years, men and women, in the city of Mecca. As for the questionnaire, it was distributed via the social networking program (WhatsApp) for the purpose of distancing for fear of the presence of the Corona virus. 400 questionnaires were distributed, and 380 responses were obtained via email to the principal researcher.

The Impact of Nurses Completing their Educational Attainment on the Health Services Provided to Patients and Reviews in Health Centers

This current study aims to know the impact of a nurse completing his educational attainment and its impact on the health services provided to society in general. It is also important to know the effect of completing his educational attainment on the quality of work and better dealing with patients and medical staff. It is also important to know its impact on increasing the organization of his time at work. Knowing its impact on increasing his efficiency in his work environment, A questionnaire was prepared via Google Drive and distributed to the population aged 25-55 years, men and women, in the city of Mecca. As for the questionnaire, it was distributed via the social networking program (WhatsApp) for the purpose of distancing for fear of the presence of the Corona virus. 400 questionnaires were distributed, and 395 responses were obtained via email to the principal researcher. The current study concluded that the impact of completing the educational attainment of male and female nurses and its impact on the health service provided was a very positive impact of 94.8%, and it also helped improve the health service provided to patients by a greater percentage of 90%.